Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 9, 2005, Pages 3395-3400

  Burgess, Michael R ^a   Skaggs, Brian J ^a   Shah, Neil P ^b   Lee, Francis Y ^c   Sawyers, Charles L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

BMS 354825; Chronic myeloid leukemia; Imatinib mutagenesis

Indexed keywords

BCR ABL PROTEIN; DASATINIB; IMATINIB; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CELL GROWTH; CONTROLLED STUDY; DRUG BINDING SITE; DRUG EFFECT; DRUG SENSITIVITY; ENZYME CONFORMATION; GENE MUTATION; IC 50; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL;

BASE SEQUENCE; CELL LINE; DNA PRIMERS; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES;

EID: 14744274624     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0409770102     Document Type: Article

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