Attenuation of allergic contact dermatitis through the endocannabinoid system

Science

Volumn 316, Issue 5830, 2007, Pages 1494-1497

  Karsak, Meliha ^a   Gaffal, Evelyn ^a   Date, Rahul ^a   Wang Eckhardt, Lihua ^b   Rehnelt, Jennifer ^a   Petrosino, Stefania ^c   Starowicz, Katarzyna ^c   Steuder, Regina ^a   Schlicker, Eberhard ^a   Cravatt, Benjamin ^d   Mechoulam, Raphael ^e   Buettner, Reinhard ^a   Werner, Sabine ^f   Di Marzo, Vincenzo ^c   Tüting, Thomas ^a   Zimmer, Andreas ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Life and Brain Center   (Germany)

^c CNR   (Italy)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^f ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; ENDOCANNABINOID; FATTY ACID AMIDASE;

ENZYME; FATTY ACID; IMMUNE RESPONSE; NERVOUS SYSTEM; OCCUPATIONAL EXPOSURE; RODENT; SKIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTACT ALLERGY; CONTROLLED STUDY; DISEASE EXACERBATION; INDUSTRIALIZATION; INFLAMMATION; MOUSE; NONHUMAN; OCCUPATIONAL ALLERGY; PRIORITY JOURNAL; SKIN ALLERGY;

ANIMALS; ARACHIDONIC ACIDS; BORNANES; CANNABINOIDS; CHEMOKINES; DERMATITIS, ALLERGIC CONTACT; DINITROFLUOROBENZENE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENDOCANNABINOIDS; FEMALE; GLYCERIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PIPERIDINES; POLYUNSATURATED ALKAMIDES; PYRAZOLES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; SKIN; TETRAHYDROCANNABINOL; UP-REGULATION;

ANIMALIA; MUS;

EID: 34250209535     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1142265     Document Type: Article

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25. This work was supported by grants from the Deutsche Forschungsgemeinschaft [SFB645 and GRK804 (to M.K. and A.Z.) and Tu90/S-1 (to T.T.)J, by a Bonfor stipend to E.G., and a grant from Epitech S.r.l. to V.D.M. We thank M. Krampert for her help in wound healing experiments, L. Cristino for her help with immunohistochemistry, and J. Essig, A. Zimmer, E. Erxlebe, and I. Heim for technical assistance.