Dexamethasone suppresses iNOS gene expression by inhibiting NF-κB in vascular smooth muscle cells

Life Sciences

Volumn 69, Issue 9, 2001, Pages 1067-1077

  Matsumura, Mihoko ^a   Kakishita, Hirobumi ^a   Suzuki, Manabu ^a   Banba, Nobuyuki ^a   Hattori, Yoshiyuki ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Dexamethasone; Nitric oxide synthase; Nuclear factor B; Vascular smooth muscle

Indexed keywords

DACTINOMYCIN; DEXAMETHASONE; GAMMA INTERFERON; I KAPPA B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LUCIFERASE; MESSENGER RNA; MIFEPRISTONE; NITRIC OXIDE SYNTHASE; NITROGEN OXIDE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC TRANSCRIPTION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE FIBER;

ANIMALS; AORTA, THORACIC; CELLS, CULTURED; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; GENE EXPRESSION; GLUCOCORTICOIDS; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MALE; MIFEPRISTONE; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

BACTERIA (MICROORGANISMS);

EID: 0035919647     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01196-1     Document Type: Article

References (31)

1. Nitric oxide as a secretory product of mammalian cells
2. Mammalian nitric oxide synthases
3. Promoter of the mouse gene encoding calcium-independent nitric oxidesynthase confers inducibility by interferon gamma and bacterial lipopolysaccharide
4. Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages
5. Diethyldithiocarbamate inhibits induction of macrophage NO synthase
6. Pyrrolidine dithiocarbamate differentially affects interleukin 1 beta-and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells
7. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase
8. Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B
9. Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells
10. Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide-generation by vascular smooth muscle
11. Overproduction of nitric oxide in cytokine-mediated and septic shock
12. Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo
13. Peripheral vascular actions of glucocorticoids and their relationship to protection in circulatory shock
14. Inhibition of the production of nitric oxide and vasodilator prostaglandins attenuates the cardiovascular response to bacterial endotoxin in adrenalectomized rats
15. Glucocorticoid regulation of nitric oxide andtetrahydrobiopterin in a rat model of endotoxic shock
16. Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis
17. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids
18. Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors
19. The smooth muscle cell in culture
20. Cloning of inducible nitric oxide synthase in rat vascular smooth muscle cells
21. Tumor necrosis factor alpha activates NF-kappaB in acid sphingomyelinase-deficient mouse embryonic fibroblasts
22. Troglitazone upregulates nitric oxide synthesis in vascular smooth muscle cells
23. Cloning and regulation of rat GTP cyclohydrolase gene: Co-ordinate transcriptional induction with iNOS by immunostimulants
24. Glycated serumalbumin-induced nitric oxide production in vascular smooth muscle cells by nuclear factor kappaB-dependent transcriptional activation of inducible nitric oxide synthase
25. Pyrrolidine dithiocarbamate inhibits immunostimulant-induced tetrahydrobiopterin synthesis in rat vascular smooth muscle
26. Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1 beta-stimulated mesangial cells: Evidence for the involvement of transcriptional and posttranscriptional regulation
27. Transforming growth factor-beta 1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1 beta in rat smooth muscle cells
28. Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and L-arginine transport
29. Glucocorticoid regulation of nitric oxide and tetrahydrobiopterin in a rat model of endotoxic shock
30. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor
31. Dexamethasone suppresses iNOS gene expression by upregulating I-kappa B alpha and inhibiting NF-kappa B