Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: The importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation

Journal of Biological Chemistry

Volumn 279, Issue 46, 2004, Pages 48024-48037

  McAllister, Sean D ^a   Hurst, Dow P ^b,c   Barnett Norris, Judy ^b,c   Lynch, Diane ^b,c   Reggio, Patricia H ^b,c   Abood, Mary E ^a  

^a CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^b KENNESAW STATE UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BIOCHEMISTRY; CELLS; CONSTRAINT THEORY; MUTAGENESIS; STATISTICAL METHODS;

CANNABINOID (CB); LIGAND BINDING AFFINITY; MUTANT PROTEINS; STRUCTURAL MIMICRY;

PROTEINS;

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ALANINE; ANANDAMIDE; CANNABINOID 1 RECEPTOR; G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); INWARDLY RECTIFYING POTASSIUM CHANNEL; MUTANT PROTEIN; RIMONABANT;

AGONIST; ARTICLE; BINDING AFFINITY; CELL LINE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR MIMICRY; MOLECULAR MODEL; MUTATION; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STIMULATION; WILD TYPE; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; ARACHIDONIC ACIDS; CELL LINE; ENDOCANNABINOIDS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; LIGANDS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; OOCYTES; POLYUNSATURATED ALKAMIDES; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, CANNABINOID, CB1; XENOPUS LAEVIS;

EID: 9144224914     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M406648200     Document Type: Article

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