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Volumn 103, Issue 8, 2004, Pages 3167-3174

BCR/ABL kinase inhibition by imatinib mesylate enhances MAP kinase activity in chronic myelogenous leukemia CD34+ cells

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; BCR ABL PROTEIN; CD34 ANTIGEN; IMATINIB; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

EID: 1842474838     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-04-1271     Document Type: Article
Times cited : (145)

References (59)
  • 1
    • 0033614446 scopus 로고    scopus 로고
    • Chronic myeloid leukemia
    • Sawyers CL. Chronic myeloid leukemia. N Engl J Med. 1999;340:1330-1340.
    • (1999) N Engl J Med , vol.340 , pp. 1330-1340
    • Sawyers, C.L.1
  • 2
    • 85014195943 scopus 로고    scopus 로고
    • Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia
    • Holyoake TL, Jiang X, Drummond MW, Eaves AC, Eaves CJ. Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia. Leukemia. 2002;16:549-558.
    • (2002) Leukemia , vol.16 , pp. 549-558
    • Holyoake, T.L.1    Jiang, X.2    Drummond, M.W.3    Eaves, A.C.4    Eaves, C.J.5
  • 3
    • 0015694748 scopus 로고
    • A new consistent chromosome abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley JD. A new consistent chromosome abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining. Nature. 1973;243:209-213.
    • (1973) Nature , vol.243 , pp. 209-213
    • Rowley, J.D.1
  • 4
    • 0020333906 scopus 로고
    • A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukemia
    • DeKlein A, Van Kessel AG, Grosveld G, et al. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukemia. Nature. 1982;300:765-767.
    • (1982) Nature , vol.300 , pp. 765-767
    • DeKlein, A.1    Van Kessel, A.G.2    Grosveld, G.3
  • 5
    • 0001044842 scopus 로고
    • Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic leukemia-specific P210bcr/abl protein
    • Daley GQ, Baltimore D. Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic leukemia-specific P210bcr/abl protein. Proc Natl Acad Sci U S A. 1988;85:9312-9316.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 9312-9316
    • Daley, G.Q.1    Baltimore, D.2
  • 6
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
    • Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science. 1990;247:824-827.
    • (1990) Science , vol.247 , pp. 824-827
    • Daley, G.Q.1    Van Etten, R.A.2    Baltimore, D.3
  • 7
    • 0032533257 scopus 로고    scopus 로고
    • Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow
    • Pear WS, Miller JP, Xu L, et al. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood. 1998;92:3780-3792.
    • (1998) Blood , vol.92 , pp. 3780-3792
    • Pear, W.S.1    Miller, J.P.2    Xu, L.3
  • 8
    • 0025924674 scopus 로고
    • Activation of tyrosine kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins
    • McWhirter JR, Wang JYJ. Activation of tyrosine kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins. Mol Cell Biol. 1991;11:1553-1565.
    • (1991) Mol Cell Biol , vol.11 , pp. 1553-1565
    • McWhirter, J.R.1    Wang, J.Y.J.2
  • 9
    • 0025348013 scopus 로고
    • Tyrosine kinase activity and transformation potency of bcr/abl oncogene products
    • Lugo T, Pendergast A, Muller A, Witte O. Tyrosine kinase activity and transformation potency of bcr/abl oncogene products. Science. 1990;237:1079-1082.
    • (1990) Science , vol.237 , pp. 1079-1082
    • Lugo, T.1    Pendergast, A.2    Muller, A.3    Witte, O.4
  • 10
    • 0030725775 scopus 로고    scopus 로고
    • The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates GI-to-S phase transition in hematopoietic cells
    • Cortez D, Reuther G, Pendergast AM. The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates GI-to-S phase transition in hematopoietic cells. Oncogene. 1997;15:2333-2342.
    • (1997) Oncogene , vol.15 , pp. 2333-2342
    • Cortez, D.1    Reuther, G.2    Pendergast, A.M.3
  • 11
    • 0037186924 scopus 로고    scopus 로고
    • Imatinib mesylate: A new oral targeted therapy
    • Savage DG, Antman KH. Imatinib mesylate: a new oral targeted therapy. N Engl J Med. 2002;346:683-693.
    • (2002) N Engl J Med , vol.346 , pp. 683-693
    • Savage, D.G.1    Antman, K.H.2
  • 12
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker B, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 1996;2:561-566.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.1    Tamura, S.2    Buchdunger, E.3
  • 13
    • 0037254419 scopus 로고    scopus 로고
    • Imatinib alone and in combination for chronic myeloid leukemia
    • Druker BJ. Imatinib alone and in combination for chronic myeloid leukemia. Semin Hematol. 2003;40:50-58.
    • (2003) Semin Hematol , vol.40 , pp. 50-58
    • Druker, B.J.1
  • 14
    • 0000199137 scopus 로고    scopus 로고
    • Clinical efficacy and safety of an ABL specific tyrosine kinase inhibitor as targeted therapy for chronic myelogenous leukemia
    • Druker BJ, Talpaz M, Resta D, et al. Clinical efficacy and safety of an ABL specific tyrosine kinase inhibitor as targeted therapy for chronic myelogenous leukemia [abstract]. Blood. 1999;94:368A.
    • (1999) Blood , vol.94
    • Druker, B.J.1    Talpaz, M.2    Resta, D.3
  • 15
    • 0037186915 scopus 로고    scopus 로고
    • Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
    • Kantarjian H, Sawyers C, Hochhaus A, et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med. 2002;346:645-652.
    • (2002) N Engl J Med , vol.346 , pp. 645-652
    • Kantarjian, H.1    Sawyers, C.2    Hochhaus, A.3
  • 16
    • 0037085785 scopus 로고    scopus 로고
    • Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
    • Talpaz M, Silver RT, Druker BJ, et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood. 2002;99:1928-1937.
    • (2002) Blood , vol.99 , pp. 1928-1937
    • Talpaz, M.1    Silver, R.T.2    Druker, B.J.3
  • 17
    • 0037093092 scopus 로고    scopus 로고
    • Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
    • Sawyers CL, Hochhaus A, Feldman E, et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood. 2002;99:3530-3539.
    • (2002) Blood , vol.99 , pp. 3530-3539
    • Sawyers, C.L.1    Hochhaus, A.2    Feldman, E.3
  • 18
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2003;348:994-1004.
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 19
    • 0037568145 scopus 로고    scopus 로고
    • Molecular responses to imatinib (STI571) or interferon + Ara-C as initial therapy for CML: Results in the IRIS study
    • Hughes T, Kaeda J, Branford S, et al. Molecular responses to imatinib (STI571) or interferon + Ara-C as initial therapy for CML: results in the IRIS study [abstract]. Blood. 2002;100:93A.
    • (2002) Blood , vol.100
    • Hughes, T.1    Kaeda, J.2    Branford, S.3
  • 20
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myelogenous leukemia and in acute lymphoblastic lymphoma with the Philadelphia chromosome
    • Druker BJ, Sawyers CS, Kantarjian H, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myelogenous leukemia and in acute lymphoblastic lymphoma with the Philadelphia chromosome. N Engl J Med. 2001;344:1038-1042.
    • (2001) N Engl J Med , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.S.2    Kantarjian, H.3
  • 21
    • 0037093082 scopus 로고    scopus 로고
    • Gleevec (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation
    • Holtz M, Slovak M, Zhang F, Sawyers C, Forman S, Bhatia R. Gleevec (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation. Blood. 2002;99:3792-3800.
    • (2002) Blood , vol.99 , pp. 3792-3800
    • Holtz, M.1    Slovak, M.2    Zhang, F.3    Sawyers, C.4    Forman, S.5    Bhatia, R.6
  • 22
    • 0034018326 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor STI571, like interferon-alpha, preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors from patients with chronic myeloid leukemia
    • Marley S, Deininger M, Davidson RJ, Goldman J, Gordon M. The tyrosine kinase inhibitor STI571, like interferon-alpha, preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors from patients with chronic myeloid leukemia. Exp Hematol. 2000;28:551-557.
    • (2000) Exp Hematol , vol.28 , pp. 551-557
    • Marley, S.1    Deininger, M.2    Davidson, R.J.3    Goldman, J.4    Gordon, M.5
  • 23
    • 0030853063 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells
    • Deininger MW, Goldman JM, Lydon N, Melo JV. The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells. Blood. 1997;90:3691-3698.
    • (1997) Blood , vol.90 , pp. 3691-3698
    • Deininger, M.W.1    Goldman, J.M.2    Lydon, N.3    Melo, J.V.4
  • 24
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    • Graham SM, Jorgensen HG, Allan E, et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 2002;99:319-325.
    • (2002) Blood , vol.99 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3
  • 25
    • 0038454621 scopus 로고    scopus 로고
    • Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
    • Bhatia R, Holtz M, Niu N, et al. Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood. 2003;101:4701-4707.
    • (2003) Blood , vol.101 , pp. 4701-4707
    • Bhatia, R.1    Holtz, M.2    Niu, N.3
  • 26
    • 0030471795 scopus 로고    scopus 로고
    • The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway
    • Cortez D, Stoica G, Pierce JH, Pendergast AM. The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway. Oncogene. 1996;13:2589-2594.
    • (1996) Oncogene , vol.13 , pp. 2589-2594
    • Cortez, D.1    Stoica, G.2    Pierce, J.H.3    Pendergast, A.M.4
  • 27
    • 0029087475 scopus 로고
    • Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene
    • Goga A, McLaughlin J, Afar DEH, Saffran DC, Witte ON. Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene. Cell. 1995;82:981-988.
    • (1995) Cell , vol.82 , pp. 981-988
    • Goga, A.1    McLaughlin, J.2    Afar, D.E.H.3    Saffran, D.C.4    Witte, O.N.5
  • 28
    • 0034997845 scopus 로고    scopus 로고
    • Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
    • Pearson G, Robinson F, Beers Gibson T, et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev. 2001;22:153-183.
    • (2001) Endocr Rev , vol.22 , pp. 153-183
    • Pearson, G.1    Robinson, F.2    Beers Gibson, T.3
  • 29
    • 0034719381 scopus 로고    scopus 로고
    • A conditionally active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells
    • Blalock WL, Pearce M, Steelman LS, et al. A conditionally active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells. Oncogene. 2000;19:526-536.
    • (2000) Oncogene , vol.19 , pp. 526-536
    • Blalock, W.L.1    Pearce, M.2    Steelman, L.S.3
  • 30
    • 0037806885 scopus 로고    scopus 로고
    • Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ ERK pathway
    • Chang F, Steelman LS, Shelton JG, et al. Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (review). Int J Oncol. 2003;22:469-480.
    • (2003) Int J Oncol , vol.22 , pp. 469-480
    • Chang, F.1    Steelman, L.S.2    Shelton, J.G.3
  • 31
    • 0034001970 scopus 로고    scopus 로고
    • The inhibition of ERK/MAPK not the activation of JNK/SAPK is primarily required to induce apoptosis in chronic myelogenous leukemic K562 cells
    • Kang CD, Yoo SD, Hwang BW, et al. The inhibition of ERK/MAPK not the activation of JNK/SAPK is primarily required to induce apoptosis in chronic myelogenous leukemic K562 cells. Leuk Res. 2000;24:527-534.
    • (2000) Leuk Res , vol.24 , pp. 527-534
    • Kang, C.D.1    Yoo, S.D.2    Hwang, B.W.3
  • 32
    • 0027851829 scopus 로고
    • Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line
    • Matulonis U, Salgia R, Okuda K, Druker B, Griffin JD. Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line. Exp Hematol. 1993;21:1460-1466.
    • (1993) Exp Hematol , vol.21 , pp. 1460-1466
    • Matulonis, U.1    Salgia, R.2    Okuda, K.3    Druker, B.4    Griffin, J.D.5
  • 33
    • 0029029421 scopus 로고
    • C-RAF-1 serine/threonine kinase is required in BCR/ABL-dependent and normal hematopoiesis
    • Skorski T, Nieborowska-Skorska M, Szczytik C, et al. C-RAF-1 serine/threonine kinase is required in BCR/ABL-dependent and normal hematopoiesis. Cancer Res. 1995;55:2275-2278.
    • (1995) Cancer Res , vol.55 , pp. 2275-2278
    • Skorski, T.1    Nieborowska-Skorska, M.2    Szczytik, C.3
  • 34
    • 0035298060 scopus 로고    scopus 로고
    • Role of ERK activation in growth and erythroid differentiation of K562 cells
    • Woessmann W, Mivechi NF. Role of ERK activation in growth and erythroid differentiation of K562 cells. Exp Cell Res. 2001;264:193-200.
    • (2001) Exp Cell Res , vol.264 , pp. 193-200
    • Woessmann, W.1    Mivechi, N.F.2
  • 35
    • 0029010504 scopus 로고
    • Abnormal function of the bone marrow microenvironment in chronic myelogenous leukemia: Role of malignant stromal macrophages
    • Bhatia R, McGlave PB, Dewald GW, Blazar BR, Verfaillie CM. Abnormal function of the bone marrow microenvironment in chronic myelogenous leukemia: role of malignant stromal macrophages. Blood. 1995;85:3636-3845.
    • (1995) Blood , vol.85 , pp. 3636-3845
    • Bhatia, R.1    McGlave, P.B.2    Dewald, G.W.3    Blazar, B.R.4    Verfaillie, C.M.5
  • 36
    • 0030849526 scopus 로고    scopus 로고
    • A clinically suitable ex vivo expansion culture system for LTC-IC and CFC using stroma-conditioned medium
    • Bhatia R, McGlave PB, Miller JS, Wissink S, Lin WN, Verfaillie CM. A clinically suitable ex vivo expansion culture system for LTC-IC and CFC using stroma-conditioned medium. Exp Hematol. 1997;25:980-991.
    • (1997) Exp Hematol , vol.25 , pp. 980-991
    • Bhatia, R.1    McGlave, P.B.2    Miller, J.S.3    Wissink, S.4    Lin, W.N.5    Verfaillie, C.M.6
  • 37
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science. 2001;293:876-880.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 38
    • 0037194613 scopus 로고    scopus 로고
    • Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571
    • Klejman A, Rushen L, Morrione A, Slupianek A, Skorski T. Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571. Oncogene. 2002;21:5868-5876.
    • (2002) Oncogene , vol.21 , pp. 5868-5876
    • Klejman, A.1    Rushen, L.2    Morrione, A.3    Slupianek, A.4    Skorski, T.5
  • 39
    • 0028142490 scopus 로고
    • Crk1 is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia
    • Oda T, Heaney C, Hagopian JR, Okuda K, Griffin JD, Druker BJ. Crk1 is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia. J Biol Chem. 1994;269:22925-22928.
    • (1994) J Biol Chem , vol.269 , pp. 22925-22928
    • Oda, T.1    Heaney, C.2    Hagopian, J.R.3    Okuda, K.4    Griffin, J.D.5    Druker, B.J.6
  • 40
    • 0031900740 scopus 로고    scopus 로고
    • Signal transduction through MAP kinase cascades
    • Lewis TS, Shapiro PS, Ahn NG. Signal transduction through MAP kinase cascades. Adv Cancer Res. 1998;74:49-139.
    • (1998) Adv Cancer Res , vol.74 , pp. 49-139
    • Lewis, T.S.1    Shapiro, P.S.2    Ahn, N.G.3
  • 41
    • 0035869396 scopus 로고    scopus 로고
    • Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling
    • Morgan MA, Dolp O, Reuter CW. Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling. Blood. 2001;97:1823-1834.
    • (2001) Blood , vol.97 , pp. 1823-1834
    • Morgan, M.A.1    Dolp, O.2    Reuter, C.W.3
  • 42
    • 0031869466 scopus 로고    scopus 로고
    • Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR-ABL tyrosine kinase, CGP 57148
    • Dan S, Naito M, Tsuruo T. Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR-ABL tyrosine kinase, CGP 57148. Cell Death Differ. 1998;5:710-715.
    • (1998) Cell Death Differ , vol.5 , pp. 710-715
    • Dan, S.1    Naito, M.2    Tsuruo, T.3
  • 43
    • 0036142963 scopus 로고    scopus 로고
    • Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells
    • Yu C, Krystal G, Varticovksi L, et al. Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells. Cancer Res. 2002;62:188-199.
    • (2002) Cancer Res , vol.62 , pp. 188-199
    • Yu, C.1    Krystal, G.2    Varticovksi, L.3
  • 44
    • 0032189475 scopus 로고    scopus 로고
    • Stem cell factor as a single agent induces selective proliferation of the Philadelphia chromosome positive fraction of chronic myeloid leukemia CD34(+) cells
    • Moore S, Haylock DN, Levesque JP, et al. Stem cell factor as a single agent induces selective proliferation of the Philadelphia chromosome positive fraction of chronic myeloid leukemia CD34(+) cells. Blood. 1998;92:2461-2470.
    • (1998) Blood , vol.92 , pp. 2461-2470
    • Moore, S.1    Haylock, D.N.2    Levesque, J.P.3
  • 45
    • 0034176883 scopus 로고    scopus 로고
    • Cytogenetics of the chronic myeloid leukemia-derived cell line K562: Karyotype clarification by multicolor fluorescence in situ hybridization, comparative genomic hybridization, and focus-specific fluorescence in situ hybridization
    • Gribble SM, Roberts I, Grace C, Andrews KM, Green AR, Nacheva EP. Cytogenetics of the chronic myeloid leukemia-derived cell line K562: karyotype clarification by multicolor fluorescence in situ hybridization, comparative genomic hybridization, and focus-specific fluorescence in situ hybridization. Cancer Genet Cytogenet. 2000;118:1-8.
    • (2000) Cancer Genet Cytogenet , vol.118 , pp. 1-8
    • Gribble, S.M.1    Roberts, I.2    Grace, C.3    Andrews, K.M.4    Green, A.R.5    Nacheva, E.P.6
  • 46
    • 0036932844 scopus 로고    scopus 로고
    • Comparison of competitive-nested PCR and real-time PCR in detecting BCR-ABL fusion transcripts in chronic myeloid leukemia patients
    • Guo JQ, Lin H, Kantarjian H, et al. Comparison of competitive-nested PCR and real-time PCR in detecting BCR-ABL fusion transcripts in chronic myeloid leukemia patients. Leukemia. 2002;16:2447-2453.
    • (2002) Leukemia , vol.16 , pp. 2447-2453
    • Guo, J.Q.1    Lin, H.2    Kantarjian, H.3
  • 47
    • 0034039177 scopus 로고    scopus 로고
    • Biological effects induced by variable levels of BCR-ABL protein in the pluripotent hematopoietic cell line UT-7
    • Issaad C, Ahmed M, Novault S, et al. Biological effects induced by variable levels of BCR-ABL protein in the pluripotent hematopoietic cell line UT-7. Leukemia. 2000;14:662-670.
    • (2000) Leukemia , vol.14 , pp. 662-670
    • Issaad, C.1    Ahmed, M.2    Novault, S.3
  • 48
    • 0031459864 scopus 로고    scopus 로고
    • p62(dok): A constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells
    • Carpino N, Wisniewski D, Strife A, et al. p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell. 1997;88:197-204.
    • (1997) Cell , vol.88 , pp. 197-204
    • Carpino, N.1    Wisniewski, D.2    Strife, A.3
  • 49
    • 0035817343 scopus 로고    scopus 로고
    • p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl)
    • Di Cristofano A, Niki M, Zhao M, et al. p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl). J Exp Med. 2001;194:275-284.
    • (2001) J Exp Med , vol.194 , pp. 275-284
    • Di Cristofano, A.1    Niki, M.2    Zhao, M.3
  • 50
    • 0033622043 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity
    • Kashige N, Carpino N, Kobayashi R. Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity. Proc Natl Acad Sci U S A. 2000;97:2093-2098.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 2093-2098
    • Kashige, N.1    Carpino, N.2    Kobayashi, R.3
  • 51
    • 0036901518 scopus 로고    scopus 로고
    • Modeling of signaling networks
    • Neves SR, Iyengar R. Modeling of signaling networks. Bioessays. 2002;24:1110-1117.
    • (2002) Bioessays , vol.24 , pp. 1110-1117
    • Neves, S.R.1    Iyengar, R.2
  • 52
    • 0033555859 scopus 로고    scopus 로고
    • Emergent properties of networks of biological signaling pathways
    • Bhalla US, Iyengar R. Emergent properties of networks of biological signaling pathways. Science. 1999;283:381-387.
    • (1999) Science , vol.283 , pp. 381-387
    • Bhalla, U.S.1    Iyengar, R.2
  • 53
    • 0033515888 scopus 로고    scopus 로고
    • Complexity in biological signaling systems
    • Weng G, Bhalla US, Iyengar R. Complexity in biological signaling systems. Science. 1999;284:92-96.
    • (1999) Science , vol.284 , pp. 92-96
    • Weng, G.1    Bhalla, U.S.2    Iyengar, R.3
  • 54
    • 13044269652 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis
    • Haseyama Y, Sawada K, Oda A, et al. Phosphatidylinositol 3-kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis. Blood. 1999;94:1568-1577.
    • (1999) Blood , vol.94 , pp. 1568-1577
    • Haseyama, Y.1    Sawada, K.2    Oda, A.3
  • 55
    • 0037866476 scopus 로고    scopus 로고
    • Critical role for PI3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation
    • Bouscary D, Pene F, Claessens YE, et al. Critical role for PI3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation. Blood. 2003;101:3436-3443.
    • (2003) Blood , vol.101 , pp. 3436-3443
    • Bouscary, D.1    Pene, F.2    Claessens, Y.E.3
  • 56
    • 0032984348 scopus 로고    scopus 로고
    • Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
    • Sebolt-Leopold JS, Dudley DT, Herrera R, et al. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat Med. 1999;5:810-816.
    • (1999) Nat Med , vol.5 , pp. 810-816
    • Sebolt-Leopold, J.S.1    Dudley, D.T.2    Herrera, R.3
  • 57
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah N, Nicoll J, Nagar B, et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell. 2002;2:117-125.
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.1    Nicoll, J.2    Nagar, B.3
  • 58
    • 0038375012 scopus 로고    scopus 로고
    • Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib
    • Corbin AS, La Rosee P, Stoffregen EP, Druker BJ, Deininger MW. Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib. Blood. 2003;101:4611-4614.
    • (2003) Blood , vol.101 , pp. 4611-4614
    • Corbin, A.S.1    La Rosee, P.2    Stoffregen, E.P.3    Druker, B.J.4    Deininger, M.W.5
  • 59
    • 9144271748 scopus 로고    scopus 로고
    • In vitro efficacy of combined treatment depends on the underlying mechanism of resistance in imatinib-resistant Bcr-Abl-positive cell lines
    • La Rosée P, Johnson K, Corbin AS, et al. In vitro efficacy of combined treatment depends on the underlying mechanism of resistance in imatinib-resistant Bcr-Abl-positive cell lines. Blood. 2003;103:208-215.
    • (2003) Blood , vol.103 , pp. 208-215
    • La Rosée, P.1    Johnson, K.2    Corbin, A.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.