Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFκB

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 11, 1999, Pages 6377-6381

  Cronstein, Bruce N ^a   Montesinos, M Carmen ^a   Weissmann, Gerald ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ACETYLSALICYLIC ACID; DEXAMETHASONE; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE INHIBITOR; SALAZOSULFAPYRIDINE; SALICYLATE SODIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SELECTIVITY; LEUKOCYTOSIS; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; OXIDATIVE PHOSPHORYLATION; PATHOGENESIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION;

ADENOSINE DEAMINASE; ANIMALS; ASPIRIN; CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FEMALE; GLUCOCORTICOIDS; INFLAMMATION; ISOENZYMES; LEUKOCYTES; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN PRECURSORS; RECEPTORS, PURINERGIC P1; SALICYLATES; SODIUM SALICYLATE; SULFASALAZINE; THEOBROMINE;

ANIMALIA; MURINAE;

EID: 0032992467     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.11.6377     Document Type: Article

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