Estradiol increases rat aorta endothelium-derived relaxing factor (EDRF) activity without changes in endothelial NO synthase gene expression: Possible role of decreased endothelium-derived superoxide anion production

Cardiovascular Research

Volumn 41, Issue 3, 1999, Pages 672-681

  Barbacanne, M A ^a   Rami, J ^a   Michel, J B ^b   Souchard, J P ^c   Philippe, M ^b   Besombes, J P ^a   Bayard, F ^a   Arnal, J F ^a  

^a CHU RANGUEIL   (France)

^b BICHAT HOSPITAL   (France)

^c Univ P S   (France)

Author keywords

Endothelial cell; Estrogens; Nitric oxide synthase; Superoxide anion

Indexed keywords

ENDOTHELIUM DERIVED RELAXING FACTOR; ESTRADIOL; MESSENGER RNA; NITRIC OXIDE SYNTHASE; SUPEROXIDE;

ANIMAL CELL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTERY ENDOTHELIUM; ARTICLE; CATTLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HORMONE ACTION; NONHUMAN; PRIORITY JOURNAL; RAT; UTERUS WEIGHT; VASODILATATION;

ANIMALS; AORTA, THORACIC; BLOTTING, WESTERN; CHEMILUMINESCENT MEASUREMENTS; ENDOTHELIUM, VASCULAR; ESTRADIOL; FEMALE; NITRATES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPEROXIDES;

EID: 0033030358     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(98)00254-5     Document Type: Article

References (57)

1. Lobo R.A., Speroff L. International consensus conference on postmenopausal therapy and the cardiovascular system. Fertil Steril. 61:1994;592-595.
2. Stampfer M., Grodstein F. Cardioprotective effect of hormone replacement therapy is not due to a selection bias. Br Med J. 309:1994;808-809.
3. Gilligan D.M., Quyyumi A.A., Cannon R.O., Johnson G.B., Schenke W.H. Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women. Circulation. 89:1994;2545-2551.
4. Hough I.L., Zilversmit D.B. Effect of 17β-estradiol on aortic cholesterol content and metabolism in cholesterol-fed rabbits. Arteriosclerosis. 6:1986;57-63.
5. Adams M.R., Kaplan J.R., Manuck S.B.et al. Inhibition of coronary artery atherosclerosis by 17β-estradiol in ovariectomized monkeys. Lack of an effect of added progesterone. Arteriosclerosis. 10:1990;1051-1057.
6. Wagner J.D., Clarkson T.B., St Clair R.W.et al. Estrogen and progesterone replacement therapy reduces LDL accumulation in the coronary arteries of surgically postmenopausal cynomolgus monkeys. J Clin Invest. 88:1991;1995-2002.
7. Furchgott R.F., Vanhoutte P.M. Endothelium-derived relaxing and contracting factors. FASEB J. 3:1989;2007-2018.
8. Ignarro L.J. Endothelium-derived nitric oxide: actions and properties. FASEB J. 3:1989;31-36.
9. Moncada S., Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 329:1993;2002-2012.
10. Förstermann U., Closs E.I., Pollock J.S.et al. Nitric oxide synthase isozymes. Characterisation, purification, molecular cloning, and functions. Hypertension. 23:1994;1121-1131.
11. Nathan C., Xie Q.W. Regulation of biosynthesis of nitric oxide. J Biol Chem. 269:1994;13725-13728.
12. Nishida K., Harrison D.G., Navas J.P.et al. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest. 90:1992;2092-2096.
13. Nadaud S., Philippe M., Arnal J.F., Michel J.B., Soubrier F. Sustained induction of aortic endothelial nitric oxide synthase expression in vivo in a model of chronic high flow. Circ Res. 79:1996;857-863.
14. Gryglewski R.J., Palmer R.M.J., Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature. 320:1986;454-456.
15. Rubanyi G.M., Vanhoutte P.M. Superoxide anion and hyperoxia inactivate endothelium-derived relaxing factor. Am. J. Physiol. 250:1986;H822-H827.
16. Gisclard V., Miller V.M., Vanhoutte P. Effect of 17β-estradiol on endothelium-dependent responses in the rabbit. J Pharmacol Exp Ther. 244:1988;19-22.
17. Bell D.R., Rensberger H.J., Koritnik D.R., Koshy A. Estrogen pretreatment directly potentiates endothelium-dependent vasorelaxation of porcine coronary arteries. Am J Physiol. 37:1995;H377-H383.
18. Hayashi T., Fukuto J.M., Ignarro L.J., Chaudhuri G. Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis. Proc Natl Acad Sci USA. 89:1992;11259-11263.
19. Keaney J.F., Shwaery G.T., Xu A.M.et al. 17beta-Estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine. Circulation. 89:1994;2251-2259.
20. Williams J.K., Honore E.K., Washburn S.A., Clarkson T.B. Effects of hormone replacement therapy on reactivity of atherosclerotic coronary arteries in cynomolgus monkeys. J Am Coll Cardiol. 24:1994;1757-1761.
21. Weiner C.P., Lizasoain I., Baylis S.A.et al. Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc Natl Acad Sci USA. 91:1994;5212-5216.
22. Goetz R., Morano I., Calovini T., Studer R., Holtz J. Increased expression of endothelial constitutive nitric oxide synthase in rat aorta during pregnancy. Biochem Biophys Res Commun. 205:1994;905-910.
23. Arnal J.F., Clamens S., Pechet C.et al. Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production. Proc Natl Acad Sci USA. 93:1996;4108-4113.
24. Gospodarovicz D., Moran J., Braun D., Birdwell C.R. Clonal growth of bovine endothelial cells in tissue culture: Fibroblast growth factor as a survival agent. Proc Natl Acad Sci USA. 73:1976;4120-4124.
25. Arnal J.-F., Yamin J., Dockery S., Harrison D.G. Regulation of endothelial nitric oxide synthase mRNA protein and activity during cell growth. Am. J. Physiol. 267:1994;C1381-C1388.
26. Bayard F, Clamens S, Delsol G, et al. Oestrogen synthesis, oestrogen metabolism and functional oestrogen receptors in bovine aortic endothelial cells. In: Non-reproductive actions of sex steroids. Ciba Symposium Foundation. Chichester: Wiley, 1995:122-138.
27. Omar H.A., Cherry P.D., Mortelliti M.P., Burke-Wolin T., Wolin M.S. Inhibition of coronary artery superoxide dismutase attenuates endothelium-dependent and -independent nitrovasodilator relaxation. Circ Res. 69:1991;601-608.
28. Ohara Y., Peterson T.E., Harrison D.G. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest. 91:1993;2546-2551.
29. Halliwell B, Gutteridge JMC. Detection of hydroxyl radicals in biological systems. In: Halliwell B, Gutteridge JMC, editors. Free radicals in biology and medicine, second ed. Oxford: Clarendon Press, 1989:47-53.
30. Mason RP, Morehouse KM. Spin trapping - the ideal method for measuring oxygen radical formation? In: Rice-Evans C, Halliwell B, editors. Free radicals: methodology and concepts. London: Richelieu, 1994:157-168.
31. Finkelstein E., Rosen G.M., Rauckman E.J., Paxton J. Spin trapping of superoxide. Mol Pharmacol. 16:1979;676-685.
32. Weiner C.P., Martinez E., Zhu L.K., Ghodsi A., Chestnut D. In vitro release of endothelium-derived relaxing factor by acetylcholine is increased during guinea pig pregnancy. Am J Obstet Gynecol. 161:1989;1599-1605.
33. Conrad K.P., Jaffe G.M., Kruszyna H.et al. Identification of increased nitric oxide biosynthesis during pregnancy in rats. FASEB J. 7:1993;566-571.
34. Magness R.R., Rosenfeld C.R., Hassan A., Shaul P.W. Endothelial vasodilator production by uterine and systemic arteries. I. Effects of ANG II on PGI2 and NO in pregnancy. Am J Physiol. 265:1996;E690-E698.
35. Nelson S.H., Steinsland O.S., Jonhson R.L.et al. Pregnancy-induced alterations of neurogenic constriction and dilation of human uterine artery. Am J Physiol. 268:1995;H1694-H1701.
36. Xu D.L., Martin P.Y., St John J.et al. Upregulation of endothelial and neuronal constitutive nitric oxide synthase in pregnant rats. Am J Physiol. 271:1996;R1739-R1745.
37. Marsden P.A., Heng H.H., Scherer S.W.et al. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem. 268:1993;7478-7488.
38. Venema R.C., Nishida K., Alexander R.W., Harrison D.G., Murphy T.J. Organization of the bovine gene encoding the endothelial nitric oxide synthase. Biochim Biophys Acta. 1218:1994;413-420.
39. Sayegh H, Ohara Y, Navas JP, et al. Estradiol does not regulate endothelial nitric oxide synthase gene expression. Circulation 1993;88:I-80.
40. Kleinert H., Wallerath T., Euchenhofer C.et al. Estrogens increase transcription of the human endothelial NO synthase gene. Analysis of the transcription factors involved. Hypertension. 31:1998;582-588.
41. Dong Y.L., Gangula P.R.R., Yallampalli C. Nitric oxide synthase isoforms in the rat uterus: differential regulation during pregnancy and labor. J Reprod Fertil. 107:1996;249-254.
42. Rosen G.M., Freeman B.A. Detection of superoxide generated by endothelial cells. Proc Natl Acad Sci USA. 81:1984;7269-7273.
43. Mohazzab H.K., Kaminski P., Wolin M. NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium. Am J Physiol. 266:1994;H2568-H2572.
44. Pagano P.J., Tornheim K., Cohen R.A. Superoxide anion production by rabbit thoracic aorta: effect of endothelium-derived nitric oxide. Am J Physiol. 265:1993;H707-H712.
45. Liochev S.I., Fridovich I. Lucigenin luminescence as a measure of intracellular superoxide dismutase activity in Escherichia coli. Proc Natl Acad Sci USA. 94:1997;2891-2896.
46. Liochev S.I., Fridovich I. Lucigenin (bis-N-methylacridinium) as a mediator of superoxide anion production. Arch Biochem Biophys. 337:1997;115-120.
47. Vasquez-Vivar J., Hogg N., Pritchard K.A. Jr., Martasek P., Kalyanaraman B. Superoxide anion formation from lucigenin: an electron spin resonance spin-trapping study. FEBS Lett. 403:1997;127-130.
48. Rajagopalan S., Kurz S., Münzel T.et al. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. J Clin Invest. 97:1996;1916-1923.
49. Brandes R.P., Barton M., Philippens K.M.H., Schweitzer G., Mügge A. Endothelium-derived superoxide anions in pig coronary arteries: evidence from lucigenin chemiluminescence and histochemical techniques. J Physiol. 500:1997;331-342.
50. Kooy N.W., Royall J.A. Agonist-induced peroxynitrite production from endothelial cells. Arch Biochem Biophys. 310:1994;352-359.
51. De Caterina R., Libby P., Peng H.-B.et al. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest. 96:1995;60-68.
52. Zeiher A., Fisslthaler B., Schray-Utz B., Busse R. Nitric oxide modulates the expression of monocytes chemoattractant protein 1 in cultured human endothelial cells. Circ Res. 76:1995;980-986.
53. Steinbrecher U.P. Role of superoxide in endothelial-cell modification of low-density lipoproteins. Biochim Biophys Acta. 959:1988;20-30.
54. Steinberg D., Parthasarathy S., Carew T.E., Khoo J.C., Witztum J.L. Beyond cholesterol: modification of low-density lipoproteins that increase its atherogenecity. N Engl J Med. 320:1989;915-924.
55. Sack M.N., Rader D.J., Cannon R.O. Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women. Lancet. 343:1994;269-270.
56. White C.R., Brock T.A., Chang L.Y.et al. Superoxide and peroxynitrite in atherosclerosis. Proc Natl Acad Sci USA. 91:1994;1044-1048.
57. Beckman J.S., Koppenol W.H. Nitric oxide, superoxide, and peroxynitrate: the good, the bad, and the ugly. Am J Physiol. 271:1996;C1424-C1437.