메뉴 건너뛰기




Volumn 9, Issue 5, 2003, Pages 575-581

The two faces of IKK and NF-κB inhibition: Prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

EID: 0038587747     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm849     Document Type: Article
Times cited : (448)

References (29)
  • 1
    • 0031897632 scopus 로고    scopus 로고
    • NF-κB Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh, S., May, M.I. & Kopp, E.B. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Ann. Rev. Immunol. 16, 225-260 (1998).
    • (1998) Ann. Rev. Immunol. , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.I.2    Kopp, E.B.3
  • 2
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-κB puzzle
    • Ghosh, S. & Karin, M. Missing pieces in the NF-κB puzzle. Cell 109, S81-596 (2002).
    • (2002) Cell , vol.109
    • Ghosh, S.1    Karin, M.2
  • 3
    • 0030615201 scopus 로고    scopus 로고
    • NF-κB - A pivotal transcription factor in chronic inflammatory diseases
    • Barnes, P.J. & Karin, M. NF-κB - a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336, 1066-1071 (1997).
    • (1997) N. Engl. J. Med. , vol.336 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 4
    • 0030611086 scopus 로고    scopus 로고
    • Role of NF-κB in the mortality of sepsis
    • Bohrer, H. et al. Role of NF-κB in the mortality of sepsis. J. Clin. Invest. 100, 972-985 (1997).
    • (1997) J. Clin. Invest. , vol.100 , pp. 972-985
    • Bohrer, H.1
  • 5
    • 0034021896 scopus 로고    scopus 로고
    • Predictive value of NF-κB activity and plasma cytokine levels in patients with sepsis
    • Arnalich, F. et al. Predictive value of NF-κB activity and plasma cytokine levels in patients with sepsis. Infect. Immun. 68, 1942-1945 (2000).
    • (2000) Infect. Immun. , vol.68 , pp. 1942-1945
    • Arnalich, F.1
  • 6
    • 0033778058 scopus 로고    scopus 로고
    • NF-κB activation in acute appendicitis: A molecular marker for extent of disease?
    • Pennington, C., Dunn, J., Li, C., Ha, T. & Browder, W. NF-κB activation in acute appendicitis: a molecular marker for extent of disease? Am. J. Surg. 66, 914-918 (2000).
    • (2000) Am. J. Surg. , vol.66 , pp. 914-918
    • Pennington, C.1    Dunn, J.2    Li, C.3    Ha, T.4    Browder, W.5
  • 8
    • 0033596123 scopus 로고    scopus 로고
    • Genetic approaches in mice to understand Rel/NF-κB and IκB function: Transgenics and knockouts
    • Gerondakis, S., Grossmann, M., Nakamura, Y., Pohl, T. & Grumont, R. Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts. Oncogene 18, 6888-6895 (1999).
    • (1999) Oncogene , vol.18 , pp. 6888-6895
    • Gerondakis, S.1    Grossmann, M.2    Nakamura, Y.3    Pohl, T.4    Grumont, R.5
  • 9
    • 0033607313 scopus 로고    scopus 로고
    • The NF-κB activation pathway: A paradigm in information transfer from membrane to nucleus
    • Rothwarf, D.M. & Karin, M. The NF-κB activation pathway: a paradigm in information transfer from membrane to nucleus. Sci. STKE 1999 (5), RE1 (1999).
    • (1999) Sci. STKE 1999 , Issue.5
    • Rothwarf, D.M.1    Karin, M.2
  • 10
    • 0033537739 scopus 로고    scopus 로고
    • Severe liver degeneration in mice lacking the IκB kinase 2 gene
    • Li, Q., Van Antwerp, D., Mercurio, F., Lee, K.-F. & Verma, I.M. Severe liver degeneration in mice lacking the IκB kinase 2 gene. Science 284, 321-325 (1999a).
    • (1999) Science , vol.284 , pp. 321-325
    • Li, Q.1    Van Antwerp, D.2    Mercurio, F.3    Lee, K.-F.4    Verma, I.M.5
  • 11
    • 0037144590 scopus 로고    scopus 로고
    • Macrophage apoptosis by anthrax lethal factor and p38 MAP kinase inhibition
    • Park, J.M., Greten, F.R., Li, Z.-W. & Karin, M. Macrophage apoptosis by anthrax lethal factor and p38 MAP kinase inhibition. Science 297, 2048-2051 (2002).
    • (2002) Science , vol.297 , pp. 2048-2051
    • Park, J.M.1    Greten, F.R.2    Li, Z.-W.3    Karin, M.4
  • 12
    • 0034036640 scopus 로고    scopus 로고
    • Pathogenesis and management of multiple organ dysfunction or failure in severe sepsis and septic shock
    • Balk, R.A. Pathogenesis and management of multiple organ dysfunction or failure in severe sepsis and septic shock. Crit. Care Clin. 16, 337-352 (2000).
    • (2000) Crit. Care Clin. , vol.16 , pp. 337-352
    • Balk, R.A.1
  • 13
    • 0024433830 scopus 로고
    • Evidence for neutrophil-related acute lung injury after intestinal ischemia-reperfusion
    • Schmeling, D.J., Caty, M.G., Oldham, K.T., Guice, K.S. & Hinshaw, D.B. Evidence for neutrophil-related acute lung injury after intestinal ischemia-reperfusion. Surgery 106, 201-202 (1989).
    • (1989) Surgery , vol.106 , pp. 201-202
    • Schmeling, D.J.1    Caty, M.G.2    Oldham, K.T.3    Guice, K.S.4    Hinshaw, D.B.5
  • 14
    • 0034053099 scopus 로고    scopus 로고
    • Pathophysiology of ischaemia-reperfusion injury
    • Carden, D.L. & Granger, D.N. Pathophysiology of ischaemia-reperfusion injury. J. Pathol. 190, 255-266 (2000).
    • (2000) J. Pathol. , vol.190 , pp. 255-266
    • Carden, D.L.1    Granger, D.N.2
  • 15
    • 0035029846 scopus 로고    scopus 로고
    • Enteral nutrition prevents remote organ injury and death after a gut ischemic insult
    • Fukatsu, K. et al. Enteral nutrition prevents remote organ injury and death after a gut ischemic insult. Ann. Surg. 233, 660-668 (2001).
    • (2001) Ann. Surg. , vol.233 , pp. 660-668
    • Fukatsu, K.1
  • 16
    • 0025648995 scopus 로고
    • Evidence for tumor necrosis factor-induced pulmonary microvascular injury after intestinal ischemia-reperfusion injury
    • Caty, M.G., Guice, K.S., Oldham, K.T., Remick, D.G. & Kunkel, S.I. Evidence for tumor necrosis factor-induced pulmonary microvascular injury after intestinal ischemia-reperfusion injury. Ann. Surg. 212, 694-700 (1990).
    • (1990) Ann. Surg. , vol.212 , pp. 694-700
    • Caty, M.G.1    Guice, K.S.2    Oldham, K.T.3    Remick, D.G.4    Kunkel, S.I.5
  • 17
    • 0027297663 scopus 로고
    • Mice deficient for the 55 kD tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
    • Pfeffer, K. et al. Mice deficient for the 55 kD tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73, 457-467(1993).
    • (1993) Cell , vol.73 , pp. 457-467
    • Pfeffer, K.1
  • 18
    • 0030610362 scopus 로고    scopus 로고
    • A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
    • DiDonato, J.A., Hayakawa, M., Rothwarf, D.M., Zandi, E. & Karin, M. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388, 548-554 (1997).
    • (1997) Nature , vol.388 , pp. 548-554
    • DiDonato, J.A.1    Hayakawa, M.2    Rothwarf, D.M.3    Zandi, E.4    Karin, M.5
  • 19
    • 0021984681 scopus 로고
    • Oxygen-derived free radicals in postischemic tissue injury
    • McCord, J.M. Oxygen-derived free radicals in postischemic tissue injury. N. Engl. J. Med. 312, 159-163 (1985).
    • (1985) N. Engl. J. Med. , vol.312 , pp. 159-163
    • McCord, J.M.1
  • 20
    • 0033532386 scopus 로고    scopus 로고
    • The IKKβ subunit of IκB kinase (IKK) is essential for NF-κB activation and prevention of apoptosis
    • Li, Z.-W. et al. The IKKβ subunit of IκB kinase (IKK) is essential for NF-κB activation and prevention of apoptosis. J. Exp. Med. 189, 1839-1845 (1999).
    • (1999) J. Exp. Med. , vol.189 , pp. 1839-1845
    • Li, Z.-W.1
  • 21
    • 16044365828 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of IκBα activates NF-κB without proteolytic degradation of IκBα
    • Imbert, V. et al. Tyrosine phosphorylation of IκBα activates NF-κB without proteolytic degradation of IκBα. Cell 86, 787-798 (1996).
    • (1996) Cell , vol.86 , pp. 787-798
    • Imbert, V.1
  • 22
    • 0038647006 scopus 로고    scopus 로고
    • IKKβ is required for peripheral B cell proliferation and survival
    • in the press
    • Li, Z.-W., Omori, S.A., Labuda, T., Karin, M. & Rickert, R.C. IKKβ is required for peripheral B cell proliferation and survival. J. Immunol. (in the press).
    • J. Immunol.
    • Li, Z.-W.1    Omori, S.A.2    Labuda, T.3    Karin, M.4    Rickert, R.C.5
  • 23
    • 0033525861 scopus 로고    scopus 로고
    • Regulatory sequences of the mouse villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of small and large intestines
    • Pinto, D., Robine, S., Jaisser, F., El Marjou, F.E. & Louvard, D. Regulatory sequences of the mouse villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of small and large intestines. J. Biol. Chem. 274, 6476-6482 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 6476-6482
    • Pinto, D.1    Robine, S.2    Jaisser, F.3    El Marjou, F.E.4    Louvard, D.5
  • 24
    • 0035127894 scopus 로고    scopus 로고
    • Endogenous PPARγ mediates anti-inflammatory activity in murine ischemia-reperfusion injury
    • Nakajima, A. et al. Endogenous PPARγ mediates anti-inflammatory activity in murine ischemia-reperfusion injury. Gastroenterology 120, 460-469 (2001).
    • (2001) Gastroenterology , vol.120 , pp. 460-469
    • Nakajima, A.1
  • 25
    • 0034829202 scopus 로고    scopus 로고
    • A low level of TNFα mediates hemorrhage-induced acute lung injury via p 55 TNF receptor
    • Song, Y. et al. A low level of TNFα mediates hemorrhage-induced acute lung injury via p55 TNF receptor. Am. J. Physiol. Lung Cell. Mol. Physiol. 281, L677-L684 (2001).
    • (2001) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.281
    • Song, Y.1
  • 26
    • 0033634663 scopus 로고    scopus 로고
    • Female mice heterozygote for IKKγ/NEMO deficiencies develop a genodermatosis similar to the human X-linked disorder incontinentia pigmenti
    • Makris, C. et al. Female mice heterozygote for IKKγ/NEMO deficiencies develop a genodermatosis similar to the human X-linked disorder incontinentia pigmenti. Mol. Cell 15, 969-979 (2000).
    • (2000) Mol. Cell , vol.15 , pp. 969-979
    • Makris, C.1
  • 27
    • 0030560670 scopus 로고    scopus 로고
    • Analysis of DNA-protein interactions in the nervous system using the electrophoretic mobility shift assay
    • Lewis, S.E. & Konradi, C. Analysis of DNA-protein interactions in the nervous system using the electrophoretic mobility shift assay. Methods 10, 301-311 (1996).
    • (1996) Methods , vol.10 , pp. 301-311
    • Lewis, S.E.1    Konradi, C.2
  • 28
    • 0033537767 scopus 로고    scopus 로고
    • Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of the IκB kinase
    • Hu, Y. et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of the IκB kinase. Science 284, 316-320 (1999).
    • (1999) Science , vol.284 , pp. 316-320
    • Hu, Y.1
  • 29
    • 17944378526 scopus 로고    scopus 로고
    • Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway
    • Senftleben, U. et al. Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway. Science 293, 1495-1499 (2001).
    • (2001) Science , vol.293 , pp. 1495-1499
    • Senftleben, U.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.