The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: Insights gained from (E)- and (Z)-naphthylidene indenes

Journal of Medicinal Chemistry

Volumn 41, Issue 26, 1998, Pages 5177-5187

  Reggio, Patricia H ^a   Basu Dutt, Sharmista ^a,b   Barnett Norris, Judy ^a   Castro, Marie T ^a   Hurst, Dow P ^a   Seltzman, Herbert H ^c   Roche, Michael J ^c   Gilliam, Anne F ^c   Thomas, Brian F ^c   Stevenson, L A ^d   Pertwee, Roger G ^d   Abood, Mary E ^e  

^a KENNESAW STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WEST GEORGIA   (United States)

^c RTI INTERNATIONAL   (United States)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

^e VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID RECEPTOR; INDENE DERIVATIVE; INDOLE DERIVATIVE; PRAVADOLINE; RIMONABANT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CIS TRANS ISOMERISM; DRUG CONFORMATION; DRUG STRUCTURE; GEOMETRY; GUINEA PIG; ILEUM; ISOMERISM; MOLECULAR MODEL; NONHUMAN; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR AFFINITY;

ANIMALS; BINDING, COMPETITIVE; CANNABINOIDS; CHO CELLS; CRICETINAE; GUINEA PIGS; ILEUM; INDENES; INDOLES; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MORPHOLINES; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYENTERIC PLEXUS; NAPHTHALENES; RATS; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; STEREOISOMERISM;

EID: 0032542329     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9801197     Document Type: Article

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