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Volumn 1072, Issue , 2006, Pages 114-122

NF-κB signaling: Pros and cons of altering NF-κB as a therapeutic approach

Author keywords

Inflammatory bowel disease; Nuclear factor kappa B

Indexed keywords

I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESALAZINE;

EID: 33749036594     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1326.009     Document Type: Conference Paper
Times cited : (47)

References (36)
  • 1
    • 0022481133 scopus 로고
    • Multiple nuclear factors interact with the immunoglobulin enhancer sequences
    • SEN, R. & D. BALTIMORE. 1986. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46: 705-716.
    • (1986) Cell , vol.46 , pp. 705-716
    • Sen, R.1    Baltimore, D.2
  • 2
    • 0022930702 scopus 로고
    • Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism
    • SEN, R. & D. BALTIMORE. 1986. Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell 47: 921-928.
    • (1986) Cell , vol.47 , pp. 921-928
    • Sen, R.1    Baltimore, D.2
  • 3
    • 0342742310 scopus 로고
    • Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B
    • OSBORN, L., S. KUNKEL & G.J. NABEL. 1989. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc. Natl. Acad. Sci. USA 86: 2336-2340.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 2336-2340
    • Osborn, L.1    Kunkel, S.2    Nabel, G.J.3
  • 4
    • 0033178735 scopus 로고    scopus 로고
    • NF-kappa B is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria
    • ELEWAUT, D. et al. 1999. NF-kappa B is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria. J. Immunol. 163: 1457-1466.
    • (1999) J. Immunol. , vol.163 , pp. 1457-1466
    • Elewaut, D.1
  • 5
    • 0032573165 scopus 로고    scopus 로고
    • Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms
    • LI, N. & M. KARIN. 1998. Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms. Proc. Natl. Acad. Sci. USA 95: 13012-13017.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 13012-13017
    • Li, N.1    Karin, M.2
  • 6
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappaB
    • HAYDEN, M.S. & S. GHOSH. 2004. Signaling to NF-kappaB. Genes Dev. 18: 2195-2224.
    • (2004) Genes Dev. , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 7
    • 0030613551 scopus 로고    scopus 로고
    • The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
    • ZANDI, E. et al. 1997. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91: 243-252.
    • (1997) Cell , vol.91 , pp. 243-252
    • Zandi, E.1
  • 8
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-kappa B system: A treasure trove for drug development
    • KARIN, M., Y. YAMAMOTO & Q.M. WANG. 2004. The IKK NF-kappa B system: a treasure trove for drug development. Nat. Rev. Drug Discov. 3: 17-26.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 9
    • 17944378526 scopus 로고    scopus 로고
    • Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
    • SENFTLEBEN, U. et al. 2001. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293: 1495-1499.
    • (2001) Science , vol.293 , pp. 1495-1499
    • Senftleben, U.1
  • 10
    • 0031595210 scopus 로고    scopus 로고
    • Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa
    • ROGLER, G. et al. 1998. Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology 115: 357-369.
    • (1998) Gastroenterology , vol.115 , pp. 357-369
    • Rogler, G.1
  • 11
    • 0031925362 scopus 로고    scopus 로고
    • Activation of nuclear factor kappa B inflammatory bowel disease
    • SCHREIBER, S., S. NIKOLAUS & J. HAMPE. 1998. Activation of nuclear factor kappa B inflammatory bowel disease. Gut 42: 477-484.
    • (1998) Gut , vol.42 , pp. 477-484
    • Schreiber, S.1    Nikolaus, S.2    Hampe, J.3
  • 12
    • 0029836444 scopus 로고    scopus 로고
    • Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice
    • NEURATH, M.F. et al. 1996. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice. Nat. Med. 2: 998-1004.
    • (1996) Nat. Med. , vol.2 , pp. 998-1004
    • Neurath, M.F.1
  • 13
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis
    • AUPHAN, N. et al. 1995. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 270: 286-290.
    • (1995) Science , vol.270 , pp. 286-290
    • Auphan, N.1
  • 14
    • 0032032469 scopus 로고    scopus 로고
    • Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B
    • WAHL, C. et al. 1998. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J. Clin. Invest. 101: 1163-1174.
    • (1998) J. Clin. Invest. , vol.101 , pp. 1163-1174
    • Wahl, C.1
  • 15
    • 0033543545 scopus 로고    scopus 로고
    • Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity
    • EGAN, L.J. et al. 1999. Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity. J. Biol. Chem. 274: 26448-26453.
    • (1999) J. Biol. Chem. , vol.274 , pp. 26448-26453
    • Egan, L.J.1
  • 16
    • 0033532386 scopus 로고    scopus 로고
    • The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
    • LI, Z.W. et al. 1999. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J. Exp. Med. 189: 1839-1845.
    • (1999) J. Exp. Med. , vol.189 , pp. 1839-1845
    • Li, Z.W.1
  • 17
    • 0033537739 scopus 로고    scopus 로고
    • Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
    • LI, Q. et al. 1999. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science 284: 321-325.
    • (1999) Science , vol.284 , pp. 321-325
    • Li, Q.1
  • 18
    • 0033634663 scopus 로고    scopus 로고
    • Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti
    • MAKRIS, C. et al. 2000. Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol. Cell. 5: 969-979.
    • (2000) Mol. Cell. , vol.5 , pp. 969-979
    • Makris, C.1
  • 19
    • 0034745021 scopus 로고    scopus 로고
    • IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis
    • SENFTLEBEN, U. et al. 2001. IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis. Immunity 14: 217-230.
    • (2001) Immunity , vol.14 , pp. 217-230
    • Senftleben, U.1
  • 20
    • 0141678951 scopus 로고    scopus 로고
    • Mature T cells depend on signaling through the IKK complex
    • SCHMIDT-SUPPRIAN, M. et al. 2003. Mature T cells depend on signaling through the IKK complex. Immunity 19: 377-389.
    • (2003) Immunity , vol.19 , pp. 377-389
    • Schmidt-Supprian, M.1
  • 21
    • 0037119628 scopus 로고    scopus 로고
    • IkappaB kinase signaling is essential for maintenance of mature B cells
    • PASPARAKIS, M., M. SCHMIDT-SUPPRIAN & K. RAJEWSKY. 2002. IkappaB kinase signaling is essential for maintenance of mature B cells. J. Exp. Med. 196: 743-752.
    • (2002) J. Exp. Med. , vol.196 , pp. 743-752
    • Pasparakis, M.1    Schmidt-Supprian, M.2    Rajewsky, K.3
  • 22
    • 0242416989 scopus 로고    scopus 로고
    • IKK beta is required for peripheral B cell survival and proliferation
    • LI, Z.W. et al. 2003. IKK beta is required for peripheral B cell survival and proliferation. J. Immunol. 170: 4630-4637.
    • (2003) J. Immunol. , vol.170 , pp. 4630-4637
    • Li, Z.W.1
  • 23
    • 0034957289 scopus 로고    scopus 로고
    • Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease
    • ITOH, J. et al. 2001. Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease. Gut 49: 35-41.
    • (2001) Gut , vol.49 , pp. 35-41
    • Itoh, J.1
  • 24
    • 0033565302 scopus 로고    scopus 로고
    • Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance
    • INA, K. et al. 1999. Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance. J. Immunol. 163: 1081-1090.
    • (1999) J. Immunol. , vol.163 , pp. 1081-1090
    • Ina, K.1
  • 25
    • 0033637315 scopus 로고    scopus 로고
    • DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA
    • CHU, W. et al. 2000. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell 103: 909-918.
    • (2000) Cell , vol.103 , pp. 909-918
    • Chu, W.1
  • 26
    • 4043088499 scopus 로고    scopus 로고
    • IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • GRETEN, F.R. et al. 2004. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118: 285-296.
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1
  • 27
    • 0036800129 scopus 로고    scopus 로고
    • Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell NF-kappaB and MAP kinase pathways and the upregulated expression of interleukin 8
    • BERIN, M.C. et al. 2002. Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell NF-kappaB and MAP kinase pathways and the upregulated expression of interleukin 8. Cell. Microbiol. 4: 635-648.
    • (2002) Cell. Microbiol. , vol.4 , pp. 635-648
    • Berin, M.C.1
  • 28
    • 0035044065 scopus 로고    scopus 로고
    • Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts
    • BERIN, M.C. et al. 2001. Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts. Am. J. Respir. Cell. Mol. Biol. 24: 382-389.
    • (2001) Am. J. Respir. Cell. Mol. Biol. , vol.24 , pp. 382-389
    • Berin, M.C.1
  • 29
    • 0034640417 scopus 로고    scopus 로고
    • Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria Salmonella
    • ECKMANN, L. et al. 2000. Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria Salmonella. J. Biol. Chem. 275: 14084-14094.
    • (2000) J. Biol. Chem. , vol.275 , pp. 14084-14094
    • Eckmann, L.1
  • 30
    • 1442306054 scopus 로고    scopus 로고
    • IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium
    • EGAN, L.J. et al. 2004. IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc. Natl. Acad. Sci. USA 101: 2452-2457.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 2452-2457
    • Egan, L.J.1
  • 31
    • 0038587747 scopus 로고    scopus 로고
    • The two faces of IKK and NF-kappaB inhibition: Prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
    • CHEN, L.W. et al. 2003. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat. Med. 9: 575-581.
    • (2003) Nat. Med. , vol.9 , pp. 575-581
    • Chen, L.W.1
  • 32
    • 0142052933 scopus 로고    scopus 로고
    • Nuclear factor-kappa B activation promotes restitution of wounded intestinal epithelial monolayers
    • EGAN, L.J. et al. 2003. Nuclear factor-kappa B activation promotes restitution of wounded intestinal epithelial monolayers. Am. J. Physiol. Cell. Physiol. 285: C1028-C1035.
    • (2003) Am. J. Physiol. Cell. Physiol. , vol.285
    • Egan, L.J.1
  • 33
    • 0037421484 scopus 로고    scopus 로고
    • NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia
    • DAJEE, M. et al. 2003. NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Nature 421: 639-643.
    • (2003) Nature , vol.421 , pp. 639-643
    • Dajee, M.1
  • 34
    • 0036742876 scopus 로고    scopus 로고
    • Cancer prevention in inflammatory bowel disease and the chemoprophylactic potential of 5-aminosalicylic acid
    • BERNSTEIN, C.N. et al. 2002. Cancer prevention in inflammatory bowel disease and the chemoprophylactic potential of 5-aminosalicylic acid. Inflamm. Bowel Dis. 8: 356-361.
    • (2002) Inflamm. Bowel Dis. , vol.8 , pp. 356-361
    • Bernstein, C.N.1
  • 35
    • 2942703810 scopus 로고    scopus 로고
    • Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo
    • JIMI, E. et al. 2004. Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat. Med. 10: 617-624.
    • (2004) Nat. Med. , vol.10 , pp. 617-624
    • Jimi, E.1
  • 36
    • 19344374949 scopus 로고    scopus 로고
    • 1{kappa}B kinase (IKK){beta}, but not lKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
    • RUOCCO, M.G. et al. 2005. 1{kappa}B kinase (IKK){beta}, but not lKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J. Exp. Med. 201: 1677-1687.
    • (2005) J. Exp. Med. , vol.201 , pp. 1677-1687
    • Ruocco, M.G.1


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