Essential role of T cell NF-κB activation in collagen-induced arthritis

Journal of Immunology

Volumn 163, Issue 3, 1999, Pages 1577-1583

  Seetharaman, Rajalakshmi ^a   Mora, Ana L ^b   Nabozny, Gerald ^c   Boothby, Mark ^b   Chen, Jin ^a,d  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; AUTOIMMUNE DISEASE; CELL ACTIVATION; CELL FUNCTION; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE EXPRESSION; IMMUNOPATHOGENESIS; LYMPHOID ORGAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPLEEN; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CATTLE; CD8-POSITIVE T-LYMPHOCYTES; CELL LINEAGE; COLLAGEN; DNA-BINDING PROTEINS; EPITOPES, T-LYMPHOCYTE; I-KAPPA B PROTEINS; IMMUNOGLOBULIN G; INCIDENCE; INTERFERON TYPE II; LYMPHOCYTE COUNT; LYMPHOID TISSUE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; NF-KAPPA B; SEVERITY OF ILLNESS INDEX; T-LYMPHOCYTES; TRANSGENES;

EID: 0033178749     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Wooley, P. H. 1988. Collagen-induced arthritis in the mouse. Methods Enzymol. 62:361.
2. Nabozny, G. H., and C. S. David. 1994. The immunogenetic basis of collagen induced arthritis in mice: an experimental model for the rational design of immuno-modulatory treatments of rheumatoid arthritis. Adv. Exp. Med. Biol. 347:55.
3. Myers, L. K., E. F. Rosloniec, M. A. Cremer, and A. H. Kang. 1997. Collagen-induced arthritis, an animal model of autoimmunity. Life Sci. 61:1861.
4. Chu, C., and M. Londei. 1996. Induction of Th2 cytokines and control of collagen-induced arthritis by nondepleting anti-CD4 Abs. J. Immunol. 157:2685.
5. Mauri, C., C. Chu, D. Woodrow, L. Mori, and M. Londei. 1997. Treatment of a newly established transgenic model of chronic arthritis with nondepleting anti-CD4 monoclonal antibody. J. Immunol. 159:5032.
6. Yoshino, S., L. G. Cleland, and G. Mayrhofer. 1991. Treatment of collagen-induced arthritis in rats with a monoclonal antibody against the α/β Τ cell antigen receptor. Arthritis Rheum. 34:1039.
7. Ranges, G. E., S. Sriram, and S. M. Cooper. 1985. Prevention of collagen-induced arthritis by in vivo treatment with anti-L3T4. J. Exp. Med. 162:1105.
8. Banerjee, S., B. Y. Wei, K. Hillman, H. S. Luthra, and C. S. David. 1988. Immunosuppression of collagen-induced arthritis in mice with an anti-IL-2 receptor antibody. J. Immunol. 141:1150.
9. Webb, L. M., M. J. Walmsley, and M. Feldman. 1996. Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 costimulatory pathway: requirement for both B7-1 and B7-2. Eur. J. Immunol. 26:2320.
10. Seki, N., Y. Sudo, T. Yoshioka, S. Sugihara, T. Fujitsu, S. Sakuma, T. Ogawa, T. Hamaoka, H. Senoh, and H. Fujiwara. 1988. Type II collagen-induced murine arthritis: induction and perpetuation of arthritis require synergy between humoral and cell-mediated immunity. J. Immunol. 140:1477.
11. Taylor, P. C., C. P. Zyberk, and R. N. Maini. 1995. The role of the B cells in the adoptive transfer of collagen-induced arthritis from DBA/1 (H-2q) to SCID (H-2d) mice. Eur. J. Immunol. 25:763.
12. Paul, W. E., and R. A. Seder. 1994. Lymphocyte response and cytokines. Cell 76:241.
13. Mauri, C., R. O. Williams, M. Walmsley, and M. Feldmann. 1996. Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis. Eur. J. Immunol. 26:1511.
14. Doncarli, A., L. M. Stasiuk, C. Foumier, and O. Abehsira-Amar. 1997. Conversion in vivo from an early dominant Th0/Th1 response to a Th2 phenotype during the development of collagen-induced arthritis. Eur. J. Immunol. 27:1451.
15. Joosten, L. A. B., E. Lubberts, P. Durez, M. M. A. Helsen, M. J. M. Jacobs, M. Goldman, and W. B. van den Berg. 1997. Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis. Arthritis Rheum. 40:249.
16. Horsfall, A. C., D. M. Butler, L. Marinova, P. L. Warden, R. O. Williams, R. N. Maini, and M. Feldmann. 1997. Suppression of collagen-induced arthritis by continuous administration of IL-4. J. Immunol. 159:5687.
17. Walmsley, M., P. D. Katsikis, E. Abney, S. Parry, R. O. Williams, R. N. Maini, and M. Feldmann. 1996. Interleukin-10 inhibition of the progression of established collagen-induced arthritis. Arthritis Rheum. 39:495.
18. Tada, Y., A. Ho, T. Matsuyama, and T. W. Mak. 1997. Reduced incidence and severity of antigen-induced autoimmune diseases in mice lacking interferon regulatory factor-1. J. Exp. Med. 185:231.
19. McIntyre, K. W., D. J. Shuster, K. M. Gillooly, R. R. Warrier, S. E. Connaughton, L. B. Hall, L. H. Arp, M. K. Gately, and J. Magram. 1996. Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice. Eur. J. Immunol. 26:2933.
20. Baldwin, A. S. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
21. Baeuerle, P. A., and D. Baltimore. 1996. NF-κB: ten years after. Cell 87:13.
22. Zandi, E., D. M. Rothwarf, M. Delhase, M. Hayakawa, and M. Karin. 1997. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91:243.
23. Mercurio, F., H. Zhu, B. W. Murray, A. Shevchenko, B. L. Bennett, J. Li, D. B. Young, M. Barbosa, M. Mann, A. Manning, and A. Rao. 1997. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278:860.
24. Verma, I. M., J. K. Stevenson, E. M. Schwarz, D. Van Antwerp, and S. Miyamoto. 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723.
25. Gerondakis, S., A. Strasser, D. Metcalf, G. Grigoriadis, J.-P. Y. Scheerlinck, and R. J. Grumont. 1996. Rel-deficient Τ cells exhibit deficits in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor. Proc. Natl. Acad. Sci. USA 93:3405.
26. Doi, T. S., T. Takahashi, O. Taguchi, T. Azuma, and Y. Obata. 1997. NF-κB RelA-deficient lymphocytes: normal development of Τ cells and B cells, impaired production of IgA and IgG1, and reduced proliferative responses. J. Exp. Med. 185:953.
27. Beg, A. A., W. C. Sha, R. T. Bronson, S. Ghosh, and D. Baltimore. 1995. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 376:167.
28. Kontgen, F., R. J. Grumont, A. Strasser, D. Metcalf, R. Li, D. Tarlinton, and S. Gerondakis. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965.
29. Sha, W. C., H. C. Liou, E. I. Tuomanen, and D. Baltimore. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80:321.
30. Weih, F., D. Carrasco, S. K. Durham, D. S. Barton, C. A. Rizzo, R. P. Ryseck, S. A. Lira, and R. Bravo. 1995. Multi-organ inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family. Cell 80:331.
31. Burkly, L., C. Hession, L. Ogata, C. Reilly, L. A. Marconi, D. Olson, R. Tizard, R. Cate, and D. Lo. 1995. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373:531.
32. Boothby, M., A. Mora, D. C. Scherer, J. A. Brockman, and D. W. Ballard. 1997. Perturbation of the Τ lymphocyte lineage in transgenic mice expressing a constitutive represser of nuclear factor (NF)-κB. J. Exp. Med. 185:1897.
33. Hicks, D. G., B. F. Stroyer, L. A. Teot, and R. J. O'Keefe. 1997. In situ hybridization in skeletal tissues utilizing non-radioactive probes. J. Histotechnol. 20:215.
34. + Τ cells play a role in initiation and regulate recovery phase of collagen-induced arthritis. J. Immunol. 156:4520.
35. Plows, D., G. Kontogeorgos, and G. Kollias. 1999. Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen. J. Immunol. 162:1018.
36. Miagkov, A. V., D. V. Kovalenko, C. E. Brown, J. R. Didsbury, J. P. Cogswell, S. A. Stimpson, A. S. Baldwin, and S. S. Makarov. 1998. NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc. Natl. Acad. Sci. USA 95:13859.
37. Ghosh, S., M. J. May, and E. B. Kopp. 1998. NF-κB and rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16:261.
38. Aune, T. M., A. L. Mora, S. Kim, M. Boothby, and A. H. Lichtman. 1999. Costimulation reverses the defect in IL-2 but not effector cytokine production by Τ cells with unpaired IκBα degradation. J. Immunol. In press.
39. Sica, A., L. Dorman, V. Viggiano, M. Cippitelli, P. Ghosh, N. Rice, and H. A. Yong. 1997. Interaction of NF-κB and NF-AT with the interferon-γ promoter. J. Biol. Chem. 272:30412.
40. Zhang, X., T. Brunner, L. Carter, R. W. Dutton, P. Rogers, L. Bradley, T. Sato, J. C. Reed, D. Green, and S. L. Swain. 1997. Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J. Exp. Med. 185:1837.
41. Mauritz, N. J., R. Holmdahl, R. Jonsson, P. H. van der Meide, A. Scheynius, and Klareskog. 1988. Treatment with γ-interferon triggers the onset of collagen arthritis in mice. Arthritis Rheum. 31:1297.
42. Boissier, M.-C., G. Chiocchia, N. Bessis, J. Hajnal, G. Garotta, F. Nicoletti, and C. Fournier. 1995. Biophasic effect of interferon-γ in murine collagen-induced arthritis. Eur. J. Immunol. 25:1184.
43. Vermeire, K., H. Heremans, M. Vandeputte, S. Huang, A. Billiau, and P. Matthys. 1997. Accelerated collagen-induced arthritis in IFN-γ receptor-deficient mice. J. Immunol. 158:5507.
44. Manoury-Schwartz, B., G. Chiocchia, N. Bessis, O. Abehsira-Amar, F. Batteux, S. Muller, S. Huang, M. C. Boissier, and C. Fournier. 1997. High susceptibility to collagen-induced arthritis in mice lacking IFN-γ receptors. J. Immunol. 158: 5501.
45. Mosmann, T. R., and S. Sad. 1996. The expanding universe of Τ-cell subsets: Th1, Th2 and more. Immunol. Today 17:138.
46. Billiau, A. 1996. Interferon-γ in autoimmunity. Cytokine Growth Factor Rev. 7:25.
47. Handel, M. L., L. B. McMorrow, and E. M. Gravallese. 1995. Nuclear factor-κB in rheumatoid synovium. Arthritis Rheum. 38:1762.
48. Marok, R., P. G. Winyard, A. Coumbe, M. L. Kus, K. Gaffney, S. Blades, P. I. Mapp, C. J. Morris, D. R. Blake, C. Kaltschmidt, and P. A. Baeuerle. 1996. Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue. Arthritis Rheum. 39:583.