Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB 2 cannabinoid ligand 1-(2′, 4′-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c] pyrazole-3-carboxamide
ARTICLE;
CELL STRAIN HL 60;
DRUG RECEPTOR BINDING;
DRUG SELECTIVITY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
EVALUATION;
HUMAN;
HUMAN CELL;
PROMYELOCYTIC LEUKEMIA;
PROTON NUCLEAR MAGNETIC RESONANCE;
REACTION ANALYSIS;
RECEPTOR AFFINITY;
STRUCTURE ANALYSIS;
A critical role for tyrosine residue in the cannabinoid receptors for ligand recognition
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International Union of Pharmacology. XXVII. Classification of cannabinoid receptors
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Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses
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Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60
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2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells
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New perspectives in the studies on endocannabinoid and cannabis: 2-Arachidonoylglycerol as a possible novel mediator of inflammation
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Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism
Carrier, E. J.; Kearn, C. S.; Barkmeier, A. J.; Breese, N. M.; Yang, W.; Nithipatikom, K.; Pfister, S. L.; Campbell, W. B.; Hillard, C. J. Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism. Mol. Pharmacol. 2004, 65, 999-1007.
Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: Novel role for endogenous and exogenous cannabinoids in immunoregulation
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Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
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2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer disease brains
2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer disease brains. J. Neurosci. 2003, 23, 11136-11141.
Preparation and formulation of tricyclic heterocycles containing a pyrazole-3-carboxamide subunit for pharmaceutical use as cannabinoid receptor antagonists
WO 01 32,629, 2001; p 35 (Sanofi-Synthelabo, France)
Barth, F.; Millan, J.; Oustric, D.; Rinaldi, M.; Vernhet, M. Preparation and formulation of tricyclic heterocycles containing a pyrazole-3-carboxamide subunit for pharmaceutical use as cannabinoid receptor antagonists. WO 01 32,629, 2001; p 35 (Sanofi-Synthelabo, France); Chem. Abstr. 2001, 134, 340501m.
2 cannabinoid receptor by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS
2 cannabinoid receptor by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 10529-10533.
SR144528, an antagonist for the peripheral cannabinoid receptor that behaves as an inverse agonist
Portier, M.; Rinaldi-Carmona, M.; Pecceu, F.; Combes, T.; Poinot-Chazel, C.; Calandra, B.; Barth, F.; Le Fur, G.; Casellas, P. SR144528, an antagonist for the peripheral cannabinoid receptor that behaves as an inverse agonist. J. Pharmacol. Exp. Ther. 1999, 288, 582-589.
Genomic and functional changes induced by the activation of the peripheral cannabinoid receptor CB2 in the promyelocytic cells HL-60. Possible involvement of the CB2 receptor in cell differentiation
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A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions
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CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain
Clayton, N.; Marshall, F. H.; Bountra, C.; O'Shaughnessy, C. T. CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. Pain 2002, 96, 253-260.
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
Effect of δ-9-tetrahydrocannabinol on phosphorylated CREB in rat cerebellum: An immunohistochemical study
Casu, M. A.; Pisu, C.; Sanna, A.; Tambaro, S.; Spada, G. P.; Mongeau, R.; Pani, L. Effect of δ-9-tetrahydrocannabinol on phosphorylated CREB in rat cerebellum: an immunohistochemical study. Brain Res. 2005, 1048, 41-47.
