The capsaicin analogue SDZ249-665 attenuates the hyper-reflexia and referred hyperalgesia associated with inflammation of the rat urinary bladder

Pain

Volumn 89, Issue 2-3, 2001, Pages 229-235

  Jaggar, Siân I ^a   Scott, Helena C F ^a   James, Iain F ^b   Rice, Andrew S C ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b Novartis Inst for Medical Research   (United Kingdom)

Author keywords

Cystitis; Pain; Visceral

Indexed keywords

CAPSAICIN DERIVATIVE; SDZ 249 665; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYSTITIS; DOSE RESPONSE; FEMALE; HYPERALGESIA; HYPERREFLEXIA; LATENT PERIOD; NONHUMAN; PRIORITY JOURNAL; RAT; VISCERAL PAIN; WITHDRAWAL REFLEX;

ALGORITHMS; ANALGESICS; ANIMALS; CAPSAICIN; CYSTITIS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERALGESIA; MALE; RATS; RATS, WISTAR; REFLEX; TIME FACTORS; TURPENTINE; URINATION;

EID: 0035125971     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(00)00366-3     Document Type: Article

References (46)

1. The effect of changes in temperature and humidity on the accuracy of von Frey hairs
2. Relief of pain following intravesical capsaicin in patients with hypersensitive disorders of the lower urinary tract
3. Sex differences in pain
4. Cellular mechanisms of the action of capsaicin
5. Sensory neuron-specific actions of capsaicin: Mechanisms and applications
6. Increased c-fos expression in the spinal neurons after irritation of the lower urinary tract in the rat
7. Sex, time-of-day and estrous variations in behavioral and bladder histological consequences of cyclophosphamide-induced cystitis in rats
8. Capsaicin in treatment of loin pain/haematuria syndrome
9. Estrous variations in behavioral responses to vaginal and uterine distension in the rat
10. The capsaicin receptor: A heat-activated ion channel in the pain pathway
11. Desensitization follows excitation of bladder primary afferents by intravesical capsaicin, as shown by c-fos activation in the rat spinal cord
12. Desensitization of bladder sensory fibers by intravesical capsaicin has long lasting clinical and urodynamic effects in patients with hyperactive or hypersensitive bladder dysfunction
13. The effect of capsaicin on nerve densities in the human urinary bladder
14. c.fos induction in a rat model of cystitis: Role of NGF
15. Capsaicin, nociception and pain
16. Intravesical capsaicin for neurogenic bladder dysfunction
17. Clinical and urodynamic effects of intravesical capsaicin treatment in patients with chronic traumatic spinal detrusor hyperreflexia
18. Recent and forgotten aspects of visceral pain
19. Spinal cord injury and management of paraplegia
20. Interstitial cystitis: Increased sympathetic innervation and related neuropeptide synthesis
21. 2 receptor antagonists upon viscero-visceral hyper-reflexia in a rat model of visceral hyperalgesia
22. The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain
23. The endogenous cannabinoid anandamide, but not the CB2 ligand palmitoylethanolamide, prevents the viscero-visceral hyper-reflexia associated with inflammation of the rat urinary bladder
24. Inflammation of the rat urinary bladder is associated with a referred thermal hyperalgesia which is nerve growth factor dependent
25. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones
26. Intravesical capsaicin for treatment of severe bladder pain: A randomized placebo controlled study
27. The effects of topical capsaicin on rat urinary bladder motility in vivo
28. Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of micturition reflex in humans
29. Cyclophosphamide-induced cystitis in rats: Involvement of capsaicin-sensitive primary afferents
30. Neuronal and behavioural consequences of chemical inflammation of the rat urinary bladder
31. Are there fundamental differences in the peripheral mechanisms of visceral and somatic pain?
32. A model for the study of visceral pain states: Chronic inflammation of the chronic decerebrate rat urinary bladder by irritant chemicals
33. Changes in the afferent innervation of the inflamed urinary bladder
34. Visceral pain
35. 1 cannabinoid receptors
36. Intravesical capsaicin for treatment of neurogenic bladder
37. Mechanical hyperalgesia is referred to the hind limb following inflammation of the urinary bladder in the rat
38. The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)
39. Characterization of a peripheral vanilloid (capsaicin) receptor in the urinary bladder of the rat
40. The vanilloid (capsaicin) receptor: Receptor types and species differences
41. Actions of capsaicin on sensory receptors
42. Dermatomes in the rat limbs as determined by antidromic stimulation of sensory C-fibres in spinal nerves
43. In vivo pharmacology of SDZ 249-665, a novel, non-pungent capsaicin analogue
44. Capsaicin and pain mechanisms
45. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide