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Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 19, 2001, Pages 10833-10838

The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

(8) Ruefli, Astrid A a Ausserlechner, Michael J c Bernhard, David c Sutton, Vivien R a Tainton, Kellie M a Kofler, Reinhard c Smyth, Mark J a Johnstone, Ricky W a,b

a PETER MACCALLUM CANCER CENTRE (Australia)

b MEDICAL UNIVERSITY OF INNSBRUCK (Austria)

c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 3; CASPASE 8; CASPASE INHIBITOR; CYTOCHROME C; HISTONE DEACETYLASE INHIBITOR; PROTEIN BCL 2; PROTEIN BID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VORINOSTAT;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; T CELL LEUKEMIA; TRANSCRIPTION REGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CASPASE 10; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CYTOCHROME C GROUP; ENZYME INHIBITORS; GENE EXPRESSION; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0035845541 PISSN: 00278424 EISSN: None Source Type: Journal
DOI: 10.1073/pnas.191208598 Document Type: Article

Times cited : (471)

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