Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation: Contribution to alterations of vasomotor tone

Journal of Clinical Investigation

Volumn 97, Issue 8, 1996, Pages 1916-1923

  Rajagopalan, Sanjay ^a   Kurz, Sabine ^a   Münzel, Thomas ^d   Tarpey, Margaret ^c   Freeman, Bruce A ^c   Griendling, Kathy K ^a   Harrison, David G ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ATLANTA VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Angiotensin II; Endothelium; Hypertension; Nitric oxide; Superoxide

Indexed keywords

ANGIOTENSIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BLOOD PRESSURE MONITORING; ENZYME ACTIVATION; HEMODYNAMIC MONITORING; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM;

ACETYLCHOLINE; ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA; ARGININE; BIPHENYL COMPOUNDS; CALCIMYCIN; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME INHIBITORS; HYPERTENSION; IMIDAZOLES; LOSARTAN; MALE; MUSCLE RELAXATION; MUSCLE TONUS; MUSCLE, SMOOTH, VASCULAR; NADH, NADPH OXIDOREDUCTASES; NITRIC OXIDE SYNTHASE; NITROGLYCERIN; NOREPINEPHRINE; OMEGA-N-METHYLARGININE; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; SUPEROXIDES; TETRAZOLES;

EID: 0030005713     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118623     Document Type: Article

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