Scaffolds, adaptors and linkers of TCR signaling: Theory and practice

Current Opinion in Immunology

Volumn 14, Issue 3, 2002, Pages 312-316

  Burack, W Richard ^a   Cheng, Alec M ^a   Shaw, Andrey S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BINDING PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN; RAS PROTEIN;

CATALYSIS; ENZYME ACTIVITY; LYMPHOCYTE; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0036604986     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(02)00347-3     Document Type: Review

References (41)

1. The role of adapter proteins in T cell activation
2. Lymphocytes with a complex: Adapter proteins in antigen receptor signaling
3. Signalling scaffolds and adaptors in T-cell immunity
4. The role of membrane-associated adaptors in T cell receptor signalling
5. The role of SLP-76 and LAT in lymphocyte development
6. Integration of T cell receptor-dependent signaling pathways by adapter proteins
7. Kinetic proofreading in T-cell receptor signal transduction
8. Akap mediated signal transduction
9. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules
10. Signal transduction: Hanging on a scaffold
11. Anchoring and scaffold proteins for kinases and phosphatases
12. Signal transduction: Signaling specificity - A complex affair
13. Mechanisms through which Sos-1 coordinates the activation of Ras and Rac
14. Association of Grb2, Gads, and phospholipase C-γ 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling
15. Identification of the minimal tyrosine residues required for linker for activation of T cell function
16. Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells
17. Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development
18. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs
19. Differential requirement for SLP-76 domains in T cell development and function
20. Differential role of SLP-76 domains in T cell development and function
21. Identification of a phospholipase C-γ1 (PLC-γ1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-γ1 and NFAT
22. Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes
23. Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes
24. Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling
25. Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling
26. Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane
27. Functional association between SLAP-130 and SLP-76 in Jurkat T cells
28. Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production
29. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton
30. Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap
31. Coupling of the TCR to integrin activation by Slap-130/Fyb
32. A novel function for the SLAP-130/FYB adapter protein in beta 1 integrin signaling and T lymphocyte migration
33. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors
34. Requirement for the SLP-76 adaptor GADS in T cell development
35. CD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of antigen receptor signaling
36. Caspase-dependent cleavage of the hematopoietic specific adaptor protein Gads alters signalling from the T cell receptor
37. HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1
38. The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR
39. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling
40. The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection
41. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling