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Volumn 29, Issue 3, 2007, Pages 261-274

Strategies that modulate inflammasomes - Insights from host-pathogen interactions

Author keywords

Host pathogen interaction; Immune modulation; Inflammasome inhibitors; Innate immunity; Pyrin domain

Indexed keywords

INFLAMMASOME INHIBITOR; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MULTIPROTEIN COMPLEX; PROTEIN INFLAMMASOME; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

EID: 34548661949     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-007-0080-5     Document Type: Review
Times cited : (15)

References (121)
  • 2
    • 1642285783 scopus 로고    scopus 로고
    • NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    • Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J (2004) NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20:319-25
    • (2004) Immunity , vol.20 , pp. 319-25
    • Agostini, L.1    Martinon, F.2    Burns, K.3    McDermott, M.F.4    Hawkins, P.N.5    Tschopp, J.6
  • 3
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4:499-511
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 4
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783-801
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 7
    • 0001848767 scopus 로고    scopus 로고
    • Virus encoded cytokines and cytokine receptors
    • Suppl
    • Barry M, McFadden G (1997) Virus encoded cytokines and cytokine receptors. Parasitology 115(Suppl):S89-S100
    • (1997) Parasitology , vol.115
    • Barry, M.1    McFadden, G.2
  • 8
    • 33947668943 scopus 로고    scopus 로고
    • Viral recognition by Toll-like receptors
    • Barton GM (2007) Viral recognition by Toll-like receptors. Semin Immunol 19:33-40
    • (2007) Semin Immunol , vol.19 , pp. 33-40
    • Barton, G.M.1
  • 9
    • 33947219338 scopus 로고    scopus 로고
    • Pyrin-only protein 2 modulates NF-{kappa}B and disrupts ASC:CLR interactions
    • Bedoya F, Sandler LL, Harton JA (2007) Pyrin-only protein 2 modulates NF-{kappa}B and disrupts ASC:CLR interactions. J Immunol 178:3837-3845
    • (2007) J Immunol , vol.178 , pp. 3837-3845
    • Bedoya, F.1    Sandler, L.L.2    Harton, J.A.3
  • 11
    • 33846246749 scopus 로고    scopus 로고
    • Translational mini-review series on Toll-like receptors: Recent advances in understanding the role of Toll-like receptors in anti-viral immunity
    • Bowie AG (2007) Translational mini-review series on Toll-like receptors: recent advances in understanding the role of Toll-like receptors in anti-viral immunity. Clin Exp Immunol 147:217-226
    • (2007) Clin Exp Immunol , vol.147 , pp. 217-226
    • Bowie, A.G.1
  • 12
    • 31744441475 scopus 로고    scopus 로고
    • Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
    • Boyden ED, Dietrich WF (2006) Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet 38:240-244
    • (2006) Nat Genet , vol.38 , pp. 240-244
    • Boyden, E.D.1    Dietrich, W.F.2
  • 13
    • 0035915992 scopus 로고    scopus 로고
    • Orthopoxvirus IL-18 binding proteins: Affinities and antagonist activities
    • Calderara S, Xiang Y, Moss B (2001) Orthopoxvirus IL-18 binding proteins: affinities and antagonist activities. Virology 279:22-26
    • (2001) Virology , vol.279 , pp. 22-26
    • Calderara, S.1    Xiang, Y.2    Moss, B.3
  • 14
    • 33847188791 scopus 로고    scopus 로고
    • NF-kappaB inhibitors for the treatment of inflammatory diseases and cancer
    • Calzado MA, Bacher S, Schmitz ML (2007) NF-kappaB inhibitors for the treatment of inflammatory diseases and cancer. Curr Med Chem 14:367-376
    • (2007) Curr Med Chem , vol.14 , pp. 367-376
    • Calzado, M.A.1    Bacher, S.2    Schmitz, M.L.3
  • 15
    • 0037349294 scopus 로고    scopus 로고
    • Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis
    • Chae JJ, Komarow HD, Cheng J, Wood G, Raben N, Liu PP, Kastner DL (2003) Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis. Mol Cell 11:591-604
    • (2003) Mol Cell , vol.11 , pp. 591-604
    • Chae, J.J.1    Komarow, H.D.2    Cheng, J.3    Wood, G.4    Raben, N.5    Liu, P.P.6    Kastner, D.L.7
  • 16
    • 33745631232 scopus 로고    scopus 로고
    • The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production
    • Chae JJ, Wood G, Masters SL, Richard K, Park G, Smith BJ, Kastner DL (2006) The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc Natl Acad Sci U S A 103:9982-9987
    • (2006) Proc Natl Acad Sci U S a , vol.103 , pp. 9982-9987
    • Chae, J.J.1    Wood, G.2    Masters, S.L.3    Richard, K.4    Park, G.5    Smith, B.J.6    Kastner, D.L.7
  • 17
    • 0027333432 scopus 로고
    • Dissociation of IL-1 beta synthesis and secretion in human blood monocytes stimulated with bacterial cell wall products
    • Chin J, Kostura MJ (1993) Dissociation of IL-1 beta synthesis and secretion in human blood monocytes stimulated with bacterial cell wall products. J Immunol 151:5574-5585
    • (1993) J Immunol , vol.151 , pp. 5574-5585
    • Chin, J.1    Kostura, M.J.2
  • 18
    • 0033676843 scopus 로고    scopus 로고
    • TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers
    • Conway KE, McConnell BB, Bowring CE, Donald CD, Warren ST, Vertino PM (2000) TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers. Cancer Res 60:6236-6242
    • (2000) Cancer Res , vol.60 , pp. 6236-6242
    • Conway, K.E.1    McConnell, B.B.2    Bowring, C.E.3    Donald, C.D.4    Warren, S.T.5    Vertino, P.M.6
  • 19
    • 0028850665 scopus 로고
    • The P2Z purinoceptor: An intriguing role in immunity, inflammation and cell death
    • Di Virgilio F (1995) The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death. Immunol Today 16:524-528
    • (1995) Immunol Today , vol.16 , pp. 524-528
    • Di Virgilio, F.1
  • 20
    • 0029979369 scopus 로고    scopus 로고
    • Biologic basis for interleukin-1 in disease
    • Dinarello CA (1996) Biologic basis for interleukin-1 in disease. Blood 87:2095-2147
    • (1996) Blood , vol.87 , pp. 2095-2147
    • Dinarello, C.A.1
  • 22
    • 0031739525 scopus 로고    scopus 로고
    • Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme
    • Dinarello CA (1998) Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme. Ann N Y Acad Sci 856:1-11
    • (1998) Ann N Y Acad Sci , vol.856 , pp. 1-11
    • Dinarello, C.A.1
  • 23
    • 4344600796 scopus 로고    scopus 로고
    • Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors
    • DiPerna G, Stack J, Bowie AG, Boyd A, Kotwal G, Zhang Z, Arvikar S, Latz E, Fitzgerald KA, Marshall WL (2004) Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors. J Biol Chem 279:6570-6578
    • (2004) J Biol Chem , vol.279 , pp. 6570-6578
    • Diperna, G.1    Stack, J.2    Bowie, A.G.3    Boyd, A.4    Kotwal, G.5    Zhang, Z.6    Arvikar, S.7    Latz, E.8    Fitzgerald, K.A.9    Marshall, W.L.10
  • 25
    • 33747340486 scopus 로고    scopus 로고
    • The inflammasome-a linebacker of innate defense
    • Drenth JP, van der Meer JW (2006) The inflammasome-a linebacker of innate defense. N Engl J Med 355:730-732
    • (2006) N Engl J Med , vol.355 , pp. 730-732
    • Drenth, J.P.1    Van Der Meer, J.W.2
  • 26
    • 0034743434 scopus 로고    scopus 로고
    • Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins
    • Druilhe A, Srinivasula SM, Razmara M, Ahmad M, Alnemri ES (2001) Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. Cell Death Differ 8:649-657
    • (2001) Cell Death Differ , vol.8 , pp. 649-657
    • Druilhe, A.1    Srinivasula, S.M.2    Razmara, M.3    Ahmad, M.4    Alnemri, E.S.5
  • 27
    • 33749036594 scopus 로고    scopus 로고
    • NF-kappaB signaling: Pros and cons of altering NF-kappaB as a therapeutic approach
    • Egan LJ, Toruner M (2006) NF-kappaB signaling: pros and cons of altering NF-kappaB as a therapeutic approach. Ann N Y Acad Sci 1072:114-122
    • (2006) Ann N Y Acad Sci , vol.1072 , pp. 114-122
    • Egan, L.J.1    Toruner, M.2
  • 33
    • 28444459897 scopus 로고    scopus 로고
    • How Toll-like receptors and Nod-like receptors contribute to innate immunity in mammals
    • Fritz JH, Girardin SE (2005) How Toll-like receptors and Nod-like receptors contribute to innate immunity in mammals. J Endotoxin Res 11:390-394
    • (2005) J Endotoxin Res , vol.11 , pp. 390-394
    • Fritz, J.H.1    Girardin, S.E.2
  • 35
    • 0043169587 scopus 로고    scopus 로고
    • IL-12 and IL-18 act in synergy to clear vaccinia virus infection: Involvement of innate and adaptive components of the immune system
    • Gherardi MM, Ramirez JC, Esteban M (2003) IL-12 and IL-18 act in synergy to clear vaccinia virus infection: involvement of innate and adaptive components of the immune system. J Gen Virol 84:1961-1972
    • (2003) J Gen Virol , vol.84 , pp. 1961-1972
    • Gherardi, M.M.1    Ramirez, J.C.2    Esteban, M.3
  • 38
    • 0032958654 scopus 로고    scopus 로고
    • Enteropathogenic E. coli, Salmonella, and Shigella: Masters of host cell cytoskeletal exploitation
    • Goosney DL, Knoechel DG, Finlay BB (1999) Enteropathogenic E. coli, Salmonella, and Shigella: masters of host cell cytoskeletal exploitation. Emerg Infect Dis 5:216-223
    • (1999) Emerg Infect Dis , vol.5 , pp. 216-223
    • Goosney, D.L.1    Knoechel, D.G.2    Finlay, B.B.3
  • 39
    • 33748598700 scopus 로고    scopus 로고
    • Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
    • Gurcel L, Abrami L, Girardin S, Tschopp J, van der Goot FG (2006) Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell 126:1135-1145
    • (2006) Cell , vol.126 , pp. 1135-1145
    • Gurcel, L.1    Abrami, L.2    Girardin, S.3    Tschopp, J.4    Van Der Goot, F.G.5
  • 40
    • 1042290321 scopus 로고    scopus 로고
    • Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra
    • Hawkins PN, Lachmann HJ, Aganna E, McDermott MF (2004) Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra. Arthritis Rheum 50:607-612
    • (2004) Arthritis Rheum , vol.50 , pp. 607-612
    • Hawkins, P.N.1    Lachmann, H.J.2    Aganna, E.3    McDermott, M.F.4
  • 43
    • 0035179970 scopus 로고    scopus 로고
    • Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
    • Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD (2001) Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet 29:301-305
    • (2001) Nat Genet , vol.29 , pp. 301-305
    • Hoffman, H.M.1    Mueller, J.L.2    Broide, D.H.3    Wanderer, A.A.4    Kolodner, R.D.5
  • 44
    • 0037216780 scopus 로고    scopus 로고
    • The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations
    • Hull KM, Shoham N, Chae JJ, Aksentijevich I, Kastner DL (2003) The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations. Curr Opin Rheumatol 15:61-69
    • (2003) Curr Opin Rheumatol , vol.15 , pp. 61-69
    • Hull, K.M.1    Shoham, N.2    Chae, J.J.3    Aksentijevich, I.4    Kastner, D.L.5
  • 45
    • 27944434620 scopus 로고    scopus 로고
    • Therapeutic targets in inflammatory disease
    • Hume DA, Fairlie DP (2005) Therapeutic targets in inflammatory disease. Curr Med Chem 12:2925-2929
    • (2005) Curr Med Chem , vol.12 , pp. 2925-2929
    • Hume, D.A.1    Fairlie, D.P.2
  • 47
    • 0035951792 scopus 로고    scopus 로고
    • Human Nod1 confers responsiveness to bacterial lipopolysaccharides
    • Inohara N, Ogura Y, Chen FF, Muto A, Nunez G (2001) Human Nod1 confers responsiveness to bacterial lipopolysaccharides. J Biol Chem 276:2551-2554
    • (2001) J Biol Chem , vol.276 , pp. 2551-2554
    • Inohara, N.1    Ogura, Y.2    Chen, F.F.3    Muto, A.4    Nunez, G.5
  • 51
    • 28844466449 scopus 로고    scopus 로고
    • A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection
    • Johnston JB, Barrett JW, Nazarian SH, Goodwin M, Ricciuto D, Wang G, McFadden G (2005) A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection. Immunity 23:587-598
    • (2005) Immunity , vol.23 , pp. 587-598
    • Johnston, J.B.1    Barrett, J.W.2    Nazarian, S.H.3    Goodwin, M.4    Ricciuto, D.5    Wang, G.6    McFadden, G.7
  • 52
    • 0034955802 scopus 로고    scopus 로고
    • Molecular pathogenesis of influenza a virus infection and virus-induced regulation of cytokine gene expression
    • Julkunen I, Sareneva T, Pirhonen J, Ronni T, Melen K, Matikainen S (2001) Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression. Cytokine Growth Factor Rev 12:171-180
    • (2001) Cytokine Growth Factor Rev , vol.12 , pp. 171-180
    • Julkunen, I.1    Sareneva, T.2    Pirhonen, J.3    Ronni, T.4    Melen, K.5    Matikainen, S.6
  • 58
    • 34248672889 scopus 로고    scopus 로고
    • Antiviral signaling through pattern recognition receptors
    • Kawai T, Akira S (2007) Antiviral signaling through pattern recognition receptors. J Biochem (Tokyo) 141:137-145
    • (2007) J Biochem (Tokyo) , vol.141 , pp. 137-145
    • Kawai, T.1    Akira, S.2
  • 60
    • 23044452084 scopus 로고    scopus 로고
    • NACHT-LRR proteins (NLRs) in bacterial infection and immunity
    • Kufer TA, Fritz JH, Philpott DJ (2005) NACHT-LRR proteins (NLRs) in bacterial infection and immunity. Trends Microbiol 13:381-388
    • (2005) Trends Microbiol , vol.13 , pp. 381-388
    • Kufer, T.A.1    Fritz, J.H.2    Philpott, D.J.3
  • 63
    • 27944450035 scopus 로고    scopus 로고
    • Inhibitors of TACE and Caspase-1 as anti-inflammatory drugs
    • Le GT, Abbenante G (2005) Inhibitors of TACE and Caspase-1 as anti-inflammatory drugs. Curr Med Chem 12:2963-2977
    • (2005) Curr Med Chem , vol.12 , pp. 2963-2977
    • Le, G.T.1    Abbenante, G.2
  • 67
    • 1342267795 scopus 로고    scopus 로고
    • Interleukin-18 improves the early defence system against influenza virus infection by augmenting natural killer cell-mediated cytotoxicity
    • Liu B, Mori I, Hossain MJ, Dong L, Takeda K, Kimura Y (2004) Interleukin-18 improves the early defence system against influenza virus infection by augmenting natural killer cell-mediated cytotoxicity. J Gen Virol 85:423-428
    • (2004) J Gen Virol , vol.85 , pp. 423-428
    • Liu, B.1    Mori, I.2    Hossain, M.J.3    Dong, L.4    Takeda, K.5    Kimura, Y.6
  • 68
    • 17244381937 scopus 로고    scopus 로고
    • Interleukin-1 blockade by anakinra improves clinical symptoms in patients with neonatal-onset multisystem inflammatory disease
    • Lovell DJ, Bowyer SL, Solinger AM (2005) Interleukin-1 blockade by anakinra improves clinical symptoms in patients with neonatal-onset multisystem inflammatory disease. Arthritis Rheum 52:1283-1286
    • (2005) Arthritis Rheum , vol.52 , pp. 1283-1286
    • Lovell, D.J.1    Bowyer, S.L.2    Solinger, A.M.3
  • 69
    • 6344227999 scopus 로고    scopus 로고
    • Secreted immunomodulatory viral proteins as novel biotherapeutics
    • Lucas A, McFadden G (2004) Secreted immunomodulatory viral proteins as novel biotherapeutics. J Immunol 173:4765-4774
    • (2004) J Immunol , vol.173 , pp. 4765-4774
    • Lucas, A.1    McFadden, G.2
  • 71
    • 26844452231 scopus 로고    scopus 로고
    • Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis
    • Mariathasan S, Weiss DS, Dixit VM, Monack DM (2005) Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis. J Exp Med 202:1043-1049
    • (2005) J Exp Med , vol.202 , pp. 1043-1049
    • Mariathasan, S.1    Weiss, D.S.2    Dixit, V.M.3    Monack, D.M.4
  • 73
    • 33845890803 scopus 로고    scopus 로고
    • Inflammasome adaptors and sensors: Intracellular regulators of infection and inflammation
    • Mariathasan S, Monack DM (2007) Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol 7:31-40
    • (2007) Nat Rev Immunol , vol.7 , pp. 31-40
    • Mariathasan, S.1    Monack, D.M.2
  • 74
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10:417-426
    • (2002) Mol Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 75
    • 7944232105 scopus 로고    scopus 로고
    • Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome
    • Martinon F, Agostini L, Meylan E, Tschopp J (2004) Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol 14:1929-1934
    • (2004) Curr Biol , vol.14 , pp. 1929-1934
    • Martinon, F.1    Agostini, L.2    Meylan, E.3    Tschopp, J.4
  • 76
    • 2542457495 scopus 로고    scopus 로고
    • Inflammatory caspases: Linking an intracellular innate immune system to autoinflammatory diseases
    • Martinon F, Tschopp J (2004) Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117:561-574
    • (2004) Cell , vol.117 , pp. 561-574
    • Martinon, F.1    Tschopp, J.2
  • 77
    • 22444433175 scopus 로고    scopus 로고
    • NLRs join TLRs as innate sensors of pathogens
    • Martinon F, Tschopp J (2005) NLRs join TLRs as innate sensors of pathogens. Trends Immunol 26:447-454
    • (2005) Trends Immunol , vol.26 , pp. 447-454
    • Martinon, F.1    Tschopp, J.2
  • 78
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440:237-241
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 79
    • 33845497181 scopus 로고    scopus 로고
    • Inflammatory caspases and inflammasomes: Master switches of inflammation
    • Martinon F, Tschopp J (2007) Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ 14:10-22
    • (2007) Cell Death Differ , vol.14 , pp. 10-22
    • Martinon, F.1    Tschopp, J.2
  • 81
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • Matzinger P (2002) The danger model: a renewed sense of self. Science 296:301-305
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 82
    • 0346734126 scopus 로고    scopus 로고
    • Extensive gene gain associated with adaptive evolution of poxviruses
    • McLysaght A, Baldi PF, Gaut BS (2003) Extensive gene gain associated with adaptive evolution of poxviruses. Proc Natl Acad Sci U S A 100:15655-15660
    • (2003) Proc Natl Acad Sci U S a , vol.100 , pp. 15655-15660
    • McLysaght, A.1    Baldi, P.F.2    Gaut, B.S.3
  • 84
    • 33746028777 scopus 로고    scopus 로고
    • Intracellular pattern recognition receptors in the host response
    • Meylan E, Tschopp J, Karin M (2006) Intracellular pattern recognition receptors in the host response. Nature 442:39-44
    • (2006) Nature , vol.442 , pp. 39-44
    • Meylan, E.1    Tschopp, J.2    Karin, M.3
  • 86
    • 0037110424 scopus 로고    scopus 로고
    • The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis
    • Minagar A, Shapshak P, Fujimura R, Ownby R, Heyes M, Eisdorfer C (2002) The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis. J Neurol Sci 202:13-23
    • (2002) J Neurol Sci , vol.202 , pp. 13-23
    • Minagar, A.1    Shapshak, P.2    Fujimura, R.3    Ownby, R.4    Heyes, M.5    Eisdorfer, C.6
  • 89
    • 29644438009 scopus 로고    scopus 로고
    • Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian Toll/interleukin-1 receptor family proteins
    • Newman RM, Salunkhe P, Godzik A, Reed JC (2006) Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian Toll/interleukin-1 receptor family proteins. Infect Immun 74:594-601
    • (2006) Infect Immun , vol.74 , pp. 594-601
    • Newman, R.M.1    Salunkhe, P.2    Godzik, A.3    Reed, J.C.4
  • 90
    • 33747191203 scopus 로고    scopus 로고
    • The inflammasome: First line of the immune response to cell stress
    • Ogura Y, Sutterwala FS, Flavell RA (2006) The inflammasome: first line of the immune response to cell stress. Cell 126:659-662
    • (2006) Cell , vol.126 , pp. 659-662
    • Ogura, Y.1    Sutterwala, F.S.2    Flavell, R.A.3
  • 92
    • 33846101728 scopus 로고    scopus 로고
    • The innate antiviral response: New insights into a continuing story
    • Paun A, Pitha PM (2007) The innate antiviral response: new insights into a continuing story. Adv Virus Res 69:1-66
    • (2007) Adv Virus Res , vol.69 , pp. 1-66
    • Paun, A.1    Pitha, P.M.2
  • 93
    • 33646165882 scopus 로고    scopus 로고
    • New approaches to the treatment of inflammatory disorders small molecule inhibitors of p38 MAP kinase
    • Peifer C, Wagner G, Laufer S (2006) New approaches to the treatment of inflammatory disorders small molecule inhibitors of p38 MAP kinase. Curr Top Med Chem 6:113-149
    • (2006) Curr Top Med Chem , vol.6 , pp. 113-149
    • Peifer, C.1    Wagner, G.2    Laufer, S.3
  • 95
    • 0033564334 scopus 로고    scopus 로고
    • Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway
    • Pirhonen J, Sareneva T, Kurimoto M, Julkunen I, Matikainen S (1999) Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway. J Immunol 162:7322-7329
    • (1999) J Immunol , vol.162 , pp. 7322-7329
    • Pirhonen, J.1    Sareneva, T.2    Kurimoto, M.3    Julkunen, I.4    Matikainen, S.5
  • 96
    • 0036882396 scopus 로고    scopus 로고
    • Irreversible inhibitors of serine, cysteine, and threonine proteases
    • Powers JC, Asgian JL, Ekici OD, James KE (2002) Irreversible inhibitors of serine, cysteine, and threonine proteases. Chem Rev 102:4639-4750
    • (2002) Chem Rev , vol.102 , pp. 4639-4750
    • Powers, J.C.1    Asgian, J.L.2    Ekici, O.D.3    James, K.E.4
  • 97
    • 0026728952 scopus 로고
    • Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme
    • Ray CA, Black RA, Kronheim SR, Greenstreet TA, Sleath PR, Salvesen GS, Pickup DJ (1992) Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. Cell 69:597-604
    • (1992) Cell , vol.69 , pp. 597-604
    • Ray, C.A.1    Black, R.A.2    Kronheim, S.R.3    Greenstreet, T.A.4    Sleath, P.R.5    Salvesen, G.S.6    Pickup, D.J.7
  • 99
    • 33645791082 scopus 로고    scopus 로고
    • Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity
    • Ren T, Zamboni DS, Roy CR, Dietrich WF, Vance RE (2006) Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. PLoS Pathog 2:e18
    • (2006) PLoS Pathog , vol.2 , pp. 18
    • Ren, T.1    Zamboni, D.S.2    Roy, C.R.3    Dietrich, W.F.4    Vance, R.E.5
  • 102
    • 2942537824 scopus 로고    scopus 로고
    • Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta
    • Schotte P, Denecker G, Van Den Broeke A, Vandenabeele P, Cornelis GR, Beyaert R (2004) Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta. J Biol Chem 279:25134-25142
    • (2004) J Biol Chem , vol.279 , pp. 25134-25142
    • Schotte, P.1    Denecker, G.2    Van Den Broeke, A.3    Vandenabeele, P.4    Cornelis, G.R.5    Beyaert, R.6
  • 103
    • 0031973493 scopus 로고    scopus 로고
    • Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells
    • Schumann RR, Belka C, Reuter D, Lamping N, Kirschning CJ, Weber JR, Pfeil D (1998) Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells. Blood 91:577-584
    • (1998) Blood , vol.91 , pp. 577-584
    • Schumann, R.R.1    Belka, C.2    Reuter, D.3    Lamping, N.4    Kirschning, C.J.5    Weber, J.R.6    Pfeil, D.7
  • 105
    • 0038363463 scopus 로고    scopus 로고
    • Triggering the interferon antiviral response through an IKK-related pathway
    • Sharma S, tenOever BR, Grandvaux N, Zhou GP, Lin R, Hiscott J (2003) Triggering the interferon antiviral response through an IKK-related pathway. Science 300:1148-1151
    • (2003) Science , vol.300 , pp. 1148-1151
    • Sharma, S.1    Tenoever, B.R.2    Grandvaux, N.3    Zhou, G.P.4    Lin, R.5    Hiscott, J.6
  • 106
    • 0141998606 scopus 로고    scopus 로고
    • Molecular identification of a danger signal that alerts the immune system to dying cells
    • Shi Y, Evans JE, Rock KL (2003) Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425:516-521
    • (2003) Nature , vol.425 , pp. 516-521
    • Shi, Y.1    Evans, J.E.2    Rock, K.L.3
  • 107
    • 1642297176 scopus 로고    scopus 로고
    • Campylobacter jejuni infection of differentiated THP-1 macrophages results in interleukin 1 beta release and caspase-1-independent apoptosis
    • Siegesmund AM, Konkel ME, Klena JD, Mixter PF (2004) Campylobacter jejuni infection of differentiated THP-1 macrophages results in interleukin 1 beta release and caspase-1-independent apoptosis. Microbiology 150:561-569
    • (2004) Microbiology , vol.150 , pp. 561-569
    • Siegesmund, A.M.1    Konkel, M.E.2    Klena, J.D.3    Mixter, P.F.4
  • 109
    • 0038682430 scopus 로고    scopus 로고
    • The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation
    • Stehlik C, Krajewska M, Welsh K, Krajewski S, Godzik A, Reed JC (2003) The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation. Biochem J 373:101-113
    • (2003) Biochem J , vol.373 , pp. 101-113
    • Stehlik, C.1    Krajewska, M.2    Welsh, K.3    Krajewski, S.4    Godzik, A.5    Reed, J.C.6
  • 110
    • 27344448749 scopus 로고    scopus 로고
    • Familial autoinflammatory diseases: Genetics, pathogenesis and treatment
    • Stojanov S, Kastner DL (2005) Familial autoinflammatory diseases: genetics, pathogenesis and treatment. Curr Opin Rheumatol 17:586-599
    • (2005) Curr Opin Rheumatol , vol.17 , pp. 586-599
    • Stojanov, S.1    Kastner, D.L.2
  • 111
    • 33244472793 scopus 로고    scopus 로고
    • Signalling pathways and molecular interactions of NOD1 and NOD2
    • Strober W, Murray PJ, Kitani A, Watanabe T (2006) Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol 6:9-20
    • (2006) Nat Rev Immunol , vol.6 , pp. 9-20
    • Strober, W.1    Murray, P.J.2    Kitani, A.3    Watanabe, T.4
  • 113
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda K, Akira S (2005) Toll-like receptors in innate immunity. Int Immunol 17:1-14
    • (2005) Int Immunol , vol.17 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 115
    • 33344476398 scopus 로고    scopus 로고
    • CATERPILLERs, pyrin and hereditary immunological disorders
    • Ting JP, Kastner DL, Hoffman HM (2006) CATERPILLERs, pyrin and hereditary immunological disorders. Nat Rev Immunol 6:183-195
    • (2006) Nat Rev Immunol , vol.6 , pp. 183-195
    • Ting, J.P.1    Kastner, D.L.2    Hoffman, H.M.3
  • 117
    • 0033561546 scopus 로고    scopus 로고
    • Endotoxin-stimulated monocytes release multiple forms of IL-1 beta, including a proIL-1 beta form whose detection is affected by export
    • Wewers MD, Winnard AV, Dare HA (1999) Endotoxin-stimulated monocytes release multiple forms of IL-1 beta, including a proIL-1 beta form whose detection is affected by export. J Immunol 162:4858-4863
    • (1999) J Immunol , vol.162 , pp. 4858-4863
    • Wewers, M.D.1    Winnard, A.V.2    Dare, H.A.3
  • 118
    • 0037320267 scopus 로고    scopus 로고
    • Molluscum contagiosum virus interleukin-18 (IL-18) binding protein is secreted as a full-length form that binds cell surface glycosaminoglycans through the C-terminal tail and a furin-cleaved form with only the IL-18 binding domain
    • Xiang Y, Moss B (2003) Molluscum contagiosum virus interleukin-18 (IL-18) binding protein is secreted as a full-length form that binds cell surface glycosaminoglycans through the C-terminal tail and a furin-cleaved form with only the IL-18 binding domain. J Virol 77:2623-2630
    • (2003) J Virol , vol.77 , pp. 2623-2630
    • Xiang, Y.1    Moss, B.2
  • 120
    • 0034194055 scopus 로고    scopus 로고
    • The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells
    • Young JL, Sukhova GK, Foster D, Kisiel W, Libby P, Schonbeck U (2000) The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells. J Exp Med 191:1535-1544
    • (2000) J Exp Med , vol.191 , pp. 1535-1544
    • Young, J.L.1    Sukhova, G.K.2    Foster, D.3    Kisiel, W.4    Libby, P.5    Schonbeck, U.6


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