Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IκBα reveals that most, but not all, inflammatory and destructive mediators are NFκB dependent

Rheumatology

Volumn 45, Issue 10, 2006, Pages 1201-1209

  Amos, N ^a   Lauder, S ^b   Evans, A ^b   Feldmann, M ^c   Bondeson, J ^b  

^a UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Adenovirus; Fibroblast; Interleukin 1; Macrophage; Matrix metalloproteinase; NF kappa B; Osteoarthritis; Synovium; Tumour necrosis factor

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; COLLAGENASE 3; CYTOKINE; GELATINASE B; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GREEN FLUORESCENT PROTEIN; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 6; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; ONCOSTATIN M; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TUMOR NECROSIS FACTOR RECEPTOR;

ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SYNTHESIS; GENE OVEREXPRESSION; GENE TRANSFER; HUMAN; HUMAN TISSUE; INFLAMMATION; MACROPHAGE; MEDIATOR RELEASE; OSTEOARTHRITIS; PRIORITY JOURNAL; REPORTER GENE; SYMPTOM; SYNOVIOCYTE; SYNOVIUM; VIRUS INFECTION;

ADENOVIRIDAE; APOPTOSIS; CELLS, CULTURED; CYTOKINES; GENE EXPRESSION; HUMANS; I-KAPPA B PROTEINS; INFLAMMATION MEDIATORS; MACROPHAGES; METALLOPROTEASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; NF-KAPPA B; OSTEOARTHRITIS; SYNOVIAL MEMBRANE; T-LYMPHOCYTES; TRANSDUCTION, GENETIC;

EID: 33749587067     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kel078     Document Type: Article

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