Role of nNOS in blood pressure regulation in eNOS null mutant mice

Hypertension

Volumn 32, Issue 5, 1998, Pages 856-861

  Kurihara, Nobutaka ^a   Alfie, Marcos E ^a   Sigmon, David H ^a   Rhaleb, Nour Eddine ^a   Shesely, Edward G ^a   Carretero, Oscar A ^a  

^a HENRY FORD HOSPITAL   (United States)

Author keywords

Blood pressure; Nitric oxide; Nitric oxide synthase, endothelial; Nitric oxide synthase, neural

Indexed keywords

7 NITROINDAZOLE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; HETEROZYGOSITY; HOMOZYGOSITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RENOVASCULAR HYPERTENSION;

EID: 0031769706     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.32.5.856     Document Type: Article

References (33)

1. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288: 373-376.
2. Rees DD, Palmer RMJ, Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci U S A. 1989;86:3375-3378.
3. Umans JG, Levi R. Nitric oxide in the regulation of blood flow and arterial pressure. Annu Rev Physiol. 1995;57:771-790.
4. Förstermann U, Closs EI, Pollock JS, Nakane M, Schwarz P, Gath I, Kleinert H. Nitric oxide synthase isozymes: characterization, purification, molecular cloning and functions. Hypertension. 1994;23:1121-1131.
5. Förstermann U, Nakane M, Tracey WR, Pollock JS. Isoforms of nitric oxide synthase: function in the cardiovascular system. Eur Heart J. 1993;14:10-15.
6. Shesely EG, Maeda N, Kim H-S, Desai KM, Krege JH, Laubach VE, Sherman PA, Sessa WC, Smithies O. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1996;93:13176-13181.
7. Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 1995;377:239-242.
8. Zanzinger J, Czachurski J, Seller H. Neuronal nitric oxide reduces sympathetic excitability by modulation of central glutamate effects in pigs. Circ Res. 1997;80:565-571.
9. G-L-arginine methyl ester, dose dependently reduce the threshold for isoflurane anesthesia. Anesthesiology. 1996;85:1111-1119.
10. Kajekar R, Moore PK, Brain SD. Essential role for nitric oxide in neurogenic inflammation in rat cutaneous microcirculation: evidence for an endothelium-independent mechanism. Circ Res. 1995;76:441-447.
11. Ollerstam A, Pittner J, Persson AEG, Thorup C. Increased blood pressure in rats after long-term inhibition of the neuronal isoform of nitric oxide synthase. J Clin Invest. 1997;99:2212-2218.
12. Zagvazdin Y, Sancesario G, Wang YX, Share L, Fitzgerald ME, Reiner A. Evidence from its cardiovascular effects that 7-nitroindazole may inhibit endothelial nitric oxide synthase in vivo. Eur J Pharmacol. 1996; 303:61-69.
13. Krege JH, Hodgin JB, Hagaman JR, Smithies O. A noninvasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension. 1995;25:1111-1115.
14. 2 receptors. Hypertension. 1997;29:483-487.
15. Mitchell JA, Kohlhaas KL, Sorrentino R, Warner TD, Murad F, Vane JR. Induction by endotoxin of nitric oxide synthase in the rat mesentery: lack of effect on action of vasoconstrictors. Br J Pharmacol. 1993;109:265-270.
16. Morrissey JJ, McCracken R, Kaneto H, Vehaskari M, Montani D, Klahr S. Location of an inducible nitric oxide synthase mRNA in the normal kidney. Kidney Int. 1994;45:998-1005.
17. Stoos BA, Carretero OA, Garvin JL. Endothelial-derived nitric oxide inhibits sodium transport by affecting apical membrane channels in cultured collecting duct cells. J Am Soc Nephrol. 1994;4:1855-1860.
18. Szabo C, Southan GJ, Thiemermann C. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci U S A. 1994;91:12472-12476.
19. Baylis C, Qiu C. Importance of nitric oxide in the control of renal hemodynamics. Kidney Int. 1996;49:1727-1731.
20. Vincent SR, Kimura H. Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience. 1992;46:755-784.
21. Egberongbe YI, Gentleman SM, Falkai P, Bongerts B, Polak JM, Roberts GW. The distribution of nitric oxide synthase immunoreactivity in the human brain. Neuroscience. 1994;59:561-578.
22. Ceccatelli S, Lundberg JM, Zhang X, Åman K, Hökfelt T. Immunohistochemical demonstration of nitric oxide synthase in the peripheral autonomie nervous system. Brain Res. 1994;656:381-395.
23. G-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo: a role for nitric oxide in the central regulation of sympathetic tone? Circ Res. 1992;70:607-611.
24. Ma S, Abboud FM, Felder RB. Effect of L-arginine-derived nitric oxide synthesis on neuronal activity in nucleus tractus solitarius. Am J Physiol. 1995;268:R487-R491.
25. Kumagai K, Suzuki H, Ichikawa M, Jimbo M, Murakami M, Ryuzaki M, Saruta T. Nitric oxide increases renal blood flow by interacting with the sympathetic nervous system. Hypertension. 1994;24:220-226.
26. Hakim MA, Hirooka Y, Coleman MJ, Bennett MR, Dampney RAL. Evidence for a critical role of nitric oxide in the tonic excitation of rabbit renal sympathetic preganglionic neurones. J Physiol. 1995;482:401-407.
27. Zanzinger J, Czachurski J, Seller H. Inhibition of basal and reflex-mediated sympathetic activity in the RVLM by nitric oxide. Am J Physiol. 1995;268:R958-R962.
28. Liu J-L, Murakami H, Zucker IH. Effects of NO on baroreflex control of heart rate and renal nerve activity in conscious rabbits. Am J Physiol. 1996;270:R1361-R1370.
29. Hansen J, Jacobsen TN, Victor RG. Is nitric oxide involved in the tonic inhibition of central sympathetic outflow in humans? Hypertension. 1994; 24:439-444.
30. Bult H, Boeckxstaens GE, Pelckmans PA, Jordaens FH, Van Maercke YM, Herman AG. Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter. Nature. 1990;345:346-347.
31. Li CG, Rand MJ. Evidence that part of the NANC relaxant response of guinea-pig trachea to electrical field stimulation is mediated by nitric oxide. Br J Pharmacol 1991;102:91-94.
32. Zagvazdin Y, Sancesario G, Fitzgerald MEC, Reiner A. The effect of 7-nitroindazole, an inhibitor of brain nitric oxide synthase (NOS), on basal cortical blood flow and on vasodilation induced by whisker stimulation. Abstr Soc Neurosci. 1994;2:999. Abstract.
33. Bland-Ward PA, Moore PK. 7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase. Life Sci. 1995;57:131-135.