Potentiation of 1-β-D-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing Bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01)

Biochemical Pharmacology

Volumn 60, Issue 10, 2000, Pages 1445-1456

  Tang, Lin ^a   Boise, Lawrence H ^b   Dent, Paul ^a   Grant, Steven ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Ara C; Bcl 2; Leukemia; PKC; UCN 01

Indexed keywords

7 HYDROXYSTAUROSPORINE; CASPASE 3; CASPASE 9; CYTARABINE; CYTOCHROME C; ENZYME PRECURSOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEPTIDE FRAGMENT; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CELL CYCLE S PHASE; CELL STRAIN U937; CELL STRUCTURE; CLONOGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME RELEASE; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ALKALOIDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CYTARABINE; DRUG SYNERGISM; ENZYME INHIBITORS; HUMAN; LEUKEMIA; MITOCHONDRIA; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-BCL-2; SUPPORT, U.S. GOV'T, P.H.S.; U937 CELLS;

EID: 0034670161     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00463-9     Document Type: Article

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