Structural basis for Chk1 inhibition by UCN-01

Journal of Biological Chemistry

Volumn 277, Issue 48, 2002, Pages 46609-46615

  Zhao, Baoguang ^a   Bower, Michael J ^a,b   McDevitt, Patrick J ^a   Zhao, Huizhen ^a   Davis, Stephen T ^a   Johanson, Kyung O ^a   Green, Susan M ^a   Concha, Nestor O ^a   Zhou, Bin Bing S ^a,b  

^a GLAXOSMITHKLINE   (United States)

^b Experimental Station   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; CONFORMATIONS; CRYSTAL STRUCTURE; DNA; ENZYME INHIBITION; HYDROGEN BONDS; PROTEINS;

DAMAGE RESPONSES;

BIOCHEMISTRY;

7 HYDROXYSTAUROSPORINE; ANTINEOPLASTIC AGENT; CHK1 KINASE; HYDROXYL GROUP; LACTAM; PROTEIN SERINE THREONINE KINASE; SB 218078; STAUROSPORINE; STAUROSPORINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE G2 PHASE; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALKALOIDS; AMINO ACID SEQUENCE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; STAUROSPORINE; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 2242421834     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M201233200     Document Type: Article

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