-
1
-
-
0036738081
-
Novel therapeutics for the treatment of graft-versus-host disease
-
Jacobsohn DA: Novel therapeutics for the treatment of graft-versus-host disease. Expert Opin Investig Drugs 2002, 11:1271-1280.
-
(2002)
Expert Opin Investig Drugs
, vol.11
, pp. 1271-1280
-
-
Jacobsohn, D.A.1
-
2
-
-
0035904293
-
Rapamycin's resurrection: A new way to target the cancer cell cycle
-
Garber K: Rapamycin's resurrection: a new way to target the cancer cell cycle. J Natl Cancer Inst 2001, 93:1517-1519.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1517-1519
-
-
Garber, K.1
-
3
-
-
0035718899
-
Structure, function, and mechanism of the Hsp90 molecular chaperone
-
Pearl LH, Prodromou C: Structure, function, and mechanism of the Hsp90 molecular chaperone. Adv Protein Chem 2001, 59:157-186.
-
(2001)
Adv Protein Chem
, vol.59
, pp. 157-186
-
-
Pearl, L.H.1
Prodromou, C.2
-
4
-
-
85047695528
-
Hsp-90-associated oncoproteins: Multiple targets of gel-danamycin and its analogs
-
Blagosklonny MV: Hsp-90-associated oncoproteins: multiple targets of gel-danamycin and its analogs. Leukemia 2002, 16:455-462.
-
(2002)
Leukemia
, vol.16
, pp. 455-462
-
-
Blagosklonny, M.V.1
-
5
-
-
0036219609
-
Hsp90 inhibitors as novel cancer chemotherapeutic agents
-
Neckers L: Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med 2002, 8:S55-S61.
-
(2002)
Trends Mol Med
, vol.8
-
-
Neckers, L.1
-
6
-
-
0036810352
-
Heat-shock protein 90, a chaperone for folding and regulation
-
Picard D: Heat-shock protein 90, a chaperone for folding and regulation. Cell Mol Life Sci 2002, 59:1640-1648.
-
(2002)
Cell Mol Life Sci
, vol.59
, pp. 1640-1648
-
-
Picard, D.1
-
7
-
-
0036919003
-
Pharmacogenomics in cancer drug discovery and development: Inhibitors of the Hsp90 molecular chaperone
-
Workman P: Pharmacogenomics in cancer drug discovery and development: inhibitors of the Hsp90 molecular chaperone. Cancer Detect Prev 2002, 26:405-410.
-
(2002)
Cancer Detect Prev
, vol.26
, pp. 405-410
-
-
Workman, P.1
-
8
-
-
0043288724
-
Heat shock protein 90 as a molecular target for cancer therapeutics
-
Isaacs JS, Xu W, Neckers L: Heat shock protein 90 as a molecular target for cancer therapeutics. Cancer Cell 2003, 3:213-217.
-
(2003)
Cancer Cell
, vol.3
, pp. 213-217
-
-
Isaacs, J.S.1
Xu, W.2
Neckers, L.3
-
9
-
-
0036461583
-
Effect of geldanamycin on androgen receptor function and stability
-
Vanaja DK, Mitchell SH, Toft DO, et al.: Effect of geldanamycin on androgen receptor function and stability. Cell Stress Chaperones 2002, 7:55-64. A comprehensive analysis of the role of Hsp90 in androgen receptor ligand binding and stability.
-
(2002)
Cell Stress Chaperones
, vol.7
, pp. 55-64
-
-
Vanaja, D.K.1
Mitchell, S.H.2
Toft, D.O.3
-
10
-
-
0036786205
-
Mechanism of antiandrogen action: Key role of Hsp90 in conformational change and transcriptional activity of the androgen receptor
-
Mosc
-
Georget V, Terouanne B, Nicolas J-C, et al.: Mechanism of antiandrogen action: key role of Hsp90 in conformational change and transcriptional activity of the androgen receptor. Biochemistry (Mosc) 2002, 41:11824-11831. A careful cell biology-based analysis of Hsp90 mediation of androgen receptor signaling.
-
(2002)
Biochemistry
, vol.41
, pp. 11824-11831
-
-
Georget, V.1
Terouanne, B.2
Nicolas, J.-C.3
-
11
-
-
0036091221
-
17-Allylamino-17-demthoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts
-
Solit D, Zheng F, Drobnjak M, et al. 17-Allylamino-17- demthoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts. Clin Cancer Res 2002:986-993. An exciting preclinical study demonstrating the in vivo effectiveness of 17-AAG in both a hormone-dependent and hormone-independent xenograft model of prostate cancer.
-
(2002)
Clin Cancer Res
, pp. 986-993
-
-
Solit, D.1
Zheng, F.2
Drobnjak, M.3
-
12
-
-
0037131187
-
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function
-
Basso AD, Solit DB, Chiosis G, et al.: Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem 2002, 277:39858-39866. A comprehensive biochemical analysis of the role of Hsp90 in the stability and function of Akt.
-
(2002)
J Biol Chem
, vol.277
, pp. 39858-39866
-
-
Basso, A.D.1
Solit, D.B.2
Chiosis, G.3
-
13
-
-
0037075232
-
Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2
-
Basso AD, Solit DB, Munster PN, et al.: Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2. Oncogene 2002, 21:1159-1166. An important study that highlights the supersensitivity of Akt to Hsp90 inhibition in the context of Her2 overexpression.
-
(2002)
Oncogene
, vol.21
, pp. 1159-1166
-
-
Basso, A.D.1
Solit, D.B.2
Munster, P.N.3
-
14
-
-
0036606332
-
Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3′-kinase-AKT-dependent pathway
-
Munster PN, Marchion DC, Basso AD, Rosen N: Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3′-kinase-AKT-dependent pathway. Cancer Res 2002, 62:3132-3137. A report of preclinical data documenting the ability of 17-AAG to enhance the toxicity of Taxol in a Her-2-overexpressing breast cancer xenograft model.
-
(2002)
Cancer Res
, vol.62
, pp. 3132-3137
-
-
Munster, P.N.1
Marchion, D.C.2
Basso, A.D.3
Rosen, N.4
-
15
-
-
0036339108
-
ErbB2 overexpression in an ovarian cancer cell line confers sensitivity to the HSP90 inhibitor geldanamycin
-
Smith V, Hobbs S, Court W, et al.: ErbB2 overexpression in an ovarian cancer cell line confers sensitivity to the HSP90 inhibitor geldanamycin. Anticancer Res 2002, 22:1993-1999.
-
(2002)
Anticancer Res
, vol.22
, pp. 1993-1999
-
-
Smith, V.1
Hobbs, S.2
Court, W.3
-
16
-
-
0036359548
-
Hypoxia - A key regulatory factor in tumor growth
-
Harris AL: Hypoxia - a key regulatory factor in tumor growth. Nat Rev Cancer 2002, 2:38-47.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
17
-
-
0033587146
-
The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang G-W, et al.: The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999, 399:271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.-W.3
-
18
-
-
0023865666
-
Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma
-
Seizinger BR, Rouleau GA, Ozelius LJ, et al.: Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature 1988, 332:268-269.
-
(1988)
Nature
, vol.332
, pp. 268-269
-
-
Seizinger, B.R.1
Rouleau, G.A.2
Ozelius, L.J.3
-
19
-
-
0029789568
-
Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of the Arnt transcription factor
-
Gradin K, McGuire J, Wenger RH, et al.: Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Mol Cell Biol 1996, 16:5221-5231.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 5221-5231
-
-
Gradin, K.1
McGuire, J.2
Wenger, R.H.3
-
20
-
-
0036841843
-
Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol
-
Hur E, Kim HH, Choi SM, et al.: Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol. Mol Pharmacol 2002, 62:975-982. A description of the effects of an alternative Hsp90 inhibitor on the stability and function of HIF-1α.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 975-982
-
-
Hur, E.1
Kim, H.H.2
Choi, S.M.3
-
21
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
-
Isaacs JS, Jung YJ, Mimnaugh EG, et al.: Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. J Biol Chem 2002, 277:29936-29944. The first report showing that Hsp90-dependent stabilization of HIF-1α is independent of VHL, thus identifying a second, chaperone-dependent HIF-1α degradative pathway.
-
(2002)
J Biol Chem
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
-
22
-
-
0036569704
-
Geldanamycin induces degradation of hypoxia-inducible factor 1α protein via the proteasome pathway in prostate cancer cells
-
Mabjeesh NJ, Post DE, Willard MT, et al.: Geldanamycin induces degradation of hypoxia-inducible factor 1α protein via the proteasome pathway in prostate cancer cells. Cancer Res 2002, 62:2478-2482. An article that documents the sensitivity of HIF-1α to Hsp90 inhibition in normoxic prostate cancer cells.
-
(2002)
Cancer Res
, vol.62
, pp. 2478-2482
-
-
Mabjeesh, N.J.1
Post, D.E.2
Willard, M.T.3
-
23
-
-
0037784052
-
Geldanamycin inhibits migration of glioma cells in vitro: A potential role for hypoxia-inducible factor (HIF-1 alpha) in glioma cell invasion
-
Zagzag D, Nomura M, Friedlander DR, et al.: Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1 alpha) in glioma cell invasion. J Cell Physiol 2003, 196:394-402. A study that correlates Hsp90 inhibition in glioma cells with inhibition of motility.
-
(2003)
J Cell Physiol
, vol.196
, pp. 394-402
-
-
Zagzag, D.1
Nomura, M.2
Friedlander, D.R.3
-
24
-
-
0036530301
-
VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition
-
Dias S, Shmelkov SV, Lam G, et al.: VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition. Blood 2002, 99:2532-2540. A comprehensive report demonstrating the key role of Hsp90 in mediating VEGF induced survival of both endothelial and cancer cells.
-
(2002)
Blood
, vol.99
, pp. 2532-2540
-
-
Dias, S.1
Shmelkov, S.V.2
Lam, G.3
-
25
-
-
0036188465
-
Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer
-
Maulik G, Kijima T, Ma PC, et al.: Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer. Clin Cancer Res 2002, 8:620-627. A key study demonstrating that Hsp90 inhibitors can downregulate Met kinase function in small-cell lung cancer cells.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 620-627
-
-
Maulik, G.1
Kijima, T.2
Ma, P.C.3
-
26
-
-
0037478437
-
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
-
Pennacchietti S, Michieli P, Galluzzo M, et al.: Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003, 3:347-361. An important article that documents hypoxia-induced activation of the Met pathway.
-
(2003)
Cancer Cell
, vol.3
, pp. 347-361
-
-
Pennacchietti, S.1
Michieli, P.2
Galluzzo, M.3
-
27
-
-
0034816327
-
Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells
-
Tacchini L, Dansi P, Matteucci E, et al.: Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells. Carcinogenesis 2001, 22:1363-1371.
-
(2001)
Carcinogenesis
, vol.22
, pp. 1363-1371
-
-
Tacchini, L.1
Dansi, P.2
Matteucci, E.3
-
28
-
-
0038172576
-
Out of air is not out of action
-
Bottaro DP, Liotta LA: Out of air is not out of action. Nature 2003, 423:593-595.
-
(2003)
Nature
, vol.423
, pp. 593-595
-
-
Bottaro, D.P.1
Liotta, L.A.2
-
29
-
-
0029812759
-
Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin
-
Mimnaugh EG, Chavany C, Neckers L: Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin. J Biol Chem 1996, 271:22796-22801.
-
(1996)
J Biol Chem
, vol.271
, pp. 22796-22801
-
-
Mimnaugh, E.G.1
Chavany, C.2
Neckers, L.3
-
30
-
-
0029963674
-
Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90
-
Schneider C, Sepp-Lorenzino L, Nimmesgern E, et al.: Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90. Proc Natl Acad Sci U S A 1996, 93:14536-14541.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 14536-14541
-
-
Schneider, C.1
Sepp-Lorenzino, L.2
Nimmesgern, E.3
-
31
-
-
0033863883
-
The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome
-
An WG, Schulte TW, Neckers LM: The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome. Cell Growth Differ 2000, 11:355-360.
-
(2000)
Cell Growth Differ
, vol.11
, pp. 355-360
-
-
An, W.G.1
Schulte, T.W.2
Neckers, L.M.3
-
32
-
-
0035680611
-
Aggresome formation in liver cells in response to different toxic mechanisms: Role of the ubiquitin-proteasome pathway and the frameshift mutant of ubiquitin
-
French BA, van Leeuwen F, Riley NE, et al.: Aggresome formation in liver cells in response to different toxic mechanisms: role of the ubiquitin-proteasome pathway and the frameshift mutant of ubiquitin. Exp Mol Pathol 2001, 71:241-246.
-
(2001)
Exp Mol Pathol
, vol.71
, pp. 241-246
-
-
French, B.A.1
Van Leeuwen, F.2
Riley, N.E.3
-
33
-
-
0034754875
-
Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation
-
Waelter S, Boeddrich A, Lurz R, et al.: Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation. Mol Biol Cell 2001, 12:1393-1407.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 1393-1407
-
-
Waelter, S.1
Boeddrich, A.2
Lurz, R.3
-
34
-
-
0036023407
-
A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies
-
Aghajanian C, Soignet S, Dizon DS, et al.: A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies. Clin Cancer Res 2002, 8:2505-2511.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2505-2511
-
-
Aghajanian, C.1
Soignet, S.2
Dizon, D.S.3
-
35
-
-
18344412545
-
Update on ... the proteasome inhibitor PS341
-
L'Allemain G: [Update on ... the proteasome inhibitor PS341]. Bull Cancer 2002, 89:29-30.
-
(2002)
Bull Cancer
, vol.89
, pp. 29-30
-
-
L'Allemain, G.1
-
36
-
-
0242496212
-
Molecular sequelae of proteasome inhibition in human multiple myeloma cells
-
Mitsiades N, Mitsiades CS, Poulaki V, et al.: Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc Natl Acad Sci USA 2002, 99:14374-14379. A study showing that simultaneous addition of an Hsp90 inhibitor enhances the toxicity of a proteasome inhibitor in myeloma cells.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 14374-14379
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
-
37
-
-
0030003813
-
Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)
-
Fujimoto J, Shiota M, Iwahara T, et al.: Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5). Proc Natl Acad Sci USA 1996, 93:4181-4186.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 4181-4186
-
-
Fujimoto, J.1
Shiota, M.2
Iwahara, T.3
-
38
-
-
0036494113
-
Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: Down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin
-
Bonvini P, Gastaldi T, Falini B, et al.: Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17- demethoxygeldanamycin. Cancer Res 2002, 62:1559-1566. The first report to identify the lymphoma associated chimeric kinase NPM-ALK as an Hsp90 client sensitive to 17-AAG.
-
(2002)
Cancer Res
, vol.62
, pp. 1559-1566
-
-
Bonvini, P.1
Gastaldi, T.2
Falini, B.3
-
39
-
-
0002470404
-
FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy
-
Naoe T, Kiyoe H, Yamamoto Y, et al.: FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy. Cancer Chemother Pharmacol 2001, 48:S27-S30.
-
(2001)
Cancer Chemother Pharmacol
, vol.48
-
-
Naoe, T.1
Kiyoe, H.2
Yamamoto, Y.3
-
40
-
-
0036050018
-
Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors
-
Minami Y, Kiyoi H, Yamamoto Y, et al.: Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors. Leukemia 2002, 16:1535-1540. A study demonstrating the Hsp90 dependence of mutated FLT3 kinase, and the enhanced sensitivity of leukemia cells harboring this mutation to Hsp90 inhibition.
-
(2002)
Leukemia
, vol.16
, pp. 1535-1540
-
-
Minami, Y.1
Kiyoi, H.2
Yamamoto, Y.3
-
41
-
-
0034665760
-
Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex
-
Shiotsu Y, Neckers LM, Wortman I, et al.: Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex. Blood 2000, 96:2284-2291.
-
(2000)
Blood
, vol.96
, pp. 2284-2291
-
-
Shiotsu, Y.1
Neckers, L.M.2
Wortman, I.3
-
42
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker BJ, Tamura S, Buchdunger E, et al.: Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996, 2:561-566.
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
43
-
-
0037093092
-
Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
-
Sawyers CL, Hochhaus A, Feldman E, et al.: Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood 2002, 99:3530-3539.
-
(2002)
Blood
, vol.99
, pp. 3530-3539
-
-
Sawyers, C.L.1
Hochhaus, A.2
Feldman, E.3
-
44
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah NP, Nicoll JM, Nagar B, et al.: Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2002, 2:117-125. A demonstration that BCR-ABL kinase domain mutations that confer resistance to imatinib may be preexisting in patients with untreated chronic myeloid leukemia, and selected as a direct result of treatment with imatinib.
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.M.2
Nagar, B.3
-
45
-
-
0037108448
-
BCR-ABL point mutants isolated from patients with STI571-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90
-
Gorre ME, Ellwood-Yen K, Chiosis G, et al.: BCR-ABL point mutants isolated from patients with STI571-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90. Blood 2002, 100:3041-3044. A careful study that documents the continued Hsp90 dependence of imatinib-resistant BCR-ABL protein, and thus its continued sensitivity to 17-AAG.
-
(2002)
Blood
, vol.100
, pp. 3041-3044
-
-
Gorre, M.E.1
Ellwood-Yen, K.2
Chiosis, G.3
-
46
-
-
0037108879
-
Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin
-
Nimmanapalli R, O'Bryan E, Huang M, et al.: Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin. Cancer Res 2002, 62:5761-5769. A study that corroborates the findings reported in the previous reference, further strengthening the case for treatment of imatinib-resistant CML with 17-AAG.
-
(2002)
Cancer Res
, vol.62
, pp. 5761-5769
-
-
Nimmanapalli, R.1
O'Bryan, E.2
Huang, M.3
-
47
-
-
0000235617
-
Phase I trial of 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) in patients with advanced solid malignancies
-
Munster PN, Tong W, Schwartz L, et al.: Phase I trial of 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) in patients with advanced solid malignancies. Proc Am Soc Clin Oncol 2001b, 20:A326.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Munster, P.N.1
Tong, W.2
Schwartz, L.3
-
48
-
-
0141691597
-
A pharmacokinetically (Pk)-pharmacodynamically (Pd) driven phase I trial of the Hsp90 molecular chaperone inhibitor 17-allyamino 17- demethoxygeldanamycin (17AAG)
-
Banerji U, O'Donnell A, Scurr M, et al.: A pharmacokinetically (Pk)-pharmacodynamically (Pd) driven phase I trial of the Hsp90 molecular chaperone inhibitor 17-allyamino 17-demethoxygeldanamycin (17AAG). Proc 93rd Annu Meet Am Assoc Cancer Res 2002, 43:A1352.
-
(2002)
Proc 93rd Annu Meet Am Assoc Cancer Res
, vol.43
-
-
Banerji, U.1
O'Donnell, A.2
Scurr, M.3
-
49
-
-
0742302722
-
Clinical pharmacokinetics of 17-(allylamino)-17-demethoxygeldanamycin and the active metabolite 17-(amino)-17-demethoxygeldanamycin given as a one-hour infusion daily for 5 days
-
Agnew EB, Wilson RH, Morrison G, et al.: Clinical pharmacokinetics of 17-(allylamino)-17-demethoxygeldanamycin and the active metabolite 17-(amino)-17-demethoxygeldanamycin given as a one-hour infusion daily for 5 days. Proc 93rd Annu Meet Am Assoc Cancer Res 2002;43:A1349.
-
(2002)
Proc 93rd Annu Meet Am Assoc Cancer Res
, vol.43
-
-
Agnew, E.B.1
Wilson, R.H.2
Morrison, G.3
|