Selective inhibition of NF-κB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

Nature Medicine

Volumn 10, Issue 6, 2004, Pages 617-624

  Jimi, Eijiro ^a,e   Aoki, Kazuhiro ^b   Saito, Hiroaki ^b   D'Acquisto, Fulvio ^a   May, Michael J ^a,f   Nakamura, Ichiro ^c   Sudo, Testuo ^d   Kojima, Takefumi ^b   Okamoto, Fujio ^e   Fukushima, Hidefumi ^e   Okabe, Koji ^e   Ohya, Keiichi ^b   Ghosh, Sankar ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c Yugawara Kosei Nenkin Hospital   (Japan)

^d TORAY INDUSTRIES INC   (Japan)

^e FUKUOKA DENTAL COLLEGE   (Japan)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; I KAPPA B; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; OSTEOCLAST DIFFERENTIATION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ARTHRITIS; ARTICLE; BONE DESTRUCTION; CARTILAGE DEGENERATION; CELL DIFFERENTIATION; CELL MEMBRANE PERMEABILITY; CHRONIC INFLAMMATION; CONTROLLED STUDY; DISEASE SEVERITY; GENE TARGETING; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PERIODONTITIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BONE AND BONES; BONE MARROW CELLS; BONE RESORPTION; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; I-KAPPA B PROTEINS; INFLAMMATION; INTERLEUKIN-1; MACROPHAGES; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; NF-KAPPA B; OSTEOCLASTS; PEPTIDES; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 2942703810     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1054     Document Type: Article

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