Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals

Molecular and Cellular Biology

Volumn 21, Issue 7, 2001, Pages 2324-2336

  Von Gise, A ^a   Lorenz, P ^a   Wellbrock, C ^a   Hemmings, B ^a   Berberich Siebelt, F ^a   Rapp, U R ^a   Troppmair, J ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 3; INTERLEUKIN 3 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; RAF PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; ENZYME ACTIVATION; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; ENZYME ACTIVATION; HUMANS; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PLASMIDS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-RAF; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0035102807     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.7.2324-2336.2001     Document Type: Article

References (58)

1. Pharmacologic inhibitors of MKK1 and MKK2
2. Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1
3. Role of translocation in the activation and function of protein kinase
4. The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling
5. Mechanisms and control of programmed cell death in invertebrates
6. Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin
7. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
8. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
9. Interleukin-3 and granulocyte-macrophage colony-stimulating factor mediate rapid phosphorylation and activation of cytosolic c-raf
10. High-efficiency transformation of mammalian cells by plasmid DNA
11. Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: Conditional regulation of c-myc transcription by temperature-sensitive v-abl
12. v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells
13. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
14. Cellular survival: A play in three Akts
15. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
16. The ins and outs of Raf kinases
17. Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family
18. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
19. B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway
20. Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway
21. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
22. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85alpha
23. Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins
24. Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines
25. Cot protooncoprotein activates the dual specificity kinases MEK-1 and SEK-1 and induces differentiation of PC12 cells
26. The JNK/SAPK activator mixed lineage kinase 3 (MLK3) transforms NIH 3T3 cells in a MEK-dependent fashion
27. Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin
28. Role of raf and myc oncogenes in signal transduction
29. Akt signaling: Linking membrane events to life and death decisions
30. Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
31. Cell cycle targets of Ras/Raf signalling
32. Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1
33. Murine sarcoma growth factors affect the growth and morphology of cultured mouse epithelial cells
34. Ras promotes cell survival in Drosophila by down regulating hid expression
35. Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt
36. Transformation of mammalian cells by constitutively active MAP kinase kinase
37. Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes
38. Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta
39. Regulation of protein kinase
40. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
41. Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1)
42. A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation
43. NF-kappaB is a target of AKT in antiapoptotic PDGF signalling
44. Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt
45. Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: Involvement of MEK upstream of bad phosphorylation
46. Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase
47. Interleukin 3-dependent survival by the Akt protein kinase
48. Activated MEK stimulates expression of AP-I components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal to stimulate DNA synthesis
49. Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-I3-acetate requires Raf and is necessary for transformation
50. Activation of NF-kappa B by oncogenic Raf in HEK 293 cells occurs through autocrine recruitment of the stress kinase cascade
51. Signaling by distinct classes of phosphoinositide 3-kinases
52. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
53. Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase
54. Bcl-2 targets the protein kinase Raf-1 to mitochondria
55. Activation of phosphatidylinositol 3-kinase by a complex of p59fyn and the receptor tyrosine kinase Xmrk is involved in malignant transformation of pigment cells
56. Regulation of the p85/p110 phosphatidylinositol 3′-kinase: Stabilization and inhibition of the p110α catalytic subunit by the p85 regulatory subunit
57. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
58. Phosphorylation and regulation of Raf by Akt (protein kinase B)