메뉴 건너뛰기




Volumn , Issue , 2007, Pages 581-600

Clinical prospects of NF-κB inhibitors to further targeted therapies in rheumatology

Author keywords

[No Author keywords available]

Indexed keywords


EID: 37149018293     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (2)

References (171)
  • 1
    • 0142041982 scopus 로고    scopus 로고
    • Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases
    • Feldmann M, Maini RN. Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med 2003; 9: 1245-50.
    • (2003) Nat Med , vol.9 , pp. 1245-1250
    • Feldmann, M.1    Maini, R.N.2
  • 2
    • 0033611472 scopus 로고    scopus 로고
    • A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
    • Weinblatt ME, Kremer JM, Bankhurst AD et al. A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 1999; 340: 253-9.
    • (1999) N Engl J Med , vol.340 , pp. 253-259
    • Weinblatt, M.E.1    Kremer, J.M.2    Bankhurst, A.D.3
  • 3
    • 28444466261 scopus 로고    scopus 로고
    • Anti-TNF therapy: Where have we got to in 2005?
    • Feldmann M, Brennan FM, Foxwell BM et al. Anti-TNF therapy: where have we got to in 2005? J Autoimmun2005; 25 (Suppl): 26-8.
    • (2005) J Autoimmun , vol.25 , pp. 26-28
    • Feldmann, M.1    Brennan, F.M.2    Foxwell, B.M.3
  • 4
    • 17444394445 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
    • Bresnihan B, Alvaro-Gracia JM, Cobby M et al. Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum 1998; 41: 2196-204.
    • (1998) Arthritis Rheum , vol.41 , pp. 2196-2204
    • Bresnihan, B.1    Alvaro-Gracia, J.M.2    Cobby, M.3
  • 5
    • 0029943271 scopus 로고    scopus 로고
    • Doserange and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. The IL-1Ra Arthritis Study Group
    • Campion GV, Lebsack ME, Lookabaugh J et al. Doserange and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. The IL-1Ra Arthritis Study Group. Arthritis Rheum 1996; 39: 1092-101.
    • (1996) Arthritis Rheum , vol.39 , pp. 1092-1101
    • Campion, G.V.1    Lebsack, M.E.2    Lookabaugh, J.3
  • 6
    • 2642558925 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebocontrolled trial
    • Nishimoto N, Yoshizaki K, Miyasaka N et al. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: A multicenter, double-blind, placebocontrolled trial. Arthritis Rheum 2004; 50: 1761-9.
    • (2004) Arthritis Rheum , vol.50 , pp. 1761-1769
    • Nishimoto, N.1    Yoshizaki, K.2    Miyasaka, N.3
  • 7
    • 1542376173 scopus 로고    scopus 로고
    • The transfer of a laboratory based hypothesis to a clinically useful therapy: The development of anti-TNF therapy of rheumatoid arthritis
    • Feldmann M, Brennan FM, Williams RO et al. The transfer of a laboratory based hypothesis to a clinically useful therapy: The development of anti-TNF therapy of rheumatoid arthritis. Best Pract Res Clin Rheumatol2004; 18: 59-80.
    • (2004) Best Pract Res Clin Rheumatol , vol.18 , pp. 59-80
    • Feldmann, M.1    Brennan, F.M.2    Williams, R.O.3
  • 8
    • 0031897632 scopus 로고    scopus 로고
    • NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh S, May MJ, Kopp EB. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998; 16: 225-60.
    • (1998) Annu Rev Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 9
    • 33748360705 scopus 로고    scopus 로고
    • Philadelphia chromosomepositive acute lymphoblastic leukemia: Impact of imatinib treatmenton remission induction and allogeneic stem cell transplantation
    • Kovacsovics T, Maziarz RT. Philadelphia chromosomepositive acute lymphoblastic leukemia: impact of imatinib treatmenton remission induction and allogeneic stem cell transplantation. Curr Oncol Rep 2006; 8: 343-51.
    • (2006) Curr Oncol Rep , vol.8 , pp. 343-351
    • Kovacsovics, T.1    Maziarz, R.T.2
  • 10
    • 0036009115 scopus 로고    scopus 로고
    • NF-kappaB at the crossroads of life and death
    • Karin M, Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol 2002; 3: 221-7.
    • (2002) Nat Immunol , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 11
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kappa B and I kappa B proteins: New discoveries and insights
    • Baldwin AS Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996; 14: 649-83.
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-683
    • Baldwin, A.S.1
  • 12
    • 0028971289 scopus 로고
    • Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation
    • Verma IM, Stevenson JK, Schwarz EM et al. Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev 1995; 9: 2723-35.
    • (1995) Genes Dev , vol.9 , pp. 2723-2735
    • Verma, I.M.1    Stevenson, J.K.2    Schwarz, E.M.3
  • 13
    • 0028986194 scopus 로고
    • I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B
    • Thompson JE, Phillips RJ, Erdjument-Bromage H et al.I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell 1995; 80: 573-82.
    • (1995) Cell , vol.80 , pp. 573-582
    • Thompson, J.E.1    Phillips, R.J.2    Erdjument-Bromage, H.3
  • 14
    • 0030745885 scopus 로고    scopus 로고
    • Distinct functional properties of IkappaB alpha and IkappaB beta
    • Tran K, Merika M, Thanos D. Distinct functional properties of IkappaB alpha and IkappaB beta. Mol Cell Biol1997; 17: 5386-99.
    • (1997) Mol Cell Biol , vol.17 , pp. 5386-5399
    • Tran, K.1    Merika, M.2    Thanos, D.3
  • 15
    • 0031800762 scopus 로고    scopus 로고
    • Persistent activation of RelA by respiratory syncytial virus involves protein kinase C, under-phosphorylated IkappaBbeta, and sequestration of protein phosphatase 2A by the viral phosphoprotein
    • Bitko V, Barik S. Persistent activation of RelA by respiratory syncytial virus involves protein kinase C, under-phosphorylated IkappaBbeta, and sequestration of protein phosphatase 2A by the viral phosphoprotein. J Virol 1998; 72: 5610-18.
    • (1998) J Virol , vol.72 , pp. 5610-5618
    • Bitko, V.1    Barik, S.2
  • 16
    • 0034805902 scopus 로고    scopus 로고
    • Dysregulated NF-kappaB activation in cystic fibrosis: Evidence for a primary inflammatory disorder
    • Blackwell TS, Stecenko A A, Christman JW. Dysregulated NF-kappaB activation in cystic fibrosis: evidence for a primary inflammatory disorder. Am J Physiol Lung Cell Mol Physiol 2001; 281: L69-70.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281 , pp. L69-L70
    • Blackwell, T.S.1    Stecenko, A.A.2    Christman, J.W.3
  • 17
    • 0033531788 scopus 로고    scopus 로고
    • Nuclear IkappaBbeta maintains persistent NF-kappaB activation in HIV-1-infected myeloid cells
    • DeLuca C, Petropoulos L, Zmeureanu D et al. Nuclear IkappaBbeta maintains persistent NF-kappaB activation in HIV-1-infected myeloid cells. J Biol Chem 1999; 274: 13010-16.
    • (1999) J Biol Chem , vol.274 , pp. 13010-13016
    • Deluca, C.1    Petropoulos, L.2    Zmeureanu, D.3
  • 18
    • 0035139943 scopus 로고    scopus 로고
    • Hostile takeovers: Viral appropriation of the NF-kappaB pathway
    • Hiscott J, Kwon H, Genin P. Hostile takeovers: viral appropriation of the NF-kappaB pathway. J Clin Invest2001; 107: 143-51.
    • (2001) J Clin Invest , vol.107 , pp. 143-151
    • Hiscott, J.1    Kwon, H.2    Genin, P.3
  • 19
    • 0029666281 scopus 로고    scopus 로고
    • A sustained reduction in IkappaB-beta may contribute to persistent NF-kappaB activation in human endothelial cells
    • Johnson DR, Douglas I, Jahnke A et al. A sustained reduction in IkappaB-beta may contribute to persistent NF-kappaB activation in human endothelial cells. J Biol Chem 1996; 271: 16317-22.
    • (1996) J Biol Chem , vol.271 , pp. 16317-16322
    • Johnson, D.R.1    Douglas, I.2    Jahnke, A.3
  • 20
    • 0030831601 scopus 로고    scopus 로고
    • Parasite-mediated nuclear factor kappaB regulation in lymphoprolifération caused by Theileria parva infection
    • Palmer GH, Machado J Jr, Fernandez P et al.Parasite-mediated nuclear factor kappaB regulation in lymphoprolifération caused by Theileria parva infection. Proc Natl Acad Sci U S A 1997; 94: 12527-32.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 12527-12532
    • Palmer, G.H.1    Machado, J.2    Fernandez, P.3
  • 21
    • 0035002033 scopus 로고    scopus 로고
    • Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells
    • Stecenko AA, King G, Torii K et al. Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells. Inflammation 2001; 25: 145-55.
    • (2001) Inflammation , vol.25 , pp. 145-155
    • Stecenko, A.A.1    King, G.2    Torii, K.3
  • 22
    • 33747388013 scopus 로고    scopus 로고
    • IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression
    • Kearns JD, Basak S, Werner SL et al. IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression. J Cell Biol 2006; 173: 659-64.
    • (2006) J Cell Biol , vol.173 , pp. 659-664
    • Kearns, J.D.1    Basak, S.2    Werner, S.L.3
  • 23
    • 0027446955 scopus 로고
    • The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers
    • Bours V, Franzoso G, Azarenko V et al. The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell 1993; 72: 729-39.
    • (1993) Cell , vol.72 , pp. 729-739
    • Bours, V.1    Franzoso, G.2    Azarenko, V.3
  • 24
    • 0027175501 scopus 로고
    • The bcl-3 protooncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner
    • Nolan GP, Fujita T, Bhatia K et al. The bcl-3 protooncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner. Mol Cell Biol 1993; 13: 3557-66.
    • (1993) Mol Cell Biol , vol.13 , pp. 3557-3566
    • Nolan, G.P.1    Fujita, T.2    Bhatia, K.3
  • 25
    • 0027184023 scopus 로고
    • The candidate protooncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers
    • Fujita T, Nolan GP, Liou HC et al. The candidate protooncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers. Genes Dev 1993; 7: 1354-63.
    • (1993) Genes Dev , vol.7 , pp. 1354-1363
    • Fujita, T.1    Nolan, G.P.2    Liou, H.C.3
  • 26
    • 0033199348 scopus 로고    scopus 로고
    • NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes
    • Heissmeyer V, Krappmann D, Wulczyn FG et al.NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes. EMBO J 1999; 18: 4766-78.
    • (1999) EMBO J , vol.18 , pp. 4766-4778
    • Heissmeyer, V.1    Krappmann, D.2    Wulczyn, F.G.3
  • 27
    • 0026758170 scopus 로고
    • The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition
    • Franzoso G, Bours V, Park S et al. The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition. Nature 1992; 359: 339-42.
    • (1992) Nature , vol.359 , pp. 339-342
    • Franzoso, G.1    Bours, V.2    Park, S.3
  • 28
    • 0033519690 scopus 로고    scopus 로고
    • The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators
    • Dechend R, Hirano F, Lehmann K et al. The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. Oncogene 1999; 18: 3316-23.
    • (1999) Oncogene , vol.18 , pp. 3316-3323
    • Dechend, R.1    Hirano, F.2    Lehmann, K.3
  • 31
    • 0042493163 scopus 로고    scopus 로고
    • Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases
    • O'Neill LA. Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases. Curr Opin Pharmacol 2003; 3: 396-403.
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 396-403
    • O'Neill, L.A.1
  • 32
    • 0035920176 scopus 로고    scopus 로고
    • Novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei
    • Yamazaki S, Muta T, Takeshige K. A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei. J Biol Chem 2001; 276: 27657-62.
    • (2001) J Biol Chem , vol.276 , pp. 27657-27662
    • Yamazaki, S.1    Muta, T.2    Takeshige, K.A.3
  • 33
    • 0034680774 scopus 로고    scopus 로고
    • MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production
    • Kitamura H, Kanehira K, Okita K et al. MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production. FEBS Lett 2000; 485: 53-6.
    • (2000) FEBS Lett , vol.485 , pp. 53-56
    • Kitamura, H.1    Kanehira, K.2    Okita, K.3
  • 34
    • 0035918188 scopus 로고    scopus 로고
    • Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs
    • Haruta H, Kato A, Todokoro K. Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs. J Biol Chem 2001; 276: 12485-8.
    • (2001) J Biol Chem , vol.276 , pp. 12485-12488
    • Haruta, H.1    Kato, A.2    Todokoro, K.3
  • 35
    • 3142581432 scopus 로고    scopus 로고
    • Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta
    • Yamamoto M, Yamazaki S, Uematsu S et al. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature 2004; 430: 218-22.
    • (2004) Nature , vol.430 , pp. 218-222
    • Yamamoto, M.1    Yamazaki, S.2    Uematsu, S.3
  • 36
    • 14844344042 scopus 로고    scopus 로고
    • The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria
    • Hirotani T, Lee PY, Kuwata H et al. The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria. J Immunol2005; 174: 3650-7.
    • (2005) J Immunol , vol.174 , pp. 3650-3657
    • Hirotani, T.1    Lee, P.Y.2    Kuwata, H.3
  • 37
    • 30444456370 scopus 로고    scopus 로고
    • IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation
    • Kuwata H, Matsumoto M, Atarashi K et al. IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation. Immunity2006; 24: 41-51.
    • (2006) Immunity , vol.24 , pp. 41-51
    • Kuwata, H.1    Matsumoto, M.2    Atarashi, K.3
  • 38
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiqui-tination: The control of NF-[kappa]B activity
    • Karin M, Ben-Neriah Y. Phosphorylation meets ubiqui-tination: The control of NF-[kappa]B activity. Annu Rev Immunol 2000; 18: 621-63.
    • (2000) Annu Rev Immunol , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 39
    • 0032541657 scopus 로고    scopus 로고
    • IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
    • Rothwarf DM, Zandi E, Natoli G et al. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature 1998; 395: 297-300.
    • (1998) Nature , vol.395 , pp. 297-300
    • Rothwarf, D.M.1    Zandi, E.2    Natoli, G.3
  • 40
    • 0033634663 scopus 로고    scopus 로고
    • Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti
    • Makris C, Godfrey VL, Krahn-Senftleben G et al. Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol Cell 2000; 5: 969-79.
    • (2000) Mol Cell , vol.5 , pp. 969-979
    • Makris, C.1    Godfrey, V.L.2    Krahn-Senftleben, G.3
  • 41
    • 0033537739 scopus 로고    scopus 로고
    • Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
    • Li Q, Van Antwerp D, Mercurio F et al. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science 1999; 284: 321-5.
    • (1999) Science , vol.284 , pp. 321-325
    • Li, Q.1    Van Antwerp, D.2    Mercurio, F.3
  • 42
    • 0033532386 scopus 로고    scopus 로고
    • The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
    • Li ZW, Chu W, Hu Y et al. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 1999; 189: 1839-45.
    • (1999) J Exp Med , vol.189 , pp. 1839-1845
    • Li, Z.W.1    Chu, W.2    Hu, Y.3
  • 43
    • 0038587747 scopus 로고    scopus 로고
    • The two faces of IKK and NF-kappaB inhibition: Prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
    • Chen LW, Egan L, Li ZW et al. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 2003; 9: 575-81.
    • (2003) Nat Med , vol.9 , pp. 575-581
    • Chen, L.W.1    Egan, L.2    Li, Z.W.3
  • 44
    • 0033537767 scopus 로고    scopus 로고
    • Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase
    • Hu Y, Baud V, Delhase M et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science 1999; 284: 316-20.
    • (1999) Science , vol.284 , pp. 316-320
    • Hu, Y.1    Baud, V.2    Delhase, M.3
  • 45
    • 0035809983 scopus 로고    scopus 로고
    • IKKalpha controls formation of the epidermis independently of NF-kappaB
    • Hu Y, Baud V, Oga T et al. IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature2001; 410: 710-14.
    • (2001) Nature , vol.410 , pp. 710-714
    • Hu, Y.1    Baud, V.2    Oga, T.3
  • 46
    • 17844386319 scopus 로고    scopus 로고
    • IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation
    • Lawrence T, Bebien M, Liu GY et al. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature 2005; 434: 1138-43.
    • (2005) Nature , vol.434 , pp. 1138-1143
    • Lawrence, T.1    Bebien, M.2    Liu, G.Y.3
  • 47
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kappaB puzzle
    • Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell 2002; 109 (Suppl): S81-S96.
    • (2002) Cell , vol.109 , pp. S81-S96
    • Ghosh, S.1    Karin, M.2
  • 48
    • 18644380147 scopus 로고    scopus 로고
    • The lympho-toxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways
    • Dejardin E, Droin NM, Delhase M et al. The lympho-toxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity2002; 17: 525-35.
    • (2002) Immunity , vol.17 , pp. 525-535
    • Dejardin, E.1    Droin, N.M.2    Delhase, M.3
  • 49
    • 17944378526 scopus 로고    scopus 로고
    • Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
    • Senftleben U, Cao Y, Xiao G et al. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 2001; 293: 1495-9.
    • (2001) Science , vol.293 , pp. 1495-1499
    • Senftleben, U.1    Cao, Y.2    Xiao, G.3
  • 50
    • 0742324860 scopus 로고    scopus 로고
    • TLR signaling pathways
    • Takeda K, Akira S. TLR signaling pathways. Semin Immunol 2004; 16: 3-9.
    • (2004) Semin Immunol , vol.16 , pp. 3-9
    • Takeda, K.1    Akira, S.2
  • 51
    • 2342522110 scopus 로고    scopus 로고
    • Shaping the nuclear action of NF-kappaB
    • Chen LF, Greene WC. Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol 2004; 5: 392-401.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 392-401
    • Chen, L.F.1    Greene, W.C.2
  • 52
    • 5644235488 scopus 로고    scopus 로고
    • NF-kappaB: A multifaceted transcription factor regulated at several levels
    • Schmitz ML, Mattioli I, Buss H et al. NF-kappaB: A multifaceted transcription factor regulated at several levels. Chembiochem 2004; 5: 1348-58.
    • (2004) Chembiochem , vol.5 , pp. 1348-1358
    • Schmitz, M.L.1    Mattioli, I.2    Buss, H.3
  • 53
    • 0037011056 scopus 로고    scopus 로고
    • Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB
    • Chen LF, Mu Y, Greene WC. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J 2002; 21: 6539-48.
    • (2002) EMBO J , vol.21 , pp. 6539-6548
    • Chen, L.F.1    Mu, Y.2    Greene, W.C.3
  • 54
    • 0037462725 scopus 로고    scopus 로고
    • Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65
    • Kiernan R, Bres V, Ng RW et al. Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65. J Biol Chem 2003; 278: 2758-66.
    • (2003) J Biol Chem , vol.278 , pp. 2758-2766
    • Kiernan, R.1    Bres, V.2    Ng, R.W.3
  • 55
    • 24344468250 scopus 로고    scopus 로고
    • NF-kappaB RelA phosphorylation regulates RelA acetylation
    • Chen LF, Williams SA, Mu Y et al. NF-kappaB RelA phosphorylation regulates RelA acetylation. Mol Cell Biol 2005; 25: 7966-75.
    • (2005) Mol Cell Biol , vol.25 , pp. 7966-7975
    • Chen, L.F.1    Williams, S.A.2    Mu, Y.3
  • 56
    • 1642553460 scopus 로고    scopus 로고
    • To be, or not to be: NF-kappaB is the answer - role of Rel/NF-kappaB in the regulation of apoptosis
    • Kucharczak J, Simmons MJ, Fan Y et al. To be, or not to be: NF-kappaB is the answer - role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene 2003; 22: 8961-82.
    • (2003) Oncogene , vol.22 , pp. 8961-8982
    • Kucharczak, J.1    Simmons, M.J.2    Fan, Y.3
  • 57
    • 0026708394 scopus 로고
    • Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B
    • Fujita T, Nolan GP, Ghosh S et al. Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B. Genes Dev 1992; 6: 775-87.
    • (1992) Genes Dev , vol.6 , pp. 775-787
    • Fujita, T.1    Nolan, G.P.2    Ghosh, S.3
  • 58
    • 0026774239 scopus 로고
    • Selection of optimal kappa B/Rel DNA-binding motifs: Interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation
    • Kunsch C, Ruben SM, Rosen CA. Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation. Mol Cell Biol 1992; 12: 4412-21.
    • (1992) Mol Cell Biol , vol.12 , pp. 4412-4421
    • Kunsch, C.1    Ruben, S.M.2    Rosen, C.A.3
  • 59
    • 0142105387 scopus 로고    scopus 로고
    • Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities
    • Hoffmann A, Leung TH, Baltimore D. Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities. EMBO J 2003; 22: 5530-9.
    • (2003) EMBO J , vol.22 , pp. 5530-5539
    • Hoffmann, A.1    Leung, T.H.2    Baltimore, D.3
  • 60
    • 0037025364 scopus 로고    scopus 로고
    • The x-ray crystal structure of the NF-kappa B p50.P65 heterodimer bound to the interferon beta -kappa B site
    • Berkowitz B, Huang DB, Chen-Park FE et al. The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site. J Biol Chem 2002; 277: 24694-700.
    • (2002) J Biol Chem , vol.277 , pp. 24694-24700
    • Berkowitz, B.1    Huang, D.B.2    Chen-Park, F.E.3
  • 61
    • 0033596120 scopus 로고    scopus 로고
    • Regulation of DNA binding by Rel/NF-kappaB transcription factors: Structural views
    • Chen FE, Ghosh G. Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views. Oncogene 1999; 18: 6845-52.
    • (1999) Oncogene , vol.18 , pp. 6845-6852
    • Chen, F.E.1    Ghosh, G.2
  • 62
    • 0037025395 scopus 로고    scopus 로고
    • The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription
    • Chen-Park FE, Huang DB, Noro B et al. The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription. J Biol Chem 2002; 277: 24701-8.
    • (2002) J Biol Chem , vol.277 , pp. 24701-24708
    • Chen-Park, F.E.1    Huang, D.B.2    Noro, B.3
  • 63
    • 0036124647 scopus 로고    scopus 로고
    • Structure of NF-kappaB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter
    • Escalante CR, Shen L, Thanos D et al. Structure of NF-kappaB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter. Structure 2002; 10: 383-91.
    • (2002) Structure , vol.10 , pp. 383-391
    • Escalante, C.R.1    Shen, L.2    Thanos, D.3
  • 64
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappaB
    • Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev 2004; 18: 2195-224.
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 65
    • 0342742310 scopus 로고
    • Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B
    • Osborn L, Kunkel S, Nabel GJ. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc Natl Acad Sci U S A 1989; 86: 2336-40.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 2336-2340
    • Osborn, L.1    Kunkel, S.2    Nabel, G.J.3
  • 66
    • 30044442866 scopus 로고    scopus 로고
    • How Toll-like receptors signal: What we know and what we don't know
    • O'Neill LA. How Toll-like receptors signal: what we know and what we don't know. Curr Opin Immunol2006; 18: 3-9.
    • (2006) Curr Opin Immunol , vol.18 , pp. 3-9
    • O'Neill, L.A.1
  • 67
    • 22444433175 scopus 로고    scopus 로고
    • NLRs join TLRs as innate sensors of pathogens
    • Martinon F, Tschopp J. NLRs join TLRs as innate sensors of pathogens. Trends Immunol 2005; 26: 447-54.
    • (2005) Trends Immunol , vol.26 , pp. 447-454
    • Martinon, F.1    Tschopp, J.2
  • 68
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity 2004; 21: 467-76.
    • (2004) Immunity , vol.21 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 69
    • 0033567388 scopus 로고    scopus 로고
    • ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
    • Kopp E, Medzhitov R, Carothers J et al. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev 1999; 13: 2059-71.
    • (1999) Genes Dev , vol.13 , pp. 2059-2071
    • Kopp, E.1    Medzhitov, R.2    Carothers, J.3
  • 70
    • 0030298294 scopus 로고    scopus 로고
    • Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death
    • Liu ZG, Hsu H, Goeddel DV et al. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 1996; 87: 565-76.
    • (1996) Cell , vol.87 , pp. 565-576
    • Liu, Z.G.1    Hsu, H.2    Goeddel, D.V.3
  • 71
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
    • Beg AA, Baltimore D. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science1996; 274: 782-4.
    • (1996) Science , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 72
    • 0029992609 scopus 로고    scopus 로고
    • Suppression of TNF-alpha-induced apoptosis by NF-kappaB
    • Van Antwerp DJ, Martin SJ, Kafri T et al. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science1996; 274: 787-9.
    • (1996) Science , vol.274 , pp. 787-789
    • Van Antwerp, D.J.1    Martin, S.J.2    Kafri, T.3
  • 73
    • 0029858387 scopus 로고    scopus 로고
    • TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappaB
    • Wang CY, Mayo MW, Baldwin AS Jr. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 1996; 274: 784-7.
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.Y.1    Mayo, M.W.2    Baldwin, A.S.3
  • 74
    • 14844327760 scopus 로고    scopus 로고
    • Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    • Kamata H, Honda S, Maeda S et al. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005; 120: 649-61.
    • (2005) Cell , vol.120 , pp. 649-661
    • Kamata, H.1    Honda, S.2    Maeda, S.3
  • 75
    • 8344260568 scopus 로고    scopus 로고
    • Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species
    • Pham CG, Bubici C, Zazzeroni F et al. Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. Cell 2004; 119: 529-42.
    • (2004) Cell , vol.119 , pp. 529-542
    • Pham, C.G.1    Bubici, C.2    Zazzeroni, F.3
  • 76
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • Karin M. Nuclear factor-kappaB in cancer development and progression. Nature 2006; 441: 431-6.
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 77
    • 24944586285 scopus 로고    scopus 로고
    • Achieving stability of lipopolysaccharide-induced NF-kappaB activation
    • Covert MW, Leung TH, Gaston JE et al. Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science 2005; 309: 1854-7.
    • (2005) Science , vol.309 , pp. 1854-1857
    • Covert, M.W.1    Leung, T.H.2    Gaston, J.E.3
  • 78
    • 21344449546 scopus 로고    scopus 로고
    • The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis
    • Andreakos E, Sacre S, Foxwell BM et al. The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis. Front Biosci 2005; 10: 2478-88.
    • (2005) Front Biosci , vol.10 , pp. 2478-2488
    • Andreakos, E.1    Sacre, S.2    Foxwell, B.M.3
  • 79
    • 0029552889 scopus 로고
    • High DNA-binding activity of transcription factor NF-kappa B in synovial membranes of patients with rheumatoid arthritis
    • Asahara H, Asanuma M, Ogawa N et al. High DNA-binding activity of transcription factor NF-kappa B in synovial membranes of patients with rheumatoid arthritis. Biochem Mol Biol Int 1995; 37: 827-32.
    • (1995) Biochem Mol Biol Int , vol.37 , pp. 827-832
    • Asahara, H.1    Asanuma, M.2    Ogawa, N.3
  • 81
    • 15844384253 scopus 로고    scopus 로고
    • Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue
    • Marok R, Winyard PG, Coumbe A et al. Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue. Arthritis Rheum 1996; 39: 583-91.
    • (1996) Arthritis Rheum , vol.39 , pp. 583-591
    • Marok, R.1    Winyard, P.G.2    Coumbe, A.3
  • 83
    • 0032493278 scopus 로고    scopus 로고
    • Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent
    • Foxwell B, Browne K, Bondeson J et al. Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent. Proc Natl Acad Sci U S A 1998; 95: 8211-15.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8211-8215
    • Foxwell, B.1    Browne, K.2    Bondeson, J.3
  • 84
    • 0033545863 scopus 로고    scopus 로고
    • Defining therapeutic targets by using adenovirus: Blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares antiinflammatory mediators
    • Bondeson J, Foxwell B, Brennan F et al. Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares antiinflammatory mediators. Proc Natl Acad Sci U S A 1999; 96: 5668-73.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 5668-5673
    • Bondeson, J.1    Foxwell, B.2    Brennan, F.3
  • 85
    • 33749587067 scopus 로고    scopus 로고
    • Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent
    • Amos N, Lauder S, Evans A et al. Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent. Rheumatology (Oxford) 2006; 45: 1201-9.
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 1201-1209
    • Amos, N.1    Lauder, S.2    Evans, A.3
  • 86
    • 0038575364 scopus 로고    scopus 로고
    • Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: Implications for therapy
    • Andreakos E, Smith C, Kiriakidis S et al. Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy. Arthritis Rheum 2003; 48: 1901-12.
    • (2003) Arthritis Rheum , vol.48 , pp. 1901-1912
    • Andreakos, E.1    Smith, C.2    Kiriakidis, S.3
  • 87
    • 0037289728 scopus 로고    scopus 로고
    • Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction
    • Andreakos E, Smith C, Monaco C et al. Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction. Blood 2003; 101: 983-91.
    • (2003) Blood , vol.101 , pp. 983-991
    • Andreakos, E.1    Smith, C.2    Monaco, C.3
  • 88
    • 0030715563 scopus 로고    scopus 로고
    • Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2
    • Iotsova V, Caamano J, Loy J et al. Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med 1997; 3: 1285-9.
    • (1997) Nat Med , vol.3 , pp. 1285-1289
    • Iotsova, V.1    Caamano, J.2    Loy, J.3
  • 89
    • 2942703810 scopus 로고    scopus 로고
    • Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo
    • Jimi E, Aoki K, Saito H et al. Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med 2004; 10: 617-24.
    • (2004) Nat Med , vol.10 , pp. 617-624
    • Jimi, E.1    Aoki, K.2    Saito, H.3
  • 90
    • 0034603036 scopus 로고    scopus 로고
    • Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha
    • Murakami S, Lefebvre V, de Crombrugghe B. Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha. J Biol Chem 2000; 275: 3687-92.
    • (2000) J Biol Chem , vol.275 , pp. 3687-3692
    • Murakami, S.1    Lefebvre, V.2    De Crombrugghe, B.3
  • 91
    • 0033813919 scopus 로고    scopus 로고
    • Transcriptional mechanisms of chondrocyte differentiation
    • de Crombrugghe B, Lefebvre V, Behringer RR et al.Transcriptional mechanisms of chondrocyte differentiation. Matrix Biol 2000; 19: 389-94.
    • (2000) Matrix Biol , vol.19 , pp. 389-394
    • De Crombrugghe, B.1    Lefebvre, V.2    Behringer, R.R.3
  • 92
    • 2642517290 scopus 로고    scopus 로고
    • Increased synovial tissue NF-kappa B1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis
    • Benito MJ, Murphy E, Murphy EP et al. Increased synovial tissue NF-kappa B1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum 2004; 50: 1781-7.
    • (2004) Arthritis Rheum , vol.50 , pp. 1781-1787
    • Benito, M.J.1    Murphy, E.2    Murphy, E.P.3
  • 93
    • 0033917674 scopus 로고    scopus 로고
    • Distinct roles for the NF-kappaB1 (P50) and c-Rel transcription factors in inflammatory arthritis
    • Campbell IK, Gerondakis S, O'Donnell K et al. Distinct roles for the NF-kappaB1 (p50) and c-Rel transcription factors in inflammatory arthritis. J Clin Invest 2000; 105: 1799-806.
    • (2000) J Clin Invest , vol.105 , pp. 1799-1806
    • Campbell, I.K.1    Gerondakis, S.2    O'Donnell, K.3
  • 94
    • 0033178749 scopus 로고    scopus 로고
    • Essential role of T cell NF-kappa B activation in collagen-induced arthritis
    • Seetharaman R, Mora AL, Nabozny G et al. Essential role of T cell NF-kappa B activation in collagen-induced arthritis. J Immunol 1999; 163: 1577-83.
    • (1999) J Immunol , vol.163 , pp. 1577-1583
    • Seetharaman, R.1    Mora, A.L.2    Nabozny, G.3
  • 95
    • 13044316560 scopus 로고    scopus 로고
    • Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis
    • Palombella VJ, Conner EM, Fuseler JW et al. Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis. Proc Natl Acad Sci U S A 1998; 95: 15671-6.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15671-15676
    • Palombella, V.J.1    Conner, E.M.2    Fuseler, J.W.3
  • 96
    • 0142165030 scopus 로고    scopus 로고
    • The mechanism of action of aspirin
    • Vane JR, Botting RM. The mechanism of action of aspirin. Thromb Res 2003; 110: 255-8.
    • (2003) Thromb Res , vol.110 , pp. 255-258
    • Vane, J.R.1    Botting, R.M.2
  • 97
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    • Yuan M, Konstantopoulos N, Lee J et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001; 293: 1673-7.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3
  • 98
    • 33645823692 scopus 로고    scopus 로고
    • Is sulfasalazine effective in ankylosing spondylitis? A systematic review of randomized controlled trials
    • Chen J, Liu C. Is sulfasalazine effective in ankylosing spondylitis? A systematic review of randomized controlled trials. J Rheumatol 2006; 33: 722-31.
    • (2006) J Rheumatol , vol.33 , pp. 722-731
    • Chen, J.1    Liu, C.2
  • 99
    • 0032992467 scopus 로고    scopus 로고
    • Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB
    • Cronstein BN, Montesinos MC, Weissmann G. Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB. Proc Natl Acad Sci U S A 1999; 96: 6377-81.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 6377-6381
    • Cronstein, B.N.1    Montesinos, M.C.2    Weissmann, G.3
  • 100
    • 0032853234 scopus 로고    scopus 로고
    • Sulfasalazine prevents T-helper 1 immune response by suppressing interleukin-12 production in macrophages
    • Kang BY, Chung SW, Im SY et al. Sulfasalazine prevents T-helper 1 immune response by suppressing interleukin-12 production in macrophages. Immunology 1999; 98: 98-103.
    • (1999) Immunology , vol.98 , pp. 98-103
    • Kang, B.Y.1    Chung, S.W.2    Im, S.Y.3
  • 101
    • 4644263340 scopus 로고    scopus 로고
    • Effects of glucocorticoids on gene transcription
    • Hayashi R, Wada H, Ito K et al. Effects of glucocorticoids on gene transcription. Eur J Pharmacol 2004; 500: 51-62.
    • (2004) Eur J Pharmacol , vol.500 , pp. 51-62
    • Hayashi, R.1    Wada, H.2    Ito, K.3
  • 102
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis
    • Auphan N, DiDonato JA, Rosette C et al.Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 1995; 270: 286-90.
    • (1995) Science , vol.270 , pp. 286-290
    • Auphan, N.1    Didonato, J.A.2    Rosette, C.3
  • 103
    • 0028879819 scopus 로고
    • Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids
    • Scheinman RI, Cogswell PC, Lofquist AK et al. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science 1995; 270: 283-6.
    • (1995) Science , vol.270 , pp. 283-286
    • Scheinman, R.I.1    Cogswell, P.C.2    Lofquist, A.K.3
  • 104
    • 0027402820 scopus 로고
    • Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene
    • Drouin J, Sun YL, Chamberland M et al. Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. EMBO J 1993; 12: 145-56.
    • (1993) EMBO J , vol.12 , pp. 145-156
    • Drouin, J.1    Sun, Y.L.2    Chamberland, M.3
  • 105
    • 0024080921 scopus 로고
    • Hormonemediated repression: A negative glucocorticoid response element from the bovine prolactin gene
    • Sakai DD, Helms S, Carlstedt-Duke J et al. Hormonemediated repression: A negative glucocorticoid response element from the bovine prolactin gene. Genes Dev1988; 2: 1144-54.
    • (1988) Genes Dev , vol.2 , pp. 1144-1154
    • Sakai, D.D.1    Helms, S.2    Carlstedt-Duke, J.3
  • 106
    • 0033485289 scopus 로고    scopus 로고
    • Mechanisms of glucocorticoid-receptor-mediated repression of gene expression
    • Webster JC, Cidlowski JA. Mechanisms of glucocorticoid-receptor-mediated repression of gene expression. Trends Endocrinol Metab 1999; 10: 396-402.
    • (1999) Trends Endocrinol Metab , vol.10 , pp. 396-402
    • Webster, J.C.1    Cidlowski, J.A.2
  • 107
    • 0344012614 scopus 로고    scopus 로고
    • Putting the brake on inflammatory responses: The role of glucocorticoids
    • Hermoso MA, Cidlowski JA. Putting the brake on inflammatory responses: The role of glucocorticoids. IUBMB Life 2003; 55: 497-504.
    • (2003) IUBMB Life , vol.55 , pp. 497-504
    • Hermoso, M.A.1    Cidlowski, J.A.2
  • 108
    • 33745728301 scopus 로고    scopus 로고
    • From willow bark to peptides: The ever widening spectrum of NF-kappaB inhibitors
    • D'Acquisto F, Ianaro A. From willow bark to peptides: The ever widening spectrum of NF-kappaB inhibitors. Curr Opin Pharmacol 2006; 6: 387-92.
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 387-392
    • D'acquisto, F.1    Ianaro, A.2
  • 109
    • 33646475553 scopus 로고    scopus 로고
    • Ciclesonide reduces the need for oral steroid use in adult patients with severe, persistent asthma
    • Bateman E, Karpel J, Casale T et al. Ciclesonide reduces the need for oral steroid use in adult patients with severe, persistent asthma. Chest 2006; 129: 1176-87.
    • (2006) Chest , vol.129 , pp. 1176-1187
    • Bateman, E.1    Karpel, J.2    Casale, T.3
  • 110
    • 0030885575 scopus 로고    scopus 로고
    • Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling
    • Peraldi P, Xu M, Spiegelman BM. Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling. J Clin Invest 1997; 100: 1863-9.
    • (1997) J Clin Invest , vol.100 , pp. 1863-1869
    • Peraldi, P.1    Xu, M.2    Spiegelman, B.M.3
  • 111
    • 0037709247 scopus 로고    scopus 로고
    • Hepatotoxicity of the thiazolidinediones
    • Tolman KG, Chandramouli J. Hepatotoxicity of the thiazolidinediones. Clin Liver Dis 2003; 7: 369-79, vi.
    • (2003) Clin Liver Dis , vol.7
    • Tolman, K.G.1    Chandramouli, J.2
  • 112
    • 0026607265 scopus 로고
    • Treatment of insulin-resistant mice with the oral antidiabetic agent pioglitazone: Evaluation of liver GLUT2 and phosphoenolpyruvate carboxykinase expression
    • Hofmann CA, Edwards CW 3rd, Hillman RM et al.Treatment of insulin-resistant mice with the oral antidiabetic agent pioglitazone: evaluation of liver GLUT2 and phosphoenolpyruvate carboxykinase expression. Endocrinology 1992; 130: 735-40.
    • (1992) Endocrinology , vol.130 , pp. 735-740
    • Hofmann, C.A.1    Edwards, C.W.2    Hillman, R.M.3
  • 113
    • 0028076266 scopus 로고
    • A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat
    • Oakes ND, Kennedy CJ, Jenkins AB et al. A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat. Diabetes 1994; 43: 1203-10.
    • (1994) Diabetes , vol.43 , pp. 1203-1210
    • Oakes, N.D.1    Kennedy, C.J.2    Jenkins, A.B.3
  • 114
    • 10744224449 scopus 로고    scopus 로고
    • Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma
    • Cuzzocrea S, Mazzon E, Dugo L et al. Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma. Arthritis Rheum 2003; 48: 3544-56.
    • (2003) Arthritis Rheum , vol.48 , pp. 3544-3556
    • Cuzzocrea, S.1    Mazzon, E.2    Dugo, L.3
  • 115
    • 0035668404 scopus 로고    scopus 로고
    • An open-label trial of the PPAR-gamma ligand rosiglitazone for active ulcerative colitis
    • Lewis JD, Lichtenstein GR, Stein RB et al. An open-label trial of the PPAR-gamma ligand rosiglitazone for active ulcerative colitis. Am J Gastroenterol 2001; 96: 3323-8.
    • (2001) Am J Gastroenterol , vol.96 , pp. 3323-3328
    • Lewis, J.D.1    Lichtenstein, G.R.2    Stein, R.B.3
  • 116
    • 26044455885 scopus 로고    scopus 로고
    • Risk of hospitalization for heart failure associated with thiazolidinedione therapy: A Medicaid claims-based case-control study
    • Hartung DM, Touchette DR, Bultemeier NC et al. Risk of hospitalization for heart failure associated with thiazolidinedione therapy: A Medicaid claims-based case-control study. Pharmacotherapy 2005; 25: 1329-36.
    • (2005) Pharmacotherapy , vol.25 , pp. 1329-1336
    • Hartung, D.M.1    Touchette, D.R.2    Bultemeier, N.C.3
  • 117
    • 22644445633 scopus 로고    scopus 로고
    • Changes in liver tests during 1-year treatment of patients with Type 2 diabetes with pioglitazone, metformin or gliclazide
    • Belcher G, Schernthaner G. Changes in liver tests during 1-year treatment of patients with Type 2 diabetes with pioglitazone, metformin or gliclazide. Diabetic Med2005; 22: 973-9.
    • (2005) Diabetic Med , vol.22 , pp. 973-979
    • Belcher, G.1    Schernthaner, G.2
  • 118
    • 0035045084 scopus 로고    scopus 로고
    • Suppression of nuclear factor-kappaB and stimulation of inhibitor kappaB by troglitazone: Evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese
    • Ghanim H, Garg R, Aljada A et al. Suppression of nuclear factor-kappaB and stimulation of inhibitor kappaB by troglitazone: evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese. J Clin Endocrinol Metab 2001; 86: 1306-12.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1306-1312
    • Ghanim, H.1    Garg, R.2    Aljada, A.3
  • 119
    • 0034742613 scopus 로고    scopus 로고
    • Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: Evidence of an antiinflammatory action?
    • Aljada A, Garg R, Ghanim H et al. Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action?J Clin Endocrinol Metab 2001; 86: 3250-6.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3250-3256
    • Aljada, A.1    Garg, R.2    Ghanim, H.3
  • 120
    • 2942655390 scopus 로고    scopus 로고
    • Evidence for a potent antiinflammatory effect of rosiglitazone
    • Mohanty P, Aljada A, Ghanim H et al. Evidence for a potent antiinflammatory effect of rosiglitazone. J Clin Endocrinol Metab 2004; 89: 2728-35.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2728-2735
    • Mohanty, P.1    Aljada, A.2    Ghanim, H.3
  • 121
    • 1842474424 scopus 로고    scopus 로고
    • Disappearance of Crohn's ulcers in the terminal ileum after thalidomide therapy
    • Hershfield NB. Disappearance of Crohn's ulcers in the terminal ileum after thalidomide therapy. Can J Gastroenterol 2004; 18: 101-4.
    • (2004) Can J Gastroenterol , vol.18 , pp. 101-104
    • Hershfield, N.B.1
  • 122
    • 14044250162 scopus 로고    scopus 로고
    • Thalidomide as an immunotherapeutic agent: The effects on neutrophilmediated inflammation
    • Yasui K, Kobayashi N, Yamazaki T et al. Thalidomide as an immunotherapeutic agent: The effects on neutrophilmediated inflammation. Curr Pharm Des 2005; 11: 395-401.
    • (2005) Curr Pharm Des , vol.11 , pp. 395-401
    • Yasui, K.1    Kobayashi, N.2    Yamazaki, T.3
  • 123
    • 3442884264 scopus 로고    scopus 로고
    • The effects of thalidomide on the stimulation of NF-kappaB activity and TNF-alpha production by lipopolysaccharide in a human colonic epithelial cell line
    • Kim YS, Kim JS, Jung HC et al. The effects of thalidomide on the stimulation of NF-kappaB activity and TNF-alpha production by lipopolysaccharide in a human colonic epithelial cell line. Mol Cells 2004; 17: 210-16.
    • (2004) Mol Cells , vol.17 , pp. 210-216
    • Kim, Y.S.1    Kim, J.S.2    Jung, H.C.3
  • 124
    • 0036963968 scopus 로고    scopus 로고
    • Thalidomide suppresses the interleukin 1beta-induced NFkappaB signaling pathway in colon cancer cells
    • Jin SH, Kim TI, Han DS et al. Thalidomide suppresses the interleukin 1beta-induced NFkappaB signaling pathway in colon cancer cells. Ann N Y Acad Sci 2002; 973: 414-18.
    • (2002) Ann N Y Acad Sci , vol.973 , pp. 414-418
    • Jin, S.H.1    Kim, T.I.2    Han, D.S.3
  • 125
    • 0036481989 scopus 로고    scopus 로고
    • Early studies on the safety and efficacy of thalidomide for symptomatic inflammatory bowel disease
    • Bariol C, Meagher AP, Vickers CR et al. Early studies on the safety and efficacy of thalidomide for symptomatic inflammatory bowel disease. J Gastroenterol Hepatol2002; 17: 135-9.
    • (2002) J Gastroenterol Hepatol , vol.17 , pp. 135-139
    • Bariol, C.1    Meagher, A.P.2    Vickers, C.R.3
  • 126
    • 0030939874 scopus 로고    scopus 로고
    • A potential new treatment for rheumatoid arthritis: Thunder god vine
    • Lipsky PE, Tao XL. A potential new treatment for rheumatoid arthritis: Thunder god vine. Semin Arthritis Rheum 1997; 26: 713-23.
    • (1997) Semin Arthritis Rheum , vol.26 , pp. 713-723
    • Lipsky, P.E.1    Tao, X.L.2
  • 127
    • 0028962950 scopus 로고
    • The identity of immunosuppressive components of the ethyl acetate extract and chloroform methanol extract (T2) of Tripterygium wilfordii Hook. F
    • Tao X, Cai JJ, Lipsky PE. The identity of immunosuppressive components of the ethyl acetate extract and chloroform methanol extract (T2) of Tripterygium wilfordii Hook. F. J Pharmacol Exp Ther 1995; 272: 1305-12.
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 1305-1312
    • Tao, X.1    Cai, J.J.2    Lipsky, P.E.3
  • 128
    • 0033532177 scopus 로고    scopus 로고
    • Immunosuppressant PG490 (Triptolide) inhibits T-cell interleukin-2 expressi on at the level of purin e-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation
    • Qiu D, Zhao G, Aoki Y et al. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expressi on at the level of purin e-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. J Biol Chem 1999; 274: 13443-50.
    • (1999) J Biol Chem , vol.274 , pp. 13443-13450
    • Qiu, D.1    Zhao, G.2    Aoki, Y.3
  • 129
    • 0042662901 scopus 로고    scopus 로고
    • Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook
    • Qiu D, Kao PN. Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f. Drugs R D 2003; 4: 1-18.
    • (2003) Drugs R D , vol.4 , pp. 1-18
    • Qiu, D.1    Kao, P.N.2
  • 130
    • 85047700175 scopus 로고    scopus 로고
    • Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells
    • Jiang XH, Wong BC, Lin MC et al. Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells. Oncogene 2001; 20: 8009-18.
    • (2001) Oncogene , vol.20 , pp. 8009-8018
    • Jiang, X.H.1    Wong, B.C.2    Lin, M.C.3
  • 131
    • 0036065039 scopus 로고    scopus 로고
    • Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: A double-blind, placebo-controlled study
    • Tao X, Younger J, Fan FZ et al. Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: A double-blind, placebo-controlled study. Arthritis Rheum 2002; 46: 1735-43.
    • (2002) Arthritis Rheum , vol.46 , pp. 1735-1743
    • Tao, X.1    Younger, J.2    Fan, F.Z.3
  • 132
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-kappa B system: A treasure trove for drug development
    • Karin M, Yamamoto Y, Wang QM. The IKK NF-kappa B system: A treasure trove for drug development. Nat Rev Drug Discov 2004; 3: 17-26.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 133
    • 0142156224 scopus 로고    scopus 로고
    • Signal transduction networks in rheumatoid arthritis
    • Hammaker D, Sweeney S, Firestein GS. Signal transduction networks in rheumatoid arthritis. Ann Rheum Dis 2003; 62 (Suppl 2): ii86-9.
    • (2003) Ann Rheum Dis , vol.62
    • Hammaker, D.1    Sweeney, S.2    Firestein, G.S.3
  • 134
    • 0037449711 scopus 로고    scopus 로고
    • BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice
    • Burke JR, Pattoli MA, Gregor KR et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem 2003; 278: 1450-6.
    • (2003) J Biol Chem , vol.278 , pp. 1450-1456
    • Burke, J.R.1    Pattoli, M.A.2    Gregor, K.R.3
  • 135
    • 33748768735 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinase-9 gene expression and cell migration by NF-kappaB in response to CpG-oligodeoxy-nucleotides in RAW 264.7 cells
    • Rhee JW, Lee KW, Sohn WJ et al. Regulation of matrix metalloproteinase-9 gene expression and cell migration by NF-kappaB in response to CpG-oligodeoxy-nucleotides in RAW 264.7 cells. Mol Immunol 2007; 44: 1393-400.
    • (2007) Mol Immunol , vol.44 , pp. 1393-1400
    • Rhee, J.W.1    Lee, K.W.2    Sohn, W.J.3
  • 136
    • 0141676361 scopus 로고    scopus 로고
    • A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice
    • McIntyre KW, Shuster DJ, Gillooly KM et al. A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis Rheum2003; 48: 2652-9.
    • (2003) Arthritis Rheum , vol.48 , pp. 2652-2659
    • McIntyre, K.W.1    Shuster, D.J.2    Gillooly, K.M.3
  • 137
    • 33646767823 scopus 로고    scopus 로고
    • A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells
    • Wen D, Nong Y, Morgan JG et al. A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells. J Pharmacol Exp Ther 2006; 317: 989-1001.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 989-1001
    • Wen, D.1    Nong, Y.2    Morgan, J.G.3
  • 138
    • 33746217403 scopus 로고    scopus 로고
    • Validation of the anti-inflammatory properties of small-molecule IkB kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle
    • Catley MC, Sukkar MB, Chung KF et al. Validation of the anti-inflammatory properties of small-molecule IkB kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle. Mol Pharmacol 2006; 70: 697-705.
    • (2006) Mol Pharmacol , vol.70 , pp. 697-705
    • Catley, M.C.1    Sukkar, M.B.2    Chung, K.F.3
  • 139
    • 0028970734 scopus 로고
    • Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway
    • Alkalay I, Yaron A, Hatzubai A et al. Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A 1995; 92: 10599-603.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 10599-10603
    • Alkalay, I.1    Yaron, A.2    Hatzubai, A.3
  • 140
    • 33644691858 scopus 로고    scopus 로고
    • Proteasome inhibition: A new approach for the treatment of malignancies
    • Spano JP, Bay JO, Blay JY et al. Proteasome inhibition: A new approach for the treatment of malignancies. Bull Cancer 2005; 92: E61-6, 945-52.
    • (2005) Bull Cancer , vol.92
    • Spano, J.P.1    Bay, J.O.2    Blay, J.Y.3
  • 141
    • 5644250621 scopus 로고    scopus 로고
    • A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma
    • Jagannath S, Barlogie B, Berenson J et al. A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. Br J Haematol 2004; 127: 165-72.
    • (2004) Br J Haematol , vol.127 , pp. 165-172
    • Jagannath, S.1    Barlogie, B.2    Berenson, J.3
  • 142
    • 20044376092 scopus 로고    scopus 로고
    • Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma
    • O'Connor OA, Wright J, Moskowitz C et al. Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma. J Clin Oncol2005; 23: 676-84.
    • (2005) J Clin Oncol , vol.23 , pp. 676-684
    • O'Connor, O.A.1    Wright, J.2    Moskowitz, C.3
  • 143
    • 33745700031 scopus 로고    scopus 로고
    • Folate-linked lipid-based nanoparticles deliver a NFkappaB decoy into activated murine macrophage-like RAW264.7 cells
    • Hattori Y, Sakaguchi M, Maitani Y. Folate-linked lipid-based nanoparticles deliver a NFkappaB decoy into activated murine macrophage-like RAW264.7 cells. Biol Pharm Bull 2006; 29: 1516-20.
    • (2006) Biol Pharm Bull , vol.29 , pp. 1516-1520
    • Hattori, Y.1    Sakaguchi, M.2    Maitani, Y.3
  • 144
    • 0029006149 scopus 로고
    • Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
    • Lin YZ, Yao SY, Veach RA et al. Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J Biol Chem1995; 270: 14255-8.
    • (1995) J Biol Chem , vol.270 , pp. 14255-14258
    • Lin, Y.Z.1    Yao, S.Y.2    Veach, R.A.3
  • 145
    • 27644498849 scopus 로고    scopus 로고
    • Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation
    • Ledeboer A, Gamanos M, Lai W et al. Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation. Eur J Neurosci 2005; 22: 1977-86.
    • (2005) Eur J Neurosci , vol.22 , pp. 1977-1986
    • Ledeboer, A.1    Gamanos, M.2    Lai, W.3
  • 146
    • 2442522378 scopus 로고    scopus 로고
    • Suppression of staphylococcal enterotoxin B-induced toxicity by a nuclear import inhibitor
    • Liu D, Liu XY, Robinson D et al. Suppression of staphylococcal enterotoxin B-induced toxicity by a nuclear import inhibitor. J Biol Chem 2004; 279: 19239-46.
    • (2004) J Biol Chem , vol.279 , pp. 19239-19246
    • Liu, D.1    Liu, X.Y.2    Robinson, D.3
  • 147
    • 20044384169 scopus 로고    scopus 로고
    • A nuclear import inhibitory peptide ameliorates the severity of cholecys-tokinin-induced acute pancreatitis
    • Letoha T, Somlai C, Takacs T et al. A nuclear import inhibitory peptide ameliorates the severity of cholecys-tokinin-induced acute pancreatitis. World J Gastroenterol2005; 11: 990-9.
    • (2005) World J Gastroenterol , vol.11 , pp. 990-999
    • Letoha, T.1    Somlai, C.2    Takacs, T.3
  • 148
    • 20944442872 scopus 로고    scopus 로고
    • Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice
    • Saika S, Miyamoto T, Yamanaka O et al. Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice. Am J Pathol 2005; 166: 1393-403.
    • (2005) Am J Pathol , vol.166 , pp. 1393-1403
    • Saika, S.1    Miyamoto, T.2    Yamanaka, O.3
  • 149
    • 0032400997 scopus 로고    scopus 로고
    • Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50
    • Torgerson TR, Colosia AD, Donahue JP et al.Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50. J Immunol 1998; 161: 6084-92.
    • (1998) J Immunol , vol.161 , pp. 6084-6092
    • Torgerson, T.R.1    Colosia, A.D.2    Donahue, J.P.3
  • 150
    • 2442572230 scopus 로고    scopus 로고
    • Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis
    • Takada Y, Singh S, Aggarwal BB. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J Biol Chem 2004; 279: 15096-104.
    • (2004) J Biol Chem , vol.279 , pp. 15096-15104
    • Takada, Y.1    Singh, S.2    Aggarwal, B.B.3
  • 151
    • 0034284715 scopus 로고    scopus 로고
    • Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex
    • May MJ, D'Acquisto F, Madge LA et al. Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science 2000; 289: 1550-4.
    • (2000) Science , vol.289 , pp. 1550-1554
    • May, M.J.1    D'acquisto, F.2    Madge, L.A.3
  • 152
    • 4444306858 scopus 로고    scopus 로고
    • The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis
    • Dai S, Hirayama T, Abbas S et al. The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. J Biol Chem 2004; 279: 37219-22.
    • (2004) J Biol Chem , vol.279 , pp. 37219-37222
    • Dai, S.1    Hirayama, T.2    Abbas, S.3
  • 153
    • 14944353807 scopus 로고    scopus 로고
    • Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation
    • di Meglio P, Ianaro A, Ghosh S. Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation. Arthritis Rheum 2005; 52: 951-8.
    • (2005) Arthritis Rheum , vol.52 , pp. 951-958
    • Di Meglio, P.1    Ianaro, A.2    Ghosh, S.3
  • 154
    • 70350545937 scopus 로고    scopus 로고
    • Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation
    • Tas SW, Vervoordeldonk MJ, Hajji N et al. Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation. Arthritis Res Ther2006; 8: R86.
    • (2006) Arthritis Res Ther , vol.8 , pp. R86
    • Tas, S.W.1    Vervoordeldonk, M.J.2    Hajji, N.3
  • 155
    • 28844496621 scopus 로고    scopus 로고
    • High-throughput screening for inhibitors of the E3 ubiquitin ligase APC
    • Huang J, Sheung J, Dong G et al. High-throughput screening for inhibitors of the E3 ubiquitin ligase APC. Methods Enzymol 2005; 399: 740-54.
    • (2005) Methods Enzymol , vol.399 , pp. 740-754
    • Huang, J.1    Sheung, J.2    Dong, G.3
  • 156
    • 21244503601 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide
    • Doyle SL, Jefferies CA, O'Neill LA. Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide. J Biol Chem 2005; 280: 23496-501.
    • (2005) J Biol Chem , vol.280 , pp. 23496-23501
    • Doyle, S.L.1    Jefferies, C.A.2    O'Neill, L.A.3
  • 157
    • 33646838453 scopus 로고    scopus 로고
    • Improved lead-finding for kinase targets using high-throughput docking
    • McInnes C. Improved lead-finding for kinase targets using high-throughput docking. Curr Opin Drug Discov Devel 2006; 9: 339-47.
    • (2006) Curr Opin Drug Discov Devel , vol.9 , pp. 339-347
    • McInnes, C.1
  • 158
    • 31344467156 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
    • Mansell A, Smith R, Doyle SL et al. Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol 2006; 7: 148-55.
    • (2006) Nat Immunol , vol.7 , pp. 148-155
    • Mansell, A.1    Smith, R.2    Doyle, S.L.3
  • 159
    • 33744967486 scopus 로고    scopus 로고
    • Dynamic nuclear pore complexes: Life on the edge
    • Tran EJ, Wente SR. Dynamic nuclear pore complexes: life on the edge. Cell 2006; 125: 1041-53.
    • (2006) Cell , vol.125 , pp. 1041-1053
    • Tran, E.J.1    Wente, S.R.2
  • 160
    • 7444262946 scopus 로고    scopus 로고
    • Structure and function of HIV-1 auxiliary regulatory protein Vpr: Novel clues to drug design
    • Zhao LJ, Zhu H. Structure and function of HIV-1 auxiliary regulatory protein Vpr: novel clues to drug design. Curr Drug Targets Immune Endocr Metabol Disord 2004; 4: 265-75.
    • (2004) Curr Drug Targets Immune Endocr Metabol Disord , vol.4 , pp. 265-275
    • Zhao, L.J.1    Zhu, H.2
  • 161
    • 33644671435 scopus 로고    scopus 로고
    • Effect of a small molecule inhibitor of nuclear factor-kappaB nuclear translocation in a murine model of arthritis and cultured human synovial cells
    • Wakamatsu K, Nanki T, Miyasaka N et al. Effect of a small molecule inhibitor of nuclear factor-kappaB nuclear translocation in a murine model of arthritis and cultured human synovial cells. Arthritis Res Ther 2005; 7: R1348-59.
    • (2005) Arthritis Res Ther , vol.7 , pp. R1348-R1359
    • Wakamatsu, K.1    Nanki, T.2    Miyasaka, N.3
  • 162
    • 33750577799 scopus 로고    scopus 로고
    • Amelioration of arthritis by intraarticular dominant negative Ikkbeta gene therapy using adeno-associated virus type 5
    • Tas SW, Adriaansen J, Hajji N et al. Amelioration of arthritis by intraarticular dominant negative Ikkbeta gene therapy using adeno-associated virus type 5. Hum Gene Ther 2006; 17: 821-32.
    • (2006) Hum Gene Ther , vol.17 , pp. 821-832
    • Tas, S.W.1    Adriaansen, J.2    Hajji, N.3
  • 163
    • 0032792213 scopus 로고    scopus 로고
    • Immunosuppressive effect of triptolide in vitro
    • Lu H, Hachida M, Enosawa S et al. Immunosuppressive effect of triptolide in vitro. Transplant Proc 1999; 31: 2056-7.
    • (1999) Transplant Proc , vol.31 , pp. 2056-2057
    • Lu, H.1    Hachida, M.2    Enosawa, S.3
  • 165
    • 0035790067 scopus 로고    scopus 로고
    • Activation of HIV in human skin by ultraviolet B radiation and its inhibition by NFkappaB blocking agents
    • Breuer-McHam J, Simpson E, Dougherty I et al.Activation of HIV in human skin by ultraviolet B radiation and its inhibition by NFkappaB blocking agents. Photochem Photobiol 2001; 74: 805-10.
    • (2001) Photochem Photobiol , vol.74 , pp. 805-810
    • Breuer-McHam, J.1    Simpson, E.2    Dougherty, I.3
  • 167
    • 0033506335 scopus 로고    scopus 로고
    • Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynu-cleotides as a gene therapy
    • Tomita T, Takeuchi E, Tomita N et al. Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynu-cleotides as a gene therapy. Arthritis Rheum 1999; 42: 2532-42.
    • (1999) Arthritis Rheum , vol.42 , pp. 2532-2542
    • Tomita, T.1    Takeuchi, E.2    Tomita, N.3
  • 168
    • 0035229589 scopus 로고    scopus 로고
    • Short-term low-dose corticosteroids vs placebo and nonsteroidal antiinflammatory drugs in rheumatoid arthritis
    • Gotzsche PC, Johansen HK. Short-term low-dose corticosteroids vs placebo and nonsteroidal antiinflammatory drugs in rheumatoid arthritis. Cochrane Database Syst Rev 2004: CD000189.
    • (2004) Cochrane Database Syst Rev
    • Gotzsche, P.C.1    Johansen, H.K.2
  • 169
    • 33744915526 scopus 로고    scopus 로고
    • Ankylosing spondylitis and symptom-modifying vs diseasemodifying therapy
    • Akkoc N, van der Linden S, Khan MA. Ankylosing spondylitis and symptom-modifying vs diseasemodifying therapy. Best Pract Res Clin Rheumatol2006; 20: 539-57.
    • (2006) Best Pract Res Clin Rheumatol , vol.20 , pp. 539-557
    • Akkoc, N.1    Van Der Linden, S.2    Khan, M.A.3
  • 170
    • 29144466435 scopus 로고    scopus 로고
    • Immunological consequences of thalidomide treatment in Sjogren's syndrome
    • Moutsopoulos NM, Angelov N, Sankar V et al.Immunological consequences of thalidomide treatment in Sjogren's syndrome. Ann Rheum Dis 2006; 65: 112-14.
    • (2006) Ann Rheum Dis , vol.65 , pp. 112-114
    • Moutsopoulos, N.M.1    Angelov, N.2    Sankar, V.3
  • 171
    • 27344446522 scopus 로고    scopus 로고
    • Update on the pathogenesis and treatment of systemic onset juvenile rheumatoid arthritis
    • Adams A, Lehman TJ. Update on the pathogenesis and treatment of systemic onset juvenile rheumatoid arthritis. Curr Opin Rheumatol 2005; 17: 612-16.
    • (2005) Curr Opin Rheumatol , vol.17 , pp. 612-616
    • Adams, A.1    Lehman, T.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.