The emetic and anti-emetic effects of the capsaicin analogue resiniferatoxin in Suncus murinus, the house musk shrew

British Journal of Pharmacology

Volumn 130, Issue 6, 2000, Pages 1247-1254

  Andrews, P L R ^a   Okada, F ^b   Woods, A J ^a   Hagiwara, H ^b   Kakaimoto, S ^b   Toyoda, M ^b   Matsuki, N ^b  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Anti emetic; Capsaicin; Emesis; Motion; Resiniferatoxin; Substance P; Vanilloid receptors; Vomiting

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; ANTIEMETIC AGENT; CAPSAICIN; CAPSAICIN DERIVATIVE; CISPLATIN; COPPER SULFATE; EMETIC AGENT; MORPHINE; NEUROKININ 1 RECEPTOR ANTAGONIST; NICOTINE; RESINIFERATOXIN; SEROTONIN 3 ANTAGONIST; TROPISETRON;

ANIMAL EXPERIMENT; ANTIEMETIC ACTIVITY; AREA POSTREMA; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; INSECTIVORE; MALE; MOTION SICKNESS; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; SOLITARY TRACT NUCLEUS; VOMITING;

EID: 0033925364     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703428     Document Type: Article

References (43)

1. ABE, H. (1967). Classification and biology of Japanese Insectivore (Mammalia). I. Studies on variation and classification. J. Fac. Agric. Hokkaido Univ., 55, 191-265.
2. ANDREWS, P.L.R. & BHANDARI, P. (1993). Resiniferatoxin, an ultrapotent capsaicin analogue, has anti-emetic properties in the ferret. Neuropharmacology 32, 799-806.
3. ANDREWS, P.L.R., TORII, Y., SAITO, H. & MATSUKI, N. (1996). The pharmacology of the emetic response to upper gastrointestinal tract stimulation in Suncus murinus. Eur. J. Pharmacol., 307, 305-313.
4. BEVAN, S.J. & DOCHERTY, R.J. (1993). Cellular mechanisms of the action of capsaicin. In Capsaicin in the Study of Pain. ed. Wood, J.N., pp. 27-44. London, U.K: Academic Press.
5. 3 receptors. Neuropharmacology, 31, 735-742.
6. 1 receptor antagonist, CP-99,994, in ferrets. Eur. J. Pharmacol., 249, R3-R4.
7. COLBERT, E.H. (1958). Evolution of the Vertebrates. New York, U.S.A: John Willey & Sons.
8. de VRIES, D.J. & BLUMBERG, P.M. (1989). Thermoregulatory effects of resiniferatoxin in the mouse: comparison with capsaicin. Life Sci., 44, 711-715.
9. 1 receptor antagonist is mediated centrally in the ferret. Br. J. Pharmacol., 112, 516P.
10. LIU, L., WANG, Y. & SIMON, S.A. (1996). Capsaicin activated currents in rat dorsal root ganglion cells. Pain, 64, 191-195.
11. 1A receptor antagonists as anti-emetics. In Serotonin and the scientific basis of anti-emetic therapy. ed. Reynolds, D.J.M., Andrews, P.L.R. & Davis C.J. pp. 222-227 Oxford, U.K: Oxford Clin. Comm.
12. LUCOT, J.B.,OBACH, R.S., MCLEAN, S. &WATSON, J.W. (1 997). The effect of CP-99,994 on the responses to provocative motion in the cat. Br. J. Pharmacol., 120, 116-120.
13. MACLEAN, D.B., WHEELER, F. & HAYES, E. (1990). Basal and stimulated release of substance P from dissociated cultures of vagal sensory neurons. Brain Res., 519, 308-314.
14. MANTYH, P.W., DEMASTER, E., MALHOTRA, A., GHILHARDI, J.R., ROGERS, S.D., MANTYH, C.R., LIU, H., BASBAUM, A.I., VINGA, S.R., MAGGIO, J.E. & SIMONE, D.A. (1995). Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science, 268, 1629-1632.
15. MATSUKI, N., TORII, Y., UENO, S. & SAITO, H. (1992). Suncus murinus as an experimental animal model for emesis and motion sickness. In Mechanisms and Control of Emesis, ed. Bianchi, A.L., Grelot, L., Miller, A.D. & King, G.I. pp. 323-329, Montrouge, France: INSERM John Libbey Eurotext, Paris.
16. MUTOH, M., IMANISHI, H., TORII, Y., TAMURA, M., SAITO, H. & MATSUKI, N. (1992). Cisplatin-Induced Emesis in Suncus murinus. Japan. J. Pharmacol., 58, 321-324.
17. 1A-Receptor Agonists in Suncus murinus. Japan. J. Pharmacol., 64, 109-114.
18. PAPIR-KRICHELI, D., FREY, J., LAUFER, R., GILON, C, CHOREV, M., SELINGER, Z. & DEVOR M. (1987). Behavioural effects of receptor-specific substance P agonists. Pain, 31, 263-276.
19. 3 receptor antagonist granisetron (BRL 43964). Brain Res., 565, 231-236.
20. RITTER, S. & DINH, T.T. (1988). Capsaicin-induced neuronal degeneration: Silver impregnation of cell bodies, axons and terminals in the central nervous system of the adult rat. J. Comp. Neurol., 271, 79-90.
21. RITTER, S. & DINH, T.T. (1993). Capsaicin-induced degeneration in rat brain and retina. In Capsaicin in the study of pain, ed. Wood, J.N. pp. 105-138, New York: Academic Press.
22. RUDD, J.A. & NAYLOR, R.J. (1995). Opioid receptor involvement in emesis and anti-emesis. In Serotonin and the scientific basis of anti-emetic therapy, ed. Reynolds, D.J.M., Andrews, P.L.R. & Davis C.J. pp. 208-221 Oxford: Oxford Clin. Comm.
23. 1 receptor antagonists. Eur. J. Pharmacol., 265, 179-183.
24. SAHA, S., BATTEN, T.F.C. & MCWILLIAM, P.N. ( 1995). Glutamate, γ-aminobutyric acid and tachykinin-immunoreactive synapses in the cat nucleus tractus solitarii. J. Neurocytol., 24, 55-60.
25. SELVE, N., FRIDERICHS, E., REIMANN, W. & REINARTZ, S. (1994). Absence of emetic effects of morphine and loperamide in Suncus murinus. Eur. J. Pharmacol., 256, 287-293.
26. SHIROSHITA, Y., KOGA, T. & FUKUDA, H. (1997). Capsaicin in the 4th ventricle abolishes retching and transmission of emetic vagal afferents to solitary nucleus neurons. Eur. J. Pharmacol., 339, 183-192.
27. SZALLASI, A. (1994). The vanilloid (capsaicin) receptor: receptor types and species differences. Gen. Pharmacol., 25, 223-243.
28. SZALLASI, A. (1995). Autoradiographic visualisation and pharmacological characterization of vanilloid (capsaicin) receptors in several species, including man. Acta. Physiol. Scand., 155, Suppl. 629, 1-68.
29. SZALLASI, A. & BLUMBERG, P.M. (1989). Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper. Neuroscience, 20, 515-520.
30. SZALLASI, A. & BLUMBERG, P.M. (1990). Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor. Life Sciences, 47, 1399-1408.
31. SZALLASI, A., NILSSON, S., FARKAS-SZALLASI, T., BLUMBERG, P.M., HÖKFELT, T. & LUNDBERG, J.M. (1995). Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in spinal cord, axonal transport to the periphery, and depletion by systemic vanilloid treatment. Brain Res., 703, 175-221.
32. 1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology. 35, 1121-1129.
33. 1 receptor antagonist CP-99,994 attenuates cisplatin-induced emesis in the ferret. Eur. J. Pharmacol., 250, R5-R6.
34. TATTERSALL, F.D., RYCROFT, W., HILL, R.G. & HARGREAVES, R.J. (1994). Enantioselective inhibition of apomorphine-induced emesis in the ferret by the neurokinin1 receptor antagonist CP-99,994. Neuropharmacology, 33, 259-260.
35. 1) receptor antagonist CP-99,994. Neuropharmacology, 34, 1697-1699.
36. TORII, Y., SAITO, H. & MATSUKI, N. (1991a). 5-hydroxytryptamine is emetogenic in the house musk shrew, Suncus murinus. Naunyn-Schmiedeberg's Arch. Pharmacol., 344, 564-567.
37. 3 receptor antagonists in Suncus murinus. Japan. J. Pharmacol., 55, 107-113.
38. TORII, Y., SHIKITA, M., SAITO, H. & MATSUKI, N. (1993). X-Irradiation-Induced Emesis in Suncus murinus. J. Radiat. Res., 34, 164-170.
39. UENO, S., MATSUKI, N. & SAITO, H. (1988). Suncus murinus as a new experimental model for motion sickness. Life Sciences, 43, 413-420.
40. 1 receptor. Br. J. Pharmacol., 115, 84-94.
41. WATSON, J.W., NAGAHISA, A., LUCOT, J.B. & ANDREWS, P.L.R. (1995b). The tachykinins and emesis: towards complete control. In Serotonin and the scientific basis of anti-emetic therapy, ed. Reynolds, D.J.M., Andrews, P.L.R. & Davis, C.J. pp. 233-238 Oxford, UK: Oxford Clin. Comm.
42. WINTER, J., DRAY, A., WOOD, J.N., YEATS, J.C. & BEVAN S. (1990). Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin. Brain Res., 520, 131-140.
43. WOODS, A.J., STOCK, M.J., GUPTA, A.N., WONG, T.T.L. & ANDREWS, P.L.R. (1994). Thermoregulatory effects of resiniferatoxin in the rat. Eur. J. Pharmacol., 264, 125-133.