Daily body temperature rhythm and heat tolerance in TRPV1 knockout and capsaicin pretreated mice

European Journal of Neuroscience

Volumn 19, Issue 5, 2004, Pages 1421-1424

  Szelenyi Z ^a   Hummel, Z ^a   Szolcsanyi J ^a,b   Davis, J B ^c  

^a UNIVERSITY OF PÉCS   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Biotelemetry; Body temperature; Capsaicin; Heat tolerance; TRPV1 knockout mice

Indexed keywords

CAPSAICIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; CORE TEMPERATURE; DESENSITIZATION; HEAT TOLERANCE; IN VIVO STUDY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; TELEMETRY; WILD TYPE;

ANIMALS; BODY TEMPERATURE; CAPSAICIN; CIRCADIAN RHYTHM; HEAT; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, DRUG;

EID: 1642368112     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2004.03221.x     Document Type: Article

References (23)

1. Benham, C.D., Davis, J.B. & Randall, A.D. (2002) Vanilloid and TRP channels: a family of lipid-gated cation channels. Neuropharmacology, 42, 873-888.
2. Caterina, M.J., Leffler, L., Malmberg, A.B., Martin, W.J., Trafton, J., Petersen-Zeitz, K.R., Koltzenburg, M., Basbaum, A.I. & Julius, D. (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science, 288, 306-313.
3. Caterina, M.J., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D. & Julius, D. (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature, 389, 816-824.
4. Davis, J.B., Gray, J., Gunthorpe, M.J., Hatcher, J.P., Davey, P.T., Overend, P., Harries, M.H., Latcham, J., Clapham, C., Atkinson, K., Hughes, S.A., Rance, K., Grau, E., Harper, A.J., Pugh, P.L., Rogers, D.C., Bingham, S., Randall, A. & Sheardowns, S.A. (2000) Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature, 405, 183-187.
5. Gordon, C.J. (1993) Temperature Regulation in Laboratory Rodents. Cambridge University Press, Cambridge.
6. Güler, A.D., Lee, H., Iida, T., Shimizu, I., Tominaga, M. & Caterina, M. (2002) Heat-evoked activation of the ion channel, TRPV4. J. Neurosci., 22, 6408-6414.
7. Hayes, P., Meadows, H.J., Gunthorpe, M.J., Harries, M.H., Duckworth, D.M., Cairns, W., Harrison, D.C., Clarke, C.E., Ellington, K., Prinjha, R.K., Barton, A.J.L., Medhurst, A.D., Smith, G.D., Topp, S., Murdock, P., Sanger, G.J., Terrett, J., Jenkins, O., Benham, C.D., Randall, A.D., Gloger, I.S. & Davis, J.B. (2000) Cloning and functional expression of a human orthologue of rat vanilloid receptor-1. Pain, 88, 205-215.
8. Hori, T. (1984) Capsaicin and central control of thermoregulation. Pharmac. Ther., 26, 389-416.
9. Jancsó-Gábor, A., Szolcsányi, J. & Jancsó, N. (1970a) Irreversible impairment of thermoregulation induced by capsaicin and similar pungent substances in rats and guinea-pigs. J. Physiol. (Lond.), 206, 495-507.
10. Jancsó-Gábor, A., Szolcsányi, J. & Jancsó, N. (1970b) Stimulation and desensitization of the hypothalamic heat-sensitive structures by capsaicin in rats. J. Physiol. (Lond.), 208, 449-459.
11. Kozak, W., Conn, C.A. & Kluger, M.J. (1994) Lipopolysaccaride induces fever and depresses locomotor activity in unrestrained mice. Am. J. Physiol., 266, R125-R135.
12. Leon, R.L. (2002) Invited Review: Cytokine regulation of fever: studies using gene knockout mice. J. Appl. Physiol., 92, 2648-2655.
13. McKemy, D.D., Neuhausser, W.M. & Julius, D. (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature, 416, 52-58.
14. Nilius, B., Watanabe, H. & Vries, J. (2003) The TRP4 channel: structure-function relationship and promiscuous behaviour. Pflügers Arch., 446, 298-303.
15. Refinetti, R. (1992) The circadian rhythm of body temperature. Physiol. Behav., 51, 613-637.
16. Smith, G.D., Gunthorpe, M.J., Kelsell, R.E., Hayes, P.D., Reilly, P., Facer, P., Wright, J.E., Jerman, J.C., Wahlin, J.-P., Ooi, L., Egerton, J., Charles, K.J., Smart, D., Randall, A.D., Anand, P. & Davis, J.B. (2002) TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature, 418, 186-190.
17. Suzuki, M., Mizuno, A., Kodaira, K. & Imai, M. (2003) Impaired pressure sensation in mice lacking TRPV4. J. Biol. Chem., 278, 22664-22668.
18. Szelényi, Z., Hummel, Z. & Székely, M. (2000) Circadian and ultradian body core temperature rhythms of rats as influenced by cold exposure and/or food restriction. J. Physiol. (Lond.), 526, 169P.
19. Szolcsányi, J. (1983) Disturbances of thermoregulation induced by capsaicin. J. Therm. Biol., 8, 207-212.
20. Szolcsányi, J. (2002) Capsaicin receptors as target molecules on nociceptors for development of novel analgesic agents. In Kéri, G. & Toth, I. (Ed.), Molecular Pathomechanisms and New Trends in Drug Research. Taylor & Francis, London and New York, pp. 319-333.
21. Szolcsányi, J., Joó, F. & Jancsó-Gábor, A. (1971) Mitochondrial changes in preoptic neurones after capsaicin desensitization of the hypothalamic thermodetectors in rats. Nature, 229, 116-117.
22. Weinert, D. & Waterhouse, J. (1998) Diurnally changing effects of locomotor activity on body temperature in laboratory mice. Physiol. Behav., 63, 837-843.
23. Xu, H., Ramsey, I.S., Kotecha, S.A., Moran, M.M., Chong, J.A., Lawson, D., Ge, P., Lilly, J., Silos-Santiago, I., Xie, Y., DiStefano, P.S., Curtis, R. & Clapham, D.E. (2002) TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature, 418, 181-186.