CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 8, 2005, Pages 3093-3098

  Ibrahim, Mohab M ^a   Porreca, Frank ^a   Lai, Josephine ^a   Albrecht, Phillip J ^b   Rice, Frank L ^b   Khodorova, Alla ^c   Davar, Gudarz ^d   Makriyannis, Alexandros ^e   Vanderah, Todd W ^a   Mata, Heriberto P ^a   Malan Jr , T Philip ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b ALBANY MEDICAL COLLEGE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d AMGEN INC   (United States)

^e UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

endorphin; Keratinocyte; Nociception; Pain; Skin

Indexed keywords

3 (2 IODO 5 NITROBENZOYL) 1 (1 METHYL 2 PIPERIDINYLMETHYL)INDOLE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; BETA ENDORPHIN; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; MU OPIATE RECEPTOR; NALOXONE; OPIATE; UNCLASSIFIED DRUG; ANALGESIC AGENT; CANNABINOID; ENDOTHELIN B RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ANTINOCICEPTION; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG EFFECT; EPIDERMIS; INFLAMMATION; KERATINOCYTE; MALE; MEDIATOR RELEASE; NEUROPATHIC PAIN; NEUROPHARMACOLOGY; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RECEPTOR BLOCKING; RECEPTOR INTRINSIC ACTIVITY; THERMAL STIMULATION; ANIMAL; DRUG POTENTIATION; HUMAN; PHYSIOLOGY; SECRETION; SPRAGUE DAWLEY RAT;

ANALGESICS; ANIMALS; BETA-ENDORPHIN; CANNABINOIDS; CELLS, CULTURED; HUMANS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB2; RECEPTOR, ENDOTHELIN B;

EID: 20044368975     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0409888102     Document Type: Article

References (31)

1. Malan, T. P., Ibrahim, M. M., Deng, H., Liu, Q., Mata, H. P., Vanderah, T., Porreca, F. & Makriyannis, A. (2001) Pain 93, 239-245.
2. Clayton, N., Marshall, F. H., Bountra, C. & O'Shaughnessey, C. T. (2002) Pain 96, 253-260.
3. Quartilho, A., Mata, H. P., Ibrahim, M. M., Vanderah, T. W, Porreca, F., Makriyannis, A. & Malan, T. P. (2003) Anesthesiology 99, 955-960.
4. Nackley, A. G, Makriyannis, A. & Hohmann, A. G. (2003) Neuroscience 119, 747-757.
5. Ibrahim, M. M., Deng, H., Zvonok, A., Cockayne, D. A., Kwan, J., Mata, H. P., Vanderah, T. W., Lai, J., Porreca, F., Makriyannis, A. & Malan, T. P., Jr. (2003) Proc. Natl. Acad. Sci. USA 100, 10529-10533.
6. Hanus, L., Breuer, A., Tchilibon, S., Shiloah, S., Goldenberg, D., Horowitz, M., Pertwee, R. G., Ross, R. A., Mechoulam, R. & Fride, E. (1999) Proc. Natl. Acad. Sci. USA 96, 14228-14233.
7. Munro, S., Thomas, K. L. & Abu-Shaar, M. (1993) Nature 365, 61-65.
8. Facci, L., Toso, R. D., Romanello, S., Buriani, A., Skaper, S. D. & Leon, A. (1995) Proc. Natl. Acad. Sci. USA 92, 3376-3380.
9. Schatz, A. R., Lee, M., Condie, R. B., Pulaski, J. T. & Kaminski, N. E. (1997) Toxicol. Appl. Pharmacol. 142, 278-287.
10. Zimmer, A., Zimmer, A. M., Hohmann, A. G, Herkenham, M. & Bonner, T. I. (1999) Proc. Natl. Acad. Sci. USA 96, 5780-5785.
11. Casanova, M. L., Blazquez, C., Martinez-Palacio, J., Villanueva, C., Fernandez-Acenero, M. J., Huffman, J. W., Jorcano, J. L. & Guzman, M. (2003) J. Clin. Invest. 111, 43-50.
12. Cabot, P. J., Carter, L., Gaiddon, C., Zhang, Q., Schafer, M., Loefflerm J. P. & Stein, C. (1997) J. Clin. Invest. 100, 142-148.
13. Rittner, H. L., Brack, A., Machelska, H., Mousa, S. A., Bauer, M., Schafer, M. & Stein, C. (2001) Anesthesiology 95, 500-508.
14. Kauser, S., Schallreuter, K., Thody, A., Gummer, C. & Tobin, D. (2003) J. Invest. Dermatol. 120, 1073-1080.
15. Buckley, N. E., McCoy, K. L., Mezey, E., Bonner, T., Zimmer, A., Felder, C. C., Glass, M. & Zimmer, A. (2000) Eur. J. Pharmacol. 396, 141-149.
16. Sora, I., Takahashi, N., Funada, M., Ujike, H., Revay, R. S., Donovan, D. M, Miner, L. L. & Uhl, G. R. (1997) Proc. Natl. Acad. Sci. USA 94, 1544-1549.
17. Ross, R. A, Brockie, H. C., Stevenson, L. A., Murphy, V. L., Templeton, F., Makriyannis, A. & Pertwee, R. G. (1999) Br. J. Pharmacol. 126, 665-672.
18. Hosohata, Y., Quock, R. M., Hosohata, K., Makriyannis, A., Consroe, P., Roeske, W. R. & Yamamura, H. I. (1997) Eur. J. Pharmacol. 321, R1-R3.
19. Hargreaves, K. M., Dubner, R., Brown, F., Flores, C. & Joris, J. (1988) Pain 32, 77-88.
20. Breitkreutz, D., Schoop, V. M., Mirancea, N., Baur, M., Stark, H. J. & Fusenig, N. E. (1998) Eur. J. Cell Biol. 75, 273-286.
21. Paré, M., Elde, R., Mazurkiewicz, J. E., Smith, A. M. & Rice, F. L. (2001) J. Neurosci. 21, 7236-7246.
22. Helmeste, D. M. & Li, C. H. (1986) Proc. Natl. Acad. Sci. USA 83, 67-71.
23. Khodorova, A., Navarro, B., Jouaville, L. S., Murphy, J. E., Rice, F. L., Mazurkiewicz, J. E., Long-Woodward, D., Stoffel, M., Strichartz, G. R., et al. (2003) Nat. Med. 9, 1055-1061.
24. Galiegue, S., Mary, S., Marchand, J., Dussossoy, D., Carriere, D., Carayon, P., Bouaboula, M., Shire, D., Le Fur, G. & Casellas, P. (1995) Eur. J. Biochem. 232, 54-61.
25. Wintzen, M., Yaar, M., Burbach, P. & Gilchrest, B. (1996) J. Invest. Dermatol. 106, 673-678.
26. Stein, C., Hassan, A. H. S., Przewlocki, R., Gramsch, C., Peter, K. & Herz, A. (1990) Proc. Natl. Acad. Sci. USA 87, 5935-5939.
27. Bayewitch, M., Avidor-Reiss, T., Levy, R., Barg, J., Mechoulam, R. & Vogel, Z. (1995) FEBS Lett. 375, 143-147.
28. Ho, B. Y., Uezono, Y., Takada, S., Takase, I. & Izumi, F. (1999) Recept. Channels 6, 363-374.
29. Shefler, I., Seger, R. & Sagi-Eisenberg, R. (1999) J. Pharmacol. Exp. Ther. 289, 1654-1661.
30. Conant, K., Haughey, N., Nath, A., St. Hillaire, C., Gary, D. S., Pardo, C. A., Wahl, L. M., Bilak, M., Milward, E. & Mattson, M. P. (2002) J. Neurochem. 82, 885-893.
31. Ferry, X., Eichwald, V., Daeffler, L. & Landry, Y. (2001) J. Immunol. 197, 4805-4813.