A highly selective inhibitor of IκB kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice

Arthritis and Rheumatism

Volumn 48, Issue 9, 2003, Pages 2652-2659

  McIntyre, Kim W ^a   Shuster, David J ^a   Gillooly, Kathleen M ^a   Dambach, Donna M ^a   Pattoli, Mark A ^a   Lu, Pin ^a   Zhou, Xia Di ^a   Qiu, Yuping ^a   Zusi, F Christopher ^a   Burke, James R ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2' AMINOETHYL)AMINO 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; BMS 345541; COLLAGEN TYPE 2; I KAPPA B KINASE; I KAPPA B KINASE INHIBITOR; INTERLEUKIN 1BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; HISTOLOGY; INFLAMMATION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ADMINISTRATION, ORAL; ANIMALS; ARTHRITIS, EXPERIMENTAL; CHRONIC DISEASE; ENZYME INHIBITORS; I-KAPPA B KINASE; IMIDAZOLES; JOINTS; MALE; MICE; MICE, INBRED DBA; PROTEIN-SERINE-THREONINE KINASES; QUINOXALINES;

EID: 0141676361     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.11131     Document Type: Article

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