Defective smooth muscle regulation in cGMP kinase I-deficient mice

EMBO Journal

Volumn 17, Issue 11, 1998, Pages 3045-3051

  Pfeifer, Alexander ^e   Klatt, Peter ^e   Massberg, Steffen ^a   Ny, Lars ^b   Sausbier, Matthias ^e   Hirneiß, Christoph ^e   Wang, Ge Xing ^e   Korth, Michael ^e   Aszódi, Attila ^c,d   Andersson, Karl Erik ^b   Krombach, Fritz ^a   Mayerhofer, Artur ^e   Ruth, Peter ^e   Fässler, Reinhard ^c,d   Hofmann, Franz ^f  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^d LUND UNIVERSITY   (Sweden)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f Inst fur Pharmakol und Toxikologie ^*

Author keywords

Blood pressure; cGMP dependent protein kinase; Gene targeting; Nitric oxide; Regulation of smooth muscle tone

Indexed keywords

CYCLIC AMP; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GASTROINTESTINAL DISEASE; GENE REPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE RELAXATION; VASCULAR DISEASE;

ANIMALS; AORTA, THORACIC; CELL SEPARATION; CULTURE TECHNIQUES; CYCLIC AMP; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; GASTRIC FUNDUS; GASTROINTESTINAL MOTILITY; GENE TARGETING; INTESTINAL MUCOSA; MICE; MICE, KNOCKOUT; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; SIGNAL TRANSDUCTION;

ANIMALIA; MURINAE;

EID: 0032101741     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.11.3045     Document Type: Article

References (40)

1. Burns, A.J., Lomax, A.E.J., Torihashi, S., Sanders, K.M. and Ward, S.M. (1996) Interstitial cells of Cajal mediate inhibitory neurotransmission. Proc. Natl Acad. Sci. USA, 93, 12008-12013.
2. - channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase. EMBO J., 13, 1065-1072.
3. 2+ levels in cultured vascular smooth muscle cells. J. Biol. Chem., 264, 1146-1155.
4. Desai, K.M., Zembowicz, A., Sessa, W.C. and Vane, J.R. (1991) Nitroxergic nerves mediate vagally induced relaxation in the isolated stomach of the guinea pig. Proc. Natl Acad. Sci. USA, 88, 11490-11494.
5. Fässler, R. and Meyer, M. (1995) Consequences of lack of β1 integrin gene expression in mice. Genes Dev., 9, 1896-1908.
6. Felbel, J., Trockur, B., Ecker, T., Landgraf, W. and Hofmann, F. (1988) Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea. J. Biol. Chem., 263, 16764-16771.
7. Fleming, I. and Busse, R. (1995) Control and consequences of endothelial nitric oxide formation. Adv. Pharmacol., 34, 187-206.
8. Francis, S.H. and Corbin, J.D. (1994) Progress in understanding the mechanism and function of cyclic GMP-dependent protein kinase. Adv. Pharmacol., 26, 115-167.
9. Furchgott, R.F. and Zawadzki, J.V. (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288, 373-376.
10. Geiger, J., Nolte, C., Butt, E., Sage, S.O. and Walter, U. (1992) Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets. Proc. Natl Acad. Sci. USA, 89, 1031-1035.
11. Hanks, S.K., Quinn, A.M. and Hunter, T. (1988) The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science, 241, 42-52.
12. Hofmann, F., Dostmann, W., Keilbach, A., Landgraf, W. and Ruth, P. (1992) Structure and physiological role of cGMP-dependent protein kinase. Biochim. Biophys. Acta, 1135, 51-60.
13. Huang, P.L., Huang, Z, Mashimo, H., Bloch, K.D., Moskowitz, M.A., Bevan, J.A. and Fishman, M. (1995) Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature, 377, 239-242.
14. Ignarro, L.J., Buga, G.M., Word, K.S., Byrns, R.E. and Chauduri, G. (1987) Endothelium-derivcd relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl Acad. Sci. USA, 84, 9265-9269.
15. Jarchau, T., Häusler, C., Markert, T., Pöhler, D., Vandekerckhove, J., De Jonge, H.R., Lohmann, S. and Walter, U. (1994) Cloning, expression, and in situ localization of rat intestinal cGMP-dependent protein kinase II. Proc. Natl Acad. Sci. USA, 91, 9426-9430.
16. Jiang, H., Colbran, J.L., Francis, S.H. and Corbin, J.D. (1992) Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries. J. Biol. Chem., 267, 1015-1019.
17. Jin, J.G., Murthy, K.S., Grider, J.R. and Makhlouf, G.M. (1996) Stoichiometry of neurally induced VIP release, NO formation, and relaxation in rabbit and rat gastric muscle. Am. J. Physiol., 271, G357-G369.
18. Keilbach, A., Ruth, P. and Hofmann, F. (1992) Detection of cGMP-dependent protein kinase isozymes by specific antibodies. Eur. J. Biochem., 208, 467-473.
19. Kleppisch, T. and Nelson, M.T. (1995) Adenosine activates ATP-sensitive potassium channels in arterial myocytes via A2 receptors and cAMP-dependent protein kinase. Proc. Natl Acad. Sci. USA, 92, 12441-12445
20. Landgraf, W., Hullin, R., Göbel, C. and Hofmann, F. (1986) Phosphorylation of cGMP-dependent protein kinase increases the affinity for cyclic AMP. Eur. J. Biochem., 154, 113-117.
21. 2+ by cAMP in vascular smooth muscle cells. Am. J. Physiol., 258, C399-C407.
22. Lincoln, T.M., Komalavilas, P. Mac-Millan-Crow, L.A. and Cornwell, T.L. (1995) cGMP signaling through cAMP-and cGMP-dependent protein kinases. Adv. Pharmacol., 34, 305-322.
23. Lohmann, S.M., Vaandrager, A.B., Smolenski, A., Walter, U. and De Jonge, H.R. (1997) Distinct and specific functions of cGMP-dependent protein kinases. Trends Biochem. Sci., 22, 307-312.
24. Murad, F. (1994) Regulation of cytosolic guanylyl cyclase by nitric oxide: the NO-cyclic GMP signal transduction system. Adv. Phannacol., 26, 19-33.
25. 2+ transients and human lower oesophagal sphincter. Br. J. Pharmacol., 116, 2873-2880.
26. Orstavik, S., Natarajan, V., Tasken, K., Jahnsen, T. and Sandberg, M. (1997) Characterization of the human gene encoding the type Iα and type Iβ cGMP-dependent protein kinase (PRKG1). Genomics, 42, 311-318.
27. Palmer, R.M.J., Ferridge, A.G. and Moncada, S. (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature, 327, 524-526.
28. Pfeifer, A., Asztódi, A., Seidler, U., Ruth, P., Hofmann, F. and Fässler, R. (1996) Intestinal secretory defects and dwarfism in mice lacking aGMP-dependent protein kinase II. Science, 274, 2082-2086.
29. Rapoport, R.M., Draznin, M.B. and Murad, F. (1983) Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature, 306, 174-176.
30. 2+ and cAMP messenger system in regulation of airway smooth muscle contraction. Am. J. Physiol., 258, L279-L288.
31. Ruth, P., Wang, G.-X., Boekhoff, I., May, B., Pfeifer, A., Penner, R., Korth, M., Breer, H. and Hofmann, F. (1993) Transfected cGMP-dependent protein kinase suppresses calcium transients by inhibition of inositol 1,4,5-triphosphate production. Proc. Natl Acad. Sci. USA, 90, 2623-2627.
32. Sandberg, M., Natarajan, V., Ronander, I., Kalderon, D., Walter, U., Lohmann, S. and Jahnsen, T. (1989) Molecular cloning and predicted full-length amino acid sequence of the type Iβ isozyme of cGMP-dependent protein kinase from human placenta. FEBS Lett., 255, 321-329.
33. Sanders, K.M. and Ward, S.M. (1992) Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission. Am. J. Physiol., 262, G379-G392.
34. Shesely, E.G., Maeda, N., Kim, H.S., Desai, K.M., Krege, J.H., Laubach, V.E., Sherman, P.A., Sessa, W.C. and Smithies, O. (1996) Elevated blood pressure in mice lacking endothelial nitric oxide synthase. Proc. Natl Acad. Sci. USA, 93, 13176-13181.
35. Smith, J.A., Francis, S.H., Walsh, K.A., Kumar, S. and Corbin, J.D. (1996) Autophosphorylation of type I beta cGMP-dependent protein kinase increases basal catalytic activity and enhances allosteric activation by cGMP or cAMP. J. Biol. Chem., 271, 20756-20762.
36. Somlyo, A.P. (1997) Signal transduction. Rhomantic interludes raise blood pressure. Nature, 389, 908-909.
37. Somlyo, A.P. and Somlyo, A.V. (1994) Signal transduction and regulation in smooth muscle. Nature, 372, 231-236.
38. Uhler, M. (1993) Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain. J. Biol. Chem., 268, 13586-13591.
39. Waldmann, R., Bauer, S., Gobel, C., Hofmann, F., Jakobs, K.H. and Walter, U. (1986) Demonstration of cGMP-dependent protein kinase and cGMP-dependent phosphorylation in cell-free extracts of platelets. Eur. J. Biochem., 158, 203-210.
40. Wernet, W., Flockerzi, V. and Hofmann, F. (1989) The cDNA of the two isoforms of bovine cGMP-dependent protein kinase. FEBS Lett., 251, 191-196.