Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists

Current Medicinal Chemistry

Volumn 15, Issue 14, 2008, Pages 1428-1443

  Ashton, John C ^a   Wright, Jason L ^b   McPartland, John M ^c   Tyndall, Joel D A ^b  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c Porton Down Science Park   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2 ARACHIDONOYLGLYCEROL; 2 METHYL 3 (1 NAPHTHOYL) 1 PROPYLINDOLE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 3 (2 IODO 5 NITROBENZOYL) 1 (1 METHYL 2 PIPERIDINYLMETHYL)INDOLE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 4 [4 (1,1 DIMETHYLHEPTYL) 2,6 DIMETHOXYPHENYL] 6,6 DIMETHYLBICYCLO[3.1.1]HEPT 2 EN 2 YLMETHANOL; AJULEMIC ACID; ANANDAMIDE; CANNABIDIOL; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 1 RECEPTOR ANTAGONIST; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; CANNABINOL; DEXANABINOL; DRONABINOL; ENDOCANNABINOID; INDOLE DERIVATIVE; LIGAND; METHANANDAMIDE; NABILONE; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; RIMONABANT; SR 144258; UNINDEXED DRUG;

AMINO ACID SEQUENCE; ANTIINFLAMMATORY ACTIVITY; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CLINICAL RESEARCH; COMPUTER MODEL; DEGENERATIVE DISEASE; DRUG DESIGN; DRUG EFFICACY; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG PURIFICATION; DRUG SELECTIVITY; DRUG STRUCTURE; HUMAN; IMMUNOMODULATION; INFLAMMATION; LIGAND BINDING; MOLECULAR EVOLUTION; MULTIPLE SCLEROSIS; NEUROPATHIC PAIN; NONHUMAN; PHYLOGENY; RECEPTOR INTRINSIC ACTIVITY; REVIEW; SKIN ALLERGY;

ANIMALS; ARACHIDONIC ACIDS; BENZOXAZINES; CANNABINOIDS; CYCLOHEXANOLS; HUMANS; LIGANDS; MORPHOLINES; NAPHTHALENES; POLYUNSATURATED ALKAMIDES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2;

EID: 47349126394     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986708784567716     Document Type: Review

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