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Volumn 18, Issue 17, 1999, Pages 4766-4778

NF-κB p105 is a target of IκB kinases and controls signal induction of Bcl-3-p50 complexes

Author keywords

Kinases; Oncogene; Proteasome; Transcription activation

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR; INTERLEUKIN 1BETA; PHORBOL ESTER; PHOSPHOTRANSFERASE; PROTEASOME; TRANSACTIVATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA; CHUK PROTEIN, HUMAN; I KAPPA B; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; IKBKE PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN PRECURSOR; PROTEIN SERINE THREONINE KINASE; PROTO ONCOGENE PROTEIN BCL 3; PROTO-ONCOGENE PROTEIN BCL-3; TRANSCRIPTION FACTOR;

EID: 0033199348     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.17.4766     Document Type: Article
Times cited : (178)

References (78)
  • 1
    • 0028970734 scopus 로고
    • Stimulation-dependent IκBα phosphorylation marks the NF-κB inhibitor for degradation via the ubiquitin-proteasome pathway
    • Alkalay, I., Yaron, A., Hatzubai, A., Orian, A., Ciechanover, A. and Ben Neriah, Y. (1995) Stimulation-dependent IκBα phosphorylation marks the NF-κB inhibitor for degradation via the ubiquitin-proteasome pathway. Proc. Natl Acad. Sci. USA, 92, 10599-105603.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 10599-105603
    • Alkalay, I.1    Yaron, A.2    Hatzubai, A.3    Orian, A.4    Ciechanover, A.5    Ben Neriah, Y.6
  • 2
    • 0030271387 scopus 로고    scopus 로고
    • NF-κB: Ten years after
    • Baeuerle, P.A. and Baltimore, D. (1996) NF-κB: ten years after. Cell, 87, 13-20.
    • (1996) Cell , vol.87 , pp. 13-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 3
    • 0028174061 scopus 로고
    • Function and activation of NF-κB in the immune system
    • Baeuerle, P.A. and Henkel, T. (1994) Function and activation of NF-κB in the immune system. Annu. Rev. Immunol., 12, 141-179.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 4
    • 0030070803 scopus 로고    scopus 로고
    • Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of IκB-α
    • Baldi, L., Brown, K., Franzoso, G. and Siebenlist, U. (1996) Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of IκB-α. J. Biol. Chem., 271, 376-379.
    • (1996) J. Biol. Chem. , vol.271 , pp. 376-379
    • Baldi, L.1    Brown, K.2    Franzoso, G.3    Siebenlist, U.4
  • 5
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • Baldwin, A.S.,Jr (1996) The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol., 14, 649-683.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649-683
    • Baldwin A.S., Jr.1
  • 6
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
    • Barnes, P.J. and Karin, M. (1997) Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med., 336, 1066-1071.
    • (1997) N. Engl. J. Med. , vol.336 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 7
    • 0033611544 scopus 로고    scopus 로고
    • TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105
    • Belich, M.P., Salmeron, A., Johnston, L.H. and Ley, S.C. (1999) TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105. Nature, 397, 363-368.
    • (1999) Nature , vol.397 , pp. 363-368
    • Belich, M.P.1    Salmeron, A.2    Johnston, L.H.3    Ley, S.C.4
  • 8
    • 0029843343 scopus 로고    scopus 로고
    • Differential regulation of NF-κB2 (p100) processing and control by amino-terminal sequences
    • Betts, J.C. and Nabel, G.J. (1996) Differential regulation of NF-κB2 (p100) processing and control by amino-terminal sequences. Mol. Cell. Biol., 16, 6363-6371.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 6363-6371
    • Betts, J.C.1    Nabel, G.J.2
  • 9
    • 0027446955 scopus 로고
    • The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers
    • Bours, V., Franzoso, G., Azarenko, V., Park, S., Kanno, T., Brown, K. and Siebenlist, U. (1993) The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell 72, 729-739.
    • (1993) Cell , vol.72 , pp. 729-739
    • Bours, V.1    Franzoso, G.2    Azarenko, V.3    Park, S.4    Kanno, T.5    Brown, K.6    Siebenlist, U.7
  • 11
    • 0028986075 scopus 로고
    • Control of IκBα proteolysis by site-specific, signal-induced phosphorylation
    • Brown, K., Gerstberger, S., Carlson, L., Franzoso, G. and Siebenlist, U. (1995) Control of IκBα proteolysis by site-specific, signal-induced phosphorylation. Science, 267, 1485-1488.
    • (1995) Science , vol.267 , pp. 1485-1488
    • Brown, K.1    Gerstberger, S.2    Carlson, L.3    Franzoso, G.4    Siebenlist, U.5
  • 12
    • 0031455585 scopus 로고    scopus 로고
    • Diverse effects of BCL3 phosphorylation on its modulation of NF-κB p52 homodimer binding to DNA
    • Bundy, D.L. and McKeithan, T.W. (1997) Diverse effects of BCL3 phosphorylation on its modulation of NF-κB p52 homodimer binding to DNA. J. Biol. Chem., 272, 33132-33139.
    • (1997) J. Biol. Chem. , vol.272 , pp. 33132-33139
    • Bundy, D.L.1    McKeithan, T.W.2
  • 13
    • 0029665444 scopus 로고    scopus 로고
    • Constitutive expression of Bcl-3 in thymocytes increases the DNA binding of NF-κB1 (p50) homodimers in vivo
    • Caamano, J.H., Perez, P., Lira, S.A. and Bravo, R. (1996) Constitutive expression of Bcl-3 in thymocytes increases the DNA binding of NF-κB1 (p50) homodimers in vivo. Mol. Cell. Biol., 16, 1342-1348.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1342-1348
    • Caamano, J.H.1    Perez, P.2    Lira, S.A.3    Bravo, R.4
  • 14
    • 0029146930 scopus 로고
    • Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway
    • Chen, Z., Hagler, J., Palombella, V.J., Melandri, F., Scherer, D., Ballard, D. and Maniatis, T. (1995) Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway. Genes Dev., 9, 1586-1597.
    • (1995) Genes Dev. , vol.9 , pp. 1586-1597
    • Chen, Z.1    Hagler, J.2    Palombella, V.J.3    Melandri, F.4    Scherer, D.5    Ballard, D.6    Maniatis, T.7
  • 15
    • 0032541670 scopus 로고    scopus 로고
    • IKAP is a scaffold protein of the IκB kinase complex
    • Cohen, L., Henzel, W.J. and Baeuerle, P.A. (1998) IKAP is a scaffold protein of the IκB kinase complex. Nature, 395, 292-296.
    • (1998) Nature , vol.395 , pp. 292-296
    • Cohen, L.1    Henzel, W.J.2    Baeuerle, P.A.3
  • 17
    • 0029670083 scopus 로고    scopus 로고
    • Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation
    • DiDonato, J., Mercurio, F., Rosette, C., Wu Li, J., Suyang, H., Ghosh, S. and Karin, M. (1996) Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol., 16, 1295-1304.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1295-1304
    • DiDonato, J.1    Mercurio, F.2    Rosette, C.3    Wu Li, J.4    Suyang, H.5    Ghosh, S.6    Karin, M.7
  • 18
    • 0030610362 scopus 로고    scopus 로고
    • A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
    • DiDonato, J.A., Hayakawa, M., Rothwarf, D.M., Zandi, E. and Karin, M. (1997) A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature, 388, 548-554.
    • (1997) Nature , vol.388 , pp. 548-554
    • DiDonato, J.A.1    Hayakawa, M.2    Rothwarf, D.M.3    Zandi, E.4    Karin, M.5
  • 19
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam, J.D., Lebovitz, R.M. and Roeder, R.G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res., 11, 1475-1489.
    • (1983) Nucleic Acids Res. , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 20
    • 0028985248 scopus 로고
    • Proteolytic processing of NF-κB/IκB in human monocytes. ATP-dependent induction by pro-inflammatory mediators
    • Donald, R., Ballard, D.W. and Hawiger, J. (1995) Proteolytic processing of NF-κB/IκB in human monocytes. ATP-dependent induction by pro-inflammatory mediators. J. Biol. Chem., 270, 9-12.
    • (1995) J. Biol. Chem. , vol.270 , pp. 9-12
    • Donald, R.1    Ballard, D.W.2    Hawiger, J.3
  • 21
    • 0033105577 scopus 로고    scopus 로고
    • Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation
    • Drier, E.A., Huang, L.H. and Steward, R. (1999) Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation. Genes Dev., 13, 556-568.
    • (1999) Genes Dev. , vol.13 , pp. 556-568
    • Drier, E.A.1    Huang, L.H.2    Steward, R.3
  • 22
    • 0026758170 scopus 로고
    • The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-κB-mediated inhibition
    • Franzoso, G., Bours, V., Park, S., Tomita Yamaguchi, M., Kelly, K. and Siebenlist, U. (1992) The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-κB-mediated inhibition. Nature, 359, 339-342.
    • (1992) Nature , vol.359 , pp. 339-342
    • Franzoso, G.1    Bours, V.2    Park, S.3    Tomita Yamaguchi, M.4    Kelly, K.5    Siebenlist, U.6
  • 23
    • 17144433112 scopus 로고    scopus 로고
    • Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture and germinal center reactions
    • Franzoso, G. et al. (1997) Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture and germinal center reactions. Immunity, 6, 479-490.
    • (1997) Immunity , vol.6 , pp. 479-490
    • Franzoso, G.1
  • 24
    • 0027184023 scopus 로고
    • The candidate proto-oncogene Bcl-3 encodes a transcriptional coactivator that activates through NF-κB p50 homodimers
    • Fujita, T., Nolan, G.P., Liou, H.C., Scott, M.L. and Baltimore, D. (1993) The candidate proto-oncogene Bcl-3 encodes a transcriptional coactivator that activates through NF-κB p50 homodimers. Genes Dev., 7, 1354-1363.
    • (1993) Genes Dev. , vol.7 , pp. 1354-1363
    • Fujita, T.1    Nolan, G.P.2    Liou, H.C.3    Scott, M.L.4    Baltimore, D.5
  • 25
    • 0019258624 scopus 로고
    • Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate and renaturation of enzymatic activity: Results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase and other enzymes
    • Hager, D.A. and Burgess, R.R. (1980) Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate and renaturation of enzymatic activity: results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase and other enzymes. Anal. Biochem., 109, 76-86.
    • (1980) Anal. Biochem. , vol.109 , pp. 76-86
    • Hager, D.A.1    Burgess, R.R.2
  • 26
    • 0029984104 scopus 로고    scopus 로고
    • Inhibition of p105 processing by NF-κB proteins in transiently transfected cells
    • Harhaj, E.W., Maggirwar, S.B. and Sun, S.C. (1996) Inhibition of p105 processing by NF-κB proteins in transiently transfected cells. Oncogene, 12, 2385-2392.
    • (1996) Oncogene , vol.12 , pp. 2385-2392
    • Harhaj, E.W.1    Maggirwar, S.B.2    Sun, S.C.3
  • 27
    • 0027165587 scopus 로고
    • Common structural constituents confer IκB activity to NF-κB p105 and IκB/MAD-3
    • Hatada, E.N., Naumann, M. and Scheidereit, C. (1993) Common structural constituents confer IκB activity to NF-κB p105 and IκB/MAD-3. EMBO J., 12, 2781-2788.
    • (1993) EMBO J. , vol.12 , pp. 2781-2788
    • Hatada, E.N.1    Naumann, M.2    Scheidereit, C.3
  • 29
    • 0029840377 scopus 로고    scopus 로고
    • Characterization of ES cells deficient for the p105 precursor (NF-κB1): Role of p50 NLS
    • Ishikawa, H., Ryseck, R.P. and Bravo, R. (1996) Characterization of ES cells deficient for the p105 precursor (NF-κB1): role of p50 NLS. Oncogene, 13, 255-263.
    • (1996) Oncogene , vol.13 , pp. 255-263
    • Ishikawa, H.1    Ryseck, R.P.2    Bravo, R.3
  • 30
    • 0029002899 scopus 로고
    • A role for phosphorylation and degradation in the control of NF-κB activity
    • Israel, A. (1995) A role for phosphorylation and degradation in the control of NF-κB activity. Trends Genet., 11, 203-205.
    • (1995) Trends Genet. , vol.11 , pp. 203-205
    • Israel, A.1
  • 31
    • 0029850997 scopus 로고    scopus 로고
    • Different mechanisms control signal-induced degradation and basal turnover of the NF-κB inhibitor IκBα in vivo
    • Krappmann, D., Wulczyn, F.G. and Scheidereit, C. (1996) Different mechanisms control signal-induced degradation and basal turnover of the NF-κB inhibitor IκBα in vivo. EMBO J., 15, 6716-6726.
    • (1996) EMBO J. , vol.15 , pp. 6716-6726
    • Krappmann, D.1    Wulczyn, F.G.2    Scheidereit, C.3
  • 34
    • 0029924035 scopus 로고    scopus 로고
    • A glycine-rich region in NF-κB p105 functions as a processing signal for the generation of the p50 subunit
    • Lin, L. and Ghosh, S. (1996) A glycine-rich region in NF-κB p105 functions as a processing signal for the generation of the p50 subunit. Mol. Cell. Biol., 16, 2248-2254.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2248-2254
    • Lin, L.1    Ghosh, S.2
  • 35
    • 0032549815 scopus 로고    scopus 로고
    • Cotranslational biogenesis of NF-κB p50 by the 26S proteasome
    • Lin, L., DeMartino, G.N. and Greene, W.C. (1998) Cotranslational biogenesis of NF-κB p50 by the 26S proteasome. Cell, 92, 819-828.
    • (1998) Cell , vol.92 , pp. 819-828
    • Lin, L.1    DeMartino, G.N.2    Greene, W.C.3
  • 36
    • 0033082990 scopus 로고    scopus 로고
    • The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-κB acting through the NF-κB-inducing kinase and IκB kinases
    • Lin, X., Cunningham, E.T.J., Mu, Y., Geleziunas, R. and Greene, W.C. (1999) The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-κB acting through the NF-κB-inducing kinase and IκB kinases. Immunity, 10, 271-280.
    • (1999) Immunity , vol.10 , pp. 271-280
    • Lin, X.1    Cunningham, E.T.J.2    Mu, Y.3    Geleziunas, R.4    Greene, W.C.5
  • 37
    • 0029866197 scopus 로고    scopus 로고
    • Phosphorylation of p105 PEST sequence via a redox-insensitive pathway up-regulates processing of p50 NF-κB
    • MacKichan, M.L., Logeat, F. and Israel, A. (1996) Phosphorylation of p105 PEST sequence via a redox-insensitive pathway up-regulates processing of p50 NF-κB. J. Biol. Chem., 271, 6084-6091.
    • (1996) J. Biol. Chem. , vol.271 , pp. 6084-6091
    • MacKichan, M.L.1    Logeat, F.2    Israel, A.3
  • 38
    • 0031017618 scopus 로고    scopus 로고
    • MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1
    • Malinin, N.L., Boldin, M.P., Kovalenko, A.V. and Wallach, D. (1997) MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature, 385, 540-544.
    • (1997) Nature , vol.385 , pp. 540-544
    • Malinin, N.L.1    Boldin, M.P.2    Kovalenko, A.V.3    Wallach, D.4
  • 39
    • 0030613646 scopus 로고    scopus 로고
    • Catalysis by a multiprotein IκB kinase complex
    • Maniatis, T. (1997) Catalysis by a multiprotein IκB kinase complex. Science, 278, 818-819.
    • (1997) Science , vol.278 , pp. 818-819
    • Maniatis, T.1
  • 40
    • 0031126702 scopus 로고    scopus 로고
    • Rel/NF-κB and IκB proteins: An overview
    • May, M.J. and Ghosh, S. (1997) Rel/NF-κB and IκB proteins: an overview. Semin. Cancer Biol., 8, 63-73.
    • (1997) Semin. Cancer Biol. , vol.8 , pp. 63-73
    • May, M.J.1    Ghosh, S.2
  • 41
    • 0027520473 scopus 로고
    • Proteolytic degradation of MAD3 (IκBα) and enhanced processing of the NF-κB precursor p105 are obligatory steps in the activation of NF-κB
    • Mellits, K.H., Hay, R.T. and Goodbourn, S. (1993) Proteolytic degradation of MAD3 (IκBα) and enhanced processing of the NF-κB precursor p105 are obligatory steps in the activation of NF-κB. Nucleic Acids Res., 21, 5059-5066.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 5059-5066
    • Mellits, K.H.1    Hay, R.T.2    Goodbourn, S.3
  • 42
    • 0027243576 scopus 로고
    • p105 and p98 precursor proteins play an active role in NF-κB-mediated signal transduction
    • Mercurio, F., DiDonato, J.A., Rosette, C. and Karin, M. (1993) p105 and p98 precursor proteins play an active role in NF-κB-mediated signal transduction. Genes Dev., 7, 705-718.
    • (1993) Genes Dev. , vol.7 , pp. 705-718
    • Mercurio, F.1    DiDonato, J.A.2    Rosette, C.3    Karin, M.4
  • 43
    • 0030685825 scopus 로고    scopus 로고
    • IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation
    • Mercurio, F. et al. (1997) IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science, 278, 860-866.
    • (1997) Science , vol.278 , pp. 860-866
    • Mercurio, F.1
  • 44
    • 0032589935 scopus 로고    scopus 로고
    • IκB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
    • Mercurio, F. et al. (1999) IκB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol. Cell. Biol., 19, 1526-1538.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1526-1538
    • Mercurio, F.1
  • 45
    • 0026071770 scopus 로고
    • Cloning of the DNA-binding subunit of human nuclear factor κB: The level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor α
    • Meyer, R. et al. (1991) Cloning of the DNA-binding subunit of human nuclear factor κB: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor α. Proc. Natl Acad. Sci. USA, 88, 966-970.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 966-970
    • Meyer, R.1
  • 46
    • 0028170265 scopus 로고
    • Activation of NF-κB in vivo is regulated by multiple phosphorylations
    • Naumann, M. and Scheidereit, C. (1994) Activation of NF-κB in vivo is regulated by multiple phosphorylations. EMBO J., 13, 4597-4607.
    • (1994) EMBO J. , vol.13 , pp. 4597-4607
    • Naumann, M.1    Scheidereit, C.2
  • 47
    • 0027313506 scopus 로고
    • NF-κB precursor p100 inhibits nuclear translocation and DNA binding of NF-κB/rel-factors
    • Naumann, M., Nieters, A., Hatada, E.N. and Scheidereit, C. (1993a) NF-κB precursor p100 inhibits nuclear translocation and DNA binding of NF-κB/rel-factors. Oncogene, 8, 2275-2281.
    • (1993) Oncogene , vol.8 , pp. 2275-2281
    • Naumann, M.1    Nieters, A.2    Hatada, E.N.3    Scheidereit, C.4
  • 48
    • 0027472317 scopus 로고
    • The NF-κB precursor p105 and the proto-oncogene product Bcl-3 are IκB molecules and control nuclear translocation of NF-κB
    • Naumann, M., Wulczyn, F.G. and Scheidereit, C. (1993b) The NF-κB precursor p105 and the proto-oncogene product Bcl-3 are IκB molecules and control nuclear translocation of NF-κB. EMBO J., 12, 213-222.
    • (1993) EMBO J. , vol.12 , pp. 213-222
    • Naumann, M.1    Wulczyn, F.G.2    Scheidereit, C.3
  • 49
    • 0026476683 scopus 로고
    • Identification of complex formation between two intracellular tyrosine kinase substrates: Human c-Rel and the p105 precursor of p50 NF-κB
    • Neumann, M., Tsapos, K., Scheppler, J.A., Ross, J. and Franza, B.R.,Jr (1992) Identification of complex formation between two intracellular tyrosine kinase substrates: human c-Rel and the p105 precursor of p50 NF-κB. Oncogene, 7, 2095-2104.
    • (1992) Oncogene , vol.7 , pp. 2095-2104
    • Neumann, M.1    Tsapos, K.2    Scheppler, J.A.3    Ross, J.4    Franza B.R., Jr.5
  • 50
    • 0027175501 scopus 로고
    • The Bcl-3 proto-oncogene encodes a nuclear IκB-like molecule that preferentially interacts with NF-κB p50 and p52 in a phosphorylation-dependent manner
    • Nolan, G.P., Fujita, T., Bhatia, K., Huppi, C., Liou, H.C., Scott, M.L. and Baltimore, D. (1993) The Bcl-3 proto-oncogene encodes a nuclear IκB-like molecule that preferentially interacts with NF-κB p50 and p52 in a phosphorylation-dependent manner. Mol. Cell. Biol., 13, 3557-3566.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3557-3566
    • Nolan, G.P.1    Fujita, T.2    Bhatia, K.3    Huppi, C.4    Liou, H.C.5    Scott, M.L.6    Baltimore, D.7
  • 51
    • 0027980321 scopus 로고
    • The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
    • Palombella, V.J., Rando, O.J., Goldberg, A.L. and Maniatis, T. (1994) The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell, 78, 773-785.
    • (1994) Cell , vol.78 , pp. 773-785
    • Palombella, V.J.1    Rando, O.J.2    Goldberg, A.L.3    Maniatis, T.4
  • 52
    • 0029155736 scopus 로고
    • Regulation of the human P-selectin promoter by Bcl-3 and specific homodimeric members of the NF-κB/Rel family
    • Pan, J. and McEver, R.P. (1995) Regulation of the human P-selectin promoter by Bcl-3 and specific homodimeric members of the NF-κB/Rel family. J. Biol. Chem., 270, 23077-23083.
    • (1995) J. Biol. Chem. , vol.270 , pp. 23077-23083
    • Pan, J.1    McEver, R.P.2
  • 53
    • 0027937795 scopus 로고
    • Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase
    • Patriotis, C., Makris, A., Chernoff, J. and Tsichlis, P.N. (1994) Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase. Proc. Natl Acad. Sci. USA, 91, 9755-9759.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 9755-9759
    • Patriotis, C.1    Makris, A.2    Chernoff, J.3    Tsichlis, P.N.4
  • 54
    • 0031586174 scopus 로고    scopus 로고
    • Identification and characterization of an IκB kinase
    • Regnier, C.H., Song, H.Y., Gao, X., Goeddel, D.V., Cao, Z. and Rothe, M. (1997) Identification and characterization of an IκB kinase. Cell, 90, 373-383.
    • (1997) Cell , vol.90 , pp. 373-383
    • Regnier, C.H.1    Song, H.Y.2    Gao, X.3    Goeddel, D.V.4    Cao, Z.5    Rothe, M.6
  • 55
    • 0026742527 scopus 로고
    • The precursor of NF-κB p50 has IκB-like functions
    • Rice, N.R., MacKichan, M.L. and Israel, A. (1992) The precursor of NF-κB p50 has IκB-like functions. Cell, 71, 243-253.
    • (1992) Cell , vol.71 , pp. 243-253
    • Rice, N.R.1    MacKichan, M.L.2    Israel, A.3
  • 58
    • 0032541657 scopus 로고    scopus 로고
    • IKK-γ is an essential regulatory subunit of the IκB kinase complex
    • Rothwarf, D.M., Zandi, E., Natoli, G. and Karin, M. (1998) IKK-γ is an essential regulatory subunit of the IκB kinase complex. Nature, 395, 297-300.
    • (1998) Nature , vol.395 , pp. 297-300
    • Rothwarf, D.M.1    Zandi, E.2    Natoli, G.3    Karin, M.4
  • 59
    • 0030059508 scopus 로고    scopus 로고
    • Activation of MEK-1 and SEK-1 by Tpl-2 protooncoprotein, a novel MAP kinase kinase kinase
    • Salmeron, A., Ahmad, T.B., Carlile, G.W., Pappin, D., Narsimhan, R.P. and Ley,S.C. (1996) Activation of MEK-1 and SEK-1 by Tpl-2 protooncoprotein, a novel MAP kinase kinase kinase. EMBO J., 15, 817-826.
    • (1996) EMBO J. , vol.15 , pp. 817-826
    • Salmeron, A.1    Ahmad, T.B.2    Carlile, G.W.3    Pappin, D.4    Narsimhan, R.P.5    Ley, S.C.6
  • 61
    • 0031045073 scopus 로고    scopus 로고
    • Immunological defects in mice with a targeted disruption in Bcl-3
    • Schwarz, E.M., Krimpenfort, P., Berns, A. and Verma, I.M. (1997) Immunological defects in mice with a targeted disruption in Bcl-3. Genes Dev., 11, 187-197.
    • (1997) Genes Dev. , vol.11 , pp. 187-197
    • Schwarz, E.M.1    Krimpenfort, P.2    Berns, A.3    Verma, I.M.4
  • 62
    • 0031892786 scopus 로고    scopus 로고
    • NF-κB p105 processing via the ubiquitin-proteasome pathway
    • Sears, C., Olesen, J., Rubin, D., Finley, D. and Maniatis, T. (1998) NF-κB p105 processing via the ubiquitin-proteasome pathway. J. Biol. Chem., 273, 1409-1419.
    • (1998) J. Biol. Chem. , vol.273 , pp. 1409-1419
    • Sears, C.1    Olesen, J.2    Rubin, D.3    Finley, D.4    Maniatis, T.5
  • 63
    • 0028804551 scopus 로고
    • Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
    • Sha, W.C., Liou, H.C., Tuomanen, E.I. and Baltimore, D. (1995) Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell, 80, 321-330.
    • (1995) Cell , vol.80 , pp. 321-330
    • Sha, W.C.1    Liou, H.C.2    Tuomanen, E.I.3    Baltimore, D.4
  • 64
    • 0033083158 scopus 로고    scopus 로고
    • Signal-induced ubiquitination of IκBα by the F-box protein Slimb/β-TrCP
    • Spencer, E., Jiang, J. and Chen, Z.J. (1999) Signal-induced ubiquitination of IκBα by the F-box protein Slimb/β-TrCP. Genes Dev., 13, 284-294.
    • (1999) Genes Dev. , vol.13 , pp. 284-294
    • Spencer, E.1    Jiang, J.2    Chen, Z.J.3
  • 65
    • 0030613758 scopus 로고    scopus 로고
    • NF-κB activation: The IκB kinase revealed?
    • Stancovski, I. and Baltimore, D. (1997) NF-κB activation: the IκB kinase revealed? Cell, 91, 299-302.
    • (1997) Cell , vol.91 , pp. 299-302
    • Stancovski, I.1    Baltimore, D.2
  • 66
    • 0028978032 scopus 로고
    • Phosphorylation of human IκBα on serines 32 and 36 controls IκBα proteolysis and NF-κB activation in response to diverse stimuli
    • Traenckner, E.B., Pahl, H.L., Henkel, T., Schmidt, K.N., Wilk, S. and Baeuerle, P.A. (1995) Phosphorylation of human IκBα on serines 32 and 36 controls IκBα proteolysis and NF-κB activation in response to diverse stimuli. EMBO J., 14, 2876-2883.
    • (1995) EMBO J. , vol.14 , pp. 2876-2883
    • Traenckner, E.B.1    Pahl, H.L.2    Henkel, T.3    Schmidt, K.N.4    Wilk, S.5    Baeuerle, P.A.6
  • 67
    • 0032548117 scopus 로고    scopus 로고
    • Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-κB
    • Tsatsanis, C., Patriotis, C. and Tsichlis, P.N. (1998) Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-κB. Oncogene, 17, 2609-2618.
    • (1998) Oncogene , vol.17 , pp. 2609-2618
    • Tsatsanis, C.1    Patriotis, C.2    Tsichlis, P.N.3
  • 69
    • 0030988261 scopus 로고    scopus 로고
    • Regulation of NFκB1 proteins by the candidate oncoprotein BCL-3: Generation of NF-κB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation
    • Watanabe, N., Iwamura, T., Shinoda, T. and Fujita, T. (1997) Regulation of NFκB1 proteins by the candidate oncoprotein BCL-3: generation of NF-κB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation. EMBO J., 16, 3609-3620.
    • (1997) EMBO J. , vol.16 , pp. 3609-3620
    • Watanabe, N.1    Iwamura, T.2    Shinoda, T.3    Fujita, T.4
  • 70
    • 0029122799 scopus 로고
    • N- and C-terminal sequences control degradation of MAD3/IκBα in response to inducers of NF-αB activity
    • Whiteside, S.T., Ernst, M.K., LeBail, O., Laurent Winter, C., Rice, N. and Israel, A. (1995) N- and C-terminal sequences control degradation of MAD3/IκBα in response to inducers of NF-αB activity. Mol. Cell. Biol., 15, 5339-5345.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5339-5345
    • Whiteside, S.T.1    Ernst, M.K.2    LeBail, O.3    Laurent Winter, C.4    Rice, N.5    Israel, A.6
  • 71
    • 0033068154 scopus 로고    scopus 로고
    • The SCFβ-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro
    • Winston, J.T., Strack, P., Beer Romero, P., Chu, C.Y., Elledge, S.J. and Harper, J.W. (1999) The SCFβ-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro. Genes Dev., 13, 270-283.
    • (1999) Genes Dev. , vol.13 , pp. 270-283
    • Winston, J.T.1    Strack, P.2    Beer Romero, P.3    Chu, C.Y.4    Elledge, S.J.5    Harper, J.W.6
  • 72
    • 0030611595 scopus 로고    scopus 로고
    • IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK
    • Woronicz, J.D., Gao, X., Cao, Z., Rothe, M. and Goeddel, D.V. (1997) IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science, 278, 866-869.
    • (1997) Science , vol.278 , pp. 866-869
    • Woronicz, J.D.1    Gao, X.2    Cao, Z.3    Rothe, M.4    Goeddel, D.V.5
  • 73
    • 0026783677 scopus 로고
    • Candidate protooncogene Bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB
    • Wulczyn, F.G., Naumann, M. and Scheidereit, C. (1992) Candidate protooncogene Bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB. Nature, 358, 597-599.
    • (1992) Nature , vol.358 , pp. 597-599
    • Wulczyn, F.G.1    Naumann, M.2    Scheidereit, C.3
  • 74
    • 0029836595 scopus 로고    scopus 로고
    • The NF-κB/Rel and IκB gene families: Mediators of immune response and inflammation
    • Wulczyn, F.G., Krappmann, D. and Scheidereit, C. (1996) The NF-κB/Rel and IκB gene families: mediators of immune response and inflammation. J. Mol. Med., 74, 749-769.
    • (1996) J. Mol. Med. , vol.74 , pp. 749-769
    • Wulczyn, F.G.1    Krappmann, D.2    Scheidereit, C.3
  • 75
    • 0032052253 scopus 로고    scopus 로고
    • Signal-dependent degradation of IκBα is mediated by an inducible destruction box that can be transferred to NF-κB, Bcl-3 or p53
    • Wulczyn, F.G., Krappmann, D. and Scheidereit, C. (1998) Signal-dependent degradation of IκBα is mediated by an inducible destruction box that can be transferred to NF-κB, Bcl-3 or p53. Nucleic Acids Res., 26, 1724-1730.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 1724-1730
    • Wulczyn, F.G.1    Krappmann, D.2    Scheidereit, C.3
  • 76
    • 0032568792 scopus 로고    scopus 로고
    • Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation
    • Yamaoka, S., Courtois, G., Bessia, C., Whiteside, S.T., Weil, R., Agou, F., Kirk, H.E., Kay, R.J. and Israel, A. (1998) Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell, 93, 1231-1240.
    • (1998) Cell , vol.93 , pp. 1231-1240
    • Yamaoka, S.1    Courtois, G.2    Bessia, C.3    Whiteside, S.T.4    Weil, R.5    Agou, F.6    Kirk, H.E.7    Kay, R.J.8    Israel, A.9
  • 77
    • 17944401842 scopus 로고    scopus 로고
    • Identification of the receptor component of the IκBα-ubiquitin ligase
    • Yaron, A. et al. (1998) Identification of the receptor component of the IκBα-ubiquitin ligase. Nature, 396, 590-594.
    • (1998) Nature , vol.396 , pp. 590-594
    • Yaron, A.1
  • 78
    • 0030613551 scopus 로고    scopus 로고
    • The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation
    • Zandi, E., Rothwarf, D.M., Delhase, M., Hayakawa, M. and Karin, M. (1997) The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell, 91, 243-252.
    • (1997) Cell , vol.91 , pp. 243-252
    • Zandi, E.1    Rothwarf, D.M.2    Delhase, M.3    Hayakawa, M.4    Karin, M.5


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