Nitric oxide and the vascular endothelium

Handbook of Experimental Pharmacology

Volumn 176, Issue PART1, 2006, Pages 213-254

  Moncada, S ^a   Higgs, E A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cytochrome c oxidase; eNOS; Free radicals; Guanylate cyclase; Mitochondria; Nitric oxide

Indexed keywords

CELL RECEPTOR; CYTOCHROME C OXIDASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENZYME INHIBITOR; GUANYLATE CYCLASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; SOLUBLE GUANYLYL CYCLASE;

ANIMAL; CARDIOVASCULAR DISEASE; CELL ADHESION; CELL PROLIFERATION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; LEUKOCYTE; METABOLISM; REVIEW; THROMBOCYTE; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ANIMALS; BLOOD PLATELETS; CARDIOVASCULAR DISEASES; CELL ADHESION; CELL PROLIFERATION; ELECTRON TRANSPORT COMPLEX IV; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GUANYLATE CYCLASE; HUMANS; LEUKOCYTES; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 34247093334     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/3-540-32967-6_7     Document Type: Article

References (364)

1. Abu Soud HM, Stuehr DJ (1993) Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer. Proc Natl Acad Sci USA 90:10769-10772
2. Adak S,Wang Q, Stuehr DJ (2000) Arginine conversion to nitroxide by tetrahydrobiopterinfree neuronal nitric oxide synthase. J Biol Chem 275:33554-33561
3. Ahn KY,Mohaupt MG,Madsen KM, et al. (1994) In situ hybridization localization of mRNA encoding inducible nitric oxide synthase in rat kidney. Am J Physiol 267:F748-F757
4. Albina JE (1995) On the expression of nitric oxide synthase by human macrophages. Why no NO? J Leukoc Biol 58:643-649
5. Alderton WK, Cooper CE, Knowles RG (2001) Nitric oxide synthases: structure, function and inhibition. Biochem J 357:593-615
6. Alderton WK, Angell AD, Craig C, et al. (2005) GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo. Br J Pharmacol 145:301-312
7. Aliev G, Bodin P, Burnstock G (1998) Free radical generators cause changes in endothelial and inducible nitric oxide synthases and endothelin-1 immunoreactivity in endothelial cells from hyperlipidemic rabbits. Mol Genet Metab 63:191-197
8. Aoyagi M, Arvai AS, Tainer JA, et al. (2003) Structural basis for endothelial nitric oxide synthase binding to calmodulin. EMBO J 22:766-775
9. Arnet UA, McMillan A, Dinerman JL, et al. (1996) Regulation of endothelial nitric oxide synthase during hypoxia. J Biol Chem 271:15069-15073
10. Asselbergs FW, van der Harst P, Jessurun GAJ, et al. (2005) Clinical impact of vasomotor function assessment and the role of ACE-inhibitors and statins. Vascul Pharmacol 42:125-140
11. Ayajiki K, Kindermann M,Hecker M, et al. (1996) Intracellular pH and tyrosine phosphorylation but not calciumdetermine shear stress-induced nitric oxide production in native endothelial cells. Circ Res 78:750-758
12. Azadzoi KM, Master TA, Siroky MB (2004) Effect of chronic ischemia on constitutive and inducible nitric oxide synthase expression in erectile tissue. J Androl 25:382-388
13. Azuma H, Ishikawa M, Sekizaki S (1986) Endothelium-dependent inhibition of platelet aggregation. Br J Pharmacol 88:411-415
14. Baek KJ, Thiel BA, Lucas S, et al. (1993) Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme. J Biol Chem 268:21120-21129
15. Balligand JL, Kelly RA, Marsden PA, et al. (1993) Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. Proc Natl Acad Sci USA 90:347-351
16. Barbacanne MA, Rami J, Michel JB, et al. (1999) Estradiol increases rat aorta endotheliumderived relaxing factor (EDRF) activity without changes in endothelial NO synthase gene expression: possible role of decreased endothelium-derived superoxide anion production. Cardiovasc Res 41:672-681
17. Barbato JE, Tzeng E (2004) Nitric oxide and arterial disease. J Vasc Surg 40:187-193
18. Barouch LA, Harrison RW, Skaf MW, et al. (2002) Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature 416:337-339
19. Bates TE, Loesch A, Burnstock G, et al. (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochem Biophys Res Commun 213:896-900
20. Bauer PM, Fulton D, Boo YC (2003) Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of functionmutants ofmultiple serine phosphorylation sites in endothelial nitric oxide synthase. J Biol Chem 278:14841-14849
21. Bauersachs J, Fleming I, ScholzD, et al. (1997) Endothelium-derived hyperpolarizing factor, but not nitric oxide, is reversibly inhibited by brefeldin A. Hypertension 30:1598-1605
22. Beckman JS, Beckman TW, Chen J, et al. (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury fromnitric oxide and superoxide. Proc Natl Acad Sci USA 87:1620-1624
23. Beierwaltes WH, Potter DL, Shesely EG (2002) Renal baroreceptor- stimulated renin in the eNOS knockout mouse. Am J Physiol 282:F59-F64
24. Beltran B, Orsi A, Clementi E, et al. (2000) Oxidative stress and S-nitrosylation of proteins in cells. Br J Pharmacol 129:953-960
25. Benjafield AV, Morris BJ (2000) Association analyses of endothelial nitric oxide synthase gene polymorphisms in essential hypertension. Am J Hypertens 13:994-998
26. Berkels R, Stockklauser K, Rosen P, et al. (1997) Current status of platelet NO synthases. Thromb Res 87:51-55
27. Bernal-Mizrachi C, GatesAC,Weng S, et al. (2005)Vascular respiratory uncoupling increases blood pressure and atherosclerosis. Nature 435:502-506
28. Biffl WL, Moore EE, Moore FA, et al. (1996) Nitric oxide reduces endothelial expression of intercellular adhesion molecule (ICAM)-1. J Surg Res 63:328-332
29. Blatter LA, Wier WG (1994) Nitric oxide decreases [Ca2+]i in vascular smooth muscle by inhibition of the calcium current. Cell Calcium 15:122-131
30. Blot S, Arnal JF, Xu Y, et al. (1994) Spinal cord infarcts during long-terminhibition of nitric oxide synthase in rats. Stroke 25:1666-1673
31. Boger RH, Bode-Boger SM, Szuba A, et al. (1998) Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation 98:1842-1847
32. Bolotina VM, Najibi S, Palacino JJ, et al. (1994) Nitric oxide directly activates calciumdependent potassium channels in vascular smooth muscle. Nature 368:850-853
33. Boo YC, Jo H (2003) Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases. Am J Physiol 285:C499-C508
34. Boo YC, Sorescu G, Boyd N, et al. (2002) Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A. J Biol Chem 277:3388-3396
35. Boo YC, Sorescu GP, Bauer PM, et al. (2003) Phosphorylation of eNOS at Ser635 stimulates NO production in a Ca2+-independent manner. FASEB J 17:A805
36. Bouloumie A, Schini-Kerth VB, Busse R (1999) Vascular endothelial growth factor upregulates nitric oxide synthase expression in endothelial cells. Cardiovasc Res 41:773-780
37. Boutin JA (1997) Myristoylation. Cell Commun Signal 9:15-35
38. Bowen R,Haslam RJ (1991) Effects of nitrovasodilators on platelet cyclic nucleotide levels in rabbit blood; role for cyclic AMP in synergistic inhibition of platelet function by SIN-1 and prostaglandin E1. J Cardiovasc Pharmacol 17:424-433
39. Brandes RP, Schmitz-Winnenthal FH, Feletou M, et al. (2000) An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endotheliumdependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice. Proc Natl Acad Sci USA 97:9747-9752
40. Bredt DS, Snyder SH (1990) Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA 87:682-685
41. Bredt DS, Hwang PM, Glatt CE, et al. (1991) Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 351:714-718
42. Brouet A, Sonveaux P, Dessy C, et al. (2001) Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins. Circ Res 89:866-873
43. Brown GC (1999) Nitric oxide and mitochondrial respiration. Biochim Biophys Acta 1411:351-369
44. Brown GC, Cooper CE (1994) Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett 356:295-298
45. Bucci M, Gratton JP, Rudic RD, et al. (2000) In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Nat Med 6:1362-1367
46. Busconi L, Michel T (1993) Endothelial nitric oxide synthase: N-terminal myristoylation determines subcellular localization. J Biol Chem 268:8410-8413
47. Busse R, Mulsch A (1990) Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin. FEBS Lett 265:133-136
48. Buttery LD, Springall DR, Chester AH, et al. (1996) Inducible nitric oxide synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxynitrite. Lab Invest 75:77-85
49. Cai H, Harrison DG (2000) Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87:840-844
50. Cai H, Davis ME, Drummond GR, et al. (2001) Induction of endothelial NO synthase by hydrogen peroxide via a Ca2+/calmodulin-dependent protein kinase II/janus kinase 2-dependent pathway. Arterioscler Thromb Vasc Biol 21:1571-1576
51. Cao S, Yao J, Shah V (2003) The proline-rich domain of dynamin-2 is responsible for dynamin-dependent in vitro potentiation of endothelial nitric oxide synthase activity via selective effects on reductase domain function. J Biol Chem 278:5894-5901
52. Carr A, Frei B (2000) The role of natural antioxidants in preserving the biological activity of endothelium-derived nitric oxide. Free Radic Biol Med 28:1806-1814
53. Caulin-Glaser T, Garcia-Cardena G, Sarrel P, et al. (1997) 17 β-Estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization. Circ Res 81:885-892
54. Chambliss KL, Shaul PW (2002) Rapid activation of endothelial NO synthase by estrogen: evidence for a steroid receptor fast-action complex (SRFC) in caveolae. Steroids 67:413-419
55. Chance B, Sies B, Boveris A (1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev 59:527-605
56. Charles IG, Palmer RM, Hickery MS, et al. (1993) Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc Natl Acad Sci USA 90:11419-11423
57. Chartrain NA, Geller DA, Koty PP, et al. (1994) Molecular cloning, structure and chromosomal localization of the human inducible nitric oxide synthase gene. J Biol Chem 269:6765-6772
58. Chen LY, Mehta JL (1996) Further evidence of the presence of constitutive and inducible nitric oxide synthase isoforms in human platelets. J Cardiovasc Pharmacol 27:154-158
59. Chen ZP, Mitchelhill KI, Michell BJ, et al. (1999) AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett 443:285-289
60. Choi YB, Lipton SA (2000) Redox modulation of the NMDA receptor. Cell Mol Life Sci 57:1535-1541
61. Chowdhary S, Townend JN (1999) Role of nitric oxide in the regulation of cardiovascular autonomic control. Clin Sci (Lond) 97:5-17
62. Cieslik K,Abrams CS,WuKK(2001)Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma/Janus kinase 2/MEK-1-dependent pathway. J Biol Chem 276:1211-1219
63. CleeterMW,Cooper JM, Darley-UsmarVM,et al. (1994)Reversible inhibitionof cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett 345:50-54
64. Clementi E, Brown GC, Feelisch M, et al. (1998) Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc Natl Acad Sci USA 95:7631-7636
65. Clementi E, Brown GC, Foxwell N, et al. (1999) On the mechanism by which vascular endothelial cells regulate their oxygen consumption. Proc Natl Acad Sci USA 96:1559-1562
66. Cohen RA (2005) The endothelium-derived hyperpolarizing factor puzzle. A mechanism without a mediator? Circulation 111:724-727
67. Cooke JP (2003) NO and angiogenesis. Atheroscler Suppl 4:53-60
68. Cornwell TL, Pryzwansky KB,Wyatt TA, et al. (1991) Regulation of sarcoplasmic reticulum protein phosphorylation by localized cyclic GMP-dependent protein kinase in vascular smooth muscle cells. Mol Pharmacol 40:923-931
69. CraneBR,ArvaiAS,GachhuiR, et al. (1997) The structure of nitric oxide synthase oxygenase domain and inhibitor complexes. Science 278:425-431
70. Cromheeke KM, Kockx MM, De Meyer GR, et al. (1999) Inducible nitric oxide synthase colocalizes with signs of lipid oxidation/peroxidation in human atherosclerotic plaques. Cardiovasc Res 43:744-754
71. Cubberley RR, Alderton WK, Boyhan A, et al. (1997) Cysteine-200 of human inducible nitric oxide synthase is essential for dimerization of haem domains and for binding of haem, nitroarginine and tetrahydrobiopterin. Biochem J 323:131-146
72. D'Uscio LV,Milstien S, Richardson D, et al. (2003) Long-termvitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circ Res 92:88-95
73. Daff S, Sagami I, Shimizu T (1999) The 42-amino acid insert in theFMNdomain of neuronal nitric-oxide synthase exerts control overCa(2+)/calmodulin-dependent electron transfer. J Biol Chem 274:30589-30595
74. Davis ME, Grumbach IM, Fukai T, et al. (2004) Shear stress regulates endothelial nitricoxide synthase promoter activity through nuclear factor kappaB binding. J Biol Chem 279:163-168
75. De Caterina R, Libby P, Peng HB, et al. (1995) Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest 96:60-68
76. Dedio J, Konig P, Wohlfart P, et al. (2001) NOSIP, a novel modulator of endothelial nitric oxide synthase activity. FASEB J 15:79-89
77. DeMeyerGR,KockxMM,Cromheeke KM, et al. (2000) Periadventitial inducible nitric oxide synthase expressionandintimal thickening.Arterioscler ThrombVascBiol 20:1896-1902
78. De Meyer GR, De Cleen DM, Cooper S, et al. (2002) Platelet phagocytosis and processing of beta-amyloid precursor protein as a mechanism of macrophage activation in atherosclerosis. Circ Res 90:1197-1204
79. Denninger JW,MarlettaMA(1999) Guanylate cyclase and the NO/cGMP signaling pathway. Biochim Biophys Acta 1411:334-350
80. Dimmeler S, Fleming I, Fisslthaler B, et al. (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399:601-605
81. Ding H, Kubes P, Triggle C (2000) Potassium- and acetylcholine-induced vasorelaxation in mice lacking endothelial nitric oxide synthase. Br J Pharmacol 129:1194-1200
82. Djordjevic S, Roberts DL, Wang M (1995) Crystallization and preliminary X-ray studies of NADPH-cytochrome P450 reductase. Proc Natl Acad Sci USA 92:3214-3218
83. Dobrucki LW, Kalinowski L, Dobrucki IT, et al. (2001) Statin-stimulated nitric oxide release from endothelium. Med Sci Monit 7:622-627
84. Dunphy JT, Linder ME (1998) Signalling functions of protein palmitoylation. Biochem Biophys Acta 1436:245-261
85. Durante W, Schini VB, Scott-Burden T, et al. (1991) Platelet inhibition by an l-argininederived substance released by IL-1 beta-treated vascular smoothmuscle cells.AmJ Physiol 261:H2024-H2030
86. Endres M, Laufs U, Huang Z, et al. (1998) Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci USA 95:8880-8885
87. Esaki T, Hayashi T, Muto E, et al. (1997) Expression of inducible nitric oxide synthase in T lymphocytes and macrophages of cholesterol-fed rabbits. Atherosclerosis 128:39-46
88. Fard A, Tuck CH, Donis JA, et al. (2000) Acute elevations of plasma asymmetric dimethylarginine and impaired endothelial function in response to a high-fat meal in patients with type 2 diabetes. Arterioscler Thromb Vasc Biol 20:2039-2044
89. Feng Y, Venema VJ, Venema RC, et al. (1999) VEGF-induced permeability increase is mediated by caveolae. Invest Ophthalmol Vis Sci 40:157-167
90. Feron O, Saldana F, Michel JB, et al. (1998) The endothelial nitric oxide synthase-caveolin regulatory cycle. J Biol Chem 273:3125-3128
91. Feron O, Dessy C,Moniotte S, et al. (1999)Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase. J Clin Invest 103:897-905
92. Fichtlscherer S, Dimmeler S, Breuer S, et al. (2004) Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patientswith coronary artery disease. Circulation 109:178-183
93. Fischmann TO, Hruza A, Niu XD, et al. (1999) Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation. Nat Struct Biol 6:233-242
94. Fisslthaler B, Dimmeler S, Hermann C, et al. (2000) Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress. Acta Physiol Scand 168:81-88
95. Fisslthaler B, Benzing T, Busse R, et al. (2003) Insulin enhances the expression of the endothelial nitric oxide synthase in native endothelial cells: a dual role for Akt and AP-1. Nitric Oxide 8:253-261
96. Fleming I (2001) Cytochrome p450 and vascular homeostasis. Circ Res 89:753-762
97. Fleming I, Busse R (2003)Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol 284:R1-R12
98. Fleming I, Fisslthaler B, Dimmeler S, et al. (2001) Phosphorylation of Thr495 regulates Ca2+/calmodulin-dependent endothelial nitric oxide synthase activity. Circ Res 88:e68-e75
99. Fleming I, Schulz C, Fichtlscherer B, et al. (2003) AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets. Thromb Haemost 90:863-871
100. Fliser D (2005) Asymmetric dimethylarginine (ADMA): the silent transition from an 'uraemic toxin' to a global cardiovascular risk molecule. Eur J Clin Invest 35:71-79
101. Fstermann U, Pollock JS, Schmidt HH, et al. (1991) Calmodulin-dependent endotheliumderived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. Proc Natl Acad Sci USA 88:1788-1792
102. Fstermann U, Closs EI, Pollock JS, et al. (1994) Nitric oxide synthase isozymes. Characterization, purification, molecular cloning and functions. Hypertension 23:1121-1131
103. Freedman JE, Sauter R, Battinelli EM, et al. (1999) Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene. Circ Res 84:1416-1421
104. Frost MT, Wang Q, Moncada S, et al. (2005) Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages.AmJ Physiol 288:R394-R400
105. Fukuchi M, Giaid A (1999) Endothelial expression of endothelial nitric oxide synthase and endothelin-1 in human coronary artery disease. Specific reference to underlying lesion. Lab Invest 79:659-670
106. Fulton D, Gratton JP, McCabe TJ, et al. (1999) Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399:597-601
107. Fulton D, Babbitt R, Zoellner S, et al. (2004) Targeting of endothelial nitric oxide synthase to the cytoplasmic face of the golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release. J Biol Chem 279:30349-30357
108. Fung HL (2004) Biochemical mechanism of nitroglycerin action and tolerance: is this old mystery solved? Annu Rev Pharmacol Toxicol 44:67-85
109. Furchgott RF, Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288:373-376
110. Gaboury J,Woodman RC, Granger DN, et al. (1993) Nitric oxide prevents leukocyte adherence: role of superoxide. Am J Physiol 265:H862-H867
111. Gao S, Chen J, Brodsky SV, et al. (2004) Docking of endothelial nitric oxide synthase (eNOS) to the mitochondrial outer membrane: a pentabasic amino acid sequence in the autoinhibitory domain of eNOS targets a proteinase K-cleavable peptide on the cytoplasmic face of mitochondria. J Biol Chem 279:15968-15974
112. Garcia-Cardena G, Oh P, Liu J, et al. (1996) Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc Natl Acad Sci USA 93:6448-6453
113. Garcia-Cardena G, Fan R, Shah V, et al. (1998) Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature 392:821-824
114. Garg UC, Hassid A (1989) Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 83:1774-1777
115. Gauthier TW,Davenpeck KL, Lefer AM(1994)Nitric oxide attenuates leukocyte-endothelial interaction via P-selectin in splanchnic ischemia-reperfusion. Am J Physiol 267:G562-G568
116. Geiger J, Nolte C, Walter U (1994) Regulation of calcium mobilization and entry in human platelets by endothelium-derived factors. Am J Physiol 267:C236-C244
117. Geller DA, Lowenstein CJ, Shapiro RA, et al. (1993) Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc Natl Acad Sci USA 90:3491-3495
118. Gewaltig MT, Kojda G (2002) Vasoprotection by nitric oxide: mechanisms and therapeutic potential. Cardiovasc Res 55:250-260
119. Ghafourifar P, Richter C (1997) Nitric oxide synthase activity in mitochondria. FEBS Lett 418:291-296
120. Giulivi C, Poderoso JJ, Boveris A (1998) Production of nitric oxide by mitochondria. J Biol Chem 273:11038-11043
121. Go YM, Park H, Maland MC, et al. (1998) Phosphatidylinositol 3-kinase γ mediates shear stress-dependent activation of JNK in endothelial cells. Am J Physiol 275:H1898-H1904
122. Go YM, Gipp JJ, Mulcahy RT, et al. (2004) H2O2-dependent activation of GCLC-ARE4 reporter occurs by mitogen-activated protein kinase pathways without oxidation of cellular glutathione or thioredoxin-1. J Biol Chem 279:5837-5845
123. Govers R, Rabelink TJ (2001) Cellular regulation of endothelial nitric oxide synthase. Am J Physiol Renal Physiol 280:F193-F206
124. GoversR, van der Sluijs P, vanDonselaar E, et al. (2002) Endothelial nitric oxide synthase and its negative regulator caveolin-1 localize to distinct perinuclear organelles. J Histochem Cytochem 50:779-788
125. Gow AJ, Stamler JS (1998) Reactions between nitric oxide and haemoglobin under physiological conditions. Nature 391:169-173
126. Gratton JP, Fontana J,O'ConnorDS, et al. (2000)Reconstitution of an endothelial nitric oxide synthase (eNOS), hsp90, and caveolin-1 complex in vivo. J Biol Chem 275:22268-22272
127. Greenacre SA, Ischiropoulos H (2001) Tyrosine nitration: localization, quantification, consequences for protein function and signal transduction. Free Radic Res 34:541-581
128. GrishamMB, Jourd'HeuilD,WinkDA(1999)Nitric oxide. I.Physiological chemistry of nitric oxide and its metabolites: implications in inflammation. Am J Physiol 276:G315-G321
129. Hagen T, Taylor CT, Lam F, et al. (2003) Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1α. Science 302:1975-1978
130. Harris MB, Ju H, Venema VJ, et al. (2001) Reciprocal phosphorylation and regulation of endothelial nitric oxide synthase in response to bradykinin stimulation. J Biol Chem 276:16587-16591
131. Hattori Y, Nakanishi N, Kasai K (2002) Statin enhances cytokine-mediated induction of nitric oxide synthesis in vascular smooth muscle cells. Cardiovasc Res 54:649-658
132. Heitzer T, Yla-Herttuala S, Luoma J, et al. (1996) Cigarette smoking potentiates endothelial dysfunction of forearmresistance vessels in patients with hypercholesterolemia. Role of oxidized LDL. Circulation 93:1346-1353
133. Hernandez-Perera O, Perez-Sala D, Navarro-Antolin J, et al. (1998) Effects of the 3-hydroxy- 3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J Clin Invest 101:2711-2719
134. Hess DT, Matsumoto A, Kim SO, et al. (2005) Protein S-nitrosylation: purview and parameters. Nat Rev Mol Cell Biol 6:150-166
135. Hibbs JB, Taintor RR, Vavrin Z, et al. (1990) Synthesis of nitric oxide from a terminal guanidine nitrogen atom of l-arginine: a molecular mechanism regulating cellular proliferation that targets intracellular iron. In:Moncada S,Higgs EA (eds) Nitric oxide from l-arginine: a bioregulatory system. Elsevier, Amsterdam, pp 189-223
136. Hingorani AD, Liang CF, Fatibene J, et al. (1999) A common variant of the endothelial nitric oxide synthase (Glu298Asp) is a major risk factor for coronary artery disease in the UK. Circulation 100:1515-1520
137. Hink U, Li H, Mollnau H, et al. (2001) Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 88:E14-E22
138. Hobbs AJ, Higgs A, Moncada S (1999) Inhibition of nitric oxide synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol 39:191-220
139. Hood JD, Meininger CJ, Ziche M, et al. (1998) VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells. Am J Physiol 274:H1054-H1058
140. Hoyer J, Kler R, Distler A (1998)Mechanosensitive Ca2+ oscillations and STOC activation in endothelial cells. FASEB J 12:359-366
141. Huang A, Sun D, Koller A, et al. (1998) Gender difference in flow-induced dilation and regulation of shear stress: role of estrogen and nitric oxide. Am J Physiol 275:R1571-R1577
142. Huang A, Sun D, Carroll MA, et al. (2001) EDHF mediates flow-induced dilation in skeletal muscle arterioles of female eNOS-KO mice. Am J Physiol 280:H2462-H2469
143. Huang PL, Huang Z, Mashimo H, et al. (1995) Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 377:239-242
144. InoueN,Venema RC, Sayegh HS, et al. (1995)Molecular regulation of the bovine endothelial cell nitric oxide synthase by transforming growth factor-beta 1. Arterioscler Thromb Vasc Biol 15:1255-1261
145. Ito A, Tsao PS, Adimoolam S, et al. (1999) Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 99:3092-3095
146. Jaffrey SR, Erdjument-Bromage H, Ferris CD, et al. (2001) Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol 3:193-197
147. Janssens S, Flaherty D, Nong Z, et al. (1998) Human endothelial nitric oxide synthase gene transfer inhibits vascular smooth muscle cell proliferation and neointima formation after balloon injury in rats. Circulation 97:1274-1281
148. Janssens SP, Shimouchi A, Quertermous T, et al. (1992) Cloning and expression of a cDNA encoding humanendothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem 267:14519-14522
149. Jenkins DC, Charles IG, Thomsen LL, et al. (1995) Roles of nitric oxide in tumor growth. Proc Natl Acad Sci USA 92:4392-4396
150. Jiang J,CyrD,BabbittRW, et al. (2003) Chaperone-dependent regulation of endothelial nitric oxide synthase intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP. J Biol Chem 278:49332-49341
151. Jobin CM, Chen H, Lin AJ, et al. (2003) Receptor-regulated dynamic interaction between endothelial nitric oxide synthase and calmodulin revealed by fluorescence resonance energy transfer in living cells. Biochemistry 42:11716-11725
152. Kanai AJ, Pearce LL, Clemens PR, et al. (2001) Identification of a neuronal nitric oxide synthase in isolated cardiac mitochondria using electrochemical detection. Proc Natl Acad Sci USA 98:14126-14131
153. Kanwar S, Kubes P (1995) Nitric oxide is an antiadhesive molecule for leukocytes. New Horiz 3:93-104
154. Karantzoulis-Fegaras F, Antoniou H, Lai SL, et al. (1999) Characterization of the human endothelial nitric-oxide synthase promoter. J Biol Chem 274:3076-3093
155. KhanBV,HarrisonDG, OlbrychMT, et al. (1996)Nitric oxide regulates vascular cell adhesion molecule 1 gene expressionandredox-sensitive transcriptional events inhumanvascular endothelial cells. Proc Natl Acad Sci USA 93:9114-9119
156. Kilbourn RG, Jubran A, Gross SS, et al. (1990) Reversal of endotoxin-mediated shock byNGmethyl- l-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Commun 172:1132-1138
157. Kim JW, Kang KW, Oh GT, et al. (2002) Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro. Exp Mol Med 34:137-144
158. Kimura S, Zhang GX, Nishiyama A (2005) Mitochondria-derived reactive oxygen species and vascular MAP kinases: comparison of angiotensin II and diazoxide. Hypertension 45:438-444
159. KnowlesRG, Palacios M, Palmer RMJ, et al. (1989) Formation of nitric oxide froml-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. Proc Natl Acad Sci USA 86:5159-5162
160. Knowles RG, Salter M, Brooks SL, et al. (1990) Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat. Biochem Biophys Res Commun 172:1042-1048
161. Kobzik L, Stringer B, Balligand JL, et al. (1995) Endothelial type nitric oxide synthase in skeletal muscle fibers: mitochondrial relationships. Biochem Biophys Res Commun 211:375-381
162. Kojda G, Cheng YC, Burchfield J, et al. (2001) Dysfunctional regulation of endothelial nitric oxide synthase (eNOS) expression in response to exercise in mice lacking one eNOS gene. Circulation 103:2839-2844
163. Korhonen R, Lahti A, Hamalainen M, et al. (2002) Dexamethasone inhibits inducible nitric oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages. Mol Pharmacol 62:698-704
164. Kroll J,Waltenberger J (1998) VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR). Biochem Biophys Res Commun 252:743-746
165. Kubes P (1995) Nitric oxide affects microvascular permeability in the intact and inflamed vasculature. Microcirculation 2:235-244
166. Kubes P, SuzukiM, Granger DN (1991) Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 88:4651-4655
167. Kuhlencordt PJ,Gyurko R,Han F, et al. (2001a)Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice. Circulation 104:448-454
168. Kuhlencordt PJ, Chen J, Han F, et al. (2001b) Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice. Circulation 103:3099-3104
169. Kuhlencordt PJ, Rosel E, Gerszten RE, et al. (2004) Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells. Am J Physiol 286:C1195-C1202
170. Kureishi Y, Luo Z, Shiojima I, et al. (2000) The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 6:1004-1010
171. Kurihara N, Alfie ME, Sigmon DH, et al. (1998) Role of nNOS in blood pressure regulation in eNOS null mutant mice. Hypertension 32:856-861
172. Kurtz A,Wagner C (1998) Role of nitric oxide in the control of renin secretion. Am J Physiol 275:F849-F862
173. Lablanche JM, Grollier G, Lusson JR, et al. (1997) Effect of the direct nitric oxide donors linsidomine and molsidomine on angiographic restenosis after coronary balloon angioplasty. The ACCORD Study. Angioplastic Coronaire Corvasal Diltiazem. Circulation 95:83-89
174. Lamas S, Marsden PA, Li GK, et al. (1992) Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci USA 89:6348-6352
175. Landmesser U, Dikalov S, Price SR, et al. (2003) Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest 111:1201-1209
176. Lane P,Gross SS (2002) Disabling a C-terminal autoinhibitory control element in endothelial nitric-oxide synthase by phosphorylation provides a molecular explanation for activation of vascular NO synthesis by diverse physiological stimuli. J Biol Chem 277:19087-19094
177. Lane P, Hao G, Gross SS (2001) S-nitrosylation is emerging as a specific and fundamental post-translational protein modification: head-to-head comparison with O-phosphorylation. Sci STKE 86:RE1
178. Lantoine F, Brunet A, Bedioui F, et al. (1995) Direct measurement of nitric oxide production in platelets: relationship with cytosolic Ca2+ concentration. Biochem Biophys Res Commun 215:842-848
179. Laszlo F, Whittle BJR, Moncada S (1994) Time-dependent enhancement or inhibition of endotoxin-induced vascular injury in rat intestine by nitric oxide synthase inhibitors. Br J Pharmacol 111:1309-1315
180. Laufs U, Fata VL, Liao JK (1997) Inhibition of 3-hydroxy-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase. J Biol Chem 272:31725-31729
181. Leibovich SJ, Polverini PJ, Fong TW, et al. (1994) Production of angiogenic activity by human monocytes requires an l-arginine/nitric oxide-synthase-dependent effector mechanism. Proc Natl Acad Sci USA 91:4190-4194
182. Leiper JM, Santa Maria J, Chubb A, et al. (1999) Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. Biochem J 343:209-214
183. Leopold JA, Loscalzo J (2005) Oxidative enzymopathies and vascular disease. Arterioscler Thromb Vasc Biol 25:1332-1340
184. Levine GN, Frei B, Koulouris SN, et al. (1996) Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 93:1107-1113
185. Lin MI, Fulton D, Babbitt R, et al. (2003) Phosphorylation of threonine 497 in endothelial nitric oxide synthase coordinates the coupling of l-arginine metabolism to efficient nitric oxide production. J Biol Chem 278:44719-44726
186. Liu J, Garcia Cardena G, Sessa WC (1995) Biosynthesis and palmitoylation of endothelial nitric oxide synthase: mutagenesis of palmitoylation sites, cysteines-15 and/or -26, argues against depalmitoylation-induced translocation of the enzyme. Biochemistry 34:12333-12340
187. LiuJ,Hughes TE, SessaWC(1997) The first 35aminoacids and fatty acylationsites determine the molecular targeting of endothelial nitric oxide synthase into the golgi region of cells: a green fluorescent protein study. J Cell Biol 137:1525-1535
188. Lopez-Ongil S, Hernandez-Perera O, Navarro-Antolin J, et al. (1998) Role of reactive oxygen species in the signalling cascade of cyclosporine A-mediated up-regulation of eNOS in vascular endothelial cells. Br J Pharmacol 124:447-454
189. Lu JL, Schmiege LM 3rd, Kuo L, et al. (1996) Downregulation of endothelial constitutive nitric oxide synthase expression by lipopolysaccharide. Biochem Biophys Res Commun 225:1-5
190. Lu TM, Ding YA, Charng MJ, et al. (2003) Asymmetrical dimethylarginine: a novel risk factor for coronary artery disease. Clin Cardiol 26:458-464
191. Luckhoff A, Pohl U, Mulsch A, et al. (1988) Differential role of extra- and intracellular calcium in the release of EDRF and prostacyclin from cultured endothelial cells. Br J Pharmacol 95:189-196
192. Luo Z, Fujio Y, Kureishi Y, et al. (2000) Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo. J Clin Invest 106:493-499
193. Luoma JS, Stralin P, Marklund SL, et al. (1998) Expression of extracellular SOD and iNOS in macrophages and smooth muscle cells in human and rabbit atherosclerotic lesions: colocalization with epitopes characteristic of oxidized LDL and peroxynitrite-modified proteins. Arterioscler Thromb Vasc Biol 18:157-167
194. Luscher TF, Tanner FC, TschudiMR, et al. (1993) Endothelial dysfunction in coronary artery disease. Annu Rev Med 44:395-418
195. MacNaul KL,Hutchinson NI (1993) Differential expression of iNOS and cNOS mRNA in human vascular smoothmuscle cells and endothelial cells under normal and inflammatory conditions. Biochem Biophys Res Commun 196:1330-1334
196. Malinski T, Radomski MW, Taha Z, et al. (1993) Direct electrochemical measurement of nitric oxide released fromhuman platelets. Biochem Biophys Res Commun 194:960-965
197. Mann GE, Yudilevich DL, Sobrevia L (2003) Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells. Physiol Rev 83:183-252
198. Mannick JB, Hausladen A, Liu L, et al. (1999) Fas-induced caspase denitrosylation. Science 284:651-654
199. Marrero MB, Venema VJ, Ju H, et al. (1999) Endothelial nitric oxide synthase interactions with G-protein-coupled receptors. Biochem J 343:335-340
200. Marsden PA, Shappert KT, Chen HS, et al. (1992)Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett 307:287-293
201. Marsden PA,Heng HH, SchererSW, et al. (1993) Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem 268:17478-17488
202. Massberg S, Sausbier M, Klatt P, et al. (1999) Increased adhesion and aggregation of platelets lacking cyclic guanosine 3′,5′- monophosphate kinase I. J Exp Med 189:1255-1264
203. Massion PB, FeronO, Dessy C, et al. (2003)Nitric oxide and cardiac function: ten years after, and continuing. Circ Res 93:388-398
204. Matsumura M, Kakishita H, Suzuki M, et al. (2001) Dexamethasone suppresses iNOS gene expression by inhibiting NF-κB in vascular smooth muscle cells. Life Sci 69:1067-1077
205. Mattson DL, Bellehumeur TG (1996) Neural nitric oxide synthase in the renal medulla and blood pressure regulation. Hypertension 28:297-303
206. Mattson DL, Lu S, Cowley AW Jr (1997) Role of nitric oxide in the control of the renal medullary circulation. Clin Exp Pharmacol Physiol 24:587-590
207. Maxwell AJ (2002) Mechanisms of dysfunction of the nitric oxide pathway in vascular diseases. Nitric Oxide 6:101-124
208. McCabe TJ, FultonD,Roman LJ, et al. (2000) Enhanced electron flux and reduced calmodulin dissociation may explain calcium-independent eNOS activation by phosphorylation. J Biol Chem 275:6123-6128
209. Mete A, Connolly S (2003) Inhibitors of the NOS enzymes: a patent review. IDrugs 6:57-65
210. Michel T, Gordon K, Busconi L (1993) Phosphorylation and subcellular translocation of endothelial nitric oxide synthase. Proc Natl Acad Sci USA 90:6252-6256
211. Michell BJ, Chen Z, Tiganis T, et al. (2001) Coordinated control of endothelial NO synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem 276:17625-17628
212. Mitchell JA, Fstermann U, Warner TD, et al. (1991) Endothelial cells have a particulate enzyme system responsible for EDRF formation: measurement by vascular relaxation. Biochem Biophys Res Commun 176:1417-1423
213. Miyamoto Y, Saito Y, Kajiyama N, et al. (1998) Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension 32:3-8
214. Moncada S (1989) Introduction. In:Moncada S,Higgs EA(eds)Nitric oxide froml-arginine: a bioregulatory system. Elsevier, Amsterdam, pp 1-4
215. Moncada S (2006) Adventures in vascular biology: a tale of two mediators. Phil Trans Roy Soc B 361:735-759
216. Moncada S, Erusalimsky JD (2002) Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nat Rev Mol Cell Biol 3:214-220
217. Moncada S, Higgs EA (2006) The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol 147:S193-S201
218. Moncada S, Palmer RM, Higgs EA (1989) Biosynthesis of nitric oxide from l-arginine. A pathway for the regulation of cell function and communication. Biochem Pharmacol 38:1709-1715
219. Moncada S, Palmer RMJ, Higgs EA (1991) Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43:109-142
220. Moroi M, Zhang L, Yasuda T, et al. (1998) Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice. J Clin Invest 101:1225-1232
221. Morris SM Jr, Billiar TR (1994) New insights into the regulation of inducible nitric oxide synthesis. Am J Physiol 266:E829-E839
222. Mueller CF, Laude K, McNally JS, et al. (2005) Redox mechanisms in blood vessels. Arterioscler Thromb Vasc Biol 25:274-278
223. Munzel T, Kurz S, Heitzer T, et al. (1996) New insights into mechanisms underlying nitrate tolerance. Am J Cardiol 77:24C-30C
224. Muruganandam A,Mutus B (1994) Isolation of nitric oxide synthase fromhuman platelets. Biochim Biophys Acta 1200:1-6
225. Nagareddy PR, Xia Z, McNeill JH, et al. (2005) Increased expression of iNOS is associated with endothelial dysfunction and impaired pressor responsiveness in streptozotocininduced diabetes. Am J Physiol Heart Circ Physiol 289:H2144-H2152
226. Nakane M, Schmidt HH, Pollock JS, et al. (1993) Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS Lett 316:175-180
227. Nakayama T, Soma M, Takahashi Y, et al. (1997) Association analysis of CA repeat polymorphism of the endothelial nitric oxide synthase gene with essential hypertension in Japanese. Clin Genet 51:26-30
228. Nathan C, Xie QW(1994) Nitric oxide synthases: roles, tolls and controls. Cell 78:915-918
229. Navarro J, Sanchez A, Saiz J, et al. (1994) Hormonal, renal and metabolic alterations during hypertension induced by chronic inhibition ofNOin rats.AmJ Physiol 267:R1516-R1521
230. Navarro-Antolin J, Rey-Campos J, Lamas S (2000) Transcriptional induction of endothelial nitric oxide gene by cyclosporine A. A role for activator protein-1. J Biol Chem 275:3075-3080
231. Nedvetsky PI, SessaWC, SchmidtHH(2002) There'sNObinding like NOS binding: protein- protein interactions in NO/cGMP signaling. Proc Natl Acad Sci USA 99:16510-16512
232. Neunteufl T, Heher S, Katzenschlager R, et al. (2000) Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain. Am J Cardiol 86:207-210
233. Nishida CR, Ortiz de Montellano PR (1999) Autoinhibition of endothelial nitric-oxide synthase. Identificationof an electrontransfer control element. JBiolChem274:14692-14698
234. Nishida K, Harrison DG, Navas JP, et al. (1992) Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest 90:2092-2096
235. Nisoli E, Clementi E, Paolucci C, et al. (2003) Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 299:896-899
236. Nisoli E, Tonello C, Cardile A, et al. (2005) Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 310:314-317
237. OhashiY,Kawashima S,Hirata K, et al. (1998)Hypotension and reduced nitric oxide-elicited vasorelaxationin transgenic mice overexpressing endothelial nitric oxide synthase. JClin Invest 102:2061-2071
238. Ortiz PA, Garvin JL (2003) Cardiovascular and renal control in NOS-deficientmousemodels. Am J Physiol 284:R628-R638
239. Ortiz PA,Hong NJ, Garvin JL (2001)NOdecreases thick ascending limb chloride absorption by reducing Na+-K+-2Cl? cotransporter activity. Am J Physiol 281:F819-F825
240. Palacios-Callender M, Quintero M, Hollis VS, et al. (2004) Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase. Proc Natl Acad Sci USA 101:7630-7635
241. Pallone TL, Mattson DL (2002) Role of nitric oxide in regulation of the renal medulla in normal and hypertensive kidneys. Curr Opin Nephrol Hypertens 11:93-98
242. Palmer RM, Ferrige AG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524-526
243. Palmer RM, Ashton DS,Moncada S (1988) Vascular endothelial cells synthesize nitric oxide from l-arginine. Nature 333:664-666
244. Palmer RMJ, Moncada S (1989) A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells. Biochem Biophys Res Commun 158:348-352
245. Papapetropoulos A, Garcia-Cardena G, Madri JA, et al. (1997) Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest 100:3131-3139
246. Paulus WJ, Shah AM (1999) NO and cardiac diastolic function. Cardiovasc Res 43:595-606
247. Pelligrino DA, Ye S, Tan F, et al. (2000) Nitric oxide-dependent pial arteriolar dilation in the female rat: effects of chronic estrogen depletion and repletion. Biochem Biophys Res Commun 269:165-171
248. Perez-Mato I, Castro C,Ruiz FA, et al. (1999)Methionine adenosyltransferase S-nitrosylation is regulated by the basic and acidic amino acids surrounding the target thiol. J Biol Chem 274:17075-17079
249. Persichini T,Mazzone V, Polticelli F, et al. (2005) Mitochondrial type I nitric oxide synthase physically interacts with cytochrome c oxidase. Neurosci Lett 384:254-259
250. PetroffMG, Kim SH, Pepe S, et al. (2001) Endogenous nitric oxide mechanismsmediate the stretch dependence of Ca2+ release in cardiomyocytes. Nat Cell Biol 3:867-873
251. Pfeifer A, Klatt P, Massberg S, et al. (1998) Defective smooth muscle regulation in cGMP kinase I-deficient mice. EMBO J 17:3045-3051
252. Poderoso JJ, Carreras MC, Lisdero C, et al. (1996) Nitric oxide inhibits electron transfer and increases superoxide radicalproductionin rat heart mitochondria and submitochondrial particles. Arch Biochem Biophys 328:85-92
253. Pollock JS, Fstermann U, Mitchell JA, et al. (1991) Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc Natl Acad Sci USA 88:10480-10484
254. Pollock JS, Klinghofer V, Fstermann U, et al. (1992) Endothelial nitric oxide synthase is myristoylated. FEBS Lett 309:402-404
255. Prabhakar P, ChengV,Michel T (2000) A chimeric transmembrane domain directs endothelial nitric oxide synthase palmitoylation and targeting to plasmalemmal caveolae. J Biol Chem 275:19416-19421
256. Pritchard KA Jr, Ackerman AW, Gross ER, et al. (2001) Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric oxide synthase. J Biol Chem 276:17621-17624
257. Quintero M, Colombo S, Godfrey A,Moncada S (2006) Mitochondria as signaling organelles in the vascular endothelium. Proc Natl Acad Sci USA 103:5379-5384
258. Radomski MW, Palmer RMJ, Moncada S (1987a) Comparative pharmacology of endothelium- derived relaxing factor, nitric oxide and prostacyclin in platelets. Br J Pharmacol 92:181-187
259. RadomskiMW,PalmerRMJ,Moncada S (1987b) The role of nitric oxide andcGMPin platelet adhesion to vascular endothelium. Biochem Biophys Res Commun 148:1482-1489
260. RadomskiMW, Palmer RMJ,Moncada S (1987c) The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br J Pharmacol 92:639-646
261. Radomski MW, Palmer RMJ, Moncada S (1990a) Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci USA 87:10043-10047
262. RadomskiMW, Palmer RMJ,Moncada S (1990b) An l-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci USA 87:5193-5197
263. Radomski MW, Palmer RMJ, Moncada S (1990c) Characterization of the l-arginine:nitric oxide pathway in human platelets. Br J Pharmacol 101:325-328
264. Rajagopalan S, Kurz S, Munzel T, et al. (1996) Angiotensin II-mediated hypertension in the rat increases vascular superoxide production viamembrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J Clin Invest 97:1916-1923
265. Raman CS, Li H,Martasek P,KralV, et al. (1998) Crystal structure of constitutive endothelial nitric oxide synthase: a paradigmfor pterin function involving a novel metal center. Cell 95:939-950
266. Randiramboavonjy V, Schrader J, Busse R, et al. (2004) Insulin induces the release of vasodilator compounds from platelets by a nitric oxide-G-kinase-VAMP-3-dependent pathway. J Exp Med 199:347-356
267. Rao GH, Krishnamurthi S, Raij L, et al. (1990) Influence of nitric oxide on agonist-mediated calcium mobilization in platelets. Biochem Med Metab Biol 43:271-275
268. Razani B, Engelman JA, Wang XB, et al. (2001) Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem 276:38121-38138
269. Reddy KG, Nair RN, Sheehan HM, et al. (1994) Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis. J Am Coll Cardiol 23:833-843
270. Rees DD, Palmer RMJ, Moncada S (1989) Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci USA 86:3375-3378
271. Rees DD, Higgs EA, Moncada S (2000) Nitric oxide and the vessel wall. In: Colman RW, Hirsch J,Marder VJ, ClowesAW, George NJ (eds)Hemostasis and thrombosis. Lippincott Williams andWilkins, Philadelphia, pp 673-682
272. Robinson LJ,Michel T (1995)Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting. Proc Natl Acad Sci USA 92:11776-11780
273. Robinson LJ, Busconi L, Michel T (1995) Agonist-modulated palmitoylation of endothelial nitric oxide synthase. J Biol Chem 270:995-998
274. Rosenkranz-Weiss P, SessaWC,Milstien S, et al. (1994) Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity. J Clin Invest 93:2236-2243
275. Russell KS,Haynes MP, Caulin-Glaser T, et al. (2000) Estrogen stimulates heat shock protein 90 binding to endothelial nitric oxide synthase in human vascular endothelial cells. Effects on calcium sensitivity and NO release. J Biol Chem 275:5026-5030
276. Salerno JC, Harris DE, Irizarry K, et al. (1997) An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase. J Biol Chem 272:29769-29777
277. Santolini J,Meade AL, StuehrDJ (2001) Differences in three kinetic parameters underpin the unique catalytic profiles of nitric-oxide synthases I, II, and III. J Biol Chem 276:48887-48898
278. Saura M, Zaragoza C, CaoW, et al. (2002) Smad2 mediates transforming growth factor-beta induction of endothelial nitric oxide synthase expression. Circ Res 91:806-813
279. Sausbier M, Schubert R, Voigt V, et al. (2000) Mechanisms of NO/cGMP-dependent vasorelaxation. Circ Res 87:825-830
280. Schachinger V, Britten MB, Zeiher AM (2000) Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101:1899-1906
281. Schlossmann J,Hofmann F (2005)cGMP-dependent protein kinases in drug discovery. Drug Discov Today 10:627-634
282. Schlossmann J, Ammendola A, Ashman K, et al. (2000) Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Iβ. Nature 404:197-201
283. SchmidtH, Hofmann H, Schindler U, et al. (1996) No NO fromNO synthase. Proc Natl Acad Sci USA 93:14492-14497
284. Schneider MP, Erdmann J, Delles C, et al. (2000) Functional gene testing of the Glu298Asp polymorphism of the endothelial NO synthase. J Hypertens 18:1767-1773
285. Schwarz UR, Walter U, Eigenthaler M (2001) Taming platelets with cyclic nucleotides. Biochem Pharmacol 62:1153-1161
286. SchweizerM,RichterC(1994)Nitricoxidepotentlyandreversibly deenergizes mitochondria at low oxygen tension. Biochem Biophys Res Commun 204:169-175
287. Scotland RS, Chauhan S, Vallance PJ, et al. (2001) An endothelium-derived hyperpolarizing factor-like factor moderates myogenic constriction of mesenteric resistance arteries in the absence of endothelial nitric oxide synthase-derived nitric oxide. Hypertension 38:833-839
288. Scotland RS,Morales-Ruiz M, Chen Y, et al. (2002) Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion. Circ Res 90:904-910
289. Scotland RS, Madhani M, Chauhan S, et al. (2005) Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice. Key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo. Circulation 111:796-803
290. SessaWC (2004) eNOS at a glance. J Cell Sci 117:2427-2429
291. SessaWC,Harrison JK, Barber CM, et al. (1992)Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase. J Biol Chem 267:15274-15276
292. Shaul PA, Smart EJ, Robinson LJ, et al. (1996) Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae. J Biol Chem 271:6518-6522
293. Sherman PA, Laubach VE, Reep BR, et al. (1993) Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line. Biochemistry 32:11600-11605
294. Shesely EG, Maeda N, Kim HS, et al. (1996) Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci USA 93:13176-13181
295. Shimasaki Y, Yasue H, Yoshimura M, et al. (1998) Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction. J Am Coll Cardiol 31:1506-1510
296. SiddhantaU,Wu C,Abu-Soud HM, et al. (1996)Hemeiron reduction and catalysis by a nitric oxide synthase heterodimer containing one reductase and two oxygenase domains. J Biol Chem 271:7309-7312
297. Silacci P, Formentin K, Bouzourene K, et al. (2000) Unidirectional and oscillatory shear stress differentially modulate NOS III gene expression. Nitric Oxide 4:47-56
298. Simon DI, Stamler JS, Loh E, et al. (1995) Effect of nitric oxide synthase inhibition on bleeding time in humans. J Cardiovasc Pharmacol 26:339-342
299. Simoncini T, Hafezi-Moghadam A, Brazil DP, et al. (2000) Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature 407:538-541
300. Slater TF (1972) Free radical mechanisms in tissue injury. Pion, London
301. Solzbach U, Hornig B, JeserichM, et al. (1997) Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients. Circulation 96:1513-1519
302. SowaG,LiuJ,Papapetropoulos A, et al. (1999)Traffickingof endothelial nitricoxide synthase in living cells. J Biol Chem 274:22524-22531
303. Stagliano NE, Zhao W, Prado R, et al. (1997) The effect of nitric oxide synthase inhibition on acute platelet accumulation and hemodynamic depression in a rat model of thromboembolic stroke. J Cereb Blood Flow Metab 17:1182-1190
304. Stamler JS,Hausladen A (1998)Oxidative modifications in nitrosative stress. Nat Struct Biol 5:247-249
305. Stamler JS, Simon DI, Osborne JA, et al. (1992) S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. ProcNatlAcad Sci USA 89:444-448
306. Stauss HM, Godecke A, Mrowka R, et al. (1999) Enhanced blood pressure variability in eNOS knock-out mice. Hypertension 33:1359-1363
307. Stauss HM, Nafz B, Mrowka R, et al. (2000) Blood pressure control in eNOS knock-out mice: comparison with other species under NO blockade. Acta Physiol Scand 168:155-160
308. Stemerman MB (1981) Vascular injury: platelets and smooth muscle cell response. Philos Trans R Soc Lond B Biol Sci 294:217-224
309. Stroes E, Kastelein J, Cosentino F, et al. (1997) Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J Clin Invest 99:41-46
310. Stuehr D, Pou S, Rosen GM (2001) Oxygen reduction by nitric oxide synthases. J Biol Chem 276:14533-14536
311. Sun D, Huang A, Smith CJ, et al. (1999) Enhanced release of prostaglandins contributes to flow-induced arteriolar dilation in eNOS knockout mice. Circ Res 85:288-293
312. Sun J, Liao JK (2002) Functional interaction of endothelial nitric oxide synthase with a voltage-dependent anion channel. Proc Natl Acad Sci USA 99:13108-13113
313. Taddei S, Virdis A, Mattei P, et al. (1996) Defective l-arginine-nitric oxide pathway in offspring of essential hypertensive patients. Circulation 94:1298-1303
314. Tai SC, Robb GB,Marsden PA (2004) Endothelial nitric oxide synthase: a new paradigm for gene regulation in the injured blood vessel. Arterioscler Thromb Vasc Biol 24:405-412
315. Tiefenbacher CP, Chilian WM, Mitchell M, et al. (1996) Restoration of endothelium-dependent vasodilation after reperfusion injury by tetrahydrobiopterin. Circulation 94:1423-1429
316. Ting HH, Timimi FK, Boles KS, et al. (1996) Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 97:22-28
317. Tracy RP (2002) Diabetes and atherothrombotic disease: linked through inflammation? Semin Vasc Med 2:67-73
318. TrovatiM,Massucco P,Mattiello L, et al. (1996) The insulin-induced increase of guanosine- 3′,5′-cyclic monophosphate in human platelets is mediated by nitric oxide. Diabetes 45:768-770
319. Turrens JF (2003) Mitochondrial formation of reactive oxygen species. J Physiol 552:335-344
320. Uematsu M, Ohara Y, Navas JP, et al. (1995) Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am J Physiol 269:C1371-C1378
321. Uwabo J, Soma M, Nakayama T, et al. (1998) Association of a variable number of tandem repeats in the endothelial constitutive nitric oxide synthase gene with essential hypertension in Japanese. Am J Hypertens 11:125-128
322. Vallance P, Moncada S (1993) Role of endogenous nitric oxide in septic shock. New Horiz 1:77-86
323. Vallance P, Collier J, Moncada S (1989) Nitric oxide synthesized from l-arginine mediates endothelium-dependent dilatation in human veins in vivo. Cardiovasc Res 23:1053-1057
324. Vallance P, Leone A, Calver A, et al. (1992) Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339:572-575
325. van der Zee R,Murohara T, Luo Z, et al. (1997) Vascular endothelial growth factor/vascular permeability factor augments nitric oxide release from quiescent rabbit and human vascular endothelium. Circulation 95:1030-1037
326. van Geel PP, Pinto YM, Buikema H, et al. (1998) Is the A1166C polymorphism of the angiotensin II type 1 receptor involved in cardiovascular disease? Eur Heart J 19:G13-G17
327. Varenne O, Pislaru S, Gillijns H, et al. (1998) Local adenovirus-mediated transfer of human endothelial nitric oxide synthase reduces luminal narrowing after coronary angioplasty in pigs. Circulation 98:919-926
328. Vasquez-Vivar J, Kalyanaraman B, Martasek P, et al. (1998) Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci USA 95:9220-9225
329. Venema RC, Venema VJ, Ju H, et al. (2003) Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase. Am J Physiol 285:H669-H678
330. Viner RI,Williams TD, Schoneich C (1999) Peroxynitrite modification of protein thiols: oxidation, nitrosylation, and S-glutathiolation of functionally important cysteine residue(s) in the sarcoplasmic reticulum Ca-ATPase. Biochemistry 38:12408-12415
331. Virdis A, Schiffrin EL (2003) Vascular inflammation: a role in vascular disease in hypertension? Curr Opin Nephrol Hypertens 12:181-187
332. Vodovotz Y, Chesler L, Chong H, et al. (1999) Regulation of transforming growth factor β1 by nitric oxide. Cancer Res 59:2142-2149
333. von der Leyen HE, Dzau VJ (2001) Therapeutic potential of nitric oxide synthase gene manipulation. Circulation 103:2760-2765
334. Vouldoukis I, Riveros-Moreno V, Dugas B, et al. (1995) The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen. Proc Natl Acad Sci USA 92:7804-7808
335. Wagner AH, Kohler T, Ruckschloss U, et al. (2000a) Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol 20:61-69
336. Wagner C, Godecke A, FordM, et al. (2000b) Regulation of renin gene expression in kidneys of eNOS- and nNOS-deficient mice. Pflugers Arch 439:567-572
337. Walker G, Pfeilshifter J, Kunz D (1997) Mechanisms of suppression of inducible nitric oxide synthase (iNOS) expression in interferon (IFN)-γ-stimulated RAW 264.7 cells by dexamethasone. Evidence for glucocorticoid-induced degradation of iNOS protein by calpain as a key step in post-transcriptional regulation. J Biol Chem 272:16679-16687
338. Wallerath T, Gath I, Aulitzky WE, et al. (1997) Identification of the NO synthase isoforms expressed in human neutrophil granulocytes, megakaryocytes and platelets. Thromb Haemost 77:163-167
339. Wang X, Wang J, Trudinger B (2003) Gene expression of nitric oxide synthase by human umbilical vein endothelial cells: the effect of fetal plasma frompregnancy with umbilical placental vascular disease. Br J Obstet Gynaecol 110:53-58
340. Wang XL, Wang J (2000) Endothelial nitric oxide synthase gene sequence variations and vascular disease. Mol Genet Metab 70:241-251
341. Wattanapitayakul SK,MihmMJ, Young AP, et al. (2001) Therapeutic implications of human endothelial nitric oxide synthase gene polymorphism. Trends Pharmacol Sci 22:361-368
342. Wedgwood S, Mitchell CJ, Fineman JR, et al. (2003) Developmental differences in the shear stress-induced expression of endothelial NO synthase: changing role of AP-1. Am J Physiol Lung Cell Mol Physiol 284:L650-L662
343. Wei CC, Wang ZQ, Meade AL, et al. (2002) Why do nitric oxide synthases use tetrahydrobiopterin? J Inorg Biochem 91:6618-6624
344. Weiner CP, Lizasoain I, Baylis SA, et al. (1994) Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc Natl Acad Sci USA 91:5212-5216
345. Werner ER, Gorren AC, Heller R, et al. (2003) Tetrahydrobiopterin and nitric oxide: mechanistic and pharmacological aspects. Exp Biol Med 228:1291-1302
346. White KA, Marletta MA (1992) Nitric oxide synthase is a cytochrome P-450 type hemoprotein. Biochemistry 31:6627-6631
347. Whittle BJR (1997) Nitric oxide-a mediator of inflammation or mucosal defence. Eur J Gastroenterol Hepatol 9:1026-1032
348. Wilcox JN, Subramanian RR, Sundell CL, et al. (1997) Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels. Arterioscler Thromb Vasc Biol 17:2479-2488
349. Xie QW, Cho HJ, Calaycay J, et al. (1992) Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256:225-228
350. Xu HL, Galea E, Santizo RA, et al. (2001) The key role of caveolin-1 in estrogen-mediated regulation of endothelial nitric oxide synthase function in cerebral arterioles in vivo. J Cereb Blood Flow Metab 21:907-913
351. Xu KY, Huso DL, Dawson TM, et al. (1999) Nitric oxide synthase in cardiac sarcoplasmic reticulum. Proc Natl Acad Sci USA 96:657-662
352. Xu L, Eu JP, Meissner G, et al. (1998) Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation. Science 279:234-237
353. Yang Y, Loscalzo J (2005) S-nitrosoprotein formation and localization in endothelial cells. Proc Natl Acad Sci USA 102:117-122
354. Yeh DC, Duncan JA, Yamashita S, et al. (1999) Depalmitoylation of endothelial nitric oxide synthase by acyl-protein thioesterase 1 is potentiated by Ca2+-calmodulin. J Biol Chem 274:33148-33154
355. Zabel U, Kleinschnitz C, Oh P, et al. (2002) Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide. Nat Cell Biol 4:307-311
356. Zembowicz A, Tang JL,Wu KK (1995) Transcriptional induction of endothelial nitric oxide synthase type III by lysophosphatidylcholine. J Biol Chem 270:17006-17010
357. Zhang R, Min W, Sessa WC (1995) Functional analysis of the human endothelial nitric oxide synthase promoter. Sp1 and GATA factors are necessary for basal transcription in endothelial cells. J Biol Chem 270:15320-15326
358. Zhao G, Bernstein RD, Hintze TH (1999) Nitric oxide and oxygen utilization: exercise, heart failure and diabetes. Coron Artery Dis 10:315-320
359. Zhao YY, Liu Y, Stan RV, et al. (2002) Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. ProcNatl Acad Sci USA 99:11375-11380
360. Ziche M, Morbidelli L (2000) Nitric oxide and angiogenesis. J Neurooncol 50:139-148
361. Ziche M,Morbidelli L,Masini E, et al. (1994) Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest 94:2036-2044
362. Ziche M, Morbidelli L, Choudhuri R, et al. (1997) Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factorinduced angiogenesis. J Clin Invest 99:2625-2634
363. Ziegler T, Silacci P, Harrison VJ, et al. (1998) Nitric oxide synthase expression in endothelial cells exposed to mechanical forces. Hypertension 32:351-355
364. Zimmermann K, Optiz N, Dedio J, et al. (2002) NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. Proc Natl Acad Sci USA 99:17167-17172