Simultaneous interruption of signal transduction and cell cycle regulatory pathways: Implications for new approaches to the treatment of childhood leukemias

Current Drug Targets

Volumn 8, Issue 6, 2007, Pages 751-759

  Grant, Steven ^a,b   Dent, Paul ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Cell cycle; Leukemia; Signal transduction

Indexed keywords

4 [N (2 HYDROXYETHYL) N [2 (3 INDOLYL)ETHYL]AMINOMETHYL]CINNAMOHYDROXAMIC ACID; 4 PHENYLBUTYRIC ACID; BORTEZOMIB; CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR; DEPSIPEPTIDE; FLAVOPIRIDOL; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; IMATINIB; MITOGEN ACTIVATED PROTEIN KINASE; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN BCL 2; VALPROIC ACID; VORINOSTAT; ANTINEOPLASTIC AGENT;

ACUTE LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CELL CYCLE; CELL CYCLE G1 PHASE; CELL SURVIVAL; CHRONIC MYELOID LEUKEMIA; DRUG INHIBITION; DRUG POTENTIATION; HUMAN; IN VITRO STUDY; PROTEIN DEGRADATION; REVIEW; SIGNAL TRANSDUCTION; CHILD; DRUG DELIVERY SYSTEM; DRUG EFFECT; LEUKEMIA; PATHOLOGY;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL CYCLE; CHILD; DRUG DELIVERY SYSTEMS; DRUG SYNERGISM; HUMANS; LEUKEMIA; SIGNAL TRANSDUCTION;

EID: 34447539610     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945007780830764     Document Type: Review

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