Altered mitochondrial function and overgeneration of reactive oxygen species precede the induction of apoptosis by 1-O-octadecyl-2-methyl-rac-glycero-3-phosphocholine in p53-defective hepatocytes

FASEB Journal

Volumn 15, Issue 10, 2001, Pages 1739-1744

  Vrablic, Angelica S ^a   Albright, Craig D ^a   Craciunescu, Corneliu N ^a   Salganik, Rudolf I ^a   Zeisel, Steven H ^a,b  

^a University of North Carolina ^*  (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Apoptosis; Cancer; Edelfosine; Mitochondria; Phosphatidylcholine; Reactive oxygen species

Indexed keywords

ALPHA TOCOPHEROL; BENZIMIDAZOLE DERIVATIVE; CARBOCYANINE; EDELFOSINE; NITROBLUE TETRAZOLIUM; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; LIVER CELL; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; ANTIOXIDANTS; APOPTOSIS; CELL LINE, TRANSFORMED; ELECTROPHORESIS, AGAR GEL; HEPATOCYTES; INTRACELLULAR MEMBRANES; MALE; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; NITROBLUE TETRAZOLIUM; PHOSPHATIDYLCHOLINES; PHOSPHOLIPID ETHERS; RATS; RATS, INBRED F344; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53; VITAMIN E;

ANIMALIA;

EID: 0034903053     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00-0300com     Document Type: Article

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