Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice

Journal of Clinical Investigation

Volumn 101, Issue 6, 1998, Pages 1225-1232

  Moroi, Masao ^a   Zhang, Lin ^a   Yasuda, Tsunehiro ^a   Virmani, Renu ^b   Gold, Herman K ^a   Fishman, Mark C ^a   Huang, Paul L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

Author keywords

Animal disease models; Atherosclerosis; Transgenic mice; Tunica intima; Vascular endothelium

Indexed keywords

NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; ENZYME DEFECT; FEMALE; GENETIC PREDISPOSITION; MALE; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; SEX DIFFERENCE;

EID: 0032520872     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1293     Document Type: Article

References (25)

1. Mooradian, D.L., T.C. Hutsell, and L.K. Keefer. 1995. Nitric oxide (NO) donor molecules: effect of NO release rate on vascular smooth muscle cell proliferation in vitro. J. Cardiovasc. Pharmacol. 25:674-678.
2. Radomski, M.W., R.M. Palmer, and S. Moncada. 1991. Modulation of platelet aggregation by an L-arginine-nitric oxide pathway. Trends Pharmacol. Sci. 12:87-88.
3. Bath, P.M.W. 1993. The effect of nitric oxide donating vasodilators on monocytic chemotaxis and intracellular cGMP concentrations in vitro. Eur. J. Clin. Pharmacol. 45:53-58.
4. Lefer, A.M. and X. Ma. 1993. Decreased basal nitric oxide release in hypercholesterolemia increases neutrophil adherence to rabbit coronary artery endothelium. Arterioscler. Thromb. 13:771-776.
5. Flavahan, N.A. 1992. Atherosclerosis or lipoprotein induced endothelial dysfunction: potential mechanisms underlying reduction in EDRF/nitric oxide activity. Circulation. 85:1927-1938.
6. Freiman, P.C., G.C. Mitchell, D.D. Heistad, M.L. Armstrong, and D.G. Harrison. 1986. Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates. Circ. Res. 58:783-789.
7. Linder, L., W. Kiowski, F.R. Buhler, and T.F. Luscher. 1990. Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo: blunted response in essential hypertension. Circulation. 81: 1762-1767.
8. King, G.L., T. Shiba, J. Oliver, T. Inoguchi, and S.E. Bursell. 1994. Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus. Ann. Rev. Med. 45:179-188.
9. Celermajer, D.S., K.E. Sorensen, V.M. Gooch, D.J. Spiegelhalter, O.I. Miller, I.D. Sullivan, J.K. Lloyd, and J.E. Deanfield. 1992. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 340:1111-1115.
10. Booth, R.F.G., J.F. Martin, A.C. Honey, D.G. Hassall, J.E. Beesley, and S. Moncada. 1989. Rapid development of atherosclerotic lesions in the rabbit carotid artery induced by perivascular manipulation. Atherosclerosis. 76:257-268.
11. Kockx, M.M., G.R.Y. De Meyer, L.J. Andires, H. Bult, W.A. Jacob, and A.G. Herman. 1993. The endothelium during cuff-induced neointima formation in the rabbit carotid artery. Arterioscler. Thromb. 13:1874-1884.
12. Huang, P.L., Z. Huang, H. Mashimo, K.D. Bloch, M.A. Moskowitz, J.A. Bevan, and M.C. Fishman. 1995. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 377:239-242.
13. Lindner, V., J. Fingerle, and M.A. Reidy. 1993. Mouse model of arterial injury. Circ. Res. 73:792-796.
14. Hansson, G.K., Y.J. Geng, J. Holm, P. Hardhammar, A. Wennmalm, and E. Jennische. 1994. Arterial smooth muscle cells express nitric oxide synthase in response to endothelial injury. J. Exp. Med. 180:733-738.
15. Ferns, G.A.A., A.L. Stewart-Lee, and E.E. Anggard. 1992. Arterial response to mechanical injury: balloon catheter de-endothelialization. Atherosclerosis. 92:89-104.
16. Sullivan, T.R., R.H. Karas, M. Aronovitz, G. Faller, J. Smith, T. O'Donnell, and M.E. Mendelsohn. 1995. Estrogen inhibits the response to injury in a mouse carotid artery model. J. Clin. Invest. 96:2482-2488.
17. Yong, A.C., G. Townley, and G.W. Boyd. 1991. Hemodynamic changes in the Moncada model of atherosclerosis. Clin. Exp. Pharmacol. Physiol. 19: 334-342.
18. Guo, J.P., M.M. Panday. P.M. Consigny, and A.M. Lefer. 1995. Mechanisms of vascular preservation by a novel NO donor following rat carotid artery intimal injury. Am. J. Physiol. 269:H1122-H1131.
19. Gauthier, T.W., R. Scalia, T. Murohara, J.P. Guo, and A.M. Lefer. 1995. Nitric oxide protects against leukocyte-endothelium interactions in the early stages of hypercholesterolemia. Arterioscler. Thromb. Vasc. Biol. 15:1652-1659.
20. Gauthier, T.W., K.L. Davenpeck, and A.M. Lefer. 1994. Nitric oxide attenuates leukocyte-endothelial interaction via P-selectin in splanchnic ischemia-reperfusion. Am. J. Physiol. 267:G562-G568.
21. Davenpeck, K.L., T.W. Gauthier, and A.M. Lefer. 1994. Inhibition of endothelial-derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation. Gastroenterology. 107:1050-1058.
22. De Caterina, R., P. Libby, H.B. Peng, V.J. Thannickal, T.B. Rajavashisth, M.A. Gimbrone, Jr., W.S. Shin, and J.K. Liao. 1995. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokincs. J. Clin. Invest. 96:60-68.
23. Arthur, J.F., Z.L. Yin, H.M. Young, and G.J. Dusting. 1997. Induction of nitric oxide synthase in the neointima induced by a periarterial collar in rabbits. Arterioscler. Thromb. Vasc. Biol. 17:737-740.
24. Akishita, M., Y. Ouchi, H. Miyoshi, K. Kozaki, S. Inoue, M. Ishikawa, M. Eto, K. Toba, and H. Orimo. 1997. Estrogen inhibits cuff-induced intimal thickening of rat femoral artery: effects on migration and proliferation of vascular smooth muscle cells. Atherosclerosis. 130:1-10.
25. Iafrati, M.D., R.H. Karas, M. Aronovitz, S. Kim, T.R. Sullivan, D.B. Lubahn, T.F. O'Donnel, K.S. Korach, and M.E. Mendelsohn. 1997. Estrogen inhibits the vascular injury response in estrogen receptor alpha deficient mice. Nat. Med. 3:545-548.