The nuclear IκB protein IκBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria

Journal of Immunology

Volumn 174, Issue 6, 2005, Pages 3650-3657

  Hirotani, Tomonori ^a,b   Lee, Pui Y ^a,e   Kuwata, Hirotaka ^d   Yamamoto, Masahiro ^a,c   Matsumoto, Makoto ^d   Kawase, Ichiro ^b   Akira, Shizuo ^a,c   Takeda, Kiyoshi ^d  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

^e UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; CD11B ANTIGEN; I KAPPA B; I KAPPA BNS; INTERLEUKIN 10; INTERLEUKIN 6; LENTIVIRUS VECTOR; LIPOPOLYSACCHARIDE; LUCIFERASE; PROTEIN BCL 3; PROTEIN P50; SMALL INTERFERING RNA; STAT3 PROTEIN; SYNAPTOTAGMIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; DNA; IKAPPABNS PROTEIN, MOUSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN; PROTEIN PRECURSOR; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLITIS; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; DNA MICROARRAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; HELPER CELL; IMMUNOPRECIPITATION; LAMINA PROPRIA; MACROPHAGE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; ULCERATIVE COLITIS; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; COLON; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; IN VITRO STUDY; INTESTINE MUCOSA; METABOLISM; MOUSE MUTANT; NUCLEOTIDE SEQUENCE;

ANIMALS; ANTIGENS, CD11B; BASE SEQUENCE; CELL LINE; COLON; DNA; GENE EXPRESSION; HUMANS; INTERLEUKIN-6; INTESTINAL MUCOSA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; PROMOTER REGIONS (GENETICS); PROTEIN PRECURSORS; PROTEINS; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 14844344042     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.6.3650     Document Type: Article

References (40)

1. Podolsky, D. K. 1991. Inflammatory bowel disease. N. Engl. J. Med. 325:928.
2. Strober, W., I. J. Fuss, and R. S. Blumberg. 2002. The immunology of mucosal models of inflammation. Annu. Rev. Immunol. 20:495.
3. Bouma, G., and W. Strober. 2003. The immunological and genetic basis of inflammatory bowel disease. Nat. Rev. Immunol. 3:521.
4. Neurath, M. F., S. Finotto, and L. H. Glimcher. The role of Th1/Th2 polarization in mucosal immunity. Nat. Med. 6:567.
5. Maloy, K. J., and F. Powrie. 2001. Regulatory T cells in the control of immune pathology. Nat. Immunol. 9:816.
6. + regulatory T cells. J. Immunol. 170:3939.
7. Mizoguchi, A., E. Mizoguchi, H. Takedatsu, R. S. Blumberg, and A. K. Bhan. 2002. Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity 16:219.
8. Janeway, C. A. Jr., and R. Medzhitov. 2002. Innate immune recognition. Annu. Rev. Immunol. 20:197.
9. Akira, S., K. Takeda, and T. Kaisho. 2001. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2:675.
10. Takeda, K., T. Kaisho, and S. Akira. 2003. Toll-like receptors. Annu. Rev. Immunol. 21:335.
11. Akira, S., and K. Takeda. 2004. Toll-like receptor signaling. Nat. Rev. Immunol. 4:499.
12. Takeda, K., B. Clausen, T. Kaisho, T. Tsujimura, N. Terada, I. Förster, and S. Akira. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10:39.
13. Kuhn, R., J. Lohler, D. Rennick, K. Rajewsky, and W. Muller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263.
14. + TH1-like responses. J. Clin. Invest. 98:1010.
15. Kobayashi, M., M. Kweon, H. Kuwata, H. Kiyono, K. Takeda, and S. Akira. 2003. Toll-like receptor-dependent IL-12p40 production causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J. Clin. Invest. 111:1297.
16. Ogura, Y., D. K. Bonen, N. Inohara, D. L. Nicolae, F. F. Chen, R. Ramos, H. Britton, T. Moran, R. Karaliuskas, R. H. Duerr, et al. 2001. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411:603.
17. Hugot, J. P., M. Chamaillard, H. Zouali, S. Lesage, J. P. Cezard, J. Belaiche, S. Almer, C. Tysk, C. A. O'Morain, M. Gassull, et al. 2001. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411:599.
18. Inohara, N., and G. Nunez. 2003. NODs: intracellular proteins involved in inflammation and apoptosis. Nat. Rev. Immunol. 3:371.
19. Mizoguchi, E., R. J. Xavier, H. C. Reinecker, H. Uchin, A. K. Bhan, D. K. Podolsky, and A. Mizoguchi. 2003. Colonic epithelial functional phenotype varies with type and phase of experimental colitis. Gastroenterology 125:148.
20. Matsumoto, M., D. Einhaus, E. S. Gold, and A. Aderem. 2004. Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factors. J. Immunol. 172:7377.
21. Yamamoto, M., S. Yamazaki, S. Uematsu, S. Sato, H. Hemmi, K. Hoshino, T. Kaisho, H. Kuwata, O. Takeuchi, K. Takeshige, et al. 2004. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ. Nature 430:218.
22. Kuwata, H., Y. Watanabe, H. Miyoshi, M. Yamamoto, T. Kaisho, K. Takeda, and S. Akira. 2003. IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-α production in macrophages. Blood 102:4123.
23. Williams, L., G. Jarai, A. Smith, and P. Finan. 2002. IL-10 expression profiling in human monocytes. J. Leukocyte Biol. 72:800.
24. Sulahian, T. H., P. Hogger, A. E. Wahner, K. Wardwell, N. J. Goulding, C. Sorg, A. Droste, M. Stehling, P. K. Wallace, P. M. Morganelli, and P. M. Guyre. 2000. Human monocytes express CD163, which is upregulated by IL-10 and identical to p155. Cytokine 12:1312.
25. Buechler, C., M. Ritter, E. Orso, T. Langmann, J. Klucken, and G. Schmitz. 2000. Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli. J. Leukocyte Biol. 67:97.
26. Fiorini, E., I. Schmitz, W. E. Marissen, S. L. Osborn, M. Touma, T. Sasada, P. A. Reche, E. V. Tibaldi, R. E. Hussey, A. M. Kruisbeek, et al. 2002. Peptide-induced negative selection of thymocytes activates transcription of an NF-κB inhibitor. Mol. Cell. 9:637.
27. Miyoshi, H., U. Blomer, M. Takahashi, F. H. Gage, and I. M. Verma. 1998. Development of a self-inactivating lentivirus vector. J. Virol. 72:8150.
28. Nolan, G. P., T. Fujita, K. K. Bhatia, C. Huppi, H. C. Liou, M. L. Scott, and D. Baltimore. 1993. The Bcl-3 proto-oncogene encodes a nuclear IκB-like molecule that preferentially interacts with NF-κB p50 and p52 in a phosphorylation-dependent manner. Mol. Cell. Biol. 13:3557.
29. + T cell-induced colitis. Eur. J. Immunol. 33:1073.
30. Rogler, G., T. Andus, E. Aschenbrenner, D. Vogl, W. Falk, J. Scholmerich, and V. Gross. 1997. Alterations of the phenotype of colonic macrophages in inflammatory bowel disease. Eur. J. Gastroenterol. Hepatol. 9:893.
31. Allison, M. C., S. Cornwall, L. W. Poulter, A. P. Dhillon, and R. E. Pounder. 1998. Macrophage heterogeneity in normal colonic mucosa and in inflammatory bowel disease. Gut 29:1531.
32. Mahida, Y. R., S. Patel, P. Gionchetti, D. Vaux, and D. P. Jewell. 1989. Macrophage subpopulations in lamina propria of normal and inflamed colon and terminal ileum. Gut 30:826.
33. Mahida, Y. R., K. C. Wu, and D. P. Jewell. 1988. Characterization of antigen-presenting activity of intestinal mononuclear cells isolated from normal and inflammatory bowel disease colon and ileum. Immunology 65:543.
34. + monocyte derived cells. Gut 37:367.
35. McAlindon, M. E., A. Galvin, B. McKaig, T. Gray, H. F. Sewell, and Y. R. Mahida. 1999. Investigation of the expression of IL-1β converting enzyme and apoptosis in normal and inflammatory bowel disease (IBD) mucosal macrophages. Clin. Exp. Immunol. 116:251.
36. Lang, R., D. Patel, J. J. Morris, R. L. Rutschman, and P. Murray. 2002. Shaping gene expression in activated and resting primary macrophages by IL-10. J. Immunol. 169:2253.
37. Yamazaki, S., T. Muta, and K. Takeshige. 2001. A novel IκB protein, IκB-ζ, induced by proinflammatory stimuli, negatively regulates nuclear factor-κB in the nuclei. J. Biol. Chem. 276:27657.
38. Kitamura, H., K. Kanehira, K. Okita, M. Morimatsu, and M. Saito. 2000. MAIL, a novel nuclear IκB protein that potentiates LPS-induced IL-6 production. FEBS Lett. 485:53.
39. Haruta, H., A. Kato, and K. Todokoro. 2001. Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs. J. Biol. Chem. 276:12485.
40. Watanabe, T., A. Kitani, P. J. Murray, and W. Strober. 2004. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat. Immunol. 5:800.