-
1
-
-
19344372271
-
Systems biology: Its practice and challenges
-
Aderem, A. (2005). Systems biology: Its practice and challenges. Cell, 121, 511-513.
-
(2005)
Cell
, vol.121
, pp. 511-513
-
-
Aderem, A.1
-
2
-
-
0024237766
-
Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP
-
Arora, K. K., & Pedersen, P. L. (1988). Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP. Journal of Biological Chemistry, 263, 17422-17428.
-
(1988)
Journal of Biological Chemistry
, vol.263
, pp. 17422-17428
-
-
Arora, K.K.1
Pedersen, P.L.2
-
3
-
-
32644472628
-
Cancer's sweet tooth: The Janus effect of glucose metabolism in tumorigenesis
-
Ashrafian, H. (2006). Cancer's sweet tooth: The Janus effect of glucose metabolism in tumorigenesis. Lancet, 367, 618-621.
-
(2006)
Lancet
, vol.367
, pp. 618-621
-
-
Ashrafian, H.1
-
4
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
Bensaad, K., Tsuruta, A., Selak, M. A., et al. (2006). TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell, 126, 107-120.
-
(2006)
Cell
, vol.126
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
-
5
-
-
0037085584
-
Metabolic profiling of cell growth and death in cancer: Applications in drug discovery
-
Boros, L. G., Cascante, M., & Paul Lee, W.-N. (2002). Metabolic profiling of cell growth and death in cancer: Applications in drug discovery. Drug Discovery Today, 7, 364-372.
-
(2002)
Drug Discovery Today
, vol.7
, pp. 364-372
-
-
Boros, L.G.1
Cascante, M.2
Paul Lee, W.-N.3
-
6
-
-
0031974007
-
Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: Is cancer a disease of cellular glucose metabolism?
-
Boros, L. G., Lee, P. W. N., Brandes, J. L., et al. (1998). Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: Is cancer a disease of cellular glucose metabolism? Medical Hypotheses, 50, 55-59.
-
(1998)
Medical Hypotheses
, vol.50
, pp. 55-59
-
-
Boros, L.G.1
Lee, P.W.N.2
Brandes, J.L.3
-
7
-
-
0030758923
-
Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation
-
Boros, L. G., Puigjaner, J., Cascante, M., et al. (1997). Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation. Cancer Research, 57, 4242-4248.
-
(1997)
Cancer Research
, vol.57
, pp. 4242-4248
-
-
Boros, L.G.1
Puigjaner, J.2
Cascante, M.3
-
8
-
-
33847711354
-
Hypoxia signalling controls metabolic demand
-
Brahimi-Horn, M. C., Chiche, J., & Pouyssegur, J. (2007). Hypoxia signalling controls metabolic demand. Current Opinion in Cell Biology, 19, 223-229.
-
(2007)
Current Opinion in Cell Biology
, vol.19
, pp. 223-229
-
-
Brahimi-Horn, M.C.1
Chiche, J.2
Pouyssegur, J.3
-
9
-
-
23044482013
-
RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells
-
Brusselmans, K., De Schrijver, E., Verhoeven, G., & Swinnen, J. V. (2005). RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells. Cancer Research, 65, 6719-6725.
-
(2005)
Cancer Research
, vol.65
, pp. 6719-6725
-
-
Brusselmans, K.1
De Schrijver, E.2
Verhoeven, G.3
Swinnen, J.V.4
-
10
-
-
33744826296
-
Cancer's sweet tooth
-
Bui, T., & Thompson, C. B. (2006). Cancer's sweet tooth. Cancer Cell, 9, 419-420.
-
(2006)
Cancer Cell
, vol.9
, pp. 419-420
-
-
Bui, T.1
Thompson, C.B.2
-
11
-
-
0034885978
-
Using positron emission tomography with [(18)F]FDG to predict tumor behavior in experimental colorectal cancer
-
Burt, B. M., Humm, J. L., Kooby, D. A., et al. (2001). Using positron emission tomography with [(18)F]FDG to predict tumor behavior in experimental colorectal cancer. Neoplasia, 3, 189-195.
-
(2001)
Neoplasia
, vol.3
, pp. 189-195
-
-
Burt, B.M.1
Humm, J.L.2
Kooby, D.A.3
-
12
-
-
22744453364
-
Isolated mouse liver mitochondria are devoid of glucokinase
-
Bustamante, E., Pediaditakis, P., He, L., & Lemasters, J. J. (2005). Isolated mouse liver mitochondria are devoid of glucokinase. Biochemical and Biophysical Research Communications, 334, 907-910.
-
(2005)
Biochemical and Biophysical Research Communications
, vol.334
, pp. 907-910
-
-
Bustamante, E.1
Pediaditakis, P.2
He, L.3
Lemasters, J.J.4
-
13
-
-
33745788590
-
Glyceraldehyde 3-phosphate dehydrogenase is a SET-binding protein and regulates cyclin B-cdk1 activity
-
Carujo, S., Estanyol, J. M., Ejarque, A., et al. (2006). Glyceraldehyde 3-phosphate dehydrogenase is a SET-binding protein and regulates cyclin B-cdk1 activity. Oncogene, 25, 4033-4042.
-
(2006)
Oncogene
, vol.25
, pp. 4033-4042
-
-
Carujo, S.1
Estanyol, J.M.2
Ejarque, A.3
-
14
-
-
0036195958
-
Metabolic control analysis in drug discovery and disease
-
Cascante, M., Boros, L. G., Comin-Anduix, B., et al. (2002). Metabolic control analysis in drug discovery and disease. Nature Biotechnology, 20, 243-249.
-
(2002)
Nature Biotechnology
, vol.20
, pp. 243-249
-
-
Cascante, M.1
Boros, L.G.2
Comin-Anduix, B.3
-
15
-
-
0033917915
-
Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation
-
Cascante, M., Centelles, J. J., Veech, R. L., Lee, W. N., & Boros, L. G. (2000). Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation. Nutrition and Cancer, 36, 150-154.
-
(2000)
Nutrition and Cancer
, vol.36
, pp. 150-154
-
-
Cascante, M.1
Centelles, J.J.2
Veech, R.L.3
Lee, W.N.4
Boros, L.G.5
-
16
-
-
0036674501
-
Dissemination and growth of cancer cells in metastatic sites
-
Chambers, A. F., Groom, A. C., & MacDonald, I. C. (2002). Dissemination and growth of cancer cells in metastatic sites. Nature Reviews Cancer, 2, 563-572.
-
(2002)
Nature Reviews Cancer
, vol.2
, pp. 563-572
-
-
Chambers, A.F.1
Groom, A.C.2
MacDonald, I.C.3
-
17
-
-
33746075170
-
The application of systems biology to drug discovery
-
Cho, C. R., Labow, M., Reinhardt, M., van Oostrum, J., & Peitsch, M. C. (2006). The application of systems biology to drug discovery. Current Opinion in Chemical Biology, 10, 294-302.
-
(2006)
Current Opinion in Chemical Biology
, vol.10
, pp. 294-302
-
-
Cho, C.R.1
Labow, M.2
Reinhardt, M.3
van Oostrum, J.4
Peitsch, M.C.5
-
18
-
-
34447564234
-
Metabolomics: Available results, current research projects in breast cancer, and future applications
-
Claudino, W. M., Quattrone, A., Biganzoli, L., et al. (2007). Metabolomics: Available results, current research projects in breast cancer, and future applications. Journal of Clinical Oncology, 25, 2840-2846.
-
(2007)
Journal of Clinical Oncology
, vol.25
, pp. 2840-2846
-
-
Claudino, W.M.1
Quattrone, A.2
Biganzoli, L.3
-
19
-
-
21244460340
-
Mutations in the transketolase-like gene TKTL1: Clinical implications for neurodegenerative diseases, diabetes and cancer
-
Coy, J. F., Dressler, D., Wilde, J., & Schubert, P. (2005). Mutations in the transketolase-like gene TKTL1: Clinical implications for neurodegenerative diseases, diabetes and cancer. Clinical Laboratory, 51, 257-273.
-
(2005)
Clinical Laboratory
, vol.51
, pp. 257-273
-
-
Coy, J.F.1
Dressler, D.2
Wilde, J.3
Schubert, P.4
-
20
-
-
0036176751
-
Positron emission tomography scanning: Current and future applications
-
Czernin, J., & Phelps, M. E. (2002). Positron emission tomography scanning: Current and future applications. Annual Review of Medicine, 53, 89-112.
-
(2002)
Annual Review of Medicine
, vol.53
, pp. 89-112
-
-
Czernin, J.1
Phelps, M.E.2
-
22
-
-
0041357164
-
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
-
Danial, N. N., Gramm, C. F., Scorrano, L., et al. (2003). BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature, 424, 952-956.
-
(2003)
Nature
, vol.424
, pp. 952-956
-
-
Danial, N.N.1
Gramm, C.F.2
Scorrano, L.3
-
23
-
-
0035017658
-
Potential role of nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase in apoptosis and oxidative stress
-
Dastoor, Z., & Dreyer, J. L. (2001). Potential role of nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase in apoptosis and oxidative stress. Journal of Cell Science, 114, 1643-1653.
-
(2001)
Journal of Cell Science
, vol.114
, pp. 1643-1653
-
-
Dastoor, Z.1
Dreyer, J.L.2
-
24
-
-
33845314350
-
Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors
-
Denkert, C., Budczies, J., Kind, T., et al. (2006). Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors. Cancer Research, 66, 10795-10804.
-
(2006)
Cancer Research
, vol.66
, pp. 10795-10804
-
-
Denkert, C.1
Budczies, J.2
Kind, T.3
-
25
-
-
0035798097
-
Mammalian TOR: A homeostatic ATP sensor
-
Dennis, P. B., Jaeschke, A., Saitoh, M., et al. (2001). Mammalian TOR: A homeostatic ATP sensor. Science, 294, 1102-1105.
-
(2001)
Science
, vol.294
, pp. 1102-1105
-
-
Dennis, P.B.1
Jaeschke, A.2
Saitoh, M.3
-
26
-
-
0038418257
-
RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells
-
De Schrijver, E., Brusselmans, K., Heyns, W., Verhoeven, G., & Swinnen, J. V. (2003). RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells. Cancer Research, 63, 3799-3804.
-
(2003)
Cancer Research
, vol.63
, pp. 3799-3804
-
-
De Schrijver, E.1
Brusselmans, K.2
Heyns, W.3
Verhoeven, G.4
Swinnen, J.V.5
-
27
-
-
0042860122
-
Cell biology: Metabolism meets death
-
Downward, J. (2003). Cell biology: Metabolism meets death. Nature, 424, 896-897.
-
(2003)
Nature
, vol.424
, pp. 896-897
-
-
Downward, J.1
-
28
-
-
0000069903
-
New perspectives on carbohydrate metabolism in tumor cells
-
In R. Beitner (Ed.), Florida: CRC Press
-
Eigenbrodt, E., Fister, P., & Reinacher, M. (1985). New perspectives on carbohydrate metabolism in tumor cells. In R. Beitner (Ed.), Regulation of carbohydrate metabolism. Florida: CRC Press.
-
(1985)
Regulation of Carbohydrate Metabolism
-
-
Eigenbrodt, E.1
Fister, P.2
Reinacher, M.3
-
29
-
-
2542561169
-
Akt stimulates aerobic glycolysis in cancer cells
-
Elstrom, R. L., Bauer, D. E., Buzzai, M., et al. (2004). Akt stimulates aerobic glycolysis in cancer cells. Cancer Research, 64, 3892-3899.
-
(2004)
Cancer Research
, vol.64
, pp. 3892-3899
-
-
Elstrom, R.L.1
Bauer, D.E.2
Buzzai, M.3
-
30
-
-
27744557065
-
Oxidative stress and apoptosis: A new treatment paradigm in cancer
-
Engel, R. H., & Evens, A. M. (2006). Oxidative stress and apoptosis: A new treatment paradigm in cancer. Frontiers in Bioscience, 11, 300-312.
-
(2006)
Frontiers in Bioscience
, vol.11
, pp. 300-312
-
-
Engel, R.H.1
Evens, A.M.2
-
31
-
-
4143064982
-
Phosphoglycerate mutase-derived polypeptide inhibits glycolytic flux and induces cell growth arrest in tumor cell lines
-
Engel, M., Mazurek, S., Eigenbrodt, E., & Welter, C. (2004). Phosphoglycerate mutase-derived polypeptide inhibits glycolytic flux and induces cell growth arrest in tumor cell lines. Journal of Biological Chemistry, 279, 35803-35812.
-
(2004)
Journal of Biological Chemistry
, vol.279
, pp. 35803-35812
-
-
Engel, M.1
Mazurek, S.2
Eigenbrodt, E.3
Welter, C.4
-
32
-
-
33744783432
-
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
-
Fantin, V. R., St-Pierre, J., & Leder, P. (2006). Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell, 9, 425-434.
-
(2006)
Cancer Cell
, vol.9
, pp. 425-434
-
-
Fantin, V.R.1
St-Pierre, J.2
Leder, P.3
-
33
-
-
0036717382
-
Molecular imaging of cancer with positron emission tomography
-
Gambhir, S. S. (2002). Molecular imaging of cancer with positron emission tomography. Nature Reviews Cancer, 2, 683-693.
-
(2002)
Nature Reviews Cancer
, vol.2
, pp. 683-693
-
-
Gambhir, S.S.1
-
34
-
-
33744969828
-
Energy deregulation: Licensing tumors to grow
-
Garber, K. (2006). Energy deregulation: Licensing tumors to grow. Science, 312, 1158-1159.
-
(2006)
Science
, vol.312
, pp. 1158-1159
-
-
Garber, K.1
-
35
-
-
33744942376
-
Acid-mediated tumor invasion: A multidisciplinary study
-
Gatenby, R. A., Gawlinski, E. T., Gmitro, A. F., Kaylor, B., & Gillies, R. J. (2006). Acid-mediated tumor invasion: A multidisciplinary study. Cancer Research, 66, 5216-5223.
-
(2006)
Cancer Research
, vol.66
, pp. 5216-5223
-
-
Gatenby, R.A.1
Gawlinski, E.T.2
Gmitro, A.F.3
Kaylor, B.4
Gillies, R.J.5
-
36
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby, R. A., & Gillies, R. J. (2004). Why do cancers have high aerobic glycolysis? Nature Reviews Cancer, 4, 891-899.
-
(2004)
Nature Reviews Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
37
-
-
33747856339
-
Metabolomics: Building on a century of biochemistry to guide human health
-
German, J. B., Hammock, B. D., & Watkins, S. M. (2005). Metabolomics: Building on a century of biochemistry to guide human health. Metabolomics, 1, 3-9.
-
(2005)
Metabolomics
, vol.1
, pp. 3-9
-
-
German, J.B.1
Hammock, B.D.2
Watkins, S.M.3
-
38
-
-
33344467760
-
Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
-
Gottfried, E., Kunz-Schughart, L. A., Ebner, S., et al. (2006). Tumor-derived lactic acid modulates dendritic cell activation and antigen expression. Blood, 107, 2013-2021.
-
(2006)
Blood
, vol.107
, pp. 2013-2021
-
-
Gottfried, E.1
Kunz-Schughart, L.A.2
Ebner, S.3
-
39
-
-
28544446058
-
Mitochondrial tumour suppressors: A genetic and biochemical update
-
Gottlieb, E., & Tomlinson, I. P. (2005). Mitochondrial tumour suppressors: A genetic and biochemical update. Nature Reviews Cancer, 5, 857-866.
-
(2005)
Nature Reviews Cancer
, vol.5
, pp. 857-866
-
-
Gottlieb, E.1
Tomlinson, I.P.2
-
40
-
-
0028088144
-
Immunoregulation by parenteral lipids: Impact of the n-3 to n-6 fatty acid ratio
-
Grimm, H., Tibell, A., Norrlind, B., et al. (1994). Immunoregulation by parenteral lipids: Impact of the n-3 to n-6 fatty acid ratio. JPEN Journal of Parenteral and Enteral Nutrition, 18, 417-421.
-
(1994)
JPEN Journal of Parenteral and Enteral Nutrition
, vol.18
, pp. 417-421
-
-
Grimm, H.1
Tibell, A.2
Norrlind, B.3
-
41
-
-
33846942624
-
Correlation of GLUT-1 overexpression, tumor size, and depth of invasion with 18F-2-fluoro-2-deoxy-D-glucose uptake by positron emission tomography in colorectal cancer
-
Gu, J., Yamamoto, H., Fukunaga, H., et al. (2006). Correlation of GLUT-1 overexpression, tumor size, and depth of invasion with 18F-2-fluoro-2-deoxy-D-glucose uptake by positron emission tomography in colorectal cancer. Digestive Diseases and Sciences, 51, 2198-2205.
-
(2006)
Digestive Diseases and Sciences
, vol.51
, pp. 2198-2205
-
-
Gu, J.1
Yamamoto, H.2
Fukunaga, H.3
-
42
-
-
0348054921
-
Pathways of carbohydrate metabolism in microorganisms
-
Gunsalus, I. C., Horecker, B. L., & Wood, W. A. (1955). Pathways of carbohydrate metabolism in microorganisms. Bacteriological Reviews, 19, 79-128.
-
(1955)
Bacteriological Reviews
, vol.19
, pp. 79-128
-
-
Gunsalus, I.C.1
Horecker, B.L.2
Wood, W.A.3
-
43
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D., & Weinberg, R. A. (2000). The hallmarks of cancer. Cell, 100, 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
44
-
-
1842559337
-
Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain
-
Hansen, M., Le Nours, J., Johansson, E., et al. (2004). Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain. Protein Science, 13, 1031-1042.
-
(2004)
Protein Science
, vol.13
, pp. 1031-1042
-
-
Hansen, M.1
Le Nours, J.2
Johansson, E.3
-
45
-
-
26644441651
-
ATP citrate lyase inhibition can suppress tumor cell growth
-
Hatzivassiliou, G., Zhao, F., Bauer, D. E., et al. (2005). ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell, 8, 311-321.
-
(2005)
Cancer Cell
, vol.8
, pp. 311-321
-
-
Hatzivassiliou, G.1
Zhao, F.2
Bauer, D.E.3
-
47
-
-
0035503378
-
Identification of tumor markers in models of human colorectal cancer using a 19,200-element complementary DNA microarray
-
Hegde, P., Qi, R., Gaspard, R., et al. (2001). Identification of tumor markers in models of human colorectal cancer using a 19,200-element complementary DNA microarray. Cancer Research, 61, 7792-7797.
-
(2001)
Cancer Research
, vol.61
, pp. 7792-7797
-
-
Hegde, P.1
Qi, R.2
Gaspard, R.3
-
48
-
-
34047255064
-
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
-
Hewitson, K. S., Lienard, B. M., McDonough, M. A., et al. (2007). Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates. Journal of Biological Chemistry, 282, 3293-3301.
-
(2007)
Journal of Biological Chemistry
, vol.282
, pp. 3293-3301
-
-
Hewitson, K.S.1
Lienard, B.M.2
McDonough, M.A.3
-
50
-
-
32044451325
-
Cancer: A systems biology disease
-
Hornberg, J. J., Bruggeman, F. J., Westerhoff, H. V., & Lankelma, J. (2006). Cancer: A systems biology disease. Biosystems, 83, 81-90.
-
(2006)
Biosystems
, vol.83
, pp. 81-90
-
-
Hornberg, J.J.1
Bruggeman, F.J.2
Westerhoff, H.V.3
Lankelma, J.4
-
51
-
-
0037334332
-
The dual activity of pyruvate kinase type M2 from chromatin extracts of neoplastic cells
-
Ignacak, J., & Stachurska, M. B. (2003). The dual activity of pyruvate kinase type M2 from chromatin extracts of neoplastic cells. Comparative Biochemistry and Physiology. Part B, Biochemistry and Molecular Biology, 134, 425-433.
-
(2003)
Comparative Biochemistry and Physiology. Part B, Biochemistry and Molecular Biology
, vol.134
, pp. 425-433
-
-
Ignacak, J.1
Stachurska, M.B.2
-
52
-
-
23644448721
-
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
-
Isaacs, J. S., Jung, Y. J., Mole, D. R., et al. (2005). HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability. Cancer Cell, 8, 143-153.
-
(2005)
Cancer Cell
, vol.8
, pp. 143-153
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mole, D.R.3
-
53
-
-
33847682296
-
The role of the electron transport SDHC gene on lifespan and cancer
-
Ishii, N., Ishii, T., & Hartman, P. S. (2007). The role of the electron transport SDHC gene on lifespan and cancer. Mitochondrion, 7, 24-28.
-
(2007)
Mitochondrion
, vol.7
, pp. 24-28
-
-
Ishii, N.1
Ishii, T.2
Hartman, P.S.3
-
54
-
-
0347359161
-
Modification of glycolysis affects cell sensitivity to apoptosis induced by oxidative stress and mediated by mitochondria
-
Jeong, D. W., Kim, T. S., Cho, I. T., & Kim, I. Y. (2004). Modification of glycolysis affects cell sensitivity to apoptosis induced by oxidative stress and mediated by mitochondria. Biochemical and Biophysical Research Communications, 313, 984-991.
-
(2004)
Biochemical and Biophysical Research Communications
, vol.313
, pp. 984-991
-
-
Jeong, D.W.1
Kim, T.S.2
Cho, I.T.3
Kim, I.Y.4
-
55
-
-
20844449238
-
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
-
Jones, R. G., Plas, D. R., Kubek, S., et al. (2005). AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Molecular Cell, 18, 283-293.
-
(2005)
Molecular Cell
, vol.18
, pp. 283-293
-
-
Jones, R.G.1
Plas, D.R.2
Kubek, S.3
-
56
-
-
34250017042
-
NMR-based metabolomics approach to target biomarkers for human prostate cancer
-
Jordan, K. W., & Cheng, L. L. (2007). NMR-based metabolomics approach to target biomarkers for human prostate cancer. Expert Review of Proteomics, 4, 389-400.
-
(2007)
Expert Review of Proteomics
, vol.4
, pp. 389-400
-
-
Jordan, K.W.1
Cheng, L.L.2
-
57
-
-
33751356224
-
Systems biology, metabolic modelling and metabolomics in drug discovery and development
-
Kell, D. B. (2006). Systems biology, metabolic modelling and metabolomics in drug discovery and development. Drug Discovery Today, 11, 1085-1092.
-
(2006)
Drug Discovery Today
, vol.11
, pp. 1085-1092
-
-
Kell, D.B.1
-
58
-
-
14744284637
-
Multifaceted roles of glycolytic enzymes
-
Kim, J. W., & Dang, C. V. (2005). Multifaceted roles of glycolytic enzymes. Trends in Biochemical Sciences, 30, 142-150.
-
(2005)
Trends in Biochemical Sciences
, vol.30
, pp. 142-150
-
-
Kim, J.W.1
Dang, C.V.2
-
59
-
-
33749478922
-
Cancer's molecular sweet tooth and the Warburg effect
-
Kim, J. W., & Dang, C. V. (2006). Cancer's molecular sweet tooth and the Warburg effect. Cancer Research, 66, 8927-8930.
-
(2006)
Cancer Research
, vol.66
, pp. 8927-8930
-
-
Kim, J.W.1
Dang, C.V.2
-
60
-
-
0034938530
-
Potential mechanisms for the inhibition of tumor cell growth by manganese superoxide dismutase
-
Kim, K. H., Rodriguez, A. M., Carrico, P. M., & Melendez, J. A. (2001). Potential mechanisms for the inhibition of tumor cell growth by manganese superoxide dismutase. Antioxidants & Redox Signaling, 3, 361-373.
-
(2001)
Antioxidants & Redox Signaling
, vol.3
, pp. 361-373
-
-
Kim, K.H.1
Rodriguez, A.M.2
Carrico, P.M.3
Melendez, J.A.4
-
61
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
Kim, J. W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006). HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metabolism, 3, 177-185.
-
(2006)
Cell Metabolism
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
62
-
-
33746930794
-
Succinate dehydrogenase and fumarate hydratase: Linking mitochondrial dysfunction and cancer
-
King, A., Selak, M. A., & Gottlieb, E. (2006). Succinate dehydrogenase and fumarate hydratase: Linking mitochondrial dysfunction and cancer. Oncogene, 25, 4675-4682.
-
(2006)
Oncogene
, vol.25
, pp. 4675-4682
-
-
King, A.1
Selak, M.A.2
Gottlieb, E.3
-
63
-
-
0036500993
-
Systems biology: A brief overview
-
Kitano, H. (2002). Systems biology: A brief overview. Science, 295, 1662-1664.
-
(2002)
Science
, vol.295
, pp. 1662-1664
-
-
Kitano, H.1
-
64
-
-
33947520506
-
Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: Possible links between cell metabolism and stabilization of HIF
-
Koivunen, P., Hirsila, M., Remes, A. M., et al. (2007). Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: Possible links between cell metabolism and stabilization of HIF. Journal of Biological Chemistry, 282, 4524-4532.
-
(2007)
Journal of Biological Chemistry
, vol.282
, pp. 4524-4532
-
-
Koivunen, P.1
Hirsila, M.2
Remes, A.M.3
-
65
-
-
11244347171
-
Glycolytic enzymes can modulate cellular life span
-
Kondoh, H., Lleonart, M. E., Gil, J., et al. (2005). Glycolytic enzymes can modulate cellular life span. Cancer Research, 65, 177-185.
-
(2005)
Cancer Research
, vol.65
, pp. 177-185
-
-
Kondoh, H.1
Lleonart, M.E.2
Gil, J.3
-
66
-
-
0031875003
-
Expression of hypoxia-inducible genes in tumor cells
-
Kress, S., Stein, A., Maurer, P., et al. (1998). Expression of hypoxia-inducible genes in tumor cells. Journal of Cancer Research and Clinical Oncology, 124, 315-320.
-
(1998)
Journal of Cancer Research and Clinical Oncology
, vol.124
, pp. 315-320
-
-
Kress, S.1
Stein, A.2
Maurer, P.3
-
67
-
-
33846807764
-
Transketolase-like 1 expression correlates with subtypes of ovarian cancer and the presence of distant metastases
-
Krockenberger, M., Honig, A., Rieger, L., et al. (2007). Transketolase-like 1 expression correlates with subtypes of ovarian cancer and the presence of distant metastases. International Journal of Gynecological Cancer, 17, 101-106.
-
(2007)
International Journal of Gynecological Cancer
, vol.17
, pp. 101-106
-
-
Krockenberger, M.1
Honig, A.2
Rieger, L.3
-
68
-
-
33745728461
-
Fatty acid synthase and cancer: New application of an old pathway
-
Kuhajda, F. P. (2006). Fatty acid synthase and cancer: New application of an old pathway. Cancer Research, 66, 5977-5980.
-
(2006)
Cancer Research
, vol.66
, pp. 5977-5980
-
-
Kuhajda, F.P.1
-
69
-
-
0034107704
-
Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice
-
Kuo, W., Lin, J., & Tang, T. K. (2000). Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice. International Journal of Cancer, 85, 857-864.
-
(2000)
International Journal of Cancer
, vol.85
, pp. 857-864
-
-
Kuo, W.1
Lin, J.2
Tang, T.K.3
-
70
-
-
33344456073
-
Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted
-
Langbein, S., Zerilli, M., Zur Hausen, A., et al. (2006). Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted. British Journal of Cancer, 94, 578-585.
-
(2006)
British Journal of Cancer
, vol.94
, pp. 578-585
-
-
Langbein, S.1
Zerilli, M.2
Zur Hausen, A.3
-
71
-
-
19344372443
-
Systems biology, integrative biology, predictive biology
-
Liu, E. T. (2005). Systems biology, integrative biology, predictive biology. Cell, 121, 505-506.
-
(2005)
Cell
, vol.121
, pp. 505-506
-
-
Liu, E.T.1
-
72
-
-
0034212427
-
Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells
-
Lobo, C., Ruiz-Bellido, M. A., Aledo, J. C., et al. (2000). Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells. Biochemical Journal, 348(Pt 2), 257-261.
-
(2000)
Biochemical Journal
, vol.348
, Issue.PART 2
, pp. 257-261
-
-
Lobo, C.1
Ruiz-Bellido, M.A.2
Aledo, J.C.3
-
73
-
-
24344472159
-
Pyrimidine pathways in health and disease
-
Loffler, M., Fairbanks, L. D., Zameitat, E., Marinaki, A. M., & Simmonds, H. A. (2005). Pyrimidine pathways in health and disease. Trends in Molecular Medicine, 11, 430-437.
-
(2005)
Trends in Molecular Medicine
, vol.11
, pp. 430-437
-
-
Loffler, M.1
Fairbanks, L.D.2
Zameitat, E.3
Marinaki, A.M.4
Simmonds, H.A.5
-
74
-
-
0037189542
-
Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
-
Lu, H., Forbes, R. A., & Verma, A. (2002). Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. Journal of Biological Chemistry, 277, 23111-23115.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 23111-23115
-
-
Lu, H.1
Forbes, R.A.2
Verma, A.3
-
75
-
-
12944262229
-
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
-
Macheda, M. L., Rogers, S., & Best, J. D. (2005). Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. Journal of Cellular Physiology, 202, 654-662.
-
(2005)
Journal of Cellular Physiology
, vol.202
, pp. 654-662
-
-
Macheda, M.L.1
Rogers, S.2
Best, J.D.3
-
76
-
-
0038383678
-
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
-
Mack, F. A., Rathmell, W. K., Arsham, A. M., et al. (2003). Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell, 3, 75-88.
-
(2003)
Cancer Cell
, vol.3
, pp. 75-88
-
-
Mack, F.A.1
Rathmell, W.K.2
Arsham, A.M.3
-
77
-
-
9744221185
-
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
-
Majewski, N., Nogueira, V., Bhaskar, P., et al. (2004a). Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Molecular Cell, 16, 819-830.
-
(2004)
Molecular Cell
, vol.16
, pp. 819-830
-
-
Majewski, N.1
Nogueira, V.2
Bhaskar, P.3
-
78
-
-
0347986675
-
Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases
-
Majewski, N., Nogueira, V., Robey, R. B., & Hay, N. (2004b). Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Molecular and Cellular Biology, 24, 730-740.
-
(2004)
Molecular and Cellular Biology
, vol.24
, pp. 730-740
-
-
Majewski, N.1
Nogueira, V.2
Robey, R.B.3
Hay, N.4
-
79
-
-
2942724235
-
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
-
Majumder, P. K., Febbo, P. G., Bikoff, R., et al. (2004). mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nature Medicine, 10, 594-601.
-
(2004)
Nature Medicine
, vol.10
, pp. 594-601
-
-
Majumder, P.K.1
Febbo, P.G.2
Bikoff, R.3
-
80
-
-
0023955155
-
Hexose metabolism in pancreatic islets: Regulation of mitochondrial hexokinase binding
-
Malaisse-Lagae, F., & Malaisse, W. J. (1988). Hexose metabolism in pancreatic islets: Regulation of mitochondrial hexokinase binding. Biochemical Medicine and Metabolic Biology, 39, 80-89.
-
(1988)
Biochemical Medicine and Metabolic Biology
, vol.39
, pp. 80-89
-
-
Malaisse-Lagae, F.1
Malaisse, W.J.2
-
81
-
-
34250178451
-
Tumor-associated antigens and biomarkers in cancer and immune therapy
-
Malyankar, U. M. (2007). Tumor-associated antigens and biomarkers in cancer and immune therapy. International Reviews of Immunology, 26, 223-247.
-
(2007)
International Reviews of Immunology
, vol.26
, pp. 223-247
-
-
Malyankar, U.M.1
-
83
-
-
33745149291
-
p53 regulates mitochondrial respiration
-
Matoba, S., Kang, J. G., Patino, W. D., et al. (2006). p53 regulates mitochondrial respiration. Science, 312, 1650-1653.
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
-
84
-
-
23044500915
-
Pyruvate kinase type M2 and its role in tumor growth and spreading
-
Mazurek, S., Boschek, C. B., Hugo, F., & Eigenbrodt, E. (2005). Pyruvate kinase type M2 and its role in tumor growth and spreading. Seminars in Cancer Biology, 15, 300-308.
-
(2005)
Seminars in Cancer Biology
, vol.15
, pp. 300-308
-
-
Mazurek, S.1
Boschek, C.B.2
Hugo, F.3
Eigenbrodt, E.4
-
86
-
-
23044480300
-
Antitumoral actions of the anti-obesity drug orlistat (Xenical™) in breast cancer cells: Blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene
-
Menendez, J. A., Vellon, L., & Lupu, R. (2005). Antitumoral actions of the anti-obesity drug orlistat (Xenical™) in breast cancer cells: Blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene. Annals of Oncology, 16, 1253-1267.
-
(2005)
Annals of Oncology
, vol.16
, pp. 1253-1267
-
-
Menendez, J.A.1
Vellon, L.2
Lupu, R.3
-
87
-
-
0026623304
-
Clastogenicity of low pH to various cultured mammalian cells
-
Morita, T., Nagaki, T., Fukuda, I., & Okumura, K. (1992). Clastogenicity of low pH to various cultured mammalian cells. Mutation Research, 268, 297-305.
-
(1992)
Mutation Research
, vol.268
, pp. 297-305
-
-
Morita, T.1
Nagaki, T.2
Fukuda, I.3
Okumura, K.4
-
88
-
-
33947205645
-
Metabolomics by proton nuclear magnetic resonance spectroscopy of the response to chloroethylnitrosourea reveals drug efficacy and tumor adaptive metabolic pathways
-
Morvan, D., & Demidem, A. (2007). Metabolomics by proton nuclear magnetic resonance spectroscopy of the response to chloroethylnitrosourea reveals drug efficacy and tumor adaptive metabolic pathways. Cancer Research, 67, 2150-2159.
-
(2007)
Cancer Research
, vol.67
, pp. 2150-2159
-
-
Morvan, D.1
Demidem, A.2
-
89
-
-
26244453715
-
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2
-
Nutt, L. K., Margolis, S. S., Jensen, M., et al. (2005). Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell, 123, 89-103.
-
(2005)
Cell
, vol.123
, pp. 89-103
-
-
Nutt, L.K.1
Margolis, S.S.2
Jensen, M.3
-
91
-
-
17044391118
-
Integrating genomics and metabolomics for engineering plant metabolic pathways
-
Oksman-Caldentey, K. M., & Saito, K. (2005). Integrating genomics and metabolomics for engineering plant metabolic pathways. Current Opinion in Biotechnology, 16, 174-179.
-
(2005)
Current Opinion in Biotechnology
, vol.16
, pp. 174-179
-
-
Oksman-Caldentey, K.M.1
Saito, K.2
-
92
-
-
0037174638
-
Systems biology. Life's complexity pyramid
-
Oltvai, Z. N., & Barabasi, A. L. (2002). Systems biology. Life's complexity pyramid. Science, 298, 763-764.
-
(2002)
Science
, vol.298
, pp. 763-764
-
-
Oltvai, Z.N.1
Barabasi, A.L.2
-
93
-
-
0034698178
-
Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc
-
Osthus, R. C., Shim, H., Kim, S., et al. (2000). Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. Journal of Biological Chemistry, 275, 21797-21800.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 21797-21800
-
-
Osthus, R.C.1
Shim, H.2
Kim, S.3
-
94
-
-
0037371851
-
Metabonomics classifies pathways affected by bioactive compounds. Artificial neural network classification of NMR spectra of plant extracts
-
Ott, K. H., Aranibar, N., Singh, B., & Stockton, G. W. (2003). Metabonomics classifies pathways affected by bioactive compounds. Artificial neural network classification of NMR spectra of plant extracts. Phytochemistry, 62, 971-985.
-
(2003)
Phytochemistry
, vol.62
, pp. 971-985
-
-
Ott, K.H.1
Aranibar, N.2
Singh, B.3
Stockton, G.W.4
-
95
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006). HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metabolism, 3, 187-197.
-
(2006)
Cell Metabolism
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
96
-
-
0033853950
-
Cell cycle progression and apoptosis after irradiation in an acidic environment
-
Park, H. J., Lyons, J. C., Ohtsubo, T., & Song, C. W. (2000). Cell cycle progression and apoptosis after irradiation in an acidic environment. Cell Death and Differentiation, 7, 729-738.
-
(2000)
Cell Death and Differentiation
, vol.7
, pp. 729-738
-
-
Park, H.J.1
Lyons, J.C.2
Ohtsubo, T.3
Song, C.W.4
-
97
-
-
2942593991
-
ROS stress in cancer cells and therapeutic implications
-
Pelicano, H., Carney, D., & Huang, P. (2004). ROS stress in cancer cells and therapeutic implications. Drug Resistance Updates, 7, 97-110.
-
(2004)
Drug Resistance Updates
, vol.7
, pp. 97-110
-
-
Pelicano, H.1
Carney, D.2
Huang, P.3
-
98
-
-
33845718704
-
Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism
-
Pelicano, H., Xu, R. H., Du, M., et al. (2006). Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. Journal of Cell Biology, 175, 913-923.
-
(2006)
Journal of Cell Biology
, vol.175
, pp. 913-923
-
-
Pelicano, H.1
Xu, R.H.2
Du, M.3
-
99
-
-
15944391333
-
Co-expressionof glutaminase K and L isoenzymes in human tumour cells
-
Perez-Gomez, C., Campos-Sandoval, J. A., Alonso, F. J., et al. (2005). Co-expressionof glutaminase K and L isoenzymes in human tumour cells. Biochemical Journal, 386, 535-542.
-
(2005)
Biochemical Journal
, vol.386
, pp. 535-542
-
-
Perez-Gomez, C.1
Campos-Sandoval, J.A.2
Alonso, F.J.3
-
100
-
-
0035917865
-
Cooperation and competition in the evolution of ATP-producing pathways
-
Pfeiffer, T., Schuster, S., & Bonhoeffer, S. (2001). Cooperation and competition in the evolution of ATP-producing pathways. Science, 292, 504-507.
-
(2001)
Science
, vol.292
, pp. 504-507
-
-
Pfeiffer, T.1
Schuster, S.2
Bonhoeffer, S.3
-
101
-
-
20744432633
-
A robust clustering approach for NMR spectra of natural product extracts
-
Pierens, G. K., Palframan, M. E., Tranter, C. J., Carroll, A. R., & Quinn, R. J. (2005). A robust clustering approach for NMR spectra of natural product extracts. Magnetic Resonance in Chemistry, 43, 359-365.
-
(2005)
Magnetic Resonance in Chemistry
, vol.43
, pp. 359-365
-
-
Pierens, G.K.1
Palframan, M.E.2
Tranter, C.J.3
Carroll, A.R.4
Quinn, R.J.5
-
102
-
-
27844526600
-
Akt-dependent transformation: There is more to growth than just surviving
-
Plas, D. R., & Thompson, C. B. (2005). Akt-dependent transformation: There is more to growth than just surviving. Oncogene, 24, 7435-7442.
-
(2005)
Oncogene
, vol.24
, pp. 7435-7442
-
-
Plas, D.R.1
Thompson, C.B.2
-
103
-
-
26244464326
-
PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
-
Porstmann, T., Griffiths, B., Chung, Y. L., et al. (2005). PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene, 24, 6465-6481.
-
(2005)
Oncogene
, vol.24
, pp. 6465-6481
-
-
Porstmann, T.1
Griffiths, B.2
Chung, Y.L.3
-
104
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
Pouyssegur, J., Dayan, F., & Mazure, N. M. (2006). Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature, 441, 437-443.
-
(2006)
Nature
, vol.441
, pp. 437-443
-
-
Pouyssegur, J.1
Dayan, F.2
Mazure, N.M.3
-
106
-
-
0035160371
-
A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations
-
Raamsdonk, L. M., Teusink, B., Broadhurst, D., et al. (2001). A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nature Biotechnology, 19, 45-50.
-
(2001)
Nature Biotechnology
, vol.19
, pp. 45-50
-
-
Raamsdonk, L.M.1
Teusink, B.2
Broadhurst, D.3
-
107
-
-
0016300146
-
History of the Pasteur effect and its pathobiology
-
Racker, E. (1974). History of the Pasteur effect and its pathobiology. Molecular and Cellular Biochemistry, 5, 17-23.
-
(1974)
Molecular and Cellular Biochemistry
, vol.5
, pp. 17-23
-
-
Racker, E.1
-
108
-
-
0344223439
-
Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle
-
Rais, B., Comin, B., Puigjaner, J., et al. (1999). Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle. FEBS Letters, 456, 113-118.
-
(1999)
FEBS Letters
, vol.456
, pp. 113-118
-
-
Rais, B.1
Comin, B.2
Puigjaner, J.3
-
109
-
-
17844383964
-
Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
-
Ramanathan, A., Wang, C., & Schreiber, S. L. (2005). Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proceedings of the National Academy of Science USA, 102, 5992-5997.
-
(2005)
Proceedings of the National Academy of Science USA
, vol.102
, pp. 5992-5997
-
-
Ramanathan, A.1
Wang, C.2
Schreiber, S.L.3
-
110
-
-
33751569560
-
Pentose phosphate cycle oxidative and nonoxidative balance: A new vulnerable target for overcoming drug resistance in cancer
-
Ramos-Montoya, A., Lee, W. N., Bassilian, S., et al. (2006). Pentose phosphate cycle oxidative and nonoxidative balance: A new vulnerable target for overcoming drug resistance in cancer. International Journal of Cancer, 119, 2733-2741.
-
(2006)
International Journal of Cancer
, vol.119
, pp. 2733-2741
-
-
Ramos-Montoya, A.1
Lee, W.N.2
Bassilian, S.3
-
111
-
-
0141863388
-
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival
-
Rathmell, J. C., Fox, C. J., Plas, D. R., et al. (2003). Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Molecular and Cellular Biology, 23, 7315-7328.
-
(2003)
Molecular and Cellular Biology
, vol.23
, pp. 7315-7328
-
-
Rathmell, J.C.1
Fox, C.J.2
Plas, D.R.3
-
112
-
-
34247136256
-
Metabolic enzymes regulated by the Myc oncogene are possible targets for chemotherapy or chemoprevention
-
Rimpi, S., & Nilsson, J. A. (2007). Metabolic enzymes regulated by the Myc oncogene are possible targets for chemotherapy or chemoprevention. Biochemical Society Transactions, 35, 305-310.
-
(2007)
Biochemical Society Transactions
, vol.35
, pp. 305-310
-
-
Rimpi, S.1
Nilsson, J.A.2
-
113
-
-
33746927077
-
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
-
Robey, R. B., & Hay, N. (2006). Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene, 25, 4683-4696.
-
(2006)
Oncogene
, vol.25
, pp. 4683-4696
-
-
Robey, R.B.1
Hay, N.2
-
114
-
-
0842325793
-
Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells
-
Rossignol, R., Gilkerson, R., Aggeler, R., et al. (2004). Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Research, 64, 985-993.
-
(2004)
Cancer Research
, vol.64
, pp. 985-993
-
-
Rossignol, R.1
Gilkerson, R.2
Aggeler, R.3
-
115
-
-
0032975551
-
p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression
-
Ruiz-Lozano, P., Hixon, M. L., Wagner, M. W., et al. (1999). p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression. Cell Growth and Differentiation, 10, 295-306.
-
(1999)
Cell Growth and Differentiation
, vol.10
, pp. 295-306
-
-
Ruiz-Lozano, P.1
Hixon, M.L.2
Wagner, M.W.3
-
116
-
-
0040480322
-
Glucose regulates the promoter activity of aldolase A and pyruvate kinase M2 via dephosphorylation of Sp1
-
Schafer, D., Hamm-Kunzelmann, B., & Brand, K. (1997). Glucose regulates the promoter activity of aldolase A and pyruvate kinase M2 via dephosphorylation of Sp1. FEBS Letters, 417, 325-328.
-
(1997)
FEBS Letters
, vol.417
, pp. 325-328
-
-
Schafer, D.1
Hamm-Kunzelmann, B.2
Brand, K.3
-
117
-
-
2642523067
-
Metabolomics: What's happening downstream of DNA
-
Schmidt, C. W. (2004). Metabolomics: What's happening downstream of DNA. Environmental Health Perspectives, 112, A410-A415.
-
(2004)
Environmental Health Perspectives
, vol.112
-
-
Schmidt, C.W.1
-
118
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
-
Selak, M. A., Armour, S. M., MacKenzie, E. D., et al. (2005). Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell, 7, 77-85.
-
(2005)
Cancer Cell
, vol.7
, pp. 77-85
-
-
Selak, M.A.1
Armour, S.M.2
MacKenzie, E.D.3
-
119
-
-
0035226207
-
'The metabolism of tumours': 70 years later
-
discussion 260-264
-
Semenza, G. L., Artemov, D., Bedi, A., et al. (2001). 'The metabolism of tumours': 70 years later. Novartis Foundation Symposium, 240, 251-260; discussion 260-264.
-
(2001)
Novartis Foundation Symposium
, vol.240
, pp. 251-260
-
-
Semenza, G.L.1
Artemov, D.2
Bedi, A.3
-
120
-
-
0035927544
-
Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells
-
Shi, Q., Le, X., Wang, B., et al. (2001). Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells. Oncogene, 20, 3751-3756.
-
(2001)
Oncogene
, vol.20
, pp. 3751-3756
-
-
Shi, Q.1
Le, X.2
Wang, B.3
-
121
-
-
0032539534
-
A unique glucose-dependent apoptotic pathway induced by c-Myc
-
Shim, H., Chun, Y. S., Lewis, B. C., & Dang, C. V. (1998). A unique glucose-dependent apoptotic pathway induced by c-Myc. Proceedings of the National Academy of Science USA, 95, 1511-1516.
-
(1998)
Proceedings of the National Academy of Science USA
, vol.95
, pp. 1511-1516
-
-
Shim, H.1
Chun, Y.S.2
Lewis, B.C.3
Dang, C.V.4
-
122
-
-
0030921103
-
c-Myc transactivation of LDH-A: Implications for tumor metabolism and growth
-
Shim, H., Dolde, C., Lewis, B. C., et al. (1997). c-Myc transactivation of LDH-A: Implications for tumor metabolism and growth. Proceedings of the National Academy of Science USA, 94, 6658-6663.
-
(1997)
Proceedings of the National Academy of Science USA
, vol.94
, pp. 6658-6663
-
-
Shim, H.1
Dolde, C.2
Lewis, B.C.3
-
123
-
-
0032973950
-
New insights into an old protein: The functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase
-
Sirover, M. A. (1999). New insights into an old protein: The functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase. Biochimica et Biophysica Acta, 1432, 159-184.
-
(1999)
Biochimica Et Biophysica Acta
, vol.1432
, pp. 159-184
-
-
Sirover, M.A.1
-
124
-
-
15444354662
-
Low glutamine concentrations induce phenotypical and functional differentiation of U937 myelomonocytic cells
-
Spittler, A., Oehler, R., Goetzinger, P., et al. (1997). Low glutamine concentrations induce phenotypical and functional differentiation of U937 myelomonocytic cells. Journal of Nutrition, 127, 2151-2157.
-
(1997)
Journal of Nutrition
, vol.127
, pp. 2151-2157
-
-
Spittler, A.1
Oehler, R.2
Goetzinger, P.3
-
125
-
-
36148968634
-
Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer
-
Staiger, W. I., Coy, J. F., Grobholz, R., et al. (2006). Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer. Oncology Reports, 16, 657-661.
-
(2006)
Oncology Reports
, vol.16
, pp. 657-661
-
-
Staiger, W.I.1
Coy, J.F.2
Grobholz, R.3
-
126
-
-
0036347515
-
Lactate stimulates fibroblast expression of hyaluronan and CD44: The Warburg effect revisited
-
Stern, R., Shuster, S., Neudecker, B. A., & Formby, B. (2002). Lactate stimulates fibroblast expression of hyaluronan and CD44: The Warburg effect revisited. Experimental Cell Research, 276, 24-31.
-
(2002)
Experimental Cell Research
, vol.276
, pp. 24-31
-
-
Stern, R.1
Shuster, S.2
Neudecker, B.A.3
Formby, B.4
-
127
-
-
33847699250
-
Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death
-
Stetak, A., Veress, R., Ovadi, J., et al. (2007). Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death. Cancer Research, 67, 1602-1608.
-
(2007)
Cancer Research
, vol.67
, pp. 1602-1608
-
-
Stetak, A.1
Veress, R.2
Ovadi, J.3
-
128
-
-
33746291023
-
Increased lipogenesis in cancer cells: New players, novel targets
-
Swinnen, J. V., Brusselmans, K., & Verhoeven, G. (2006). Increased lipogenesis in cancer cells: New players, novel targets. Current Opinion in Clinical Nutrition and Metabolic Care, 9, 358-365.
-
(2006)
Current Opinion in Clinical Nutrition and Metabolic Care
, vol.9
, pp. 358-365
-
-
Swinnen, J.V.1
Brusselmans, K.2
Verhoeven, G.3
-
129
-
-
33344473158
-
Nutrigenomics, proteomics, metabolomics, and the practice of dietetics
-
Trujillo, E., Davis, C., & Milner, J. (2006). Nutrigenomics, proteomics, metabolomics, and the practice of dietetics. Journal of the American Dietetic Association, 106, 403-413.
-
(2006)
Journal of the American Dietetic Association
, vol.106
, pp. 403-413
-
-
Trujillo, E.1
Davis, C.2
Milner, J.3
-
130
-
-
0242607632
-
Parallel analysis of transcript and metabolic profiles: A new approach in systems biology
-
Urbanczyk-Wochniak, E., Luedemann, A., Kopka, J., et al. (2003). Parallel analysis of transcript and metabolic profiles: A new approach in systems biology. EMBO Reports, 4, 989-993.
-
(2003)
EMBO Reports
, vol.4
, pp. 989-993
-
-
Urbanczyk-Wochniak, E.1
Luedemann, A.2
Kopka, J.3
-
131
-
-
33750475205
-
Metabolomics-based systems biology and personalized medicine: Moving towards n = 1 clinical trials?
-
van der Greef, J., Hankemeier, T., & McBurney, R. N. (2006). Metabolomics-based systems biology and personalized medicine: Moving towards n = 1 clinical trials? Pharmacogenomics, 7, 1087-1094.
-
(2006)
Pharmacogenomics
, vol.7
, pp. 1087-1094
-
-
van der Greef, J.1
Hankemeier, T.2
McBurney, R.N.3
-
132
-
-
21344473888
-
K-ras codon-specific mutations produce distinctive metabolic phenotypes in NIH3T3 mice [corrected] fibroblasts
-
Vizan, P., Boros, L. G., Figueras, A., et al. (2005). K-ras codon-specific mutations produce distinctive metabolic phenotypes in NIH3T3 mice [corrected] fibroblasts. Cancer Research, 65, 5512-5515.
-
(2005)
Cancer Research
, vol.65
, pp. 5512-5515
-
-
Vizan, P.1
Boros, L.G.2
Figueras, A.3
-
133
-
-
0034903053
-
Altered mitochondrial function and overgeneration of reactive oxygen species precede the induction of apoptosis by 1-O-octadecyl-2-methyl-rac-glycero-3-phosphocholine in p53-defective hepatocytes
-
Vrablic, A. S., Albright, C. D., Craciunescu, C. N., Salganik, R. I., & Zeisel, S. H. (2001). Altered mitochondrial function and overgeneration of reactive oxygen species precede the induction of apoptosis by 1-O-octadecyl-2-methyl-rac-glycero-3-phosphocholine in p53-defective hepatocytes. FASEB Journal, 15, 1739-1744.
-
(2001)
FASEB Journal
, vol.15
, pp. 1739-1744
-
-
Vrablic, A.S.1
Albright, C.D.2
Craciunescu, C.N.3
Salganik, R.I.4
Zeisel, S.H.5
-
134
-
-
3242798360
-
Lactate in solid malignant tumors: Potential basis of a metabolic classification in clinical oncology
-
Walenta, S., Schroeder, T., & Mueller-Klieser, W. (2004). Lactate in solid malignant tumors: Potential basis of a metabolic classification in clinical oncology. Current Medicinal Chemistry, 11, 2195-2204.
-
(2004)
Current Medicinal Chemistry
, vol.11
, pp. 2195-2204
-
-
Walenta, S.1
Schroeder, T.2
Mueller-Klieser, W.3
-
136
-
-
0000459772
-
Über den Stoffwechsel der Karzinomzellen
-
Warburg, O., Posener, K., & Negelein, E. (1924). Über den Stoffwechsel der Karzinomzellen. Biochemische Zeitschrift, 152, 309-344.
-
(1924)
Biochemische Zeitschrift
, vol.152
, pp. 309-344
-
-
Warburg, O.1
Posener, K.2
Negelein, E.3
-
137
-
-
0032775641
-
Relevance of positron emission tomography (PET) in oncology
-
Weber, W. A., Avril, N., & Schwaiger, M. (1999). Relevance of positron emission tomography (PET) in oncology. Strahlentherapie und Onkologie, 175, 356-373.
-
(1999)
Strahlentherapie Und Onkologie
, vol.175
, pp. 356-373
-
-
Weber, W.A.1
Avril, N.2
Schwaiger, M.3
-
138
-
-
0033609365
-
An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: Implications for clonal selection during colorectal carcinogenesis
-
Williams, A. C., Collard, T. J., & Paraskeva, C. (1999). An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: Implications for clonal selection during colorectal carcinogenesis. Oncogene, 18, 3199-3204.
-
(1999)
Oncogene
, vol.18
, pp. 3199-3204
-
-
Williams, A.C.1
Collard, T.J.2
Paraskeva, C.3
-
139
-
-
12544256565
-
Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
-
Xu, R. H., Pelicano, H., Zhou, Y., et al. (2005). Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Research, 65, 613-621.
-
(2005)
Cancer Research
, vol.65
, pp. 613-621
-
-
Xu, R.H.1
Pelicano, H.2
Zhou, Y.3
-
140
-
-
1842786763
-
Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in mcf-7 cells
-
Yang, N. S., Shyur, L. F., Chen, C. H., Wang, S. Y., & Tzeng, C. M. (2004). Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in mcf-7 cells. Journal of Biomedical Science, 11, 418-422.
-
(2004)
Journal of Biomedical Science
, vol.11
, pp. 418-422
-
-
Yang, N.S.1
Shyur, L.F.2
Chen, C.H.3
Wang, S.Y.4
Tzeng, C.M.5
-
141
-
-
0346689991
-
Hexokinase II and VEGF expression in liver tumors: Correlation with hypoxia-inducible factor 1 alpha and its significance
-
Yasuda, S., Arii, S., Mori, A., et al. (2004). Hexokinase II and VEGF expression in liver tumors: Correlation with hypoxia-inducible factor 1 alpha and its significance. Journal of Hepatology, 40, 117-123.
-
(2004)
Journal of Hepatology
, vol.40
, pp. 117-123
-
-
Yasuda, S.1
Arii, S.2
Mori, A.3
-
142
-
-
34249905885
-
Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells
-
Zhang, S., Yang, J. H., Guo, C. K., & Cai, P. C. (2007). Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells. Cancer Letters, 253, 108-114.
-
(2007)
Cancer Letters
, vol.253
, pp. 108-114
-
-
Zhang, S.1
Yang, J.H.2
Guo, C.K.3
Cai, P.C.4
-
143
-
-
0347694776
-
Cancer metabolism: Facts, fantasy, and fiction
-
Zu, X. L., & Guppy, M. (2004). Cancer metabolism: Facts, fantasy, and fiction. Biochemical and Biophysical Research Communications, 313, 459-465.
-
(2004)
Biochemical and Biophysical Research Communications
, vol.313
, pp. 459-465
-
-
Zu, X.L.1
Guppy, M.2
|