Mechanisms of glucocorticoid-receptor-mediated repression of gene expression

Trends in Endocrinology and Metabolism

Volumn 10, Issue 10, 1999, Pages 396-402

  Webster, Jeffrey C ^a   Cidlowski, John A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; CYCLIC AMP; DEXAMETHASONE;

GENE EXPRESSION REGULATION; GENE REPRESSION; HORMONAL REGULATION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; REVIEW; TRANSCRIPTION REGULATION;

EID: 0033485289     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(99)00186-1     Document Type: Review

References (42)

1. Sanchez E.R., Housley P.R., Pratt W.B. The molybdate-stabilized glucocorticoid binding complex of L-cells contains a 98-100 kdalton steroid binding phosphoprotein and a 90 kdalton nonsteroid-binding phosphoprotein that is part of the murine heat-shock complex. J. Steroid Biochem. 1:1986;9-18.
2. Gustafsson J.A., Wikstrom A.C., Denis M. The non-activated glucocorticoid receptor: structure and activation. J. Steroid Biochem. 34:1989;3-62.
3. Chandler V.L., Maler B.A., Yamamoto K.R. DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo. Cell. 33:1983;489-499.
4. Giguere V., Hollenberg S.M., Rosenfeld M.G., Evans R.M. Functional domains of the human glucocorticoid receptor. Cell. 46:1986;645-652.
5. Strahle U., Schmid W., Schutz G. Synergistic action of the glucocorticoid receptor with transcription factors. EMBO J. 11:1988;3389-3395.
6. Drouin J.et al. Tissue-specific activity of the pro-opiomelanocortin (POMC) gene and repression by glucocorticoids. Genome. 31:1989;510-519.
7. Malkoski S.P., Handanos C.M., Dorin R.I. Localization of a negative glucocorticoid response element of the human corticotropin releasing hormone gene. Mol. Cell. Endocrinol. 127:1997;189-199.
8. Morrison N.A., Shine J., Fragonas J.C., Verkest V., McMenemy M.L., Eisman J.A. 1,25-dihydroxyvitamin D-responsive element and glucocorticoid repression in the osteocalcin gene. Science. 246:1989;1158-1161.
9. Meyer T., Carlstedt-Duke J., Starr D.B. A weak TATA box is a prerequisite for glucocorticoid-dependent repression of the osteocalcin gene. J. Biol. Chem. 272:1997;30709-30714.
10. Oakley R.H., Cidlowski J.A. Homologous down regulation of the glucocorticoid receptor: the molecular machinery. Crit. Rev. Eukaryotic Gene Expr. 3:1993;63-88.
11. Burnstein K.L., Jewell C.M., Cidlowski J.A. Human glucocorticoid receptor cDNA contains sequences sufficient for receptor down-regulation. J. Biol. Chem. 265:1990;7284-7291.
12. Burnstein K.L., Jewell C.M., Sar M., Cidlowski J.A. Intragenic sequences of the human glucocorticoid receptor complementary DNA mediate hormone-inducible receptor messenger RNA down-regulation through multiple mechanisms. Mol. Endocrinol. 12:1994;1764-1773.
13. Okret S., Poellinger L., Dong Y., Gustafsson J.A. Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone. Proc. Natl. Acad. Sci. U. S. A. 83:1986;5899-5903.
14. Webster J.C., Jewell C.M., Bodwell J.E., Munck A., Sar M., Cidlowski J.A. Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor protein. J. Biol. Chem. 272:1997;9287-9293.
15. Silva C.M., Powell-Oliver F.E., Jewell C.M., Sar M., Allgood V.E., Cidlowski J.A. Regulation of the human glucocorticoid receptor by long-term and chronic treatment with glucocorticoid. Steroids. 59:1994;436-442.
16. Wilson T.E., Fahrner T.J., Milbrandt J. The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction. Mol. Cell. Biol. 13:1993;5794-5804.
17. Perlmann T., Jansson L. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev. 9:1995;769-782.
18. Philips A.et al. Antagonism between Nur77 and glucocorticoid receptor for control of transcription. Mol. Cell. Biol. 17:1997;5952-5959.
19. Drouin J., Maira M., Philips A. Novel mechanism of action for Nur77 and antagonism by glucocorticoids: a convergent mechanism for CRH activation and glucocorticoid repression of POMC gene transcription. J. Steroid Biochem. Mol. Biol. 65:1998;59-63.
20. Pei L., Melmed S. Characterization of the rat vasoactive intestinal polypeptide receptor gene 5′ region. Biochem. J. 308:1995;719-723.
21. Pei L. Identification of a negative glucocorticoid response element in the rat type 1 vasoactive intestinal polypeptide receptor gene. J. Biol. Chem. 271:1996;20879-20884.
22. Mordacq J.C., Linzer D.I. Co-localization of elements required for phorbol ester stimulation and glucocorticoid repression of proliferin gene expression. Genes Dev. 3:1989;760-769.
23. Diamond M.I., Miner J.N., Yoshinaga S.K., Yamamoto K.R. Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science. 249:1990;1266-1272.
24. Starr D.B., Matsui W., Thomas J.R., Yamamoto K.R. Intracellular receptors use a common mechanism to interpret signaling information at response elements. Genes Dev. 10:1996;1271-1283.
25. Pearce D., Matsui W., Miner J.N., Yamamoto K.R. Glucocorticoid receptor transcriptional activity determined by spacing of receptor and nonreceptor DNA sites. J. Biol. Chem. 273:1998;30081-30085.
26. Konig H., Ponta H., Rahmsdorf H.J., Herrlich P. Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo. EMBO J. 11:1992;2241-2246.
27. Schule R.et al. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell. 62:1990;1217-1226.
28. Jonat C.et al. Antitumor promotion and anti-inflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell. 62:1990;1189-1204.
29. Scheinman R.I., Gualberto A., Jewell C.M., Cidlowski J.A., Baldwin A.S. Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Mol. Cell. Biol. 15:1995;943-953.
30. Caldenhoven E.et al. Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the anti-inflammatory action of glucocorticoids. Mol. Endocrinol. 4:1995;401-412.
31. McKay L.I., Cidlowski J.A. Cross-talk between nuclear factor-kappa B and the steroid hormone receptors: mechanisms of mutual antagonism. Mol. Endocrinol. 1:1998;45-56.
32. Schmid W., Cole T.J., Blendy J.A., Schutz G. Molecular genetic analysis of glucocorticoid signalling in development. J. Steroid Biochem. Mol. Biol. 53:1995;33-35.
33. Cole T.J.et al. Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev. 9:1995;1608-1621.
34. Reichardt H.M.et al. DNA binding of the glucocorticoid receptor is not essential for survival. Cell. 93:1998;531-541.
35. Hollenberg S.M.et al. Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature. 318:1985;635-641.
36. Oakley R.H., Sar M., Cidlowski J.A. The human glucocorticoid receptor beta isoform: expression, biochemical properties, and putative function. J. Biol. Chem. 271:1996;9550-9559.
37. Oakley R.H., Webster J.C., Sar M., Parker C.R. Jr., Cidlowski J.A. Expression and subcellular distribution of the beta-isoform of the human glucocorticoid receptor. Endocrinology. 138:1997;5028-5038.
38. de Castro M.et al. The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): tissue levels, mechanism of action, and potential physiologic role. Mol. Med. 2:1996;597-607.
39. Onate S.A., Tsai S.Y., Tsai M.J., O'Malley B.W. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science. 270:1995;1354-1357.
40. Hong H., Kohli K., Garabedian M.J., Stallcup M.R. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol. Cell. Biol. 17:1997;2735-2744.
41. Spencer T.E.et al. Steroid receptor coactivator-1 is a histone acetyltransferase. Nature. 389:1997;194-198.
42. Fontes J.D., Kanazawa S., Jean D., Peterlin B.M. Interactions between the class II transactivator and CREB binding protein increase transcription of major histocompatibility complex class II genes. Mol. Cell. Biol. 19:1999;941-947.