-
1
-
-
0142041982
-
Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases
-
Feldmann M, Maini RN. Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med 2003; 9: 1245-50.
-
(2003)
Nat Med
, vol.9
, pp. 1245-1250
-
-
Feldmann, M.1
Maini, R.N.2
-
2
-
-
0033611472
-
A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
-
Weinblatt ME, Kremer JM, Bankhurst AD et al. A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 1999; 340: 253-9.
-
(1999)
N Engl J Med
, vol.340
, pp. 253-259
-
-
Weinblatt, M.E.1
Kremer, J.M.2
Bankhurst, A.D.3
-
3
-
-
28444466261
-
Anti-TNF therapy: Where have we got to in 2005?
-
Feldmann M, Brennan FM, Foxwell BM et al. Anti-TNF therapy: where have we got to in 2005? J Autoimmun2005; 25 (Suppl): 26-8.
-
(2005)
J Autoimmun
, vol.25
, pp. 26-28
-
-
Feldmann, M.1
Brennan, F.M.2
Foxwell, B.M.3
-
4
-
-
17444394445
-
Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
-
Bresnihan B, Alvaro-Gracia JM, Cobby M et al. Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum 1998; 41: 2196-204.
-
(1998)
Arthritis Rheum
, vol.41
, pp. 2196-2204
-
-
Bresnihan, B.1
Alvaro-Gracia, J.M.2
Cobby, M.3
-
5
-
-
0029943271
-
Doserange and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. The IL-1Ra Arthritis Study Group
-
Campion GV, Lebsack ME, Lookabaugh J et al. Doserange and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. The IL-1Ra Arthritis Study Group. Arthritis Rheum 1996; 39: 1092-101.
-
(1996)
Arthritis Rheum
, vol.39
, pp. 1092-1101
-
-
Campion, G.V.1
Lebsack, M.E.2
Lookabaugh, J.3
-
6
-
-
2642558925
-
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebocontrolled trial
-
Nishimoto N, Yoshizaki K, Miyasaka N et al. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebocontrolled trial. Arthritis Rheum 2004; 50: 1761-9.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 1761-1769
-
-
Nishimoto, N.1
Yoshizaki, K.2
Miyasaka, N.3
-
7
-
-
1542376173
-
The transfer of a laboratory based hypothesis to a clinically useful therapy: The development of anti-TNF therapy of rheumatoid arthritis
-
Feldmann M, Brennan FM, Williams RO et al. The transfer of a laboratory based hypothesis to a clinically useful therapy: The development of anti-TNF therapy of rheumatoid arthritis. Best Pract Res Clin Rheumatol2004; 18: 59-80.
-
(2004)
Best Pract Res Clin Rheumatol
, vol.18
, pp. 59-80
-
-
Feldmann, M.1
Brennan, F.M.2
Williams, R.O.3
-
8
-
-
0031897632
-
NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses
-
Ghosh S, May MJ, Kopp EB. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998; 16: 225-60.
-
(1998)
Annu Rev Immunol
, vol.16
, pp. 225-260
-
-
Ghosh, S.1
May, M.J.2
Kopp, E.B.3
-
9
-
-
33748360705
-
Philadelphia chromosomepositive acute lymphoblastic leukemia: Impact of imatinib treatmenton remission induction and allogeneic stem cell transplantation
-
Kovacsovics T, Maziarz RT. Philadelphia chromosomepositive acute lymphoblastic leukemia: impact of imatinib treatmenton remission induction and allogeneic stem cell transplantation. Curr Oncol Rep 2006; 8: 343-51.
-
(2006)
Curr Oncol Rep
, vol.8
, pp. 343-351
-
-
Kovacsovics, T.1
Maziarz, R.T.2
-
10
-
-
0036009115
-
NF-kappaB at the crossroads of life and death
-
Karin M, Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol 2002; 3: 221-7.
-
(2002)
Nat Immunol
, vol.3
, pp. 221-227
-
-
Karin, M.1
Lin, A.2
-
11
-
-
0029874138
-
The NF-kappa B and I kappa B proteins: New discoveries and insights
-
Baldwin AS Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996; 14: 649-83.
-
(1996)
Annu Rev Immunol
, vol.14
, pp. 649-683
-
-
Baldwin, A.S.1
-
12
-
-
0028971289
-
Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation
-
Verma IM, Stevenson JK, Schwarz EM et al. Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev 1995; 9: 2723-35.
-
(1995)
Genes Dev
, vol.9
, pp. 2723-2735
-
-
Verma, I.M.1
Stevenson, J.K.2
Schwarz, E.M.3
-
13
-
-
0028986194
-
I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B
-
Thompson JE, Phillips RJ, Erdjument-Bromage H et al.I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell 1995; 80: 573-82.
-
(1995)
Cell
, vol.80
, pp. 573-582
-
-
Thompson, J.E.1
Phillips, R.J.2
Erdjument-Bromage, H.3
-
14
-
-
0030745885
-
Distinct functional properties of IkappaB alpha and IkappaB beta
-
Tran K, Merika M, Thanos D. Distinct functional properties of IkappaB alpha and IkappaB beta. Mol Cell Biol1997; 17: 5386-99.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 5386-5399
-
-
Tran, K.1
Merika, M.2
Thanos, D.3
-
15
-
-
0031800762
-
Persistent activation of RelA by respiratory syncytial virus involves protein kinase C, under-phosphorylated IkappaBbeta, and sequestration of protein phosphatase 2A by the viral phosphoprotein
-
Bitko V, Barik S. Persistent activation of RelA by respiratory syncytial virus involves protein kinase C, under-phosphorylated IkappaBbeta, and sequestration of protein phosphatase 2A by the viral phosphoprotein. J Virol 1998; 72: 5610-18.
-
(1998)
J Virol
, vol.72
, pp. 5610-5618
-
-
Bitko, V.1
Barik, S.2
-
16
-
-
0034805902
-
Dysregulated NF-kappaB activation in cystic fibrosis: Evidence for a primary inflammatory disorder
-
Blackwell TS, Stecenko A A, Christman JW. Dysregulated NF-kappaB activation in cystic fibrosis: evidence for a primary inflammatory disorder. Am J Physiol Lung Cell Mol Physiol 2001; 281: L69-70.
-
(2001)
Am J Physiol Lung Cell Mol Physiol
, vol.281
, pp. L69-L70
-
-
Blackwell, T.S.1
Stecenko, A.A.2
Christman, J.W.3
-
17
-
-
0033531788
-
Nuclear IkappaBbeta maintains persistent NF-kappaB activation in HIV-1-infected myeloid cells
-
DeLuca C, Petropoulos L, Zmeureanu D et al. Nuclear IkappaBbeta maintains persistent NF-kappaB activation in HIV-1-infected myeloid cells. J Biol Chem 1999; 274: 13010-16.
-
(1999)
J Biol Chem
, vol.274
, pp. 13010-13016
-
-
Deluca, C.1
Petropoulos, L.2
Zmeureanu, D.3
-
18
-
-
0035139943
-
Hostile takeovers: Viral appropriation of the NF-kappaB pathway
-
Hiscott J, Kwon H, Genin P. Hostile takeovers: viral appropriation of the NF-kappaB pathway. J Clin Invest2001; 107: 143-51.
-
(2001)
J Clin Invest
, vol.107
, pp. 143-151
-
-
Hiscott, J.1
Kwon, H.2
Genin, P.3
-
19
-
-
0029666281
-
A sustained reduction in IkappaB-beta may contribute to persistent NF-kappaB activation in human endothelial cells
-
Johnson DR, Douglas I, Jahnke A et al. A sustained reduction in IkappaB-beta may contribute to persistent NF-kappaB activation in human endothelial cells. J Biol Chem 1996; 271: 16317-22.
-
(1996)
J Biol Chem
, vol.271
, pp. 16317-16322
-
-
Johnson, D.R.1
Douglas, I.2
Jahnke, A.3
-
20
-
-
0030831601
-
Parasite-mediated nuclear factor kappaB regulation in lymphoprolifération caused by Theileria parva infection
-
Palmer GH, Machado J Jr, Fernandez P et al.Parasite-mediated nuclear factor kappaB regulation in lymphoprolifération caused by Theileria parva infection. Proc Natl Acad Sci U S A 1997; 94: 12527-32.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 12527-12532
-
-
Palmer, G.H.1
Machado, J.2
Fernandez, P.3
-
21
-
-
0035002033
-
Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells
-
Stecenko AA, King G, Torii K et al. Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells. Inflammation 2001; 25: 145-55.
-
(2001)
Inflammation
, vol.25
, pp. 145-155
-
-
Stecenko, A.A.1
King, G.2
Torii, K.3
-
22
-
-
33747388013
-
IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression
-
Kearns JD, Basak S, Werner SL et al. IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression. J Cell Biol 2006; 173: 659-64.
-
(2006)
J Cell Biol
, vol.173
, pp. 659-664
-
-
Kearns, J.D.1
Basak, S.2
Werner, S.L.3
-
23
-
-
0027446955
-
The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers
-
Bours V, Franzoso G, Azarenko V et al. The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell 1993; 72: 729-39.
-
(1993)
Cell
, vol.72
, pp. 729-739
-
-
Bours, V.1
Franzoso, G.2
Azarenko, V.3
-
24
-
-
0027175501
-
The bcl-3 protooncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner
-
Nolan GP, Fujita T, Bhatia K et al. The bcl-3 protooncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner. Mol Cell Biol 1993; 13: 3557-66.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 3557-3566
-
-
Nolan, G.P.1
Fujita, T.2
Bhatia, K.3
-
25
-
-
0027184023
-
The candidate protooncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers
-
Fujita T, Nolan GP, Liou HC et al. The candidate protooncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers. Genes Dev 1993; 7: 1354-63.
-
(1993)
Genes Dev
, vol.7
, pp. 1354-1363
-
-
Fujita, T.1
Nolan, G.P.2
Liou, H.C.3
-
26
-
-
0033199348
-
NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes
-
Heissmeyer V, Krappmann D, Wulczyn FG et al.NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes. EMBO J 1999; 18: 4766-78.
-
(1999)
EMBO J
, vol.18
, pp. 4766-4778
-
-
Heissmeyer, V.1
Krappmann, D.2
Wulczyn, F.G.3
-
27
-
-
0026758170
-
The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition
-
Franzoso G, Bours V, Park S et al. The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition. Nature 1992; 359: 339-42.
-
(1992)
Nature
, vol.359
, pp. 339-342
-
-
Franzoso, G.1
Bours, V.2
Park, S.3
-
28
-
-
0033519690
-
The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators
-
Dechend R, Hirano F, Lehmann K et al. The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. Oncogene 1999; 18: 3316-23.
-
(1999)
Oncogene
, vol.18
, pp. 3316-3323
-
-
Dechend, R.1
Hirano, F.2
Lehmann, K.3
-
31
-
-
0042493163
-
Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases
-
O'Neill LA. Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases. Curr Opin Pharmacol 2003; 3: 396-403.
-
(2003)
Curr Opin Pharmacol
, vol.3
, pp. 396-403
-
-
O'Neill, L.A.1
-
32
-
-
0035920176
-
Novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei
-
Yamazaki S, Muta T, Takeshige K. A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei. J Biol Chem 2001; 276: 27657-62.
-
(2001)
J Biol Chem
, vol.276
, pp. 27657-27662
-
-
Yamazaki, S.1
Muta, T.2
Takeshige, K.A.3
-
33
-
-
0034680774
-
MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production
-
Kitamura H, Kanehira K, Okita K et al. MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production. FEBS Lett 2000; 485: 53-6.
-
(2000)
FEBS Lett
, vol.485
, pp. 53-56
-
-
Kitamura, H.1
Kanehira, K.2
Okita, K.3
-
34
-
-
0035918188
-
Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs
-
Haruta H, Kato A, Todokoro K. Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs. J Biol Chem 2001; 276: 12485-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 12485-12488
-
-
Haruta, H.1
Kato, A.2
Todokoro, K.3
-
35
-
-
3142581432
-
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta
-
Yamamoto M, Yamazaki S, Uematsu S et al. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature 2004; 430: 218-22.
-
(2004)
Nature
, vol.430
, pp. 218-222
-
-
Yamamoto, M.1
Yamazaki, S.2
Uematsu, S.3
-
36
-
-
14844344042
-
The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria
-
Hirotani T, Lee PY, Kuwata H et al. The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria. J Immunol2005; 174: 3650-7.
-
(2005)
J Immunol
, vol.174
, pp. 3650-3657
-
-
Hirotani, T.1
Lee, P.Y.2
Kuwata, H.3
-
37
-
-
30444456370
-
IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation
-
Kuwata H, Matsumoto M, Atarashi K et al. IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation. Immunity2006; 24: 41-51.
-
(2006)
Immunity
, vol.24
, pp. 41-51
-
-
Kuwata, H.1
Matsumoto, M.2
Atarashi, K.3
-
38
-
-
0034084163
-
Phosphorylation meets ubiqui-tination: The control of NF-[kappa]B activity
-
Karin M, Ben-Neriah Y. Phosphorylation meets ubiqui-tination: The control of NF-[kappa]B activity. Annu Rev Immunol 2000; 18: 621-63.
-
(2000)
Annu Rev Immunol
, vol.18
, pp. 621-663
-
-
Karin, M.1
Ben-Neriah, Y.2
-
39
-
-
0032541657
-
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
-
Rothwarf DM, Zandi E, Natoli G et al. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature 1998; 395: 297-300.
-
(1998)
Nature
, vol.395
, pp. 297-300
-
-
Rothwarf, D.M.1
Zandi, E.2
Natoli, G.3
-
40
-
-
0033634663
-
Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti
-
Makris C, Godfrey VL, Krahn-Senftleben G et al. Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol Cell 2000; 5: 969-79.
-
(2000)
Mol Cell
, vol.5
, pp. 969-979
-
-
Makris, C.1
Godfrey, V.L.2
Krahn-Senftleben, G.3
-
41
-
-
0033537739
-
Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
-
Li Q, Van Antwerp D, Mercurio F et al. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science 1999; 284: 321-5.
-
(1999)
Science
, vol.284
, pp. 321-325
-
-
Li, Q.1
Van Antwerp, D.2
Mercurio, F.3
-
42
-
-
0033532386
-
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
-
Li ZW, Chu W, Hu Y et al. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 1999; 189: 1839-45.
-
(1999)
J Exp Med
, vol.189
, pp. 1839-1845
-
-
Li, Z.W.1
Chu, W.2
Hu, Y.3
-
43
-
-
0038587747
-
The two faces of IKK and NF-kappaB inhibition: Prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
-
Chen LW, Egan L, Li ZW et al. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 2003; 9: 575-81.
-
(2003)
Nat Med
, vol.9
, pp. 575-581
-
-
Chen, L.W.1
Egan, L.2
Li, Z.W.3
-
44
-
-
0033537767
-
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase
-
Hu Y, Baud V, Delhase M et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science 1999; 284: 316-20.
-
(1999)
Science
, vol.284
, pp. 316-320
-
-
Hu, Y.1
Baud, V.2
Delhase, M.3
-
45
-
-
0035809983
-
IKKalpha controls formation of the epidermis independently of NF-kappaB
-
Hu Y, Baud V, Oga T et al. IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature2001; 410: 710-14.
-
(2001)
Nature
, vol.410
, pp. 710-714
-
-
Hu, Y.1
Baud, V.2
Oga, T.3
-
46
-
-
17844386319
-
IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation
-
Lawrence T, Bebien M, Liu GY et al. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature 2005; 434: 1138-43.
-
(2005)
Nature
, vol.434
, pp. 1138-1143
-
-
Lawrence, T.1
Bebien, M.2
Liu, G.Y.3
-
47
-
-
0036234459
-
Missing pieces in the NF-kappaB puzzle
-
Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell 2002; 109 (Suppl): S81-S96.
-
(2002)
Cell
, vol.109
, pp. S81-S96
-
-
Ghosh, S.1
Karin, M.2
-
48
-
-
18644380147
-
The lympho-toxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways
-
Dejardin E, Droin NM, Delhase M et al. The lympho-toxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity2002; 17: 525-35.
-
(2002)
Immunity
, vol.17
, pp. 525-535
-
-
Dejardin, E.1
Droin, N.M.2
Delhase, M.3
-
49
-
-
17944378526
-
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
-
Senftleben U, Cao Y, Xiao G et al. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 2001; 293: 1495-9.
-
(2001)
Science
, vol.293
, pp. 1495-1499
-
-
Senftleben, U.1
Cao, Y.2
Xiao, G.3
-
51
-
-
2342522110
-
Shaping the nuclear action of NF-kappaB
-
Chen LF, Greene WC. Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol 2004; 5: 392-401.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 392-401
-
-
Chen, L.F.1
Greene, W.C.2
-
52
-
-
5644235488
-
NF-kappaB: A multifaceted transcription factor regulated at several levels
-
Schmitz ML, Mattioli I, Buss H et al. NF-kappaB: A multifaceted transcription factor regulated at several levels. Chembiochem 2004; 5: 1348-58.
-
(2004)
Chembiochem
, vol.5
, pp. 1348-1358
-
-
Schmitz, M.L.1
Mattioli, I.2
Buss, H.3
-
53
-
-
0037011056
-
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB
-
Chen LF, Mu Y, Greene WC. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J 2002; 21: 6539-48.
-
(2002)
EMBO J
, vol.21
, pp. 6539-6548
-
-
Chen, L.F.1
Mu, Y.2
Greene, W.C.3
-
54
-
-
0037462725
-
Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65
-
Kiernan R, Bres V, Ng RW et al. Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65. J Biol Chem 2003; 278: 2758-66.
-
(2003)
J Biol Chem
, vol.278
, pp. 2758-2766
-
-
Kiernan, R.1
Bres, V.2
Ng, R.W.3
-
55
-
-
24344468250
-
NF-kappaB RelA phosphorylation regulates RelA acetylation
-
Chen LF, Williams SA, Mu Y et al. NF-kappaB RelA phosphorylation regulates RelA acetylation. Mol Cell Biol 2005; 25: 7966-75.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 7966-7975
-
-
Chen, L.F.1
Williams, S.A.2
Mu, Y.3
-
56
-
-
1642553460
-
To be, or not to be: NF-kappaB is the answer - role of Rel/NF-kappaB in the regulation of apoptosis
-
Kucharczak J, Simmons MJ, Fan Y et al. To be, or not to be: NF-kappaB is the answer - role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene 2003; 22: 8961-82.
-
(2003)
Oncogene
, vol.22
, pp. 8961-8982
-
-
Kucharczak, J.1
Simmons, M.J.2
Fan, Y.3
-
57
-
-
0026708394
-
Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B
-
Fujita T, Nolan GP, Ghosh S et al. Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B. Genes Dev 1992; 6: 775-87.
-
(1992)
Genes Dev
, vol.6
, pp. 775-787
-
-
Fujita, T.1
Nolan, G.P.2
Ghosh, S.3
-
58
-
-
0026774239
-
Selection of optimal kappa B/Rel DNA-binding motifs: Interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation
-
Kunsch C, Ruben SM, Rosen CA. Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation. Mol Cell Biol 1992; 12: 4412-21.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 4412-4421
-
-
Kunsch, C.1
Ruben, S.M.2
Rosen, C.A.3
-
59
-
-
0142105387
-
Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities
-
Hoffmann A, Leung TH, Baltimore D. Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities. EMBO J 2003; 22: 5530-9.
-
(2003)
EMBO J
, vol.22
, pp. 5530-5539
-
-
Hoffmann, A.1
Leung, T.H.2
Baltimore, D.3
-
60
-
-
0037025364
-
The x-ray crystal structure of the NF-kappa B p50.P65 heterodimer bound to the interferon beta -kappa B site
-
Berkowitz B, Huang DB, Chen-Park FE et al. The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site. J Biol Chem 2002; 277: 24694-700.
-
(2002)
J Biol Chem
, vol.277
, pp. 24694-24700
-
-
Berkowitz, B.1
Huang, D.B.2
Chen-Park, F.E.3
-
61
-
-
0033596120
-
Regulation of DNA binding by Rel/NF-kappaB transcription factors: Structural views
-
Chen FE, Ghosh G. Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views. Oncogene 1999; 18: 6845-52.
-
(1999)
Oncogene
, vol.18
, pp. 6845-6852
-
-
Chen, F.E.1
Ghosh, G.2
-
62
-
-
0037025395
-
The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription
-
Chen-Park FE, Huang DB, Noro B et al. The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription. J Biol Chem 2002; 277: 24701-8.
-
(2002)
J Biol Chem
, vol.277
, pp. 24701-24708
-
-
Chen-Park, F.E.1
Huang, D.B.2
Noro, B.3
-
63
-
-
0036124647
-
Structure of NF-kappaB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter
-
Escalante CR, Shen L, Thanos D et al. Structure of NF-kappaB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter. Structure 2002; 10: 383-91.
-
(2002)
Structure
, vol.10
, pp. 383-391
-
-
Escalante, C.R.1
Shen, L.2
Thanos, D.3
-
64
-
-
4444376712
-
Signaling to NF-kappaB
-
Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev 2004; 18: 2195-224.
-
(2004)
Genes Dev
, vol.18
, pp. 2195-2224
-
-
Hayden, M.S.1
Ghosh, S.2
-
65
-
-
0342742310
-
Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B
-
Osborn L, Kunkel S, Nabel GJ. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc Natl Acad Sci U S A 1989; 86: 2336-40.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 2336-2340
-
-
Osborn, L.1
Kunkel, S.2
Nabel, G.J.3
-
66
-
-
30044442866
-
How Toll-like receptors signal: What we know and what we don't know
-
O'Neill LA. How Toll-like receptors signal: what we know and what we don't know. Curr Opin Immunol2006; 18: 3-9.
-
(2006)
Curr Opin Immunol
, vol.18
, pp. 3-9
-
-
O'Neill, L.A.1
-
67
-
-
22444433175
-
NLRs join TLRs as innate sensors of pathogens
-
Martinon F, Tschopp J. NLRs join TLRs as innate sensors of pathogens. Trends Immunol 2005; 26: 447-54.
-
(2005)
Trends Immunol
, vol.26
, pp. 447-454
-
-
Martinon, F.1
Tschopp, J.2
-
68
-
-
5644277476
-
Interleukin-17 family members and inflammation
-
Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity 2004; 21: 467-76.
-
(2004)
Immunity
, vol.21
, pp. 467-476
-
-
Kolls, J.K.1
Linden, A.2
-
69
-
-
0033567388
-
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
-
Kopp E, Medzhitov R, Carothers J et al. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev 1999; 13: 2059-71.
-
(1999)
Genes Dev
, vol.13
, pp. 2059-2071
-
-
Kopp, E.1
Medzhitov, R.2
Carothers, J.3
-
70
-
-
0030298294
-
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death
-
Liu ZG, Hsu H, Goeddel DV et al. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 1996; 87: 565-76.
-
(1996)
Cell
, vol.87
, pp. 565-576
-
-
Liu, Z.G.1
Hsu, H.2
Goeddel, D.V.3
-
71
-
-
0029976817
-
An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
-
Beg AA, Baltimore D. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science1996; 274: 782-4.
-
(1996)
Science
, vol.274
, pp. 782-784
-
-
Beg, A.A.1
Baltimore, D.2
-
72
-
-
0029992609
-
Suppression of TNF-alpha-induced apoptosis by NF-kappaB
-
Van Antwerp DJ, Martin SJ, Kafri T et al. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science1996; 274: 787-9.
-
(1996)
Science
, vol.274
, pp. 787-789
-
-
Van Antwerp, D.J.1
Martin, S.J.2
Kafri, T.3
-
73
-
-
0029858387
-
TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappaB
-
Wang CY, Mayo MW, Baldwin AS Jr. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 1996; 274: 784-7.
-
(1996)
Science
, vol.274
, pp. 784-787
-
-
Wang, C.Y.1
Mayo, M.W.2
Baldwin, A.S.3
-
74
-
-
14844327760
-
Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
-
Kamata H, Honda S, Maeda S et al. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005; 120: 649-61.
-
(2005)
Cell
, vol.120
, pp. 649-661
-
-
Kamata, H.1
Honda, S.2
Maeda, S.3
-
75
-
-
8344260568
-
Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species
-
Pham CG, Bubici C, Zazzeroni F et al. Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. Cell 2004; 119: 529-42.
-
(2004)
Cell
, vol.119
, pp. 529-542
-
-
Pham, C.G.1
Bubici, C.2
Zazzeroni, F.3
-
76
-
-
33745298519
-
Nuclear factor-kappaB in cancer development and progression
-
Karin M. Nuclear factor-kappaB in cancer development and progression. Nature 2006; 441: 431-6.
-
(2006)
Nature
, vol.441
, pp. 431-436
-
-
Karin, M.1
-
77
-
-
24944586285
-
Achieving stability of lipopolysaccharide-induced NF-kappaB activation
-
Covert MW, Leung TH, Gaston JE et al. Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science 2005; 309: 1854-7.
-
(2005)
Science
, vol.309
, pp. 1854-1857
-
-
Covert, M.W.1
Leung, T.H.2
Gaston, J.E.3
-
78
-
-
21344449546
-
The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis
-
Andreakos E, Sacre S, Foxwell BM et al. The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis. Front Biosci 2005; 10: 2478-88.
-
(2005)
Front Biosci
, vol.10
, pp. 2478-2488
-
-
Andreakos, E.1
Sacre, S.2
Foxwell, B.M.3
-
79
-
-
0029552889
-
High DNA-binding activity of transcription factor NF-kappa B in synovial membranes of patients with rheumatoid arthritis
-
Asahara H, Asanuma M, Ogawa N et al. High DNA-binding activity of transcription factor NF-kappa B in synovial membranes of patients with rheumatoid arthritis. Biochem Mol Biol Int 1995; 37: 827-32.
-
(1995)
Biochem Mol Biol Int
, vol.37
, pp. 827-832
-
-
Asahara, H.1
Asanuma, M.2
Ogawa, N.3
-
81
-
-
15844384253
-
Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue
-
Marok R, Winyard PG, Coumbe A et al. Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue. Arthritis Rheum 1996; 39: 583-91.
-
(1996)
Arthritis Rheum
, vol.39
, pp. 583-591
-
-
Marok, R.1
Winyard, P.G.2
Coumbe, A.3
-
83
-
-
0032493278
-
Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent
-
Foxwell B, Browne K, Bondeson J et al. Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent. Proc Natl Acad Sci U S A 1998; 95: 8211-15.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 8211-8215
-
-
Foxwell, B.1
Browne, K.2
Bondeson, J.3
-
84
-
-
0033545863
-
Defining therapeutic targets by using adenovirus: Blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares antiinflammatory mediators
-
Bondeson J, Foxwell B, Brennan F et al. Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares antiinflammatory mediators. Proc Natl Acad Sci U S A 1999; 96: 5668-73.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 5668-5673
-
-
Bondeson, J.1
Foxwell, B.2
Brennan, F.3
-
85
-
-
33749587067
-
Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent
-
Amos N, Lauder S, Evans A et al. Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent. Rheumatology (Oxford) 2006; 45: 1201-9.
-
(2006)
Rheumatology (Oxford)
, vol.45
, pp. 1201-1209
-
-
Amos, N.1
Lauder, S.2
Evans, A.3
-
86
-
-
0038575364
-
Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: Implications for therapy
-
Andreakos E, Smith C, Kiriakidis S et al. Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy. Arthritis Rheum 2003; 48: 1901-12.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 1901-1912
-
-
Andreakos, E.1
Smith, C.2
Kiriakidis, S.3
-
87
-
-
0037289728
-
Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction
-
Andreakos E, Smith C, Monaco C et al. Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction. Blood 2003; 101: 983-91.
-
(2003)
Blood
, vol.101
, pp. 983-991
-
-
Andreakos, E.1
Smith, C.2
Monaco, C.3
-
88
-
-
0030715563
-
Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2
-
Iotsova V, Caamano J, Loy J et al. Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med 1997; 3: 1285-9.
-
(1997)
Nat Med
, vol.3
, pp. 1285-1289
-
-
Iotsova, V.1
Caamano, J.2
Loy, J.3
-
89
-
-
2942703810
-
Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo
-
Jimi E, Aoki K, Saito H et al. Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med 2004; 10: 617-24.
-
(2004)
Nat Med
, vol.10
, pp. 617-624
-
-
Jimi, E.1
Aoki, K.2
Saito, H.3
-
90
-
-
0034603036
-
Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha
-
Murakami S, Lefebvre V, de Crombrugghe B. Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha. J Biol Chem 2000; 275: 3687-92.
-
(2000)
J Biol Chem
, vol.275
, pp. 3687-3692
-
-
Murakami, S.1
Lefebvre, V.2
De Crombrugghe, B.3
-
91
-
-
0033813919
-
Transcriptional mechanisms of chondrocyte differentiation
-
de Crombrugghe B, Lefebvre V, Behringer RR et al.Transcriptional mechanisms of chondrocyte differentiation. Matrix Biol 2000; 19: 389-94.
-
(2000)
Matrix Biol
, vol.19
, pp. 389-394
-
-
De Crombrugghe, B.1
Lefebvre, V.2
Behringer, R.R.3
-
92
-
-
2642517290
-
Increased synovial tissue NF-kappa B1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis
-
Benito MJ, Murphy E, Murphy EP et al. Increased synovial tissue NF-kappa B1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum 2004; 50: 1781-7.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 1781-1787
-
-
Benito, M.J.1
Murphy, E.2
Murphy, E.P.3
-
93
-
-
0033917674
-
Distinct roles for the NF-kappaB1 (P50) and c-Rel transcription factors in inflammatory arthritis
-
Campbell IK, Gerondakis S, O'Donnell K et al. Distinct roles for the NF-kappaB1 (p50) and c-Rel transcription factors in inflammatory arthritis. J Clin Invest 2000; 105: 1799-806.
-
(2000)
J Clin Invest
, vol.105
, pp. 1799-1806
-
-
Campbell, I.K.1
Gerondakis, S.2
O'Donnell, K.3
-
94
-
-
0033178749
-
Essential role of T cell NF-kappa B activation in collagen-induced arthritis
-
Seetharaman R, Mora AL, Nabozny G et al. Essential role of T cell NF-kappa B activation in collagen-induced arthritis. J Immunol 1999; 163: 1577-83.
-
(1999)
J Immunol
, vol.163
, pp. 1577-1583
-
-
Seetharaman, R.1
Mora, A.L.2
Nabozny, G.3
-
95
-
-
13044316560
-
Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis
-
Palombella VJ, Conner EM, Fuseler JW et al. Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis. Proc Natl Acad Sci U S A 1998; 95: 15671-6.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 15671-15676
-
-
Palombella, V.J.1
Conner, E.M.2
Fuseler, J.W.3
-
96
-
-
0142165030
-
The mechanism of action of aspirin
-
Vane JR, Botting RM. The mechanism of action of aspirin. Thromb Res 2003; 110: 255-8.
-
(2003)
Thromb Res
, vol.110
, pp. 255-258
-
-
Vane, J.R.1
Botting, R.M.2
-
97
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
-
Yuan M, Konstantopoulos N, Lee J et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001; 293: 1673-7.
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
-
98
-
-
33645823692
-
Is sulfasalazine effective in ankylosing spondylitis? A systematic review of randomized controlled trials
-
Chen J, Liu C. Is sulfasalazine effective in ankylosing spondylitis? A systematic review of randomized controlled trials. J Rheumatol 2006; 33: 722-31.
-
(2006)
J Rheumatol
, vol.33
, pp. 722-731
-
-
Chen, J.1
Liu, C.2
-
99
-
-
0032992467
-
Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB
-
Cronstein BN, Montesinos MC, Weissmann G. Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB. Proc Natl Acad Sci U S A 1999; 96: 6377-81.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 6377-6381
-
-
Cronstein, B.N.1
Montesinos, M.C.2
Weissmann, G.3
-
100
-
-
0032853234
-
Sulfasalazine prevents T-helper 1 immune response by suppressing interleukin-12 production in macrophages
-
Kang BY, Chung SW, Im SY et al. Sulfasalazine prevents T-helper 1 immune response by suppressing interleukin-12 production in macrophages. Immunology 1999; 98: 98-103.
-
(1999)
Immunology
, vol.98
, pp. 98-103
-
-
Kang, B.Y.1
Chung, S.W.2
Im, S.Y.3
-
101
-
-
4644263340
-
Effects of glucocorticoids on gene transcription
-
Hayashi R, Wada H, Ito K et al. Effects of glucocorticoids on gene transcription. Eur J Pharmacol 2004; 500: 51-62.
-
(2004)
Eur J Pharmacol
, vol.500
, pp. 51-62
-
-
Hayashi, R.1
Wada, H.2
Ito, K.3
-
102
-
-
0028867899
-
Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis
-
Auphan N, DiDonato JA, Rosette C et al.Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 1995; 270: 286-90.
-
(1995)
Science
, vol.270
, pp. 286-290
-
-
Auphan, N.1
Didonato, J.A.2
Rosette, C.3
-
103
-
-
0028879819
-
Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids
-
Scheinman RI, Cogswell PC, Lofquist AK et al. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science 1995; 270: 283-6.
-
(1995)
Science
, vol.270
, pp. 283-286
-
-
Scheinman, R.I.1
Cogswell, P.C.2
Lofquist, A.K.3
-
104
-
-
0027402820
-
Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene
-
Drouin J, Sun YL, Chamberland M et al. Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. EMBO J 1993; 12: 145-56.
-
(1993)
EMBO J
, vol.12
, pp. 145-156
-
-
Drouin, J.1
Sun, Y.L.2
Chamberland, M.3
-
105
-
-
0024080921
-
Hormonemediated repression: A negative glucocorticoid response element from the bovine prolactin gene
-
Sakai DD, Helms S, Carlstedt-Duke J et al. Hormonemediated repression: A negative glucocorticoid response element from the bovine prolactin gene. Genes Dev1988; 2: 1144-54.
-
(1988)
Genes Dev
, vol.2
, pp. 1144-1154
-
-
Sakai, D.D.1
Helms, S.2
Carlstedt-Duke, J.3
-
106
-
-
0033485289
-
Mechanisms of glucocorticoid-receptor-mediated repression of gene expression
-
Webster JC, Cidlowski JA. Mechanisms of glucocorticoid-receptor-mediated repression of gene expression. Trends Endocrinol Metab 1999; 10: 396-402.
-
(1999)
Trends Endocrinol Metab
, vol.10
, pp. 396-402
-
-
Webster, J.C.1
Cidlowski, J.A.2
-
107
-
-
0344012614
-
Putting the brake on inflammatory responses: The role of glucocorticoids
-
Hermoso MA, Cidlowski JA. Putting the brake on inflammatory responses: The role of glucocorticoids. IUBMB Life 2003; 55: 497-504.
-
(2003)
IUBMB Life
, vol.55
, pp. 497-504
-
-
Hermoso, M.A.1
Cidlowski, J.A.2
-
108
-
-
33745728301
-
From willow bark to peptides: The ever widening spectrum of NF-kappaB inhibitors
-
D'Acquisto F, Ianaro A. From willow bark to peptides: The ever widening spectrum of NF-kappaB inhibitors. Curr Opin Pharmacol 2006; 6: 387-92.
-
(2006)
Curr Opin Pharmacol
, vol.6
, pp. 387-392
-
-
D'acquisto, F.1
Ianaro, A.2
-
109
-
-
33646475553
-
Ciclesonide reduces the need for oral steroid use in adult patients with severe, persistent asthma
-
Bateman E, Karpel J, Casale T et al. Ciclesonide reduces the need for oral steroid use in adult patients with severe, persistent asthma. Chest 2006; 129: 1176-87.
-
(2006)
Chest
, vol.129
, pp. 1176-1187
-
-
Bateman, E.1
Karpel, J.2
Casale, T.3
-
110
-
-
0030885575
-
Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling
-
Peraldi P, Xu M, Spiegelman BM. Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling. J Clin Invest 1997; 100: 1863-9.
-
(1997)
J Clin Invest
, vol.100
, pp. 1863-1869
-
-
Peraldi, P.1
Xu, M.2
Spiegelman, B.M.3
-
112
-
-
0026607265
-
Treatment of insulin-resistant mice with the oral antidiabetic agent pioglitazone: Evaluation of liver GLUT2 and phosphoenolpyruvate carboxykinase expression
-
Hofmann CA, Edwards CW 3rd, Hillman RM et al.Treatment of insulin-resistant mice with the oral antidiabetic agent pioglitazone: evaluation of liver GLUT2 and phosphoenolpyruvate carboxykinase expression. Endocrinology 1992; 130: 735-40.
-
(1992)
Endocrinology
, vol.130
, pp. 735-740
-
-
Hofmann, C.A.1
Edwards, C.W.2
Hillman, R.M.3
-
113
-
-
0028076266
-
A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat
-
Oakes ND, Kennedy CJ, Jenkins AB et al. A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat. Diabetes 1994; 43: 1203-10.
-
(1994)
Diabetes
, vol.43
, pp. 1203-1210
-
-
Oakes, N.D.1
Kennedy, C.J.2
Jenkins, A.B.3
-
114
-
-
10744224449
-
Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma
-
Cuzzocrea S, Mazzon E, Dugo L et al. Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma. Arthritis Rheum 2003; 48: 3544-56.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 3544-3556
-
-
Cuzzocrea, S.1
Mazzon, E.2
Dugo, L.3
-
115
-
-
0035668404
-
An open-label trial of the PPAR-gamma ligand rosiglitazone for active ulcerative colitis
-
Lewis JD, Lichtenstein GR, Stein RB et al. An open-label trial of the PPAR-gamma ligand rosiglitazone for active ulcerative colitis. Am J Gastroenterol 2001; 96: 3323-8.
-
(2001)
Am J Gastroenterol
, vol.96
, pp. 3323-3328
-
-
Lewis, J.D.1
Lichtenstein, G.R.2
Stein, R.B.3
-
116
-
-
26044455885
-
Risk of hospitalization for heart failure associated with thiazolidinedione therapy: A Medicaid claims-based case-control study
-
Hartung DM, Touchette DR, Bultemeier NC et al. Risk of hospitalization for heart failure associated with thiazolidinedione therapy: A Medicaid claims-based case-control study. Pharmacotherapy 2005; 25: 1329-36.
-
(2005)
Pharmacotherapy
, vol.25
, pp. 1329-1336
-
-
Hartung, D.M.1
Touchette, D.R.2
Bultemeier, N.C.3
-
117
-
-
22644445633
-
Changes in liver tests during 1-year treatment of patients with Type 2 diabetes with pioglitazone, metformin or gliclazide
-
Belcher G, Schernthaner G. Changes in liver tests during 1-year treatment of patients with Type 2 diabetes with pioglitazone, metformin or gliclazide. Diabetic Med2005; 22: 973-9.
-
(2005)
Diabetic Med
, vol.22
, pp. 973-979
-
-
Belcher, G.1
Schernthaner, G.2
-
118
-
-
0035045084
-
Suppression of nuclear factor-kappaB and stimulation of inhibitor kappaB by troglitazone: Evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese
-
Ghanim H, Garg R, Aljada A et al. Suppression of nuclear factor-kappaB and stimulation of inhibitor kappaB by troglitazone: evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese. J Clin Endocrinol Metab 2001; 86: 1306-12.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 1306-1312
-
-
Ghanim, H.1
Garg, R.2
Aljada, A.3
-
119
-
-
0034742613
-
Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: Evidence of an antiinflammatory action?
-
Aljada A, Garg R, Ghanim H et al. Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action?J Clin Endocrinol Metab 2001; 86: 3250-6.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 3250-3256
-
-
Aljada, A.1
Garg, R.2
Ghanim, H.3
-
120
-
-
2942655390
-
Evidence for a potent antiinflammatory effect of rosiglitazone
-
Mohanty P, Aljada A, Ghanim H et al. Evidence for a potent antiinflammatory effect of rosiglitazone. J Clin Endocrinol Metab 2004; 89: 2728-35.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 2728-2735
-
-
Mohanty, P.1
Aljada, A.2
Ghanim, H.3
-
121
-
-
1842474424
-
Disappearance of Crohn's ulcers in the terminal ileum after thalidomide therapy
-
Hershfield NB. Disappearance of Crohn's ulcers in the terminal ileum after thalidomide therapy. Can J Gastroenterol 2004; 18: 101-4.
-
(2004)
Can J Gastroenterol
, vol.18
, pp. 101-104
-
-
Hershfield, N.B.1
-
122
-
-
14044250162
-
Thalidomide as an immunotherapeutic agent: The effects on neutrophilmediated inflammation
-
Yasui K, Kobayashi N, Yamazaki T et al. Thalidomide as an immunotherapeutic agent: The effects on neutrophilmediated inflammation. Curr Pharm Des 2005; 11: 395-401.
-
(2005)
Curr Pharm Des
, vol.11
, pp. 395-401
-
-
Yasui, K.1
Kobayashi, N.2
Yamazaki, T.3
-
123
-
-
3442884264
-
The effects of thalidomide on the stimulation of NF-kappaB activity and TNF-alpha production by lipopolysaccharide in a human colonic epithelial cell line
-
Kim YS, Kim JS, Jung HC et al. The effects of thalidomide on the stimulation of NF-kappaB activity and TNF-alpha production by lipopolysaccharide in a human colonic epithelial cell line. Mol Cells 2004; 17: 210-16.
-
(2004)
Mol Cells
, vol.17
, pp. 210-216
-
-
Kim, Y.S.1
Kim, J.S.2
Jung, H.C.3
-
124
-
-
0036963968
-
Thalidomide suppresses the interleukin 1beta-induced NFkappaB signaling pathway in colon cancer cells
-
Jin SH, Kim TI, Han DS et al. Thalidomide suppresses the interleukin 1beta-induced NFkappaB signaling pathway in colon cancer cells. Ann N Y Acad Sci 2002; 973: 414-18.
-
(2002)
Ann N Y Acad Sci
, vol.973
, pp. 414-418
-
-
Jin, S.H.1
Kim, T.I.2
Han, D.S.3
-
125
-
-
0036481989
-
Early studies on the safety and efficacy of thalidomide for symptomatic inflammatory bowel disease
-
Bariol C, Meagher AP, Vickers CR et al. Early studies on the safety and efficacy of thalidomide for symptomatic inflammatory bowel disease. J Gastroenterol Hepatol2002; 17: 135-9.
-
(2002)
J Gastroenterol Hepatol
, vol.17
, pp. 135-139
-
-
Bariol, C.1
Meagher, A.P.2
Vickers, C.R.3
-
126
-
-
0030939874
-
A potential new treatment for rheumatoid arthritis: Thunder god vine
-
Lipsky PE, Tao XL. A potential new treatment for rheumatoid arthritis: Thunder god vine. Semin Arthritis Rheum 1997; 26: 713-23.
-
(1997)
Semin Arthritis Rheum
, vol.26
, pp. 713-723
-
-
Lipsky, P.E.1
Tao, X.L.2
-
127
-
-
0028962950
-
The identity of immunosuppressive components of the ethyl acetate extract and chloroform methanol extract (T2) of Tripterygium wilfordii Hook. F
-
Tao X, Cai JJ, Lipsky PE. The identity of immunosuppressive components of the ethyl acetate extract and chloroform methanol extract (T2) of Tripterygium wilfordii Hook. F. J Pharmacol Exp Ther 1995; 272: 1305-12.
-
(1995)
J Pharmacol Exp Ther
, vol.272
, pp. 1305-1312
-
-
Tao, X.1
Cai, J.J.2
Lipsky, P.E.3
-
128
-
-
0033532177
-
Immunosuppressant PG490 (Triptolide) inhibits T-cell interleukin-2 expressi on at the level of purin e-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation
-
Qiu D, Zhao G, Aoki Y et al. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expressi on at the level of purin e-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. J Biol Chem 1999; 274: 13443-50.
-
(1999)
J Biol Chem
, vol.274
, pp. 13443-13450
-
-
Qiu, D.1
Zhao, G.2
Aoki, Y.3
-
129
-
-
0042662901
-
Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook
-
Qiu D, Kao PN. Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f. Drugs R D 2003; 4: 1-18.
-
(2003)
Drugs R D
, vol.4
, pp. 1-18
-
-
Qiu, D.1
Kao, P.N.2
-
130
-
-
85047700175
-
Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells
-
Jiang XH, Wong BC, Lin MC et al. Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells. Oncogene 2001; 20: 8009-18.
-
(2001)
Oncogene
, vol.20
, pp. 8009-8018
-
-
Jiang, X.H.1
Wong, B.C.2
Lin, M.C.3
-
131
-
-
0036065039
-
Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: A double-blind, placebo-controlled study
-
Tao X, Younger J, Fan FZ et al. Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: A double-blind, placebo-controlled study. Arthritis Rheum 2002; 46: 1735-43.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 1735-1743
-
-
Tao, X.1
Younger, J.2
Fan, F.Z.3
-
132
-
-
0346505340
-
The IKK NF-kappa B system: A treasure trove for drug development
-
Karin M, Yamamoto Y, Wang QM. The IKK NF-kappa B system: A treasure trove for drug development. Nat Rev Drug Discov 2004; 3: 17-26.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 17-26
-
-
Karin, M.1
Yamamoto, Y.2
Wang, Q.M.3
-
133
-
-
0142156224
-
Signal transduction networks in rheumatoid arthritis
-
Hammaker D, Sweeney S, Firestein GS. Signal transduction networks in rheumatoid arthritis. Ann Rheum Dis 2003; 62 (Suppl 2): ii86-9.
-
(2003)
Ann Rheum Dis
, vol.62
-
-
Hammaker, D.1
Sweeney, S.2
Firestein, G.S.3
-
134
-
-
0037449711
-
BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice
-
Burke JR, Pattoli MA, Gregor KR et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem 2003; 278: 1450-6.
-
(2003)
J Biol Chem
, vol.278
, pp. 1450-1456
-
-
Burke, J.R.1
Pattoli, M.A.2
Gregor, K.R.3
-
135
-
-
33748768735
-
Regulation of matrix metalloproteinase-9 gene expression and cell migration by NF-kappaB in response to CpG-oligodeoxy-nucleotides in RAW 264.7 cells
-
Rhee JW, Lee KW, Sohn WJ et al. Regulation of matrix metalloproteinase-9 gene expression and cell migration by NF-kappaB in response to CpG-oligodeoxy-nucleotides in RAW 264.7 cells. Mol Immunol 2007; 44: 1393-400.
-
(2007)
Mol Immunol
, vol.44
, pp. 1393-1400
-
-
Rhee, J.W.1
Lee, K.W.2
Sohn, W.J.3
-
136
-
-
0141676361
-
A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice
-
McIntyre KW, Shuster DJ, Gillooly KM et al. A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis Rheum2003; 48: 2652-9.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 2652-2659
-
-
McIntyre, K.W.1
Shuster, D.J.2
Gillooly, K.M.3
-
137
-
-
33646767823
-
A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells
-
Wen D, Nong Y, Morgan JG et al. A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells. J Pharmacol Exp Ther 2006; 317: 989-1001.
-
(2006)
J Pharmacol Exp Ther
, vol.317
, pp. 989-1001
-
-
Wen, D.1
Nong, Y.2
Morgan, J.G.3
-
138
-
-
33746217403
-
Validation of the anti-inflammatory properties of small-molecule IkB kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle
-
Catley MC, Sukkar MB, Chung KF et al. Validation of the anti-inflammatory properties of small-molecule IkB kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle. Mol Pharmacol 2006; 70: 697-705.
-
(2006)
Mol Pharmacol
, vol.70
, pp. 697-705
-
-
Catley, M.C.1
Sukkar, M.B.2
Chung, K.F.3
-
139
-
-
0028970734
-
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway
-
Alkalay I, Yaron A, Hatzubai A et al. Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A 1995; 92: 10599-603.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 10599-10603
-
-
Alkalay, I.1
Yaron, A.2
Hatzubai, A.3
-
140
-
-
33644691858
-
Proteasome inhibition: A new approach for the treatment of malignancies
-
Spano JP, Bay JO, Blay JY et al. Proteasome inhibition: A new approach for the treatment of malignancies. Bull Cancer 2005; 92: E61-6, 945-52.
-
(2005)
Bull Cancer
, vol.92
-
-
Spano, J.P.1
Bay, J.O.2
Blay, J.Y.3
-
141
-
-
5644250621
-
A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma
-
Jagannath S, Barlogie B, Berenson J et al. A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. Br J Haematol 2004; 127: 165-72.
-
(2004)
Br J Haematol
, vol.127
, pp. 165-172
-
-
Jagannath, S.1
Barlogie, B.2
Berenson, J.3
-
142
-
-
20044376092
-
Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma
-
O'Connor OA, Wright J, Moskowitz C et al. Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma. J Clin Oncol2005; 23: 676-84.
-
(2005)
J Clin Oncol
, vol.23
, pp. 676-684
-
-
O'Connor, O.A.1
Wright, J.2
Moskowitz, C.3
-
143
-
-
33745700031
-
Folate-linked lipid-based nanoparticles deliver a NFkappaB decoy into activated murine macrophage-like RAW264.7 cells
-
Hattori Y, Sakaguchi M, Maitani Y. Folate-linked lipid-based nanoparticles deliver a NFkappaB decoy into activated murine macrophage-like RAW264.7 cells. Biol Pharm Bull 2006; 29: 1516-20.
-
(2006)
Biol Pharm Bull
, vol.29
, pp. 1516-1520
-
-
Hattori, Y.1
Sakaguchi, M.2
Maitani, Y.3
-
144
-
-
0029006149
-
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
-
Lin YZ, Yao SY, Veach RA et al. Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J Biol Chem1995; 270: 14255-8.
-
(1995)
J Biol Chem
, vol.270
, pp. 14255-14258
-
-
Lin, Y.Z.1
Yao, S.Y.2
Veach, R.A.3
-
145
-
-
27644498849
-
Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation
-
Ledeboer A, Gamanos M, Lai W et al. Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation. Eur J Neurosci 2005; 22: 1977-86.
-
(2005)
Eur J Neurosci
, vol.22
, pp. 1977-1986
-
-
Ledeboer, A.1
Gamanos, M.2
Lai, W.3
-
146
-
-
2442522378
-
Suppression of staphylococcal enterotoxin B-induced toxicity by a nuclear import inhibitor
-
Liu D, Liu XY, Robinson D et al. Suppression of staphylococcal enterotoxin B-induced toxicity by a nuclear import inhibitor. J Biol Chem 2004; 279: 19239-46.
-
(2004)
J Biol Chem
, vol.279
, pp. 19239-19246
-
-
Liu, D.1
Liu, X.Y.2
Robinson, D.3
-
147
-
-
20044384169
-
A nuclear import inhibitory peptide ameliorates the severity of cholecys-tokinin-induced acute pancreatitis
-
Letoha T, Somlai C, Takacs T et al. A nuclear import inhibitory peptide ameliorates the severity of cholecys-tokinin-induced acute pancreatitis. World J Gastroenterol2005; 11: 990-9.
-
(2005)
World J Gastroenterol
, vol.11
, pp. 990-999
-
-
Letoha, T.1
Somlai, C.2
Takacs, T.3
-
148
-
-
20944442872
-
Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice
-
Saika S, Miyamoto T, Yamanaka O et al. Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice. Am J Pathol 2005; 166: 1393-403.
-
(2005)
Am J Pathol
, vol.166
, pp. 1393-1403
-
-
Saika, S.1
Miyamoto, T.2
Yamanaka, O.3
-
149
-
-
0032400997
-
Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50
-
Torgerson TR, Colosia AD, Donahue JP et al.Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50. J Immunol 1998; 161: 6084-92.
-
(1998)
J Immunol
, vol.161
, pp. 6084-6092
-
-
Torgerson, T.R.1
Colosia, A.D.2
Donahue, J.P.3
-
150
-
-
2442572230
-
Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis
-
Takada Y, Singh S, Aggarwal BB. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J Biol Chem 2004; 279: 15096-104.
-
(2004)
J Biol Chem
, vol.279
, pp. 15096-15104
-
-
Takada, Y.1
Singh, S.2
Aggarwal, B.B.3
-
151
-
-
0034284715
-
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex
-
May MJ, D'Acquisto F, Madge LA et al. Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science 2000; 289: 1550-4.
-
(2000)
Science
, vol.289
, pp. 1550-1554
-
-
May, M.J.1
D'acquisto, F.2
Madge, L.A.3
-
152
-
-
4444306858
-
The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis
-
Dai S, Hirayama T, Abbas S et al. The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. J Biol Chem 2004; 279: 37219-22.
-
(2004)
J Biol Chem
, vol.279
, pp. 37219-37222
-
-
Dai, S.1
Hirayama, T.2
Abbas, S.3
-
153
-
-
14944353807
-
Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation
-
di Meglio P, Ianaro A, Ghosh S. Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation. Arthritis Rheum 2005; 52: 951-8.
-
(2005)
Arthritis Rheum
, vol.52
, pp. 951-958
-
-
Di Meglio, P.1
Ianaro, A.2
Ghosh, S.3
-
154
-
-
70350545937
-
Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation
-
Tas SW, Vervoordeldonk MJ, Hajji N et al. Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation. Arthritis Res Ther2006; 8: R86.
-
(2006)
Arthritis Res Ther
, vol.8
, pp. R86
-
-
Tas, S.W.1
Vervoordeldonk, M.J.2
Hajji, N.3
-
155
-
-
28844496621
-
High-throughput screening for inhibitors of the E3 ubiquitin ligase APC
-
Huang J, Sheung J, Dong G et al. High-throughput screening for inhibitors of the E3 ubiquitin ligase APC. Methods Enzymol 2005; 399: 740-54.
-
(2005)
Methods Enzymol
, vol.399
, pp. 740-754
-
-
Huang, J.1
Sheung, J.2
Dong, G.3
-
156
-
-
21244503601
-
Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide
-
Doyle SL, Jefferies CA, O'Neill LA. Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide. J Biol Chem 2005; 280: 23496-501.
-
(2005)
J Biol Chem
, vol.280
, pp. 23496-23501
-
-
Doyle, S.L.1
Jefferies, C.A.2
O'Neill, L.A.3
-
157
-
-
33646838453
-
Improved lead-finding for kinase targets using high-throughput docking
-
McInnes C. Improved lead-finding for kinase targets using high-throughput docking. Curr Opin Drug Discov Devel 2006; 9: 339-47.
-
(2006)
Curr Opin Drug Discov Devel
, vol.9
, pp. 339-347
-
-
McInnes, C.1
-
158
-
-
31344467156
-
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
-
Mansell A, Smith R, Doyle SL et al. Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol 2006; 7: 148-55.
-
(2006)
Nat Immunol
, vol.7
, pp. 148-155
-
-
Mansell, A.1
Smith, R.2
Doyle, S.L.3
-
159
-
-
33744967486
-
Dynamic nuclear pore complexes: Life on the edge
-
Tran EJ, Wente SR. Dynamic nuclear pore complexes: life on the edge. Cell 2006; 125: 1041-53.
-
(2006)
Cell
, vol.125
, pp. 1041-1053
-
-
Tran, E.J.1
Wente, S.R.2
-
160
-
-
7444262946
-
Structure and function of HIV-1 auxiliary regulatory protein Vpr: Novel clues to drug design
-
Zhao LJ, Zhu H. Structure and function of HIV-1 auxiliary regulatory protein Vpr: novel clues to drug design. Curr Drug Targets Immune Endocr Metabol Disord 2004; 4: 265-75.
-
(2004)
Curr Drug Targets Immune Endocr Metabol Disord
, vol.4
, pp. 265-275
-
-
Zhao, L.J.1
Zhu, H.2
-
161
-
-
33644671435
-
Effect of a small molecule inhibitor of nuclear factor-kappaB nuclear translocation in a murine model of arthritis and cultured human synovial cells
-
Wakamatsu K, Nanki T, Miyasaka N et al. Effect of a small molecule inhibitor of nuclear factor-kappaB nuclear translocation in a murine model of arthritis and cultured human synovial cells. Arthritis Res Ther 2005; 7: R1348-59.
-
(2005)
Arthritis Res Ther
, vol.7
, pp. R1348-R1359
-
-
Wakamatsu, K.1
Nanki, T.2
Miyasaka, N.3
-
162
-
-
33750577799
-
Amelioration of arthritis by intraarticular dominant negative Ikkbeta gene therapy using adeno-associated virus type 5
-
Tas SW, Adriaansen J, Hajji N et al. Amelioration of arthritis by intraarticular dominant negative Ikkbeta gene therapy using adeno-associated virus type 5. Hum Gene Ther 2006; 17: 821-32.
-
(2006)
Hum Gene Ther
, vol.17
, pp. 821-832
-
-
Tas, S.W.1
Adriaansen, J.2
Hajji, N.3
-
163
-
-
0032792213
-
Immunosuppressive effect of triptolide in vitro
-
Lu H, Hachida M, Enosawa S et al. Immunosuppressive effect of triptolide in vitro. Transplant Proc 1999; 31: 2056-7.
-
(1999)
Transplant Proc
, vol.31
, pp. 2056-2057
-
-
Lu, H.1
Hachida, M.2
Enosawa, S.3
-
165
-
-
0035790067
-
Activation of HIV in human skin by ultraviolet B radiation and its inhibition by NFkappaB blocking agents
-
Breuer-McHam J, Simpson E, Dougherty I et al.Activation of HIV in human skin by ultraviolet B radiation and its inhibition by NFkappaB blocking agents. Photochem Photobiol 2001; 74: 805-10.
-
(2001)
Photochem Photobiol
, vol.74
, pp. 805-810
-
-
Breuer-McHam, J.1
Simpson, E.2
Dougherty, I.3
-
166
-
-
85056686179
-
-
accessed 12, April
-
A phase 1/2 multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-ranging study to evaluate the safety of repeated topical application of three concentrations of NF-kappaB decoy in adults with mild-to-moderate atopic dermatitis/http://clinicaltrials.gov/ct/show/NCT00153337?order=1 accessed 12, April 2007.
-
(2007)
A Phase 1/2 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, dose-ranging study to Evaluate the Safety of Repeated Topical Application of Three Concentrations of Nf-Kappab Decoy in adults with Mild-To-Moderate Atopic Dermatitis
-
-
-
167
-
-
0033506335
-
Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynu-cleotides as a gene therapy
-
Tomita T, Takeuchi E, Tomita N et al. Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynu-cleotides as a gene therapy. Arthritis Rheum 1999; 42: 2532-42.
-
(1999)
Arthritis Rheum
, vol.42
, pp. 2532-2542
-
-
Tomita, T.1
Takeuchi, E.2
Tomita, N.3
-
168
-
-
0035229589
-
Short-term low-dose corticosteroids vs placebo and nonsteroidal antiinflammatory drugs in rheumatoid arthritis
-
Gotzsche PC, Johansen HK. Short-term low-dose corticosteroids vs placebo and nonsteroidal antiinflammatory drugs in rheumatoid arthritis. Cochrane Database Syst Rev 2004: CD000189.
-
(2004)
Cochrane Database Syst Rev
-
-
Gotzsche, P.C.1
Johansen, H.K.2
-
170
-
-
29144466435
-
Immunological consequences of thalidomide treatment in Sjogren's syndrome
-
Moutsopoulos NM, Angelov N, Sankar V et al.Immunological consequences of thalidomide treatment in Sjogren's syndrome. Ann Rheum Dis 2006; 65: 112-14.
-
(2006)
Ann Rheum Dis
, vol.65
, pp. 112-114
-
-
Moutsopoulos, N.M.1
Angelov, N.2
Sankar, V.3
-
171
-
-
27344446522
-
Update on the pathogenesis and treatment of systemic onset juvenile rheumatoid arthritis
-
Adams A, Lehman TJ. Update on the pathogenesis and treatment of systemic onset juvenile rheumatoid arthritis. Curr Opin Rheumatol 2005; 17: 612-16.
-
(2005)
Curr Opin Rheumatol
, vol.17
, pp. 612-616
-
-
Adams, A.1
Lehman, T.J.2
|