Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain

Protein Science

Volumn 13, Issue 4, 2004, Pages 1031-1042

  Hansen, Majbritt ^a,b   Le Nours, Jérôme ^a   Johansson, Eva ^a,c   Antal, Torben ^a,d   Ullrich, Alexandra ^e   Löffler, Monika ^e   Larsen, Sine ^a,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Mental Health Center Glostrup   (Denmark)

^c EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^d GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^e PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Atovaquone; Brequinar; Dihydroorotate dehydrogenase; Domain movement; Inhibitor binding; Membrane association

Indexed keywords

ARGININE; ATOVAQUONE; BREQUINAR; DIHYDROOROTATE DEHYDROGENASE; HISTIDINE; PYRIMIDINE;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTHRITIS; ARTICLE; CANCER; CATALYSIS; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG DESIGN; DRUG TARGETING; ENZYME INHIBITION; ESCHERICHIA COLI; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PYRIMIDINE SYNTHESIS; RAT;

AMINO ACID SEQUENCE; ANILINE COMPOUNDS; ANIMALS; ATOVAQUONE; BIPHENYL COMPOUNDS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HYDROGEN BONDING; HYDROXYBUTYRATES; IMMUNOSUPPRESSIVE AGENTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NAPHTHOQUINONES; OROTIC ACID; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI;

EID: 1842559337     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.03533004     Document Type: Article

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