Cell cycle progression and apoptosis after irradiation in an acidic environment

Cell Death and Differentiation

Volumn 7, Issue 8, 2000, Pages 729-738

  Park, H J ^a,b   Lyons, J C ^a   Ohtsubo, T ^a   Song, C W ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b Inha University School of Medicine   (South Korea)

Author keywords

Acidic environment; Apoptosis; Cyclin B1 Cdc2 kinase; G2 M arrest; P53

Indexed keywords

CYCLIN B1; PROTEIN KINASE; PROTEIN P53;

ACIDITY; ALKALINITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL CYCLE G2 PHASE; COLORECTAL CANCER; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; IRRADIATION; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE;

EID: 0033853950     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400702     Document Type: Article

References (41)

1. Extracellular compartments of solid tumors
2. The relevance of tumour pH to the treatment of malignant disease
3. Blood flow, oxygen and nutrient supply and metabolic microenvironment of human tumours: A review
4. Intra-and extracellular pH in solid tumors
5. Identification of deoxyribose II as an endonuclease involved in apoptosis
6. Effect of intracellular acidity and ionomycin on apoptosis in HL-60 cells
7. Hydrogen ion-mediated enhancement of cytotoxicity of bis-chlorethylating drug in rat mammary carcinoma cells in vitro
8. Intra- and extracellular pH in solid tumors: Influence on therapeutic response
9. The role of low intracellular or extracellular pH in sensitization to hyperthermia
10. Increase in thermosensitivity of tumor cells by lowering intracellular pH
11. Apoptosis and perturbation of cell cycle progression in acidic environment after hyperthermia
12. The effect of pH on hyperthermic and X-ray induced cell killing
13. Radiation-induced apoptosis in different pH environments in vitro
14. Acidic environment causes apoptosis by increasing caspase activity
15. The role of p53 in the induction of polyploidity of myelomonocytic leukemic M1/2 cells
16. Participation of p53 protein in the cellular response to DNA damage
17. p53, the cellular gatekeeper for growth and division
18. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute Anticancer Drug Screen and correlations with the growth-inhibitory potency of 123 anticancer agents
19. 1 phase and p53 function in human tumor cells
20. + human tumor cells synchronized by mitotic selection
21. Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status
22. 1 arrest in established human tumor cell lines
23. Attenuation of G2 checkpoint function precedes human cell immortalization
24. Radiation and the G2 phase of the cell cycle
25. Irradiation induces G2/M cell cycle arrest and apoptosis in p53-deficient lymphoblastic leukemia cells without affecting Bcl-2 and Bax expression
26. Evidence for a second cell cycle block at G2/M by p53
27. p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts
28. Role of wild-type p53 in the G2 phase: Regulation of the γ-irradiation-induced delay and DNA repair
29. Requirement for p53 and p21 to sustain G2 arrest after DNA damage
30. p53 involvement in control of G2 exit of the cell cycle: Role in DNA damage-induced apoptosis
31. Negative regulation of Wee1 expression and Cdc2 phosphorylation during p53-mediated growth arrest and apoptosis
32. Gamma-radiation-induced apoptosis in human colorectal adenoma and carcinoma cell lines can occur in the absence of wild-type p53
33. DNA damage-associated dysregulation of the cell cycle and apoptosis control in cells with germ-line p53 mutation
34. Acid-induced denaturation of DNA in situ as a probe of chromatin structure
35. Apoptotic pathway: The roads to ruin
36. p53 is involved in but not required for ionizing radiation-induced caspase-3 activation and apoptosis in human lymphoblast cell lines
37. Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines
38. Radiation-induced apoptosis and its relationship to loss of clonogenic survival
39. Inhibition of p34(cdc2) kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells
40. Intra- and extracellular pH in solid tumors: Influence on therapeutic response
41. Effect of intracellular acidity and ionomycin on apoptosis in HL-60 cells