Molecular basis of partial agonism: Orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy

Molecular Pharmacology

Volumn 63, Issue 1, 2003, Pages 36-43

  Ebersole, Barbara J ^a   Visiers, Irache ^a   Weinstein, Harel ^a   Sealfon, Stuart C ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINE; G PROTEIN COUPLED RECEPTOR; INDOLEAMINE; LIGAND; METHYL GROUP; MUTANT PROTEIN; PARTIAL AGONIST; SERINE; SEROTONIN; SEROTONIN 2A RECEPTOR;

AGONIST; ARTICLE; BINDING SITE; COMPUTER SIMULATION; CORRELATION ANALYSIS; HUMAN; HUMAN CELL; HYDROGEN BOND; MATHEMATICAL MODEL; MOLECULAR INTERACTION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; REDUCTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; WILD TYPE;

ALANINE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BUFOTENIN; CERCOPITHECUS AETHIOPS; COS CELLS; MODELS, MOLECULAR; MUTATION; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; SERINE; SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037222467     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.1.36     Document Type: Article

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