Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

Nature

Volumn 426, Issue 6965, 2003, Pages 454-460

  Sakaguchi, Noriko ^a,b   Takahashi, Takeshi ^a   Hata, Hiroshi ^a   Nomura, Takashi ^a   Tagami, Tomoyuki ^a   Yamazaki, Sayuri ^a   Sakihama, Toshiko ^a   Matsutani, Takaji ^c   Negishi, Izumi ^d   Nakatsuru, Syuichi ^a   Sakaguchi, Shimon ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b RIKEN   (Japan)

^c SHIONOGI AND CO LTD   (Japan)

^d GUNMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BIOLOGICAL MEMBRANES; CLONING; DISEASES; JOINTS (ANATOMY); PATIENT MONITORING;

RHEUMATOID ARTHRITIS (RA); SIGNAL TRANSDUCTION;

GENES;

T LYMPHOCYTE RECEPTOR;

GENETICS; IMMUNE SYSTEM;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; GENE; GENE MUTATION; GENETIC ANALYSIS; GENETIC CODE; GENETIC LINKAGE; HETEROZYGOSITY; LYMPHOCYTE CLONE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMUS; ZAP 70 GENE;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; ARTHRITIS, RHEUMATOID; BASE SEQUENCE; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; FEMALE; MALE; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; T-LYMPHOCYTES; THYMUS GLAND; ZAP-70 PROTEIN-TYROSINE KINASE;

ANIMALIA;

EID: 0345414139     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02119     Document Type: Article

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