Induction of endothelial NO synthase by hydrogen peroxide via a Ca2+/calmodulin-dependent protein kinase II/janus kinase 2-dependent pathway

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 21, Issue 10, 2001, Pages 1571-1576

  Cai, Hua ^a   Davis, Michael E ^a   Drummond, Grant R ^a   Harrison, David G ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ca2+ calmodulin dependent protein kinase II; Endothelial NO synthase; Gene regulation; Hydrogen peroxide; Janus kinase 2

Indexed keywords

CALMODULIN INHIBITOR; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; HYDROGEN PEROXIDE; JANUS KINASE; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE (CALCIUM,CALMODULIN) II;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOCYTOCHEMISTRY; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0035724654     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/hq1001.097028     Document Type: Article

References (34)

1. Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress
2. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide
3. Signal transduction by reactive oxygen species in nonphagocytic cells
4. Interactions of oxidants with vascular signaling systems
5. Hydrogen peroxide stimulates tyrosine phosphorylation of focal adhesion kinase in vascular endothelial cells
6. Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes
7. 2 on protein tyrosine phosphatase activity in HER14 cells
8. c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1
9. Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species
10. 2
11. Hydrogen peroxide activation of cytosolic phospholipase A2 in vascular smooth muscle cells
12. Hydrogen peroxide elicits activation of bovine pulmonary arterial soluble guanylate cyclase by a mechanism associated with its metabolism by catalase
13. Epidermal growth factor (EGF)-induced generation of hydrogen peroxide: Role in EGF receptor-mediated tyrosine phosphorylation
14. Activation of the JAK-STAT pathway by reactive oxygen species
15. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells
16. Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid
17. Differential roles of Ca(2+)/calmodulin-dependent protein kinase II and mitogen-activated protein kinase activation in hippocampal long-term potentiation
18. Hydrogen peroxide induces intracellular calcium oscillations in human aortic endothelial cells
19. Evidence suggesting that iron and calcium are interrelated in oxidant-induced DNA damage
20. Hydrogen peroxide-induced DNA damage is independent of nuclear calcium but dependent on redox-active ions
21. 2+/calmodulin-dependent protein kinases
22. A working model of CaM kinase II activity in hippocampal long-term potentiation and memory
23. Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress
24. Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma/Janus kinase 2/MEK-1-dependent pathway
25. Fyn and JAK2 mediate Ras activation by reactive oxygen species
26. Herbimycin A suppresses NF-kappa B activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric oxide synthase in C6 glioma cells
27. Possible involvement of Janus kinase Jak2 in interferon-gamma induction of nitric oxide synthase in rat glial cells
28. CaM kinase II: A protein kinase with extraordinary talents germane to insulin exocytosis
29. 2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy
30. CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo
31. In situ hybridization with digoxigenin labeled oligonucleotide probes: Detection of CAMK-II gene expression in primary cultures of cerebral endothelial cells
32. Calcium/calmodulin-stimulated protein kinase II is present in primary cultures of cerebral endothelial cells
33. Thrombin-mediated ET-1 gene regulation involves CaM kinases and calcineurin in human endothelial cells
34. Phospholipase C, protein kinase C, Ca(2+)/calmodulin-dependent protein kinase II, and tyrosine phosphorylation are involved in carbachol-induced phospholipase D activation in Chinese hamster ovary cells expressing muscarinic acetylcholine receptor of Caenorhabditis elegans