Cloning and pharmacological characterization of the rat CB2 cannabinoid receptor

Journal of Pharmacology and Experimental Therapeutics

Volumn 292, Issue 3, 2000, Pages 886-894

  Griffin, Graeme ^a,b   Tao, Qing ^a   Abood, Mary E ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID; CANNABINOID RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; NUCLEIC ACID ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; SEQUENCE ANALYSIS; SPECIES DIFFERENTIATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; CYCLOHEXANOLS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; MICE; MOLECULAR SEQUENCE DATA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

EID: 0034010845     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Abadji V, Lin S, Taha G, Griffin G, Stevenson LA, Pertwee RG and Makriyannis A (1994) (R)-Methanandamide: A chiral novel anandamide possessing higher potency and metabolic stability. J Med Chem 37:1889-1893.
2. 2 cannabinoid receptors: Pharmacology of the carbonyl and ethanolamide groups. Prostaglandins Leukot Essent Fatty Acids 59:111-118.
3. 1 receptor: Determination of helix ends and helix orientation. Life Sci 56:1971-1982.
4. 50) on an enzymatic reaction. Biochem Pharmacol 22:3099-3108.
5. Compton DR, Rice KC, De Costa BR, Razdan RK, Melvin LS, Johnson MR and Martin BR (1993) Cannabinoid structure-activity relationships: Correlation of receptor binding and in vivo activities. J Pharmacol Exp Ther 265:218-226.
6. Derocq JM, Segui M, Marchand J, Le Fur G and Casellas P (1995) Cannabinoids enhance human B-cell growth at low nanomolar concentrations. FEBS Lett 369: 177-182.
7. Devane WA, Dysarz IIIFA, Johnson MR, Melvin LS and Howlett AC (1988) Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 34:605-613.
8. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A and Mechoulam R (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science (Wash DC) 258:1946-1949.
9. Di Marzo V, Melck D, Bisogno T and De Petrocellis L (1998) Endocannabinoids: Endogenous cannabinoid receptor ligands with neuromodulatory action. Trends Neurosci 21:521-528.
10. Facci L, Toso RD, Romanello S, Buriani A, Skaper SD and Leon A (1995) Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. Proc Natl Acad Sci USA 92:3376-3380.
11. 2 receptors. Mol Pharmacol 48:443-450.
12. Felder CC, Veluz JS, Williams HL, Briley EM and Matsuda LA (1992) Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones. Mol Pharmacol 42:838-845.
13. Friedman H, Klein TW, Newton C and Daaka Y (1995) Marijuana, receptors and immunomodulation. Adv Exp Med Biol 373:103-113.
14. Gerard CM, Mollereau C, Vassart G and Parmentier M (1991) Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem J 279: 129-134.
15. 35S]GTPγS binding assay in rat cerebellar membranes. J Pharmacol Exp Ther 285:553-560.
16. 2 receptor-selective antagonist, SR144528: Further evidence for cannabinoid CB2 receptor absence in the rat central nervous system. Eur J Pharmacol 377:117-125.
17. Hanus L, Gopher A, Almog S and Mechoulam R (1993) Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor. J Med Chem 36:3032-3034.
18. Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR and Rice KC (1991) Characterization and localization of cannabinoid receptors in rat brain: A quantative in vitro autographic study. J Neurosci 11:563-583.
19. 2 bradykinin receptors. Mol Pharmacol 45:1-8.
20. Hollister LE (1986) Health aspects of cannabis. Pharmacol Rev 38:1-20.
21. Howlett AC (1995) Pharmacology of cannabinoid receptors. Annu Rev Pharmacol Toxicol 35:607-634.
22. 2 receptor. J Med Chem 27:3875-3877.
23. Kaminski NE, Abood ME, Kessler FK, Martin BR and Schatz AR (1992) Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation. Mol Pharmacol 42:736-742.
24. 2A-adrenergic receptor. J Biol Chem 269:31915-31922.
25. Klein TW, Newton C and Friedman H (1998) Cannabinoid receptors and immunity. Immunol Today 19:373-381.
26. 2 receptors. Br J Pharmacol 124:619-622.
27. Matsuda LA, Lolait SJ, Brownstein MJ, Young AC and Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature (Lond) 346:561-564.
28. Mechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR, Gopher A, Almog S, Martin BR, Compton DR, Pertwee RG, Griffin G, Bayewitch M, Barg J and Vogel Z (1995) Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 50:83-90.
29. Munro S, Thomas KL and Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature (Lond) 365:61-65.
30. 1 receptor. Eur J Pharmacol 267:7-19.
31. O'Dowd BF, Hnatowich M, Caron MG, Lefkowitz RJ and Bouvier M (1989) Palmitoylation of the human β2-adrenergic receptor. J Biol Chem 264:7564-7569.
32. Rinaldi-Carmona M, Barth F, Heaulme M, Shire D, Calandra B, Congy C, Martinez S, Maruani J, Neliat G, Caput D, Ferrara P, Soubrie P, Breliere JC and Le Fur G (1994) SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 350:240-244.
33. 2 cannabinoid receptor. J Pharmacol Exp Ther 284:644-650.
34. Sambrook J, Fritsch EF and Maniatis T (1989) Molecular Cloning: A Laboratory Manual, pp 7.46-7.50, Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
35. Scatchard G (1951) The attractions of proteins for small molecules and ions. Ann NY Acad Sci 51:670-672.
36. 2: A characterization of expression and adenylate cyclase modulation within the immune system. Toxicol Appl Pharmacol 142:278-287.
37. 2 peripheral cannabinoid receptor. Biochim Biophys Acta 1307:132-136.
38. 2): Identification of cannabinoid receptor subtype selective ligands. J Pharmacol Exp Ther 278:989-999.
39. 35S]thio]-triphosphate binding. Proc Natl Acad Sci USA 92:7242-7246.
40. Simonin F, Gaveriaux-Ruff C, Befort K, Matthes H, Lannes B, Micheletti G, Mattei M-G, Charron G, Bloch B and Kieffer B (1995) κ-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology and expression pattern in the central nervous system. Proc Natl Acad Sci USA 92:7006-7010.
41. 2, disrupts G-protein coupling. J Pharmacol Exp Ther 285:651-658.