메뉴 건너뛰기




Volumn 24, Issue 2, 2008, Pages 142-154

Capsaicin (TRPV1 agonist) therapy for pain relief: Farewell or revival?

Author keywords

Capsaicin; Desensitization; Resiniferatoxin; Selective neurotoxicity; TRPV1 receptor

Indexed keywords

1 (2 BROMOPHENYL) 3 [1 (5 TRIFLUOROMETHYL 2 PYRIDINYL) 3 PYRROLIDINYL]UREA; ADLEA; ALDEA; ANALGESIC AGENT; CAPSAICIN; CAPSAICIN DERIVATIVE; CIS CAPSAICIN; NGX 4010; PLACEBO; RTX; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 AGONIST;

EID: 38549118896     PISSN: 07498047     EISSN: None     Source Type: Journal    
DOI: 10.1097/AJP.0b013e318158ed9e     Document Type: Review
Times cited : (268)

References (153)
  • 3
    • 0345616438 scopus 로고    scopus 로고
    • ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
    • Story GM, Peier AM, Reeve AJ, et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003;112:819-829.
    • (2003) Cell , vol.112 , pp. 819-829
    • Story, G.M.1    Peier, A.M.2    Reeve, A.J.3
  • 4
    • 0033119629 scopus 로고    scopus 로고
    • A capsaicin receptor homologue with a high threshold for noxious heat
    • Caterina MJ, Rosen TA, Tominaga M, et al. A capsaicin receptor homologue with a high threshold for noxious heat. Nature. 1999;398:436-441.
    • (1999) Nature , vol.398 , pp. 436-441
    • Caterina, M.J.1    Rosen, T.A.2    Tominaga, M.3
  • 5
    • 33646899582 scopus 로고    scopus 로고
    • A heat-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels
    • Brauchi S, Orta G, Salazaar M, et al. A heat-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels. J Neurosci. 2006;26:4835-4840.
    • (2006) J Neurosci , vol.26 , pp. 4835-4840
    • Brauchi, S.1    Orta, G.2    Salazaar, M.3
  • 6
    • 23044500197 scopus 로고    scopus 로고
    • Conservation of functional and pharmacological properties in the distantly related temperature sensors TRPV1 and TRPM8
    • Weil A, Moore SE, Waite SJ, et al. Conservation of functional and pharmacological properties in the distantly related temperature sensors TRPV1 and TRPM8. Mol Pharmacol. 2005;68:518-527.
    • (2005) Mol Pharmacol , vol.68 , pp. 518-527
    • Weil, A.1    Moore, S.E.2    Waite, S.J.3
  • 7
    • 34547448651 scopus 로고    scopus 로고
    • TRP channels: Targets for the relief of pain
    • Epub ahead of print
    • Levine JD, Alessandri-Haber N. TRP channels: targets for the relief of pain. Biochim Biophys Acta. 2007. [Epub ahead of print].
    • (2007) Biochim Biophys Acta
    • Levine, J.D.1    Alessandri-Haber, N.2
  • 8
    • 4644339264 scopus 로고    scopus 로고
    • TRPV1 and the gut: From a tasty receptor for a painful vanilloid to a key player in hyperalgesia
    • Holzer P. TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia. Eur J Pharmacol. 2004; 500:231-241.
    • (2004) Eur J Pharmacol , vol.500 , pp. 231-241
    • Holzer, P.1
  • 11
    • 0030777012 scopus 로고    scopus 로고
    • The capsaicin receptor: A heat-activated ion channel in the pain pathway
    • Caterina MJ, Schumacher MA, Tominaga M, et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 1997;389:816-824.
    • (1997) Nature , vol.389 , pp. 816-824
    • Caterina, M.J.1    Schumacher, M.A.2    Tominaga, M.3
  • 12
    • 0023833519 scopus 로고
    • The sensory-efferent function of capsaicinsensitive sensory neurons
    • Maggi CA, Meli A. The sensory-efferent function of capsaicinsensitive sensory neurons. Gen Pharmacol. 1988;19:1-43.
    • (1988) Gen Pharmacol , vol.19 , pp. 1-43
    • Maggi, C.A.1    Meli, A.2
  • 13
    • 9644279616 scopus 로고    scopus 로고
    • Forty years in capsaicin research for sensory pharmacology and physiology
    • Szolcsányi J. Forty years in capsaicin research for sensory pharmacology and physiology. Neuropeptides. 2004;38:377-384.
    • (2004) Neuropeptides , vol.38 , pp. 377-384
    • Szolcsányi, J.1
  • 14
    • 0034646740 scopus 로고    scopus 로고
    • Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    • Caterina MJ, Leffler A, Malmberg AB, et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science. 2000;288:306-313.
    • (2000) Science , vol.288 , pp. 306-313
    • Caterina, M.J.1    Leffler, A.2    Malmberg, A.B.3
  • 15
    • 0034636441 scopus 로고    scopus 로고
    • Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
    • Davis JB, Gray J, Gunthorpe MJ, et al. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature. 2000;405:183-187.
    • (2000) Nature , vol.405 , pp. 183-187
    • Davis, J.B.1    Gray, J.2    Gunthorpe, M.J.3
  • 16
    • 25844464116 scopus 로고    scopus 로고
    • Investigation of the role of TRPV1 in acute and chronic nociceptive processes using genedeficient mice
    • Bölcskei K, Helyes ZS, Szabó A, et al. Investigation of the role of TRPV1 in acute and chronic nociceptive processes using genedeficient mice. Pain. 2005;117:368-376.
    • (2005) Pain , vol.117 , pp. 368-376
    • Bölcskei, K.1    Helyes, Z.S.2    Szabó, A.3
  • 17
    • 33749050585 scopus 로고    scopus 로고
    • Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo
    • Christoph T, Grunweller A, Mika J, et al. Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. Biophys Biochem Res Comm. 2006;350:238-243.
    • (2006) Biophys Biochem Res Comm , vol.350 , pp. 238-243
    • Christoph, T.1    Grunweller, A.2    Mika, J.3
  • 18
    • 33847137308 scopus 로고    scopus 로고
    • Starch fossils and the domestication and dispersal of Chili peppers (Capsicum spp. L.) in the Americas
    • Perry L, Dickau R, Zarrillo S, et al. Starch fossils and the domestication and dispersal of Chili peppers (Capsicum spp. L.) in the Americas. Science. 2007;315:986-988.
    • (2007) Science , vol.315 , pp. 986-988
    • Perry, L.1    Dickau, R.2    Zarrillo, S.3
  • 19
    • 0032970173 scopus 로고    scopus 로고
    • Vanilloid (capsaicin) receptors and mechanisms
    • Szallasi A, Blumberg PM. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev. 1999;51:159-212.
    • (1999) Pharmacol Rev , vol.51 , pp. 159-212
    • Szallasi, A.1    Blumberg, P.M.2
  • 20
    • 1942467891 scopus 로고    scopus 로고
    • Systematic review of topical capsaicin for the treatment of chronic pain
    • Mason L, Moore A, Derry S, et al. Systematic review of topical capsaicin for the treatment of chronic pain. Br Med J. 2004;328:991-997.
    • (2004) Br Med J , vol.328 , pp. 991-997
    • Mason, L.1    Moore, A.2    Derry, S.3
  • 21
    • 33847104189 scopus 로고    scopus 로고
    • Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: Therapeutic targets to treat inflammatory and neuropathic pain
    • Ma W, Quirion R. Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain. Expert Opin Ther Targets. 2007;11:307-320.
    • (2007) Expert Opin Ther Targets , vol.11 , pp. 307-320
    • Ma, W.1    Quirion, R.2
  • 22
    • 34248138496 scopus 로고    scopus 로고
    • The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
    • Szallasi A, Cortright DN, Blum CA, et al. The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Disc. 2007;6:357-372.
    • (2007) Nat Rev Drug Disc , vol.6 , pp. 357-372
    • Szallasi, A.1    Cortright, D.N.2    Blum, C.A.3
  • 23
    • 38549151594 scopus 로고    scopus 로고
    • The TRPV1 receptor and nociception
    • Epub ahead of print
    • Immke DC, Gavva NR. The TRPV1 receptor and nociception. Semin Cell Develop Biol. 2007. [Epub ahead of print].
    • (2007) Semin Cell Develop Biol
    • Immke, D.C.1    Gavva, N.R.2
  • 24
    • 0034700494 scopus 로고    scopus 로고
    • Induction of vanilloid receptor channel activity by protein kinase C
    • Premkumar LS, Ahern GP. Induction of vanilloid receptor channel activity by protein kinase C. Nature. 2000;408:985-990.
    • (2000) Nature , vol.408 , pp. 985-990
    • Premkumar, L.S.1    Ahern, G.P.2
  • 25
    • 0035425705 scopus 로고    scopus 로고
    • Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide
    • Vellani V, Mapplebeck S, Moriondo A, et al. Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. J Physiol. 2001;534:813-825.
    • (2001) J Physiol , vol.534 , pp. 813-825
    • Vellani, V.1    Mapplebeck, S.2    Moriondo, A.3
  • 26
    • 0346118925 scopus 로고    scopus 로고
    • Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway
    • Mohapatra DP, Nau C. Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway. J Biol Chem. 2003;278:50080-50090.
    • (2003) J Biol Chem , vol.278 , pp. 50080-50090
    • Mohapatra, D.P.1    Nau, C.2
  • 27
    • 0035927651 scopus 로고    scopus 로고
    • Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
    • Chuang HH, Prescott ED, Kong H, et al. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature. 2001;411:957-962.
    • (2001) Nature , vol.411 , pp. 957-962
    • Chuang, H.H.1    Prescott, E.D.2    Kong, H.3
  • 28
    • 4644320317 scopus 로고    scopus 로고
    • Posttranslational mechanisms of peripheral sensitization
    • Bhave G, Gereau RW IV. Posttranslational mechanisms of peripheral sensitization. J Neurobiol. 2004;61:88-106.
    • (2004) J Neurobiol , vol.61 , pp. 88-106
    • Bhave, G.1    Gereau, R.I.2
  • 29
    • 34250202592 scopus 로고    scopus 로고
    • TRPV1 antagonists as a potential treatment for hyperalgesia
    • Roberts LA, Connor M. TRPV1 antagonists as a potential treatment for hyperalgesia. Recent Patents on CNS Drug Disc. 2006;1:65-76.
    • (2006) Recent Patents on CNS Drug Disc , vol.1 , pp. 65-76
    • Roberts, L.A.1    Connor, M.2
  • 30
    • 33746080459 scopus 로고    scopus 로고
    • TRP channels as therapeutic targets: Hot property, or time to cool down?
    • Hicks GA. TRP channels as therapeutic targets: hot property, or time to cool down? Neurogastroenterol Motil. 2006;18:590-594.
    • (2006) Neurogastroenterol Motil , vol.18 , pp. 590-594
    • Hicks, G.A.1
  • 31
    • 26244446396 scopus 로고    scopus 로고
    • TRPV1 desensitization and endogenous vanilloid involvement in the enhanced analgesia induced by capsaicin in inflamed tissues
    • Baamonde A, Lastra A, Juarez L, et al. TRPV1 desensitization and endogenous vanilloid involvement in the enhanced analgesia induced by capsaicin in inflamed tissues. Brain Res Bull. 2005;67:476-481.
    • (2005) Brain Res Bull , vol.67 , pp. 476-481
    • Baamonde, A.1    Lastra, A.2    Juarez, L.3
  • 32
    • 0034762747 scopus 로고    scopus 로고
    • Four response stages of capsaicin-sensitive primary afferent neurons to capsaicin and its analogs: Gastric acid secretion, gastric mucosal damage and protection
    • Mózsik G, Vincze A, Szolcsányi J. Four response stages of capsaicin-sensitive primary afferent neurons to capsaicin and its analogs: gastric acid secretion, gastric mucosal damage and protection. J Gastroenterol Hepatol. 2001;16:1093-1097.
    • (2001) J Gastroenterol Hepatol , vol.16 , pp. 1093-1097
    • Mózsik, G.1    Vincze, A.2    Szolcsányi, J.3
  • 33
    • 0034926291 scopus 로고    scopus 로고
    • The vanilloid receptor: A molecular gateway to the pain pathway
    • Caterina MJ, Julius D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci. 2001;24:487-517.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 487-517
    • Caterina, M.J.1    Julius, D.2
  • 34
    • 26444511606 scopus 로고    scopus 로고
    • Structure and function of TRPV1
    • Tominaga M, Tominaga T. Structure and function of TRPV1. Pfluger's Arch. 2005;451:143-150.
    • (2005) Pfluger's Arch , vol.451 , pp. 143-150
    • Tominaga, M.1    Tominaga, T.2
  • 35
    • 22944473968 scopus 로고    scopus 로고
    • Activation and activators of TRPV1 and their pharmacological implications
    • Suh YG, Oh U. Activation and activators of TRPV1 and their pharmacological implications. Curr Pharm Des. 2005;11:2687-2698.
    • (2005) Curr Pharm Des , vol.11 , pp. 2687-2698
    • Suh, Y.G.1    Oh, U.2
  • 37
    • 0015214557 scopus 로고
    • Mitochondrial changes in preoptic neurons after capsaicin desensitization of the hypothalamic thermodetectors in rats
    • Szolcsányi J, Joó F, Jancsó-Gábor A. Mitochondrial changes in preoptic neurons after capsaicin desensitization of the hypothalamic thermodetectors in rats. Nature. 1971;229:116-117.
    • (1971) Nature , vol.229 , pp. 116-117
    • Szolcsányi, J.1    Joó, F.2    Jancsó-Gábor, A.3
  • 38
    • 0032997385 scopus 로고    scopus 로고
    • Selective induction of apoptosis by capsaicin in transformed cells: The role of reactive oxygen species and calcium
    • Macho A, Calzado MA, Munoz-Blanco J, et al. Selective induction of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium. Cell Death Differ. 1999;6:155-165.
    • (1999) Cell Death Differ , vol.6 , pp. 155-165
    • Macho, A.1    Calzado, M.A.2    Munoz-Blanco, J.3
  • 39
    • 0017720392 scopus 로고
    • Pharmacologically induced selective degeneration of chemosensitive primary sensory neurons
    • Jancsó G, Király E, Jancsó-Gábor A. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurons. Nature. 1977;270:741-743.
    • (1977) Nature , vol.270 , pp. 741-743
    • Jancsó, G.1    Király, E.2    Jancsó-Gábor, A.3
  • 40
    • 0032211125 scopus 로고    scopus 로고
    • Intradermal injection of capsaicin in humans produces degeneration and subsequent reinnervation of epidermal nerve fibers: Correlation with sensory function
    • Simone DA, Nolano M, Johnson T, et al. Intradermal injection of capsaicin in humans produces degeneration and subsequent reinnervation of epidermal nerve fibers: correlation with sensory function. J Neurosci. 1998;18:8947-8959.
    • (1998) J Neurosci , vol.18 , pp. 8947-8959
    • Simone, D.A.1    Nolano, M.2    Johnson, T.3
  • 41
    • 0032954612 scopus 로고    scopus 로고
    • Topical capsaicin in humans: Parallel loss of epidermal nerve fibers and pain sensation
    • Nolano M, Simone DA, Wendelschafer-Crabb G, et al. Topical capsaicin in humans: parallel loss of epidermal nerve fibers and pain sensation. Pain. 1999;81:135-145.
    • (1999) Pain , vol.81 , pp. 135-145
    • Nolano, M.1    Simone, D.A.2    Wendelschafer-Crabb, G.3
  • 42
    • 0035693147 scopus 로고    scopus 로고
    • A light- and electronmicroscopic histopathological study of human bladder mucosa after intravesical resiniferaroxin application
    • Silva C, Avelino A, Souto-Moura C, et al. A light- and electronmicroscopic histopathological study of human bladder mucosa after intravesical resiniferaroxin application. BJU Int. 2001;88:355-360.
    • (2001) BJU Int , vol.88 , pp. 355-360
    • Silva, C.1    Avelino, A.2    Souto-Moura, C.3
  • 43
    • 27644551317 scopus 로고    scopus 로고
    • Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model
    • Brown DC, Iadarola MJ, Perkowski SZ, et al. Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model. Anesthesiology. 2005;103:1052-1059.
    • (2005) Anesthesiology , vol.103 , pp. 1052-1059
    • Brown, D.C.1    Iadarola, M.J.2    Perkowski, S.Z.3
  • 44
    • 28444467821 scopus 로고    scopus 로고
    • Analgesic effects of capsaicin and resiniferatoxin on bone cancer pain in mice
    • Menendez L, Juarez L, Garcia E, et al. Analgesic effects of capsaicin and resiniferatoxin on bone cancer pain in mice. Neurosci Lett. 2006;393:70-73.
    • (2006) Neurosci Lett , vol.393 , pp. 70-73
    • Menendez, L.1    Juarez, L.2    Garcia, E.3
  • 45
    • 0141634247 scopus 로고    scopus 로고
    • Signalling pathways involved in the sensitization of mouse nociceptive neurons by nerve growth factor
    • Bonnington JK, McNaughton PA. Signalling pathways involved in the sensitization of mouse nociceptive neurons by nerve growth factor. J Physiol. 2003;551:433-436.
    • (2003) J Physiol , vol.551 , pp. 433-436
    • Bonnington, J.K.1    McNaughton, P.A.2
  • 46
    • 17144397173 scopus 로고    scopus 로고
    • 2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMO-dependent protein kinase
    • 2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMO-dependent protein kinase. J Biol Chem. 2005;280:13424-13432.
    • (2005) J Biol Chem , vol.280 , pp. 13424-13432
    • Mohapatra, P.D.1    Rau, C.2
  • 47
    • 2942614748 scopus 로고    scopus 로고
    • Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity
    • Morenilla-Palao C, Planells-Cases R, Garcia-Sanz N, et al. Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity. J Biol Chem. 2004;279:25665-25672.
    • (2004) J Biol Chem , vol.279 , pp. 25665-25672
    • Morenilla-Palao, C.1    Planells-Cases, R.2    Garcia-Sanz, N.3
  • 48
    • 16844366973 scopus 로고    scopus 로고
    • Homo- and heteromeric assembly of TRPV channel subunits
    • Hellwig N, Albrecht N, Harteneck C, et al. Homo- and heteromeric assembly of TRPV channel subunits. J Cell Sci. 2005;118:917-928.
    • (2005) J Cell Sci , vol.118 , pp. 917-928
    • Hellwig, N.1    Albrecht, N.2    Harteneck, C.3
  • 49
    • 33748180653 scopus 로고    scopus 로고
    • The μ opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase. A pathway
    • Vetter I, Wyse BD, Monteith GR, et al. The μ opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase. A pathway. Mol Pain. 2006;2:22-26.
    • (2006) Mol Pain , vol.2 , pp. 22-26
    • Vetter, I.1    Wyse, B.D.2    Monteith, G.R.3
  • 50
    • 33746621595 scopus 로고    scopus 로고
    • The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin
    • Patwardhan AM, Jeske NA, Price JT, et al. The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Proc Natl Acad Sci USA. 2006;103:11393-11398.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11393-11398
    • Patwardhan, A.M.1    Jeske, N.A.2    Price, J.T.3
  • 51
    • 33748804164 scopus 로고    scopus 로고
    • Co-expression of the voltage-gated potassium channel Kv1.4 with transient receptor potential channels (TRPV1 and TRPV2) and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons
    • Binzen U, Greffrath W, Henessy S, et al. Co-expression of the voltage-gated potassium channel Kv1.4 with transient receptor potential channels (TRPV1 and TRPV2) and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons. Neuroscience. 2006;142:527-539.
    • (2006) Neuroscience , vol.142 , pp. 527-539
    • Binzen, U.1    Greffrath, W.2    Henessy, S.3
  • 52
    • 33644845742 scopus 로고    scopus 로고
    • Delta opioid receptors in small and medium-sized trigeminal neurons supporting the dental pulp of rats
    • Fristad I, Berggen E, Haug SR. Delta opioid receptors in small and medium-sized trigeminal neurons supporting the dental pulp of rats. Arch Oral Biol. 2006;51:273-281.
    • (2006) Arch Oral Biol , vol.51 , pp. 273-281
    • Fristad, I.1    Berggen, E.2    Haug, S.R.3
  • 53
    • 24744469860 scopus 로고    scopus 로고
    • Coversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system
    • Högesatt ED, Jönsson BAG, Ermund A, et al. Coversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J Biol Chem. 2005;280:31405-31412.
    • (2005) J Biol Chem , vol.280 , pp. 31405-31412
    • Högesatt, E.D.1    Jönsson, B.A.G.2    Ermund, A.3
  • 54
    • 33744539858 scopus 로고    scopus 로고
    • Role of TRPV1 and cannabinoid CB1 receptors in AM404-evoked hypothermia in rats
    • Rawls SM, Ding Z, Cowan A. Role of TRPV1 and cannabinoid CB1 receptors in AM404-evoked hypothermia in rats. Pharmacol Biochem Behav. 2006;83:508-516.
    • (2006) Pharmacol Biochem Behav , vol.83 , pp. 508-516
    • Rawls, S.M.1    Ding, Z.2    Cowan, A.3
  • 55
    • 33749341230 scopus 로고    scopus 로고
    • AM404, and inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain
    • Costa B, Siniscalco D, Trovato AE, et al. AM404, and inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain. Br J Pharmacol. 2006;148:1022-1032.
    • (2006) Br J Pharmacol , vol.148 , pp. 1022-1032
    • Costa, B.1    Siniscalco, D.2    Trovato, A.E.3
  • 56
    • 27644570846 scopus 로고    scopus 로고
    • Functional characterization of the S512Y mutant vanilloid human TRPV1 receptor
    • Sutton KG, Garrett EM, Rutter AR, et al. Functional characterization of the S512Y mutant vanilloid human TRPV1 receptor. Br J Pharmacol. 2005;146:702-711.
    • (2005) Br J Pharmacol , vol.146 , pp. 702-711
    • Sutton, K.G.1    Garrett, E.M.2    Rutter, A.R.3
  • 57
    • 2342439775 scopus 로고    scopus 로고
    • Identification of species-specific determination of the action of the antagonists capsazepine and the agonists PPAHV on TRPV1
    • Phillips E, Reeve A, Bevan S, et al. Identification of species-specific determination of the action of the antagonists capsazepine and the agonists PPAHV on TRPV1. J Biol Chem. 2004;279:17165-17172.
    • (2004) J Biol Chem , vol.279 , pp. 17165-17172
    • Phillips, E.1    Reeve, A.2    Bevan, S.3
  • 58
    • 0035958884 scopus 로고    scopus 로고
    • Analysis of the quaternary structure of vanilloid receptor 1
    • Kedei N, Szabó T, Lile JD, et al. Analysis of the quaternary structure of vanilloid receptor 1. J Biol Chem. 2002;276:28613-28619.
    • (2002) J Biol Chem , vol.276 , pp. 28613-28619
    • Kedei, N.1    Szabó, T.2    Lile, J.D.3
  • 59
    • 2942597685 scopus 로고    scopus 로고
    • Identification of a tetramerization domain in the C terminus of the vanilloid receptor
    • Garcia-Sanz N, Fernandez-Carjaval A, Morenilla-Palao C, et al. Identification of a tetramerization domain in the C terminus of the vanilloid receptor. J Neurosci. 2004;24:5307-5314.
    • (2004) J Neurosci , vol.24 , pp. 5307-5314
    • Garcia-Sanz, N.1    Fernandez-Carjaval, A.2    Morenilla-Palao, C.3
  • 60
    • 0035878401 scopus 로고    scopus 로고
    • The genomic organization of the gene encoding the vanilloid receptor: Evidence for multiple splice variants
    • Xue Q, Yu K, Trilk S, et al. The genomic organization of the gene encoding the vanilloid receptor: evidence for multiple splice variants. Genomics. 2001;76:14-20.
    • (2001) Genomics , vol.76 , pp. 14-20
    • Xue, Q.1    Yu, K.2    Trilk, S.3
  • 61
    • 4444258203 scopus 로고    scopus 로고
    • An alternative splicing product of the murine trpv1 gene dominant negatively modulates the activity of the TRPV1 channel
    • Wang G, Hu HZ, Colton CK, et al. An alternative splicing product of the murine trpv1 gene dominant negatively modulates the activity of the TRPV1 channel. J Biol Chem. 2004;279:37423-37430.
    • (2004) J Biol Chem , vol.279 , pp. 37423-37430
    • Wang, G.1    Hu, H.Z.2    Colton, C.K.3
  • 62
    • 15744394354 scopus 로고    scopus 로고
    • TRPV1b: A functional human vanilloid receptor splice variant
    • Lu G, Henderson D, Liu L, et al. TRPV1b: a functional human vanilloid receptor splice variant. Mol Pharmacol. 2005;67:1119-1127.
    • (2005) Mol Pharmacol , vol.67 , pp. 1119-1127
    • Lu, G.1    Henderson, D.2    Liu, L.3
  • 63
    • 33644796336 scopus 로고    scopus 로고
    • Regulation of TRPV1 by a novel renally expressed TRPV1 splice variant
    • Tian W, Wang DH, Cohen DM. Regulation of TRPV1 by a novel renally expressed TRPV1 splice variant. Am J Physiol Renal Physiol. 2006;290:F117-F126.
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Tian, W.1    Wang, D.H.2    Cohen, D.M.3
  • 64
    • 9744260945 scopus 로고    scopus 로고
    • 2+-sensitive interaction of the vanilloid receptor TRPV1 with tubulin
    • 2+-sensitive interaction of the vanilloid receptor TRPV1 with tubulin. J Neurochem. 2004;91:1092-1103.
    • (2004) J Neurochem , vol.91 , pp. 1092-1103
    • Goswami, C.1    Dreger, M.2    Jahnel, R.3
  • 65
    • 11444252856 scopus 로고    scopus 로고
    • Differential regulation of 3-beta-hydroxysteroid dehydrogenase and vanilloid receptor TRPV1 mRNA in sensory neurons by capsaicin and NGF
    • Donnerer J, Liebmann I, Schicho R. Differential regulation of 3-beta-hydroxysteroid dehydrogenase and vanilloid receptor TRPV1 mRNA in sensory neurons by capsaicin and NGF. Pharmacology. 2005;73:97-101.
    • (2005) Pharmacology , vol.73 , pp. 97-101
    • Donnerer, J.1    Liebmann, I.2    Schicho, R.3
  • 66
    • 28444442683 scopus 로고    scopus 로고
    • Molecular mechanisms of neuropathic pain-phenotype switch and initiation mechanisms
    • Ueda H. Molecular mechanisms of neuropathic pain-phenotype switch and initiation mechanisms. Pharmacol Ther. 2006;109:57-77.
    • (2006) Pharmacol Ther , vol.109 , pp. 57-77
    • Ueda, H.1
  • 67
    • 0030941590 scopus 로고    scopus 로고
    • Effects of the capsaicin analogue resiniferatoxin on spinal nociceptive mechanisms in the rat: Behavioral, electrophysiological and in situ hybridization studies
    • Xu XJ, Farkas-Szallasi T, Lundberg JM, et al. Effects of the capsaicin analogue resiniferatoxin on spinal nociceptive mechanisms in the rat: behavioral, electrophysiological and in situ hybridization studies. Brain Res. 1997;752:52-60.
    • (1997) Brain Res , vol.752 , pp. 52-60
    • Xu, X.J.1    Farkas-Szallasi, T.2    Lundberg, J.M.3
  • 68
    • 0033991857 scopus 로고    scopus 로고
    • Increased spinal cholecystokinin activity after systemic resiniferatoxin: Electrophysiological and in situ hybridization studies
    • Broberger C, Farkas-Szallasi T, Szallasi A, et al. Increased spinal cholecystokinin activity after systemic resiniferatoxin: electrophysiological and in situ hybridization studies. Pain. 2000;84:21-28.
    • (2000) Pain , vol.84 , pp. 21-28
    • Broberger, C.1    Farkas-Szallasi, T.2    Szallasi, A.3
  • 69
    • 0030307629 scopus 로고    scopus 로고
    • Vanilloid-sensitive neurons: A fundamental subdivision of the peripheral nervous system
    • Szallasi A. Vanilloid-sensitive neurons: a fundamental subdivision of the peripheral nervous system. J Periph Nerv Syst. 1996;1:6-18.
    • (1996) J Periph Nerv Syst , vol.1 , pp. 6-18
    • Szallasi, A.1
  • 70
    • 1542298215 scopus 로고    scopus 로고
    • Mechanisms involved in new therapies for overactive bladder
    • Cruz F. Mechanisms involved in new therapies for overactive bladder. Urology. 2004;63:65-73.
    • (2004) Urology , vol.63 , pp. 65-73
    • Cruz, F.1
  • 71
    • 1242306589 scopus 로고    scopus 로고
    • Intravesical vanilloid and neurogenic incontinence: Ten years experience
    • Lazzeri M, Spinelli M, Zanollo A, et al. Intravesical vanilloid and neurogenic incontinence: ten years experience. Urol Int. 2004;72:145-149.
    • (2004) Urol Int , vol.72 , pp. 145-149
    • Lazzeri, M.1    Spinelli, M.2    Zanollo, A.3
  • 72
    • 8144222402 scopus 로고    scopus 로고
    • NGF and GNDF differentially regulate TRPV1 expression that contributes to development of inflammatory thermal hyperalgesia
    • Amaya S, Shimosato G, Nagano M, et al. NGF and GNDF differentially regulate TRPV1 expression that contributes to development of inflammatory thermal hyperalgesia. Eur J Neurosci. 2004;20:2303-2310.
    • (2004) Eur J Neurosci , vol.20 , pp. 2303-2310
    • Amaya, S.1    Shimosato, G.2    Nagano, M.3
  • 73
    • 12744279751 scopus 로고    scopus 로고
    • Neurotrophin-3 suppresses thermal hyperalgesia associated with neuropathic pain and attenuates transient receptor potential vanilloid receptor-1 expression in adult sensory neurons
    • Wilson-Gerwing TD, Dmyterko MV, Zochodne DW, et al. Neurotrophin-3 suppresses thermal hyperalgesia associated with neuropathic pain and attenuates transient receptor potential vanilloid receptor-1 expression in adult sensory neurons. J Neurosci. 2005;25:758-767.
    • (2005) J Neurosci , vol.25 , pp. 758-767
    • Wilson-Gerwing, T.D.1    Dmyterko, M.V.2    Zochodne, D.W.3
  • 74
    • 33750524257 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane
    • Stein AT, Ufret-Vincenty CA, Hua L, et al. Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane. J Gen Physiol. 2006;128:509-522.
    • (2006) J Gen Physiol , vol.128 , pp. 509-522
    • Stein, A.T.1    Ufret-Vincenty, C.A.2    Hua, L.3
  • 75
    • 0019916653 scopus 로고
    • Regulation of substance P by nerve growth factor: Disruption by capsaicin
    • Miller MS, Buck SH, Sipes IG, et al. Regulation of substance P by nerve growth factor: disruption by capsaicin. Brain Res. 1982;250:193-196.
    • (1982) Brain Res , vol.250 , pp. 193-196
    • Miller, M.S.1    Buck, S.H.2    Sipes, I.G.3
  • 76
    • 0020700818 scopus 로고
    • Nerve growth factor antagonizes the neurtoxic action of capsaicin on primary sensory neurons
    • Otten U, Lorez HP, Businger F. Nerve growth factor antagonizes the neurtoxic action of capsaicin on primary sensory neurons. Nature. 1983;301:515-517.
    • (1983) Nature , vol.301 , pp. 515-517
    • Otten, U.1    Lorez, H.P.2    Businger, F.3
  • 77
    • 0035823409 scopus 로고    scopus 로고
    • Peripheral capsaicin receptors increase in the inflamed rat hindpaw: A possible mechanism for peripheral sensitization
    • Carlton SM, Coggeshall RE. Peripheral capsaicin receptors increase in the inflamed rat hindpaw: a possible mechanism for peripheral sensitization. Neurosci Lett. 2001;310:53-56.
    • (2001) Neurosci Lett , vol.310 , pp. 53-56
    • Carlton, S.M.1    Coggeshall, R.E.2
  • 78
    • 33747851354 scopus 로고    scopus 로고
    • Expression of capsaicin receptor immunoreactivity in human peripheral nervous system and in painful neuropathies
    • Lauria G, Morbin M, Lombardi R, et al. Expression of capsaicin receptor immunoreactivity in human peripheral nervous system and in painful neuropathies. J Periph Nerv Syst. 2006;11:262-271.
    • (2006) J Periph Nerv Syst , vol.11 , pp. 262-271
    • Lauria, G.1    Morbin, M.2    Lombardi, R.3
  • 79
    • 34347354387 scopus 로고    scopus 로고
    • Dual regulation of TRPV1 by phopshoinositides
    • Lukacs V, Thyagarajan B, Varnai P, et al. Dual regulation of TRPV1 by phopshoinositides. J Neurosci. 2007;27:7070-7080.
    • (2007) J Neurosci , vol.27 , pp. 7070-7080
    • Lukacs, V.1    Thyagarajan, B.2    Varnai, P.3
  • 80
    • 12144287525 scopus 로고    scopus 로고
    • Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage origin
    • Ständer S, Moorman C, Schumacher M, et al. Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage origin. Exp Dermatol. 2004;13:129-139.
    • (2004) Exp Dermatol , vol.13 , pp. 129-139
    • Ständer, S.1    Moorman, C.2    Schumacher, M.3
  • 81
    • 20244381982 scopus 로고    scopus 로고
    • A hot new twist to hair biology: Involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control
    • Bodó E, Biró T, Telek A, et al. A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control. Am J Pathol. 2005;166:985-998.
    • (2005) Am J Pathol , vol.166 , pp. 985-998
    • Bodó, E.1    Biró, T.2    Telek, A.3
  • 82
    • 34848828195 scopus 로고    scopus 로고
    • Transient receptor potential vanilloid-1 mediates heat shock-induced matrix metalloproteinase-1 expression in human epidermal keratinocytes
    • Epub ahead of print
    • Li WH, Lee YM, Kim JY, et al. Transient receptor potential vanilloid-1 mediates heat shock-induced matrix metalloproteinase-1 expression in human epidermal keratinocytes. J Invest Dermatol. 2007. [Epub ahead of print].
    • (2007) J Invest Dermatol
    • Li, W.H.1    Lee, Y.M.2    Kim, J.Y.3
  • 83
    • 34250857978 scopus 로고    scopus 로고
    • Differential expression of the capsaicin receptor TRPV1 and related receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy
    • Facer P, Casula MA, Smith GD, et al. Differential expression of the capsaicin receptor TRPV1 and related receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. BMC Neurol. 2007;7:11-18.
    • (2007) BMC Neurol , vol.7 , pp. 11-18
    • Facer, P.1    Casula, M.A.2    Smith, G.D.3
  • 84
    • 27644570051 scopus 로고    scopus 로고
    • Recent developments in vascular endothelial cell transient receptor potential channels
    • Yao X, Garland CJ. Recent developments in vascular endothelial cell transient receptor potential channels. Circ Res. 2005;97:853-863.
    • (2005) Circ Res , vol.97 , pp. 853-863
    • Yao, X.1    Garland, C.J.2
  • 85
    • 2542452122 scopus 로고    scopus 로고
    • TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells
    • Vriens J, Janssen A, Prenen J, et al. TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells. Cell Calcium. 2004;36:19-28.
    • (2004) Cell Calcium , vol.36 , pp. 19-28
    • Vriens, J.1    Janssen, A.2    Prenen, J.3
  • 87
    • 0344884588 scopus 로고    scopus 로고
    • Characterization of functional vanilloid receptors expressed by mast cells
    • Biró T, Maurer M, Modarres S, et al. Characterization of functional vanilloid receptors expressed by mast cells. Blood. 1998;91:1332-1340.
    • (1998) Blood , vol.91 , pp. 1332-1340
    • Biró, T.1    Maurer, M.2    Modarres, S.3
  • 88
    • 0034307478 scopus 로고    scopus 로고
    • New perspectives on enigmatic vanilloid receptors
    • Szallasi A, Di Marzo V. New perspectives on enigmatic vanilloid receptors. Trends Neurosci. 2000;23:491-497.
    • (2000) Trends Neurosci , vol.23 , pp. 491-497
    • Szallasi, A.1    Di Marzo, V.2
  • 89
    • 33846636000 scopus 로고    scopus 로고
    • Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice
    • Marsch R, Foeller E, Rammes G, et al. Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice. J Neurosci. 2007;27:832-839.
    • (2007) J Neurosci , vol.27 , pp. 832-839
    • Marsch, R.1    Foeller, E.2    Rammes, G.3
  • 90
    • 39449118964 scopus 로고    scopus 로고
    • The emerging role of TRPV1 and diabetes and obesity
    • In press
    • Suri A, Szallasi A. The emerging role of TRPV1 and diabetes and obesity. Trends Pharmacol Sci. 2007. In press.
    • (2007) Trends Pharmacol Sci
    • Suri, A.1    Szallasi, A.2
  • 91
    • 33845382786 scopus 로고    scopus 로고
    • + sensory neurons control β cell stress and islet inflammation in autoimmune diabetes
    • + sensory neurons control β cell stress and islet inflammation in autoimmune diabetes. Cell. 2006;127:1123-1135.
    • (2006) Cell , vol.127 , pp. 1123-1135
    • Razavi, R.1    Chan, Y.2    Afifiyan, F.N.3
  • 92
    • 0035962308 scopus 로고    scopus 로고
    • Vanilloid receptor 1 immunoreactivity in inflamed human bowel
    • Yiangou Y, Facer P, Dyer NH, et al. Vanilloid receptor 1 immunoreactivity in inflamed human bowel. Lancet. 2001;357:1338-1339.
    • (2001) Lancet , vol.357 , pp. 1338-1339
    • Yiangou, Y.1    Facer, P.2    Dyer, N.H.3
  • 93
    • 0037309871 scopus 로고    scopus 로고
    • Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency
    • Chan CL, Facer P, Davis JB, et al. Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency. Lancet. 2003;361:385-391.
    • (2003) Lancet , vol.361 , pp. 385-391
    • Chan, C.L.1    Facer, P.2    Davis, J.B.3
  • 94
    • 1542374082 scopus 로고    scopus 로고
    • Increased vanilloid receptor VR1 innervation of vulvodynia
    • Tympanidis P, Casula MA, Yiangou Y, et al. Increased vanilloid receptor VR1 innervation of vulvodynia. Eur J Pain. 2004;8:129-133.
    • (2004) Eur J Pain , vol.8 , pp. 129-133
    • Tympanidis, P.1    Casula, M.A.2    Yiangou, Y.3
  • 95
    • 4444357719 scopus 로고    scopus 로고
    • Increased capsaicin receptor TRPV1 nerve fibers in the inflamed human oesophagus
    • Matthews PJ, Aziz Q, Facer P, et al. Increased capsaicin receptor TRPV1 nerve fibers in the inflamed human oesophagus. Eur J Gastroenterol Hepatol. 2004;16:897-902.
    • (2004) Eur J Gastroenterol Hepatol , vol.16 , pp. 897-902
    • Matthews, P.J.1    Aziz, Q.2    Facer, P.3
  • 96
    • 26444436231 scopus 로고    scopus 로고
    • Increased capsaicin receptor TRPV1 in skin nerve fibers and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain
    • Gopinath P, Wan E, Holdcroft A, et al. Increased capsaicin receptor TRPV1 in skin nerve fibers and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain. BMC Women's Health. 2005;5:2-6.
    • (2005) BMC Women's Health , vol.5 , pp. 2-6
    • Gopinath, P.1    Wan, E.2    Holdcroft, A.3
  • 97
    • 33750358054 scopus 로고    scopus 로고
    • TRPV1: A therapeutic target for novel analgesic drugs?
    • Szallasi A, Cruz F, Geppetti P. TRPV1: a therapeutic target for novel analgesic drugs? Trends Mol Med. 2006;12:545-554.
    • (2006) Trends Mol Med , vol.12 , pp. 545-554
    • Szallasi, A.1    Cruz, F.2    Geppetti, P.3
  • 98
    • 16944365440 scopus 로고    scopus 로고
    • Differential activation and desensitization of sensory neurons by resiniferatoxin
    • Biró T, Modarres S, Blumberg PM. Differential activation and desensitization of sensory neurons by resiniferatoxin. J Neurosci. 1997;17:5622-5628.
    • (1997) J Neurosci , vol.17 , pp. 5622-5628
    • Biró, T.1    Modarres, S.2    Blumberg, P.M.3
  • 99
    • 0025224503 scopus 로고
    • Resiniferatoxin, an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons
    • Szolcsányi J, Szallasi A, Szallasi Z, et al. Resiniferatoxin, an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons. J Pharmacol Exp Ther. 1990;255:923-928.
    • (1990) J Pharmacol Exp Ther , vol.255 , pp. 923-928
    • Szolcsányi, J.1    Szallasi, A.2    Szallasi, Z.3
  • 100
    • 0032876069 scopus 로고    scopus 로고
    • The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons
    • Szallasi A, Blumberg PM, Anicelli LL, et al. The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons. Mol Pharmacol. 1999;56:581-587.
    • (1999) Mol Pharmacol , vol.56 , pp. 581-587
    • Szallasi, A.1    Blumberg, P.M.2    Anicelli, L.L.3
  • 101
    • 34247465445 scopus 로고    scopus 로고
    • Perineural resiniferatoxin prevents the development of hyperalgesia produced by loose ligation of the sciatic nerve in rats
    • Kissin I, Freitas CF, Bradley EL. Perineural resiniferatoxin prevents the development of hyperalgesia produced by loose ligation of the sciatic nerve in rats. Anesth Analg. 2007;104:1210-1116.
    • (2007) Anesth Analg , vol.104 , pp. 1210-1116
    • Kissin, I.1    Freitas, C.F.2    Bradley, E.L.3
  • 102
    • 0033625754 scopus 로고    scopus 로고
    • Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: A randomized, double-blind, placebo-controlled study
    • McCleane G. Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study. Br J Clin Pharmacol. 2000;49:574-579.
    • (2000) Br J Clin Pharmacol , vol.49 , pp. 574-579
    • McCleane, G.1
  • 103
    • 0026500908 scopus 로고
    • Topical capsaicin in painful diabetic neuropathy. Controlled study with long-term follow up
    • Tandan R, Lewis GA, Krushinski PB, et al. Topical capsaicin in painful diabetic neuropathy. Controlled study with long-term follow up. Diabetes Care. 1992;15:8-14.
    • (1992) Diabetes Care , vol.15 , pp. 8-14
    • Tandan, R.1    Lewis, G.A.2    Krushinski, P.B.3
  • 104
  • 105
    • 0029001059 scopus 로고
    • A double-blind comparison of topical capsaicin and oral amitriptyline in painful diabetic neuropathy
    • Biesbroeck R, Bril V, Hollander P, et al. A double-blind comparison of topical capsaicin and oral amitriptyline in painful diabetic neuropathy. Adv Ther. 1995;12:111-120.
    • (1995) Adv Ther , vol.12 , pp. 111-120
    • Biesbroeck, R.1    Bril, V.2    Hollander, P.3
  • 106
    • 0025824524 scopus 로고
    • Capsaicin: A therapeutic option for painful diabetic neuropathy
    • Basha KM, Whitehouse FW. Capsaicin: a therapeutic option for painful diabetic neuropathy. Henry Ford Hosp Med J. 1991;39:138-140.
    • (1991) Henry Ford Hosp Med J , vol.39 , pp. 138-140
    • Basha, K.M.1    Whitehouse, F.W.2
  • 107
    • 0029093399 scopus 로고
    • Double-blind, placebo-controlled study of the application of capsaicin cream in chronic distal painful polyneuropathy
    • Low PA, Opfer-Gehrking TL, Dyck PJ, et al. Double-blind, placebo-controlled study of the application of capsaicin cream in chronic distal painful polyneuropathy. Pain. 1995;62:163-168.
    • (1995) Pain , vol.62 , pp. 163-168
    • Low, P.A.1    Opfer-Gehrking, T.L.2    Dyck, P.J.3
  • 108
    • 1942467891 scopus 로고    scopus 로고
    • Systematic review of topical capsaicin for the treatment of chronic pain
    • Mason L, Moore RA, Derry S, et al. Systematic review of topical capsaicin for the treatment of chronic pain. BMJ. 2004;328:991-998.
    • (2004) BMJ , vol.328 , pp. 991-998
    • Mason, L.1    Moore, R.A.2    Derry, S.3
  • 109
    • 0029381594 scopus 로고
    • Topical capsaicin. A review of its pharmacological properties and therapeutic potential in postherpetic neuralgia, diabetic neuropathy and osteoarthritis
    • Rains C, Bryson HM. Topical capsaicin. A review of its pharmacological properties and therapeutic potential in postherpetic neuralgia, diabetic neuropathy and osteoarthritis. Drugs Aging. 1995;7:317-328.
    • (1995) Drugs Aging , vol.7 , pp. 317-328
    • Rains, C.1    Bryson, H.M.2
  • 110
    • 0025758541 scopus 로고
    • Topical capsaicin in dermatologic and peripheral pain disorders
    • Rumsfield JA, West DP. Topical capsaicin in dermatologic and peripheral pain disorders. DICP. 1991;25:381-387.
    • (1991) DICP , vol.25 , pp. 381-387
    • Rumsfield, J.A.1    West, D.P.2
  • 111
    • 0027991152 scopus 로고
    • The effectiveness of topically applied capsaicin. A metaanalysis
    • Zhang WY, Wan L, Po A. The effectiveness of topically applied capsaicin. A metaanalysis. Eur J Clin Pharmacol. 1994;46:517-522.
    • (1994) Eur J Clin Pharmacol , vol.46 , pp. 517-522
    • Zhang, W.Y.1    Wan, L.2    Po, A.3
  • 112
    • 33745775938 scopus 로고    scopus 로고
    • Neurologic complications of HIV disease and their treatments
    • Letendre S, Ellis RJ. Neurologic complications of HIV disease and their treatments. Topics HIV Med. 2006;14:21-26.
    • (2006) Topics HIV Med , vol.14 , pp. 21-26
    • Letendre, S.1    Ellis, R.J.2
  • 113
    • 0031885212 scopus 로고    scopus 로고
    • Treatment of intractable pain with topical large-dose capsaicin: Preliminary report
    • Robbins WR, Staats PS, Levine J, et al. Treatment of intractable pain with topical large-dose capsaicin: preliminary report. Anesth Analg. 1998;86:579-583.
    • (1998) Anesth Analg , vol.86 , pp. 579-583
    • Robbins, W.R.1    Staats, P.S.2    Levine, J.3
  • 114
    • 0036279515 scopus 로고    scopus 로고
    • Intranasal civamide for the treatment of episodic cluster headaches
    • Saper JR, Klapper J, Mathew NT, et al. Intranasal civamide for the treatment of episodic cluster headaches. Arch Neurol. 2002;59:990-994.
    • (2002) Arch Neurol , vol.59 , pp. 990-994
    • Saper, J.R.1    Klapper, J.2    Mathew, N.T.3
  • 115
    • 0034455035 scopus 로고    scopus 로고
    • Intranasal civamide for the acute treatment of migraine headache
    • Diamond S, Freitag F, Phillips SB, et al. Intranasal civamide for the acute treatment of migraine headache. Cephalalgia. 2000;20:597-602.
    • (2000) Cephalalgia , vol.20 , pp. 597-602
    • Diamond, S.1    Freitag, F.2    Phillips, S.B.3
  • 116
    • 38549143019 scopus 로고    scopus 로고
    • Available at
    • Available at: http://www.neurogeskx.com
  • 117
    • 38549165574 scopus 로고    scopus 로고
    • Enduring and well-tolerated analgesia for total knee arthroplasty postsurgical pain produced by a single, rapidly-eliminated, intraoperative instillation of 4975
    • Davis J, Williams H, Bramlett K, et al. Enduring and well-tolerated analgesia for total knee arthroplasty postsurgical pain produced by a single, rapidly-eliminated, intraoperative instillation of 4975. J Pain. 2007;8:S46.
    • (2007) J Pain , vol.8
    • Davis, J.1    Williams, H.2    Bramlett, K.3
  • 118
    • 38549149650 scopus 로고    scopus 로고
    • Safety, tolerability and efficacy of intraoperative ALGRX 4975 in a randomized, double-blind, placebo-controlled study of subjects undergoing bunionectomy
    • Cantillon M, Vause E, Sykes D, et al. Safety, tolerability and efficacy of intraoperative ALGRX 4975 in a randomized, double-blind, placebo-controlled study of subjects undergoing bunionectomy. J. Pain. 2005;6:S48.
    • (2005) J. Pain , vol.6
    • Cantillon, M.1    Vause, E.2    Sykes, D.3
  • 119
    • 38549153618 scopus 로고    scopus 로고
    • ALGRX 4975 reduces pain of acute lateral epicondylitis: Preliminary results from a randomized, double-blind, placebo-controlled, phase II multicenter clinical trial
    • Richards PT, Vasko G, Stasko I, et al. ALGRX 4975 reduces pain of acute lateral epicondylitis: preliminary results from a randomized, double-blind, placebo-controlled, phase II multicenter clinical trial. J. Pain. 2006;7:S3.
    • (2006) J. Pain , vol.7
    • Richards, P.T.1    Vasko, G.2    Stasko, I.3
  • 120
    • 38549111741 scopus 로고    scopus 로고
    • ALGRX 4975 reduces pain of intermetatarsal neuroma: Preliminary results from a randomized, double-blind, placebo-controlled, phase II multicenter clinical trial
    • Diamond E, Richards PT, Miller T. ALGRX 4975 reduces pain of intermetatarsal neuroma: preliminary results from a randomized, double-blind, placebo-controlled, phase II multicenter clinical trial. J Pain. 2006;7:S41.
    • (2006) J Pain , vol.7
    • Diamond, E.1    Richards, P.T.2    Miller, T.3
  • 121
    • 38549152650 scopus 로고    scopus 로고
    • Effect of wound instillation of a novel purified capsaicin formulation on postherniotomy pain
    • Aasvang EK, Hansen JB, Malmstrøm J, et al. Effect of wound instillation of a novel purified capsaicin formulation on postherniotomy pain. Anesthesiology. 2007;107:A459.
    • (2007) Anesthesiology , vol.107
    • Aasvang, E.K.1    Hansen, J.B.2    Malmstrøm, J.3
  • 122
    • 36448989370 scopus 로고    scopus 로고
    • Preliminary safety, tolerability and efficacy of ALGRX 4975 in osteoarthritis (OA) of the knee
    • Cantillon M, Vause E, Sykes D, et al. Preliminary safety, tolerability and efficacy of ALGRX 4975 in osteoarthritis (OA) of the knee. J Pain. 2005;6:S39.
    • (2005) J Pain , vol.6
    • Cantillon, M.1    Vause, E.2    Sykes, D.3
  • 123
    • 36448989370 scopus 로고    scopus 로고
    • Safety, tolerability and efficacy of ALGRX 4975 in osteoarthritis (OA) of the knee
    • Cantillon M, Vause E, Sykes D, et al. Safety, tolerability and efficacy of ALGRX 4975 in osteoarthritis (OA) of the knee. J Pain. 2005;6:S39.
    • (2005) J Pain , vol.6
    • Cantillon, M.1    Vause, E.2    Sykes, D.3
  • 124
    • 0025841729 scopus 로고
    • Treatment of painful diabetic neuropathy with topical capsaicin. A multicenter, double-blind, vehicle controlled study
    • Capsaicin Study Group
    • Capsaicin Study Group. Treatment of painful diabetic neuropathy with topical capsaicin. A multicenter, double-blind, vehicle controlled study. Arch Intern Med. 1991;151:2225-2229.
    • (1991) Arch Intern Med , vol.151 , pp. 2225-2229
  • 125
    • 0027152099 scopus 로고
    • A randomized vehiclecontrolled trial of topical capsaicin in the treatment of postherpetic neuralgia
    • Watson CP, Tyler KL, Bickers DR, et al. A randomized vehiclecontrolled trial of topical capsaicin in the treatment of postherpetic neuralgia. Clin Ther. 1993;15:510-526.
    • (1993) Clin Ther , vol.15 , pp. 510-526
    • Watson, C.P.1    Tyler, K.L.2    Bickers, D.R.3
  • 126
    • 0023197901 scopus 로고
    • Treatment of chronic postherpetic neuralgia with topical capsaicin. A preliminary study
    • Bernstein JE, Bickers DR, Dahl MV, et al. Treatment of chronic postherpetic neuralgia with topical capsaicin. A preliminary study. Am Acad Dermacol. 1987;17:93-96.
    • (1987) Am Acad Dermacol , vol.17 , pp. 93-96
    • Bernstein, J.E.1    Bickers, D.R.2    Dahl, M.V.3
  • 127
    • 0026585193 scopus 로고
    • Analgesic effect of capsaicin in idiopathic trigeminal neuralgia
    • Fusco BM, Alessandri M. Analgesic effect of capsaicin in idiopathic trigeminal neuralgia. Anesth Analg. 1992;74:375-377.
    • (1992) Anesth Analg , vol.74 , pp. 375-377
    • Fusco, B.M.1    Alessandri, M.2
  • 128
    • 0028377139 scopus 로고
    • Topical application of capsaicin for treatment of oral neuropathic pain and trigeminal neuralgia
    • Epstein JB, Marcoe JH. Topical application of capsaicin for treatment of oral neuropathic pain and trigeminal neuralgia. Oral Surg Oral Med Oral Pathol. 1994;77:135-140.
    • (1994) Oral Surg Oral Med Oral Pathol , vol.77 , pp. 135-140
    • Epstein, J.B.1    Marcoe, J.H.2
  • 129
    • 0024436963 scopus 로고
    • Relief of local stump pain by capsaicin cream
    • Rayner HC, Atkins RC, Westerman RA. Relief of local stump pain by capsaicin cream. Lancet. 1989;2:1276-1277.
    • (1989) Lancet , vol.2 , pp. 1276-1277
    • Rayner, H.C.1    Atkins, R.C.2    Westerman, R.A.3
  • 130
    • 0025151638 scopus 로고
    • Capsaicin for treatment of posttraumatic amputation stump pain
    • Weintraub M, Golik A, Rubio A. Capsaicin for treatment of posttraumatic amputation stump pain. Lancet. 1990;336:1003-1004.
    • (1990) Lancet , vol.336 , pp. 1003-1004
    • Weintraub, M.1    Golik, A.2    Rubio, A.3
  • 131
    • 0024538583 scopus 로고
    • Beneficial effect of capsaicin application to the nasal mucosa in cluster headache
    • Sicuteri F, Fusco BM, Marabini S, et al. Beneficial effect of capsaicin application to the nasal mucosa in cluster headache. Clin J Pain. 1989;5:49-53.
    • (1989) Clin J Pain , vol.5 , pp. 49-53
    • Sicuteri, F.1    Fusco, B.M.2    Marabini, S.3
  • 132
    • 0027479255 scopus 로고
    • A double-blind placebo-controlled trial of intranasal capsaicin for cluster headache
    • Marks DR, Papoport A, Padla D, et al. A double-blind placebo-controlled trial of intranasal capsaicin for cluster headache. Cephalagia. 1993;13:114-116.
    • (1993) Cephalagia , vol.13 , pp. 114-116
    • Marks, D.R.1    Papoport, A.2    Padla, D.3
  • 133
    • 0037394013 scopus 로고    scopus 로고
    • Topical agents in the treatment of cluster headache
    • Markley HG. Topical agents in the treatment of cluster headache. Curr Pain Headache Rep. 2003;7:139-143.
    • (2003) Curr Pain Headache Rep , vol.7 , pp. 139-143
    • Markley, H.G.1
  • 134
    • 0037864081 scopus 로고    scopus 로고
    • Repeated intranasal capsaicin applications to treat chronic migraine
    • Fusco BM, Barzoi G, Agro F. Repeated intranasal capsaicin applications to treat chronic migraine. Br J Anesth. 2003;90:812-815.
    • (2003) Br J Anesth , vol.90 , pp. 812-815
    • Fusco, B.M.1    Barzoi, G.2    Agro, F.3
  • 135
    • 0029010950 scopus 로고
    • Intranasal capsaicin for acute abortive treatment of migraine without aura
    • Levy RL. Intranasal capsaicin for acute abortive treatment of migraine without aura. Headache. 1995;35:277-281.
    • (1995) Headache , vol.35 , pp. 277-281
    • Levy, R.L.1
  • 136
    • 38549116968 scopus 로고    scopus 로고
    • Intranasal medications for the treatment of migraine and cluster headache
    • Rapoport AM, Bigal ME, Tepper SJ, et al. Intranasal medications for the treatment of migraine and cluster headache. Neurosci Lett. 2005;384:150-155.
    • (2005) Neurosci Lett , vol.384 , pp. 150-155
    • Rapoport, A.M.1    Bigal, M.E.2    Tepper, S.J.3
  • 137
    • 0031702784 scopus 로고    scopus 로고
    • Toxic effects of capsaicin on keratinocytes and fibroblasts
    • Ko F, Diaz M, Smith P, et al. Toxic effects of capsaicin on keratinocytes and fibroblasts. J Burn Care Rehabil. 1998;19:409-413.
    • (1998) J Burn Care Rehabil , vol.19 , pp. 409-413
    • Ko, F.1    Diaz, M.2    Smith, P.3
  • 138
    • 0026558207 scopus 로고
    • Effect of topical capsaicin in the therapy of painful osteoarthritis of the hands
    • McCarthy GM, McCarty DJ. Effect of topical capsaicin in the therapy of painful osteoarthritis of the hands. J Rheumatol. 1992;19:604-607.
    • (1992) J Rheumatol , vol.19 , pp. 604-607
    • McCarthy, G.M.1    McCarty, D.J.2
  • 139
    • 0034568613 scopus 로고    scopus 로고
    • Topical application of capsaicin for the treatment of localized pain in the temporomandibular joint area
    • Winocur E, Gavish A, Halachmi M, et al. Topical application of capsaicin for the treatment of localized pain in the temporomandibular joint area. J Orofac Pain. 2000;14:31-36.
    • (2000) J Orofac Pain , vol.14 , pp. 31-36
    • Winocur, E.1    Gavish, A.2    Halachmi, M.3
  • 140
    • 0026716771 scopus 로고
    • The postmastectomy pain syndrome and topical capsaicin: A randomized trial
    • Watson CP, Evans RJ. The postmastectomy pain syndrome and topical capsaicin: a randomized trial. Pain. 1992;51:375-379.
    • (1992) Pain , vol.51 , pp. 375-379
    • Watson, C.P.1    Evans, R.J.2
  • 141
    • 0027275767 scopus 로고
    • Treatment of the postmastectomy pain syndrome with topical capsaicin
    • Dini D, Bertelli G, Gozza A, et al. Treatment of the postmastectomy pain syndrome with topical capsaicin. Pain. 1993;54:223-226.
    • (1993) Pain , vol.54 , pp. 223-226
    • Dini, D.1    Bertelli, G.2    Gozza, A.3
  • 142
    • 0029015393 scopus 로고
    • Oral capsaicin provides temporary relief for oral mucositis pain secondary to chemotherapy/radiation therapy
    • Berger A, Henderson M, Nadoolman W, et al. Oral capsaicin provides temporary relief for oral mucositis pain secondary to chemotherapy/radiation therapy. J Pain Symptom Manage. 1995;10:243-248.
    • (1995) J Pain Symptom Manage , vol.10 , pp. 243-248
    • Berger, A.1    Henderson, M.2    Nadoolman, W.3
  • 143
    • 0030789893 scopus 로고    scopus 로고
    • Phase III placebo-controlled trial of capsaicin cream in the management of surgical neuropathic pain in cancer patients
    • Ellison N, Loprinzi CL, Kugler J, et al. Phase III placebo-controlled trial of capsaicin cream in the management of surgical neuropathic pain in cancer patients. J Clin Oncol. 1997;15:2974-2980.
    • (1997) J Clin Oncol , vol.15 , pp. 2974-2980
    • Ellison, N.1    Loprinzi, C.L.2    Kugler, J.3
  • 144
    • 33847400543 scopus 로고    scopus 로고
    • TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase
    • Shim WS, Tak MH, Lee MH, et al. TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase. J Neurosci. 2007;27:2331-2337.
    • (2007) J Neurosci , vol.27 , pp. 2331-2337
    • Shim, W.S.1    Tak, M.H.2    Lee, M.H.3
  • 145
    • 11944264672 scopus 로고
    • Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy
    • Capsaicin Study Group
    • Capsaicin Study Group. Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy. Diabetes Care. 1992;15:159-165.
    • (1992) Diabetes Care , vol.15 , pp. 159-165
  • 146
    • 0028603509 scopus 로고
    • Preventive effect of repeated nasal application of capsaicin in cluster headache
    • Fusco BM, Marabini S, Maggi CA, et al. Preventive effect of repeated nasal application of capsaicin in cluster headache. Pain. 1994;59:321-325.
    • (1994) Pain , vol.59 , pp. 321-325
    • Fusco, B.M.1    Marabini, S.2    Maggi, C.A.3
  • 147
    • 0029069614 scopus 로고
    • Treatment of cluster headache and its variants
    • Stovner LJ, Sjaastad O. Treatment of cluster headache and its variants. Curr Opin Neurol. 1995;8:243-247.
    • (1995) Curr Opin Neurol , vol.8 , pp. 243-247
    • Stovner, L.J.1    Sjaastad, O.2
  • 148
    • 38549171924 scopus 로고    scopus 로고
    • Capsaicin for allergic rhinitis in adults (review)
    • Cheng J, Yang XN, Zhang SP. Capsaicin for allergic rhinitis in adults (review). Cochrane Library. 2007;1:1-12.
    • (2007) Cochrane Library , vol.1 , pp. 1-12
    • Cheng, J.1    Yang, X.N.2    Zhang, S.P.3
  • 149
    • 0034489458 scopus 로고    scopus 로고
    • The analgesic efficacy of topical capsaicin is enhanced by glyceryl trinitrate in painful osteoarthritis: A randomized, double blind, placebo controlled study
    • McCleane G. The analgesic efficacy of topical capsaicin is enhanced by glyceryl trinitrate in painful osteoarthritis: a randomized, double blind, placebo controlled study. Eur J Pain. 2000;4:355-360.
    • (2000) Eur J Pain , vol.4 , pp. 355-360
    • McCleane, G.1
  • 150
    • 0027271830 scopus 로고
    • Topical capsaicin in treatment of hyperalgesia, allodynia and dysesthetic pain caused by malignant tumor infiltration to the skin
    • Wist E, Risberg T. Topical capsaicin in treatment of hyperalgesia, allodynia and dysesthetic pain caused by malignant tumor infiltration to the skin. Acta Oncol. 1993;32:343-345.
    • (1993) Acta Oncol , vol.32 , pp. 343-345
    • Wist, E.1    Risberg, T.2
  • 151
    • 33745607370 scopus 로고    scopus 로고
    • New and emerging treatment options for neuropathic pain
    • Gidal B, Billington R. New and emerging treatment options for neuropathic pain. Am J Manag Care. 2006;12:S269-S278.
    • (2006) Am J Manag Care , vol.12
    • Gidal, B.1    Billington, R.2
  • 152
    • 0037373066 scopus 로고    scopus 로고
    • Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts for analgesic effect of capsaicin cream in neuropathic pain
    • Rashid MH, Inoue M, Kondo S, et al. Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts for analgesic effect of capsaicin cream in neuropathic pain. J Pharmacol Exp Ther. 2003;304:940-948.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 940-948
    • Rashid, M.H.1    Inoue, M.2    Kondo, S.3
  • 153
    • 0028942018 scopus 로고
    • Cutaneous injection of the capsaicin analogue, NE-21,610, produces analgesia to heat but not to mechanical stimuli in man
    • Davis KD, Meyer RA, Turnquist JL, et al. Cutaneous injection of the capsaicin analogue, NE-21,610, produces analgesia to heat but not to mechanical stimuli in man. Pain. 1995;61:17-26.
    • (1995) Pain , vol.61 , pp. 17-26
    • Davis, K.D.1    Meyer, R.A.2    Turnquist, J.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.