Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis

Journal of Clinical Investigation

Volumn 105, Issue 12, 2000, Pages 1799-1806

  Campbell, Ian K ^a   Gerondakis, Steve ^a   O'Donnell, Kristy ^a   Wicks, Ian P ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR C REL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DISEASE ASSOCIATION; INFLAMMATION; MONARTHRITIS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

EID: 0033917674     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI8298     Document Type: Article

References (52)

1. Barnes, P.J., and Karin, M. 1997. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336:1066-1071.
2. Feldmann, M., Brennan, F.M., and Maini, R.N. 1996. Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14:397-440.
3. Myers, L.K., Rosloniec, E.F., Cremer, M.A., and Kang, A.H. 1997. Collagen-induced arthritis, an animal model of autoimmunity. Life Sci. 61:1861-1878.
4. Plows, D., Kontogeorgos, G., and Kollias, G. 1999. Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen. J. Immunol. 162:1018-1023.
5. Müller-Ladner, U., et al. 1997. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am. J. Pathol. 149:1607-1615.
6. Chen, F., Castranova, V., Shi, X., and Demers, L.M. 1999. New insights into the role of nuclear Factor-κB, a ubiquitous transcription factor in the initiation of diseases. Clin. Chem. 45:7-17.
7. Baldwin, A.S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649-681.
8. Stancovski, I., and Baltimore, D. 1997. NF-κB activation. The IκB kinase revealed? Cell. 91:299-302.
9. DiDonato, J., et al. 1996. Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol. 16:1295-1304.
10. Chen, Z.J., Parent, L., and Maniatis, T. 1996. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell. 84:853-862.
11. Siebenlist, U., Franzoso, G., and Brown, K. 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10:405-455.
12. Thanos, D., and Maniatis, T. 1995. NF-κB: a lesson in family values. Cell. 80:529-532.
13. Beg, A.A., Sha, W.C., Bronson, R.T., Ghosh, S., and Baltimore, D. 1995. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature. 376:167-170.
14. Köntgen, F., et al. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965-1977.
15. Sha, W.C., Liou, H.-C., Tuomanen, E.I., and Baltimore, D. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell. 80:321-330.
16. Burkly, L., et al. 1995. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature. 373:531-536.
17. Weih, F., et al. 1995. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family. Cell. 80:331-340.
18. Auphan, N., DiDonato, J.A., Rosette, C., Helmberg, A., and Karin, M. 1995. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science. 270:286-290.
19. Scheinman, R.I., Cogswell, P.C., Lofquist, A.K., and Baldwin, A., Jr. 1995. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science. 270:283-286.
20. Kopp, E., and Ghosh, S. 1994. Inhibition of NF-κB by sodium salicylate and aspirin. Science. 265:956-959.
21. Campbell, I.K., et al. 1998. Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice. J. Immunol. 161:3639-3644.
22. b) mice: new insights into an important disease model of rheumatoid arthritis. Eur. J. Immunol. In press.
23. Campbell, I.K., Bendele, A., Smith, D.A., and Hamilton, J.A. 1997. Granulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice. Ann. Rheum. Dis. 56:364-368.
24. Staite, N.D., et al. 1990. Induction of an acute erosive monoarticular arthritis in mice by interleukin-1 and methylated bovine serum albumin. Arthritis Rheum. 33:253-260.
25. Bischof, R.J., Zafiropoulos, D., Hamilton, J.A., and Campbell, I.K. 2000. Exacerbation of acute inflammatory arthritis by the colony-stimulating factors CSF-1 and GM-CSF: evidence of macrophage infiltration and local proliferation. Clin. Exp. Immunol. 119:361-367.
26. Stephens, L.A., et al. 1999. Tumour necrosis factor - activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic β cells. Endocrinology. 140:3219-3227.
27. Seki, N., et al. 1988. Type II collagen-induced murine arthritis. I. Induction and perpetuation of arthritis require synergy between humoral and cell-mediated immunity. J. Immunol. 140:1477-1484.
28. Handel, M.L., McMorrow, L.B., and Gravallese, E.M. 1995. Nuclear factor-κB in rheumatoid arthritis. Localization of p50 and p65. Arthritis Rheum. 38:1762-1770.
29. Marok, R., et al. 1996. Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue. Arthritis Rheum. 39:583-591.
30. Han, Z., Boyle, D.L., Manning, A.M., and Firestein, G.S. 1998. AP-1 and NF-κB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity. 28:197-208.
31. Tsao, P.W., et al. 1997. The effect of dexamethasone on the expression of activated NF-κB in adjuvant arthritis. Clin. Immunol. Immunopathol. 83:173-178.
32. H transcription and Ig class switching. J. Immunol. 159:3133-3139.
33. Watson, W.C., and Townes, A. 1985. Genetic susceptibility to murine collagen II autoimmune arthritis. Proposed relationship to the IgG2 autoantibody subclass response, complement C5, major histocompatibility complex (MHC) and non-MHC loci. J Exp. Med. 162:1878-1891.
34. Wang, Y., Rollins, S.A., Madri, J.A., and Matis, L.A. 1995. Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease. Proc. Natl. Acad. Sci. USA. 92:8955-8959.
35. Gerondakis, S., et al. 1996. Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor. Proc. Natl. Acad. Sci. USA. 93:3405-3409.
36. Hilliard, B., Samoilova, E.B., Liu, T.-S.T., Rostami, A., and Chen, Y. 1999. Experimental autoimmune encephalomyelitis in NF-κB-deficient mice: roles of NF-κB in the activation and differentiation of autoreactive T cells. J. Immunol. 163:2937-2943.
37. Yang, L., et al. 1998. Essential role of nuclear factor κB in the induction of eosinophilia in allergic airway inflammation. J. Exp. Med. 188:1739-1750.
38. Grigoriadis, G., et al. 1996. The Rel subunit of NF-κB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations. EMBO J. 15:7099-7107.
39. Michaëlsson, E., et al. 1995. Macrophages, but not dendritic cells, present collagen to T cells. Eur. J. Immunol. 25:2234-2241.
40. Marinova-Mutafchieva, L., et al. 1997. Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA). Clin. Exp. Immunol. 107:507-512.
41. van Lent, P.L.E.M., et al. 1996. Phagocytic lining cells determine local expression of inflammation in type II collagen-induced arthritis. Arthritis Rheum. 39:1545-1555.
42. Miagkov, A.V., et al. 1998. NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc. Natl. Acad. Sci. USA. 95:13859-13864.
43. Nagase, H., and Okada, Y. 1997. Proteinases and matrix degradation. In Textbook of rheumatology. W. Kelley, E. Harris, Jr., S. Ruddy, and C. Sledge, editors. W.B. Saunders Co. Philadelphia, Pennsylvania, USA. 323-341.
44. Benbow, U., and Brinckerhoff, C.E. 1997. The AP-1 site and MMP gene regulation: what is all the fuss about? Matrix Biol. 15:519-526.
45. Bondeson, J., Foxwell, B., Brennan, F., and Feldmann, M. 1999. Defining therapeutic targets by using adenovirus: blocking NF-κB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators. Proc. Natl. Acad. Sci. USA. 96:5668-5673.
46. Vincenti, M.P., Coon, C.I., and Brinckerhoff, C.E. 1998. Nuclear factor κB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1β-stimulated synovial fibroblasts. Arthritis Rheum. 41:1987-1994.
47. Fujisawa, K., et al. 1996. Activation of transcription factor NF-κB in human synovial cells in response to tumor necrosis factor α. Arthritis Rheum. 39:197-203.
48. 2 formation. J. Biol. Chem. 271:31496-31501.
49. Palombella, et al. 1998. Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis. Proc. Natl. Acad. Sci. USA. 95:15671-15676.
50. Liu, S.F., Ye, X.B., and Malik, A.B. 1997. In vivo inhibition of nuclear factor-κB activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock. J. Immunol. 159:3976-3983.
51. Essani, N.A., Fisher, M.A., and Jaeschke, H. 1997. Inhibition of NF-κB activation by dimethyl sulfoxide correlates with suppression of TNF-α formation, reduced ICAM-1 gene transcription, and protection against endotoxin-induced liver injury. Shock. 7:90-96.
52. Neurath, M.F., Pettersson, S., Meyer zum Büschenfelde, K.-H., and Strober, W. 1996. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice. Nat. Med. 2:998-1004.