Mutational analysis and molecular modelling of the antagonist SR 144528 binding site on the human cannabinoid CB2 receptor

European Journal of Pharmacology

Volumn 401, Issue 1, 2000, Pages 17-25

  Gouldson, Paul ^a   Calandra, Bernard ^a   Legoux, Pascale ^a   Kernéis, Aimée ^a   Rinaldi Carmona, Murielle ^a   Barth, Francis ^a   Le Fur, Gérard ^a   Ferrara, Pascual ^a   Shire, David ^a  

^a SANOFI   (France)

Author keywords

Cannabinoid receptor; Ligand docking; Molecular model; Mutagenesis; SR 144528; WIN 55212 2

Indexed keywords

5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; CANNABINOID RECEPTOR; CORTICOTROPIN RELEASING FACTOR; RIMONABANT; SERINE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; FLUORESCENCE; HUMAN; HUMAN CELL; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR MODEL; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BORNANES; COS CELLS; CYCLOHEXANOLS; HUMANS; LUCIFERASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MORPHOLINES; MUTAGENESIS, SITE-DIRECTED; MUTATION; NAPHTHALENES; PROTEIN STRUCTURE, TERTIARY; PYRAZOLES; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; RECOMBINANT FUSION PROTEINS;

EID: 0034726036     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00439-8     Document Type: Article

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