Mechanisms of suppression of inducible nitric-oxide synthase (iNOS) expression in interferon (IFN)-γ-stimulated RAW 264.7 cells by dexamethasone. Evidence for glucocorticoid-induced degradation of iNOS protein by calpain as a key step in post-transcriptional regulation

Journal of Biological Chemistry

Volumn 272, Issue 26, 1997, Pages 16679-16687

  Walker, Gaby ^a   Pfeilschifter, Josef ^b   Kunz, Dieter ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALPAIN; DEXAMETHASONE; GAMMA INTERFERON; GLUCOCORTICOID; MESSENGER RNA; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ARTICLE; CELL STIMULATION; DNA FLANKING REGION; ENZYME INDUCTION; ENZYME MECHANISM; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC TRANSCRIPTION; IMMUNOPRECIPITATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; CALPAIN; CELL LINE; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTERFERON TYPE II; MICE; NITRIC OXIDE SYNTHASE; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TOSYLLYSINE CHLOROMETHYL KETONE; TRANSCRIPTION, GENETIC;

ANIMALIA; BACTERIA (MICROORGANISMS); MURINAE;

EID: 0030960334     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.26.16679     Document Type: Article

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