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Volumn 60, Issue 6, 2002, Pages 348-356

Ligand based structural studies of the CB1 cannabinoid receptor

Author keywords

Affinity label; Classical cannabinoid; Covalent probe; G protein coupled receptor; Structure activity relationships

Indexed keywords

CANNABINOID 1 RECEPTOR; G PROTEIN COUPLED RECEPTOR; LIGAND;

EID: 0036950338     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2002.21069.x     Document Type: Article
Times cited : (31)

References (54)
  • 1
    • 0033843626 scopus 로고    scopus 로고
    • Towards 3D structures of G protein-coupled receptors: A multidisciplinary approach
    • Muller, G. (2002) Towards 3D structures of G protein-coupled receptors: a multidisciplinary approach. Curr. Med. 7, 861-888.
    • (2002) Curr. Med. , vol.7 , pp. 861-888
    • Muller, G.1
  • 2
    • 0034720919 scopus 로고    scopus 로고
    • Three dimensional structure of the seventh transmembrane helical domain of the G-protein receptor, rhodopsin
    • Yeagle, P.L., Danis, C., Choi, G., Alderfer, J.L. & Albert, A.D. (2000) Three dimensional structure of the seventh transmembrane helical domain of the G-protein receptor, rhodopsin. Mol. Vis. 6, 125-131.
    • (2000) Mol. Vis. , vol.6 , pp. 125-131
    • Yeagle, P.L.1    Danis, C.2    Choi, G.3    Alderfer, J.L.4    Albert, A.D.5
  • 3
    • 0033982348 scopus 로고    scopus 로고
    • Solution structure of the sixth transmembrane helix of the G-protein-coupled receptor, rhodopsin
    • Chopra, A., Yeagle, P.L., Alderfer, J.A. & Albert, A.D. (2000) Solution structure of the sixth transmembrane helix of the G-protein-coupled receptor, rhodopsin. Biochim. Biophys. Acta 1463, 1-5.
    • (2000) Biochim. Biophys. Acta , vol.1463 , pp. 1-5
    • Chopra, A.1    Yeagle, P.L.2    Alderfer, J.A.3    Albert, A.D.4
  • 4
    • 0033030794 scopus 로고    scopus 로고
    • Characterization of ligand-induced conformational states in the beta 2 adrenergic receptor
    • Kobilka, B., Gether, U., Seifert, R., Lin, S. & Ghanouni, P. (1999) Characterization of ligand-induced conformational states in the beta 2 adrenergic receptor. J. Recept. Signal Transduct. Res. 19, 293-300.
    • (1999) J. Recept. Signal Transduct. Res. , vol.19 , pp. 293-300
    • Kobilka, B.1    Gether, U.2    Seifert, R.3    Lin, S.4    Ghanouni, P.5
  • 5
    • 0029907599 scopus 로고    scopus 로고
    • Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
    • Farrens, D.L., Altenbach, C., Yang, K., Hubbell, W.L. & Khorana, H.G. (1996) Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin. Science 274, 768-770.
    • (1996) Science , vol.274 , pp. 768-770
    • Farrens, D.L.1    Altenbach, C.2    Yang, K.3    Hubbell, W.L.4    Khorana, H.G.5
  • 6
    • 0036784635 scopus 로고    scopus 로고
    • Cannabinoid receptor-G protein interactions: G (alphai1)-bound structures of IC3 and a mutant with altered G protein specificity
    • Ulfers, A.L., McMurry, J.L., Miller, A., Wang, L., Kendall, D.A. & Mierke, D.F. (2002) Cannabinoid receptor-G protein interactions: G (alphai1)-bound structures of IC3 and a mutant with altered G protein specificity. Protein Sci. 11, 2526-2531.
    • (2002) Protein Sci. , vol.11 , pp. 2526-2531
    • Ulfers, A.L.1    McMurry, J.L.2    Miller, A.3    Wang, L.4    Kendall, D.A.5    Mierke, D.F.6
  • 7
    • 0037167584 scopus 로고    scopus 로고
    • Structure of the third intracellular loop of the human cannabinoid receptor
    • Ulfers, A.L., McMurry, J.L., Kendall, D.A. & Mierke, D.F. (2002) Structure of the third intracellular loop of the human cannabinoid receptor. Biochemistry 41, 11344-11350.
    • (2002) Biochemistry , vol.41 , pp. 11344-11350
    • Ulfers, A.L.1    McMurry, J.L.2    Kendall, D.A.3    Mierke, D.F.4
  • 9
    • 0031600116 scopus 로고    scopus 로고
    • Rhodopsin: A prototypical G protein-coupled receptor
    • Sakmar, T.P. (1998) Rhodopsin: a prototypical G protein-coupled receptor. Prog. Nucl Acid Res. Mol. Biol. 59, 1-34.
    • (1998) Prog. Nucl. Acid Res. Mol. Biol. , vol.59 , pp. 1-34
    • Sakmar, T.P.1
  • 10
    • 0026517309 scopus 로고
    • On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the three-dimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors
    • Pardo, L., Ballesteros, J.A., Osman, R. & Weinstein, H. (1992) On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the three-dimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors. Proc. Natl Acad. Sci. USA 89, 4009-4012.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4009-4012
    • Pardo, L.1    Ballesteros, J.A.2    Osman, R.3    Weinstein, H.4
  • 12
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda, L.A., Lolait, S.J., Brownstein, M.J., Young, A.C. & Bonner, T.I. (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346, 561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 14
    • 0030611978 scopus 로고    scopus 로고
    • Pharmacology of cannabinoid CB1 and CB2 receptors
    • Pertwee, R.G. (1997) Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol. Ther. 74, 129-180.
    • (1997) Pharmacol. Ther. , vol.74 , pp. 129-180
    • Pertwee, R.G.1
  • 15
    • 0036669789 scopus 로고    scopus 로고
    • From cannabis to cannabinergics. New therapeutic opportunities
    • Goutopoulos, A. & Makriyannis, A. (2002) From cannabis to cannabinergics, new therapeutic opportunities. Pharmacol. Ther. 95, 103.
    • (2002) Pharmacol. Ther. , vol.95 , pp. 103
    • Goutopoulos, A.1    Makriyannis, A.2
  • 16
    • 0033850995 scopus 로고    scopus 로고
    • Natural and synthetic endocannabinoids and their structure-activity relationships
    • Palmer, S.L., Khanolkar, A.D. & Makriyannis, A. (2000) Natural and synthetic endocannabinoids and their structure-activity relationships. Curr. Pharm. Des. 6, 1381-1397.
    • (2000) Curr. Pharm. Des. , vol.6 , pp. 1381-1397
    • Palmer, S.L.1    Khanolkar, A.D.2    Makriyannis, A.3
  • 17
    • 0034929449 scopus 로고    scopus 로고
    • The endocannabinoid nervous system: Unique opportunities for therapeutic intervention
    • Porter, A.C. & Felder, C.C. (2001) The endocannabinoid nervous system: unique opportunities for therapeutic intervention. Pharmacol. Ther. 90, 45-60.
    • (2001) Pharmacol. Ther. , vol.90 , pp. 45-60
    • Porter, A.C.1    Felder, C.C.2
  • 19
    • 0001065345 scopus 로고
    • New analogs of tetrahydrocannabinol
    • Adams, R., Harfenst, M. & Lowe, S (1949) New analogs of tetrahydrocannabinol. J. Am. Chem. Soc. 71, 1624-1628.
    • (1949) J. Am. Chem. Soc. , vol.71 , pp. 1624-1628
    • Adams, R.1    Harfenst, M.2    Lowe, S.3
  • 20
    • 0023493916 scopus 로고
    • Structure-activity relationships of tricyclic and nonclassical bicyclic cannabinoids
    • Melvin, L.S. & Johnson, M.R. (1987) Structure-activity relationships of tricyclic and nonclassical bicyclic cannabinoids. NIDA Res. Monogr. 79, 31-47.
    • (1987) NIDA Res. Monogr. , vol.79 , pp. 31-47
    • Melvin, L.S.1    Johnson, M.R.2
  • 21
    • 0029064111 scopus 로고
    • Common cannabimimetic pharmacophoric requirements between aminoalkyl indoles and classical cannabinoids
    • Xie, X.Q., Eissenstat, M. & Makriyannis, A. (1995) Common cannabimimetic pharmacophoric requirements between aminoalkyl indoles and classical cannabinoids. Life Sci. 56, 1963-1970.
    • (1995) Life Sci. , vol.56 , pp. 1963-1970
    • Xie, X.Q.1    Eissenstat, M.2    Makriyannis, A.3
  • 25
    • 0029034879 scopus 로고
    • Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonist
    • Rinaldi-Carmona, M., Barth, F., Heaulme, M., Alonso, R., Shire, D., Congy, C., Soubrie, P., Breliere, J.C. & Le Fur, G. (1995) Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonist. Life Sci. 56, 1941-1947.
    • (1995) Life Sci. , vol.56 , pp. 1941-1947
    • Rinaldi-Carmona, M.1    Barth, F.2    Heaulme, M.3    Alonso, R.4    Shire, D.5    Congy, C.6    Soubrie, P.7    Breliere, J.C.8    Le Fur, G.9
  • 27
    • 0032795627 scopus 로고    scopus 로고
    • Ligand-ligand and ligand-receptor approaches to modeling the cannabinoid CB1 and CB2 receptors: Achievements and challenges
    • Reggio, P.H. (1999) Ligand-ligand and ligand-receptor approaches to modeling the cannabinoid CB1 and CB2 receptors: achievements and challenges. Curr. Med. Chem. 6, 665-683.
    • (1999) Curr. Med. Chem. , vol.6 , pp. 665-683
    • Reggio, P.H.1
  • 29
    • 0029078977 scopus 로고
    • Construction of a 3D model of the cannabinoid CB1 receptor: Determination of helix ends and helix orientation
    • Bramblett, R.D., Panu, A.M., Ballesteros, J.A. & Reggio, P.H. (1995) Construction of a 3D model of the cannabinoid CB1 receptor: determination of helix ends and helix orientation. Life Sci. 56, 1971-1982.
    • (1995) Life Sci. , vol.56 , pp. 1971-1982
    • Bramblett, R.D.1    Panu, A.M.2    Ballesteros, J.A.3    Reggio, P.H.4
  • 31
    • 0032860406 scopus 로고    scopus 로고
    • The difference between the CB (1) and CB (2) cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB(2)
    • Song, Z.H., Slowey, C.A., Hurst, D.P. & Reggio, P.H. (1999) The difference between the CB (1) and CB (2) cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB(2). Mol. Pharmacol. 56, 834-840.
    • (1999) Mol. Pharmacol. , vol.56 , pp. 834-840
    • Song, Z.H.1    Slowey, C.A.2    Hurst, D.P.3    Reggio, P.H.4
  • 34
    • 0024537502 scopus 로고
    • Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet alpha 2-adrenergic receptor
    • Matsui, H., Lefkowitz, R.J., Caron, M.G. & Regan, J.W. (1989) Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet alpha 2-adrenergic receptor. Biochemistry 28, 4125-4130.
    • (1989) Biochemistry , vol.28 , pp. 4125-4130
    • Matsui, H.1    Lefkowitz, R.J.2    Caron, M.G.3    Regan, J.W.4
  • 35
    • 0029072718 scopus 로고
    • Photoaffinity-labeled ligand binding domains on dopamine transporters identified by peptide mapping
    • Vaughan, R.A. (1995) Photoaffinity-labeled ligand binding domains on dopamine transporters identified by peptide mapping. Mol. Pharmacol. 47, 956-964.
    • (1995) Mol. Pharmacol. , vol.47 , pp. 956-964
    • Vaughan, R.A.1
  • 36
    • 0029816108 scopus 로고    scopus 로고
    • Dopamine transporter ligand binding domains. Structural and functional properties revealed by limited proteolysis
    • Vaughan, R.A. & Kuhar, M.J. (1996) Dopamine transporter ligand binding domains. Structural and functional properties revealed by limited proteolysis. J. Biol. Chem. 271, 21672-21680.
    • (1996) J. Biol. Chem. , vol.271 , pp. 21672-21680
    • Vaughan, R.A.1    Kuhar, M.J.2
  • 37
    • 0030067780 scopus 로고    scopus 로고
    • Irreversible binding of cis-(+)-3-methylfentanyl isothiocyanate to the delta opioid receptor and determination of its binding domain
    • Zhu, J., Yin, J., Law, P.Y., Claude, P.A., Rice, K.C., Evans, C.J. & Chen, C., Yu, L. & Liu-Chen, L.Y. (1996) Irreversible binding of cis-(+)-3-methylfentanyl isothiocyanate to the delta opioid receptor and determination of its binding domain. J. Biol. Chem. 271, 1430-1434.
    • (1996) J. Biol. Chem. , vol.271 , pp. 1430-1434
    • Zhu, J.1    Yin, J.2    Law, P.Y.3    Claude, P.A.4    Rice, K.C.5    Evans, C.J.6    Chen, C.7    Yu, L.8    Liu-Chen, L.Y.9
  • 38
    • 0033951038 scopus 로고    scopus 로고
    • Using photolabile ligands in drug discovery and development
    • Dorman, G. & Prestwich, G.D. (2000) Using photolabile ligands in drug discovery and development. Trends Biotechnol. 18, 64-77.
    • (2000) Trends Biotechnol. , vol.18 , pp. 64-77
    • Dorman, G.1    Prestwich, G.D.2
  • 39
    • 33947091497 scopus 로고
    • Photogenterated reagents for biological receptor-site labeling
    • Knowles, J.R. (1972) Photogenterated reagents for biological receptor-site labeling. Meth Enzymol. 5, 155-160.
    • (1972) Meth. Enzymol. , vol.5 , pp. 155-160
    • Knowles, J.R.1
  • 40
    • 0022416158 scopus 로고
    • Chemical mechanisms for photoaffinity labeling of receptors
    • Cavalla, D. & Neff, N.H. (1985) Chemical mechanisms for photoaffinity labeling of receptors. Biochem. Pharmacol. 34, 2821-2826.
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 2821-2826
    • Cavalla, D.1    Neff, N.H.2
  • 43
    • 0035304607 scopus 로고    scopus 로고
    • Affinity labels as tools for the identification of opioid receptor recognition sites
    • Portoghese, P.S., El Kouhen, R., Law, P.Y., Loh, H.H. & Le Bourdonnec, B. (2001) Affinity labels as tools for the identification of opioid receptor recognition sites. Farmaco 56, 191-196.
    • (2001) Farmaco , vol.56 , pp. 191-196
    • Portoghese, P.S.1    El Kouhen, R.2    Law, P.Y.3    Loh, H.H.4    Le Bourdonnec, B.5
  • 45
    • 0032568420 scopus 로고    scopus 로고
    • Pharmacophoric requirements for cannabinoid side chains: Multiple bond and C1′-substituted delta 8-tetrahydrocannabinols
    • Papahatjis, D.P., Kourouli, T., Abadji, V., Goutopoulos, A. & Makriyannis, A. (1998) Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1′-substituted delta 8-tetrahydrocannabinols. J. Med. Chem. 41, 1195-1200.
    • (1998) J. Med. Chem. , vol.41 , pp. 1195-1200
    • Papahatjis, D.P.1    Kourouli, T.2    Abadji, V.3    Goutopoulos, A.4    Makriyannis, A.5
  • 48
    • 0025241109 scopus 로고
    • Characterization of the lipophilicity of natural and synthetic analogs of delta 9-tetrahydrocannabinol and its relationship to pharmacological potency
    • Thomas, B.F., Compton, D.R. & Martin, B.R. (1990) Characterization of the lipophilicity of natural and synthetic analogs of delta 9-tetrahydrocannabinol and its relationship to pharmacological potency. J. Pharmacol. Exp. Ther. 255, 624-630.
    • (1990) J. Pharmacol. Exp. Ther. , vol.255 , pp. 624-630
    • Thomas, B.F.1    Compton, D.R.2    Martin, B.R.3
  • 50
    • 0029014009 scopus 로고
    • A novel electrophilic high affinity irreversible probe for the cannabinoid receptor
    • Morse, K.L., Fournier, D.J., Li, X., Grzybowska, J. & Makriyannis, A. (1995) A novel electrophilic high affinity irreversible probe for the cannabinoid receptor. Life Sci. 56, 1957-1962.
    • (1995) Life Sci. , vol.56 , pp. 1957-1962
    • Morse, K.L.1    Fournier, D.J.2    Li, X.3    Grzybowska, J.4    Makriyannis, A.5
  • 51
    • 0027961011 scopus 로고
    • (-)-11-Hydroxy-7′-isothiocyanato-1′,1′-dimethylheptyl-delta 8-THC: A novel, high-affinity irreversible probe for the cannabinoid receptor in the brain
    • Guo, Y., Abadji, V., Morse, K.L., Fournier, D.J., Li, X. & Makriyannis, A. (1994) (-)-11-Hydroxy-7′-isothiocyanato-1′,1′-dimethylheptyl-delta 8-THC: a novel, high-affinity irreversible probe for the cannabinoid receptor in the brain. J. Med. Chem. 37, 3867-3870.
    • (1994) J. Med. Chem. , vol.37 , pp. 3867-3870
    • Guo, Y.1    Abadji, V.2    Morse, K.L.3    Fournier, D.J.4    Li, X.5    Makriyannis, A.6
  • 52
    • 0002350989 scopus 로고    scopus 로고
    • The importance of the helix six beta-XX-beta motif to ligand binding and activation of the cananbinoid recpetors
    • International Cannabinoid Research Society, Burlington, VT, USA
    • Reggio, P.H., Norris, J.E., Ballesteros, J.A., Guarnieri, F. & Hurst, D.P. (2000) The importance of the helix six beta-XX-beta motif to ligand binding and activaiton of the cananbinoid recpetors. 2000 Symposium on the Cannabinoids. International Cannabinoid Research Society, Burlington, VT, USA.
    • (2000) 2000 Symposium on the Cannabinoids
    • Reggio, P.H.1    Norris, J.E.2    Ballesteros, J.A.3    Guarnieri, F.4    Hurst, D.P.5
  • 53
    • 0035937786 scopus 로고    scopus 로고
    • Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling
    • Jensen, A.D., Guarnieri, F., Rasmussen, S.G., Asmar, F., Ballesteros, J.A. & Gether, U. (2001) Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling. J. Biol. Chem. 276, 9279-9290.
    • (2001) J. Biol. Chem. , vol.276 , pp. 9279-9290
    • Jensen, A.D.1    Guarnieri, F.2    Rasmussen, S.G.3    Asmar, F.4    Ballesteros, J.A.5    Gether, U.6
  • 54
    • 0035800850 scopus 로고    scopus 로고
    • Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
    • Ballesteros, J.A., Jensen, A.D., Liapakis, G., Rasmussen, S.G., Shi, L., Gether, U. & Javitch, J.A. (2001) Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6. J. Biol. Chem. 276, 19171-29177.
    • (2001) J. Biol. Chem. , vol.276 , pp. 19171-29177
    • Ballesteros, J.A.1    Jensen, A.D.2    Liapakis, G.3    Rasmussen, S.G.4    Shi, L.5    Gether, U.6    Javitch, J.A.7


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